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P22091

- TAL1_MOUSE

UniProt

P22091 - TAL1_MOUSE

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Protein

T-cell acute lymphocytic leukemia protein 1 homolog

Gene
Tal1, Scl, Tal-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.1 Publication

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. E-box binding Source: MGI
  3. protein binding Source: UniProtKB
  4. protein heterodimerization activity Source: MGI
  5. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  8. transcription regulatory region DNA binding Source: BHF-UCL
  9. transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. astrocyte fate commitment Source: MGI
  3. basophil differentiation Source: Ensembl
  4. cell fate commitment Source: MGI
  5. definitive hemopoiesis Source: MGI
  6. embryonic hemopoiesis Source: UniProtKB
  7. erythrocyte differentiation Source: MGI
  8. erythrocyte maturation Source: MGI
  9. generation of neurons Source: MGI
  10. hemangioblast cell differentiation Source: MGI
  11. hematopoietic stem cell differentiation Source: MGI
  12. hemopoiesis Source: MGI
  13. locomotory behavior Source: MGI
  14. megakaryocyte development Source: MGI
  15. megakaryocyte differentiation Source: MGI
  16. myeloid cell differentiation Source: MGI
  17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  18. neuron differentiation Source: MGI
  19. platelet formation Source: MGI
  20. positive regulation of cell division Source: Ensembl
  21. positive regulation of chromatin assembly or disassembly Source: Ensembl
  22. positive regulation of erythrocyte differentiation Source: BHF-UCL
  23. positive regulation of mitotic cell cycle Source: Ensembl
  24. positive regulation of protein complex assembly Source: Ensembl
  25. positive regulation of transcription, DNA-templated Source: UniProtKB
  26. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  27. regulation of cell proliferation Source: MGI
  28. regulation of mast cell differentiation Source: MGI
  29. regulation of myeloid cell differentiation Source: MGI
  30. regulation of stem cell maintenance Source: MGI
  31. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. spinal cord association neuron differentiation Source: MGI
  33. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1 homolog
Short name:
TAL-1
Alternative name(s):
Stem cell protein
Gene namesi
Name:Tal1
Synonyms:Scl, Tal-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:98480. Tal1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. histone deacetylase complex Source: Ensembl
  2. Lsd1/2 complex Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. nucleus Source: UniProtKB
  5. protein complex Source: UniProtKB
  6. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Involved in chromosomal translocation in leukemic stem-cells.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221S → A: Remains stable, even in the face of severe hypoxia. 1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329T-cell acute lymphocytic leukemia protein 1 homologPRO_0000127455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221Phosphoserine; by MAPK1 Publication

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia.1 Publication
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP22091.
PRIDEiP22091.

PTM databases

PhosphoSiteiP22091.

Expressioni

Tissue specificityi

Erythroid and myeloid cells.

Gene expression databases

ArrayExpressiP22091.
BgeeiP22091.
CleanExiMM_TAL1.
GenevestigatoriP22091.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cbfa2t3O549723EBI-8006437,EBI-8006703
Ldb1P706623EBI-8006437,EBI-6272082
Tcf12Q612862EBI-8006437,EBI-8006499
Tcf3P158064EBI-8006437,EBI-81370

Protein-protein interaction databases

BioGridi203962. 11 interactions.
DIPiDIP-42839N.
IntActiP22091. 18 interactions.
MINTiMINT-2567683.
STRINGi10090.ENSMUSP00000030489.

Structurei

3D structure databases

ProteinModelPortaliP22091.
SMRiP22091. Positions 182-248.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 23953bHLHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 27210Poly-Gly

Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG307510.
HOGENOMiHOG000113414.
HOVERGENiHBG005018.
InParanoidiP22091.
KOiK09068.
OMAiEGSQRAK.
OrthoDBiEOG7SN8DF.
PhylomeDBiP22091.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22091-1 [UniParc]FASTAAdd to Basket

« Hide

MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP    50
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA 100
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG 150
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ 200
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 250
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 300
SYTEEPTPKH TSRSLHPALL PAADGAGPR 329
Length:329
Mass (Da):34,279
Last modified:August 1, 1991 - v1
Checksum:i189480B6B93CB371
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59764 mRNA. Translation: AAA40097.1.
U01530 Genomic DNA. Translation: AAA86937.1.
BC063060 mRNA. Translation: AAH63060.1.
CCDSiCCDS18486.1.
PIRiA37864.
RefSeqiNP_001274317.1. NM_001287388.1.
NP_035657.1. NM_011527.3.
XP_006502973.1. XM_006502910.1.
XP_006502975.1. XM_006502912.1.
XP_006502976.1. XM_006502913.1.
XP_006502977.1. XM_006502914.1.
XP_006502978.1. XM_006502915.1.
XP_006502979.1. XM_006502916.1.
UniGeneiMm.439685.

Genome annotation databases

EnsembliENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717.
ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717.
ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717.
GeneIDi21349.
KEGGimmu:21349.
UCSCiuc008uek.1. mouse.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59764 mRNA. Translation: AAA40097.1 .
U01530 Genomic DNA. Translation: AAA86937.1 .
BC063060 mRNA. Translation: AAH63060.1 .
CCDSi CCDS18486.1.
PIRi A37864.
RefSeqi NP_001274317.1. NM_001287388.1.
NP_035657.1. NM_011527.3.
XP_006502973.1. XM_006502910.1.
XP_006502975.1. XM_006502912.1.
XP_006502976.1. XM_006502913.1.
XP_006502977.1. XM_006502914.1.
XP_006502978.1. XM_006502915.1.
XP_006502979.1. XM_006502916.1.
UniGenei Mm.439685.

3D structure databases

ProteinModelPortali P22091.
SMRi P22091. Positions 182-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203962. 11 interactions.
DIPi DIP-42839N.
IntActi P22091. 18 interactions.
MINTi MINT-2567683.
STRINGi 10090.ENSMUSP00000030489.

PTM databases

PhosphoSitei P22091.

Proteomic databases

PaxDbi P22091.
PRIDEi P22091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030489 ; ENSMUSP00000030489 ; ENSMUSG00000028717 .
ENSMUST00000161601 ; ENSMUSP00000125202 ; ENSMUSG00000028717 .
ENSMUST00000162489 ; ENSMUSP00000124983 ; ENSMUSG00000028717 .
GeneIDi 21349.
KEGGi mmu:21349.
UCSCi uc008uek.1. mouse.

Organism-specific databases

CTDi 6886.
MGIi MGI:98480. Tal1.

Phylogenomic databases

eggNOGi NOG307510.
HOGENOMi HOG000113414.
HOVERGENi HBG005018.
InParanoidi P22091.
KOi K09068.
OMAi EGSQRAK.
OrthoDBi EOG7SN8DF.
PhylomeDBi P22091.
TreeFami TF315153.

Miscellaneous databases

NextBioi 300536.
PROi P22091.
SOURCEi Search...

Gene expression databases

ArrayExpressi P22091.
Bgeei P22091.
CleanExi MM_TAL1.
Genevestigatori P22091.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL."
    Begley C.G., Visvader J., Green A.R., Aplan P.D., Metcalf D., Kirsch I.R., Gough N.M.
    Proc. Natl. Acad. Sci. U.S.A. 88:869-873(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation."
    Visvader J.E., Mao X., Fujiwara Y., Hahm K., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 94:13707-13712(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LMO2, IDENTIFICATION IN A COMPLEX WITH LDB1 AND LMO2, SUBCELLULAR LOCATION.
  4. "Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells."
    Tang T., Arbiser J.L., Brandt S.J.
    J. Biol. Chem. 277:18365-18372(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-122, MUTAGENESIS OF SER-122, UBIQUITINATION.
  5. "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis."
    Goardon N., Lambert J.A., Rodriguez P., Nissaire P., Herblot S., Thibault P., Dumenil D., Strouboulis J., Romeo P.-H., Hoang T.
    EMBO J. 25:357-366(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.

Entry informationi

Entry nameiTAL1_MOUSE
AccessioniPrimary (citable) accession number: P22091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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