Reviewed, UniProtKB/Swiss-Prot P22090 (RS4Y1_HUMAN)

Names and origin

Protein names

Recommended name:
    40S ribosomal protein S4, Y isoform 1

Gene names

Name:	RPS4Y1
Synonyms:	RPS4Y
ORF Names:	PRO2646

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Miscellaneous	This isoform is encoded on the Y chromosome.
Sequence similarities	Belongs to the ribosomal protein S4e family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from mutant phenotype. Source: UniProtKB translational elongation Inferred from Experiment. Source: Reactome
Cellular component	cytosolic small ribosomal subunit Ref.1 Non-traceable author statement. Source: UniProtKB polysome Inferred from direct assay. Source: UniProtKB
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 263	262	40S ribosomal protein S4, Y isoform 1		PRO_0000130812
Regions
	Domain	42 – 104	63	S4 RNA-binding

Sequences

	Sequence		Length	Mass (Da)
	P22090-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 3B5D6F1ECFCB120A	FASTA	263	29,456
	10 20 30 40 50 60 MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE 70 80 90 100 110 120 VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK 130 140 150 160 170 180 YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL 190 200 210 220 230 240 CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR 250 260 GKGIRLTVAE ERDKRLATKQ SSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome." Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C. Cell 63:1205-1218(1990) [PubMed: 2124517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal liver.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M58459 mRNA. Translation: AAA63256.1. AF041427 Genomic DNA. Translation: AAB96967.1. AF116711 mRNA. Translation: AAF71131.1. AK292819 mRNA. Translation: BAF85508.1. CH471115 Genomic DNA. Translation: EAX02771.1. BC010286 mRNA. Translation: AAH10286.1.
IPI	IPI00302740.
PIR	R3HU4Y. A36338.
RefSeq	NP_000999.1.
UniGene	Hs.282376
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P22090.
PTM databases
PhosphoSite	P22090.
Proteomic databases
PRIDE	P22090.
Genome annotation databases
Ensembl	ENST00000250784; ENSP00000250784; ENSG00000129824; Homo sapiens. [Genome view]
GeneID	6192.
KEGG	hsa:6192.
NMPDR	fig|9606.3.peg.33731.
UCSC	uc004fqi.1. human.
Organism-specific databases
CTD	6192.
GeneCards	GC0YP002769. GC0YP002770.
H-InvDB	HIX0017179. HIX0064539.
HGNC	HGNC:10425. RPS4Y1.
HPA	HPA000857.
MIM	470000. gene.
PharmGKB	PA34840.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG392118.
HOVERGEN	P22090.
InParanoid	P22090.
OMA	RDKRLAT.
OrthoDB	EOG95MQQS.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P22090.
Bgee	P22090.
CleanEx	HS_RPS4Y1.
Genevestigator	P22090.
GermOnline	ENSG00000129824. Homo sapiens.
Family and domain databases
InterPro	IPR005824. KOW. IPR000876. Ribosomal_S4e. IPR013845. Ribosomal_S4e_central. IPR013843. Ribosomal_S4e_N. IPR018199. Ribosomal_S4e_N_CS. IPR002942. S4_RNA_bd. [Graphical view]
PANTHER	PTHR11581. Ribosomal_S4E. 1 hit.
Pfam	PF00467. KOW. 1 hit. PF00900. Ribosomal_S4e. 1 hit. PF08071. RS4NT. 1 hit. PF01479. S4. 1 hit. [Graphical view]
PIRSF	PIRSF002116. Ribosomal_S4. 1 hit.
ProDom	PD002667. Ribosomal_S4e_central. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00363. S4. 1 hit. [Graphical view]
PROSITE	PS00528. RIBOSOMAL_S4E. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

RS4Y1_HUMAN

Accession

Primary (citable) accession number: P22090
Secondary accession number(s): A8K9V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2007
Last modified:	December 15, 2009
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.