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Protein

T-cell acute lymphocytic leukemia protein 1 homolog

Gene

Tal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • E-box binding Source: MGI
  • enzyme binding Source: MGI
  • histone deacetylase binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  • RNA polymerase II transcription factor binding Source: MGI
  • sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  • sequence-specific DNA binding transcription factor activity Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL
  • transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  • angiogenesis Source: MGI
  • astrocyte fate commitment Source: MGI
  • basophil differentiation Source: Ensembl
  • cell fate commitment Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic hemopoiesis Source: UniProtKB
  • erythrocyte differentiation Source: MGI
  • erythrocyte maturation Source: MGI
  • generation of neurons Source: MGI
  • hemangioblast cell differentiation Source: MGI
  • hematopoietic stem cell differentiation Source: MGI
  • hemopoiesis Source: MGI
  • locomotory behavior Source: MGI
  • megakaryocyte development Source: MGI
  • megakaryocyte differentiation Source: MGI
  • myeloid cell differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron differentiation Source: MGI
  • platelet formation Source: MGI
  • positive regulation of cell division Source: MGI
  • positive regulation of chromatin assembly or disassembly Source: MGI
  • positive regulation of erythrocyte differentiation Source: BHF-UCL
  • positive regulation of mitotic cell cycle Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of mast cell differentiation Source: MGI
  • regulation of myeloid cell differentiation Source: MGI
  • regulation of stem cell maintenance Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • spinal cord association neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1 homolog
Short name:
TAL-1
Alternative name(s):
Stem cell protein
Gene namesi
Name:Tal1
Synonyms:Scl, Tal-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98480. Tal1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • histone deacetylase complex Source: Ensembl
  • Lsd1/2 complex Source: Ensembl
  • nuclear chromatin Source: MGI
  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Involved in chromosomal translocation in leukemic stem-cells.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221S → A: Remains stable, even in the face of severe hypoxia. 1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329T-cell acute lymphocytic leukemia protein 1 homologPRO_0000127455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221Phosphoserine; by MAPK1 Publication

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia.1 Publication
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP22091.
PaxDbiP22091.
PRIDEiP22091.

PTM databases

PhosphoSiteiP22091.

Expressioni

Tissue specificityi

Erythroid and myeloid cells.

Gene expression databases

BgeeiP22091.
CleanExiMM_TAL1.
ExpressionAtlasiP22091. baseline and differential.
GenevisibleiP22091. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cbfa2t3O549723EBI-8006437,EBI-8006703
Ldb1P706623EBI-8006437,EBI-6272082
Tcf12Q612862EBI-8006437,EBI-8006499
Tcf3P158064EBI-8006437,EBI-81370

Protein-protein interaction databases

BioGridi203962. 11 interactions.
DIPiDIP-42839N.
IntActiP22091. 18 interactions.
MINTiMINT-2567683.
STRINGi10090.ENSMUSP00000030489.

Structurei

3D structure databases

ProteinModelPortaliP22091.
SMRiP22091. Positions 182-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 23953bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 27210Poly-Gly

Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG307510.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG005018.
InParanoidiP22091.
KOiK09068.
OMAiVQTTELC.
OrthoDBiEOG7SN8DF.
PhylomeDBiP22091.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP
60 70 80 90 100
VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD
310 320
SYTEEPTPKH TSRSLHPALL PAADGAGPR
Length:329
Mass (Da):34,279
Last modified:August 1, 1991 - v1
Checksum:i189480B6B93CB371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59764 mRNA. Translation: AAA40097.1.
U01530 Genomic DNA. Translation: AAA86937.1.
BC063060 mRNA. Translation: AAH63060.1.
CCDSiCCDS18486.1.
PIRiA37864.
RefSeqiNP_001274317.1. NM_001287388.1.
NP_035657.1. NM_011527.3.
XP_006502973.1. XM_006502910.2.
XP_006502975.1. XM_006502912.2.
XP_006502976.1. XM_006502913.2.
XP_006502977.1. XM_006502914.2.
XP_006502978.1. XM_006502915.2.
XP_006502979.1. XM_006502916.2.
UniGeneiMm.439685.

Genome annotation databases

EnsembliENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717.
ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717.
ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717.
GeneIDi21349.
KEGGimmu:21349.
UCSCiuc008uek.1. mouse.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59764 mRNA. Translation: AAA40097.1.
U01530 Genomic DNA. Translation: AAA86937.1.
BC063060 mRNA. Translation: AAH63060.1.
CCDSiCCDS18486.1.
PIRiA37864.
RefSeqiNP_001274317.1. NM_001287388.1.
NP_035657.1. NM_011527.3.
XP_006502973.1. XM_006502910.2.
XP_006502975.1. XM_006502912.2.
XP_006502976.1. XM_006502913.2.
XP_006502977.1. XM_006502914.2.
XP_006502978.1. XM_006502915.2.
XP_006502979.1. XM_006502916.2.
UniGeneiMm.439685.

3D structure databases

ProteinModelPortaliP22091.
SMRiP22091. Positions 182-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203962. 11 interactions.
DIPiDIP-42839N.
IntActiP22091. 18 interactions.
MINTiMINT-2567683.
STRINGi10090.ENSMUSP00000030489.

PTM databases

PhosphoSiteiP22091.

Proteomic databases

MaxQBiP22091.
PaxDbiP22091.
PRIDEiP22091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717.
ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717.
ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717.
GeneIDi21349.
KEGGimmu:21349.
UCSCiuc008uek.1. mouse.

Organism-specific databases

CTDi6886.
MGIiMGI:98480. Tal1.

Phylogenomic databases

eggNOGiNOG307510.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG005018.
InParanoidiP22091.
KOiK09068.
OMAiVQTTELC.
OrthoDBiEOG7SN8DF.
PhylomeDBiP22091.
TreeFamiTF315153.

Miscellaneous databases

NextBioi300536.
PROiP22091.
SOURCEiSearch...

Gene expression databases

BgeeiP22091.
CleanExiMM_TAL1.
ExpressionAtlasiP22091. baseline and differential.
GenevisibleiP22091. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL."
    Begley C.G., Visvader J., Green A.R., Aplan P.D., Metcalf D., Kirsch I.R., Gough N.M.
    Proc. Natl. Acad. Sci. U.S.A. 88:869-873(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation."
    Visvader J.E., Mao X., Fujiwara Y., Hahm K., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 94:13707-13712(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LMO2, IDENTIFICATION IN A COMPLEX WITH LDB1 AND LMO2, SUBCELLULAR LOCATION.
  4. "Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells."
    Tang T., Arbiser J.L., Brandt S.J.
    J. Biol. Chem. 277:18365-18372(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-122, MUTAGENESIS OF SER-122, UBIQUITINATION.
  5. "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis."
    Goardon N., Lambert J.A., Rodriguez P., Nissaire P., Herblot S., Thibault P., Dumenil D., Strouboulis J., Romeo P.-H., Hoang T.
    EMBO J. 25:357-366(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.

Entry informationi

Entry nameiTAL1_MOUSE
AccessioniPrimary (citable) accession number: P22091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 22, 2015
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.