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P22091

- TAL1_MOUSE

UniProt

P22091 - TAL1_MOUSE

Protein

T-cell acute lymphocytic leukemia protein 1 homolog

Gene

Tal1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. E-box binding Source: MGI
    3. protein binding Source: UniProtKB
    4. protein heterodimerization activity Source: MGI
    5. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
    7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    8. transcription regulatory region DNA binding Source: BHF-UCL
    9. transcription regulatory region sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. astrocyte fate commitment Source: MGI
    3. basophil differentiation Source: Ensembl
    4. cell fate commitment Source: MGI
    5. definitive hemopoiesis Source: MGI
    6. embryonic hemopoiesis Source: UniProtKB
    7. erythrocyte differentiation Source: MGI
    8. erythrocyte maturation Source: MGI
    9. generation of neurons Source: MGI
    10. hemangioblast cell differentiation Source: MGI
    11. hematopoietic stem cell differentiation Source: MGI
    12. hemopoiesis Source: MGI
    13. locomotory behavior Source: MGI
    14. megakaryocyte development Source: MGI
    15. megakaryocyte differentiation Source: MGI
    16. myeloid cell differentiation Source: MGI
    17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    18. neuron differentiation Source: MGI
    19. platelet formation Source: MGI
    20. positive regulation of cell division Source: Ensembl
    21. positive regulation of chromatin assembly or disassembly Source: Ensembl
    22. positive regulation of erythrocyte differentiation Source: BHF-UCL
    23. positive regulation of mitotic cell cycle Source: Ensembl
    24. positive regulation of protein complex assembly Source: Ensembl
    25. positive regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    27. regulation of cell proliferation Source: MGI
    28. regulation of mast cell differentiation Source: MGI
    29. regulation of myeloid cell differentiation Source: MGI
    30. regulation of stem cell maintenance Source: MGI
    31. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    32. spinal cord association neuron differentiation Source: MGI
    33. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1 homolog
    Short name:
    TAL-1
    Alternative name(s):
    Stem cell protein
    Gene namesi
    Name:Tal1
    Synonyms:Scl, Tal-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:98480. Tal1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. histone deacetylase complex Source: Ensembl
    2. Lsd1/2 complex Source: Ensembl
    3. nuclear chromatin Source: Ensembl
    4. nucleus Source: UniProtKB
    5. protein complex Source: UniProtKB
    6. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Involved in chromosomal translocation in leukemic stem-cells.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi122 – 1221S → A: Remains stable, even in the face of severe hypoxia. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329T-cell acute lymphocytic leukemia protein 1 homologPRO_0000127455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Phosphoserine; by MAPK1 Publication

    Post-translational modificationi

    Phosphorylated on serine residues. Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia.1 Publication
    Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP22091.
    PRIDEiP22091.

    PTM databases

    PhosphoSiteiP22091.

    Expressioni

    Tissue specificityi

    Erythroid and myeloid cells.

    Gene expression databases

    ArrayExpressiP22091.
    BgeeiP22091.
    CleanExiMM_TAL1.
    GenevestigatoriP22091.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cbfa2t3O549723EBI-8006437,EBI-8006703
    Ldb1P706623EBI-8006437,EBI-6272082
    Tcf12Q612862EBI-8006437,EBI-8006499
    Tcf3P158064EBI-8006437,EBI-81370

    Protein-protein interaction databases

    BioGridi203962. 11 interactions.
    DIPiDIP-42839N.
    IntActiP22091. 18 interactions.
    MINTiMINT-2567683.
    STRINGi10090.ENSMUSP00000030489.

    Structurei

    3D structure databases

    ProteinModelPortaliP22091.
    SMRiP22091. Positions 182-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 23953bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi263 – 27210Poly-Gly

    Domaini

    The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307510.
    HOGENOMiHOG000113414.
    HOVERGENiHBG005018.
    InParanoidiP22091.
    KOiK09068.
    OMAiEGSQRAK.
    OrthoDBiEOG7SN8DF.
    PhylomeDBiP22091.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP    50
    VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA 100
    PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG 150
    FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ 200
    QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 250
    TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 300
    SYTEEPTPKH TSRSLHPALL PAADGAGPR 329
    Length:329
    Mass (Da):34,279
    Last modified:August 1, 1991 - v1
    Checksum:i189480B6B93CB371
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59764 mRNA. Translation: AAA40097.1.
    U01530 Genomic DNA. Translation: AAA86937.1.
    BC063060 mRNA. Translation: AAH63060.1.
    CCDSiCCDS18486.1.
    PIRiA37864.
    RefSeqiNP_001274317.1. NM_001287388.1.
    NP_035657.1. NM_011527.3.
    XP_006502973.1. XM_006502910.1.
    XP_006502975.1. XM_006502912.1.
    XP_006502976.1. XM_006502913.1.
    XP_006502977.1. XM_006502914.1.
    XP_006502978.1. XM_006502915.1.
    XP_006502979.1. XM_006502916.1.
    UniGeneiMm.439685.

    Genome annotation databases

    EnsembliENSMUST00000030489; ENSMUSP00000030489; ENSMUSG00000028717.
    ENSMUST00000161601; ENSMUSP00000125202; ENSMUSG00000028717.
    ENSMUST00000162489; ENSMUSP00000124983; ENSMUSG00000028717.
    GeneIDi21349.
    KEGGimmu:21349.
    UCSCiuc008uek.1. mouse.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59764 mRNA. Translation: AAA40097.1 .
    U01530 Genomic DNA. Translation: AAA86937.1 .
    BC063060 mRNA. Translation: AAH63060.1 .
    CCDSi CCDS18486.1.
    PIRi A37864.
    RefSeqi NP_001274317.1. NM_001287388.1.
    NP_035657.1. NM_011527.3.
    XP_006502973.1. XM_006502910.1.
    XP_006502975.1. XM_006502912.1.
    XP_006502976.1. XM_006502913.1.
    XP_006502977.1. XM_006502914.1.
    XP_006502978.1. XM_006502915.1.
    XP_006502979.1. XM_006502916.1.
    UniGenei Mm.439685.

    3D structure databases

    ProteinModelPortali P22091.
    SMRi P22091. Positions 182-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203962. 11 interactions.
    DIPi DIP-42839N.
    IntActi P22091. 18 interactions.
    MINTi MINT-2567683.
    STRINGi 10090.ENSMUSP00000030489.

    PTM databases

    PhosphoSitei P22091.

    Proteomic databases

    PaxDbi P22091.
    PRIDEi P22091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030489 ; ENSMUSP00000030489 ; ENSMUSG00000028717 .
    ENSMUST00000161601 ; ENSMUSP00000125202 ; ENSMUSG00000028717 .
    ENSMUST00000162489 ; ENSMUSP00000124983 ; ENSMUSG00000028717 .
    GeneIDi 21349.
    KEGGi mmu:21349.
    UCSCi uc008uek.1. mouse.

    Organism-specific databases

    CTDi 6886.
    MGIi MGI:98480. Tal1.

    Phylogenomic databases

    eggNOGi NOG307510.
    HOGENOMi HOG000113414.
    HOVERGENi HBG005018.
    InParanoidi P22091.
    KOi K09068.
    OMAi EGSQRAK.
    OrthoDBi EOG7SN8DF.
    PhylomeDBi P22091.
    TreeFami TF315153.

    Miscellaneous databases

    NextBioi 300536.
    PROi P22091.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22091.
    Bgeei P22091.
    CleanExi MM_TAL1.
    Genevestigatori P22091.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL."
      Begley C.G., Visvader J., Green A.R., Aplan P.D., Metcalf D., Kirsch I.R., Gough N.M.
      Proc. Natl. Acad. Sci. U.S.A. 88:869-873(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow macrophage.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation."
      Visvader J.E., Mao X., Fujiwara Y., Hahm K., Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A. 94:13707-13712(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LMO2, IDENTIFICATION IN A COMPLEX WITH LDB1 AND LMO2, SUBCELLULAR LOCATION.
    4. "Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells."
      Tang T., Arbiser J.L., Brandt S.J.
      J. Biol. Chem. 277:18365-18372(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-122, MUTAGENESIS OF SER-122, UBIQUITINATION.
    5. "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis."
      Goardon N., Lambert J.A., Rodriguez P., Nissaire P., Herblot S., Thibault P., Dumenil D., Strouboulis J., Romeo P.-H., Hoang T.
      EMBO J. 25:357-366(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBFA2T3.

    Entry informationi

    Entry nameiTAL1_MOUSE
    AccessioniPrimary (citable) accession number: P22091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3