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Protein

40S ribosomal protein S4, Y isoform 1

Gene

RPS4Y1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, Y isoform 1
Alternative name(s):
Small ribosomal subunit protein eS41 Publication
Gene namesi
Name:RPS4Y1
Synonyms:RPS4Y
ORF Names:PRO2646
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000129824.15
HGNCiHGNC:10425 RPS4Y1
MIMi470000 gene
neXtProtiNX_P22090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6192
OpenTargetsiENSG00000129824
PharmGKBiPA34840

Polymorphism and mutation databases

BioMutaiRPS4Y1
DMDMi133948

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001308121 – 26340S ribosomal protein S4, Y isoform 1Add BLAST263

Proteomic databases

EPDiP22090
MaxQBiP22090
PaxDbiP22090
PeptideAtlasiP22090
PRIDEiP22090

PTM databases

iPTMnetiP22090
PhosphoSitePlusiP22090
SwissPalmiP22090

Expressioni

Gene expression databases

BgeeiENSG00000129824
CleanExiHS_RPS4Y1
ExpressionAtlasiP22090 baseline and differential
GenevisibleiP22090 HS

Organism-specific databases

HPAiHPA000857

Interactioni

Protein-protein interaction databases

BioGridi112106, 34 interactors
CORUMiP22090
IntActiP22090, 5 interactors
STRINGi9606.ENSP00000250784

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AJ0electron microscopy3.50BE1-263[»]
5FLXelectron microscopy3.90E1-263[»]
ProteinModelPortaliP22090
SMRiP22090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378 Eukaryota
COG1471 LUCA
GeneTreeiENSGT00390000005569
HOGENOMiHOG000231325
HOVERGENiHBG000935
InParanoidiP22090
KOiK02987
OMAiVHKEKHK
OrthoDBiEOG091G0MYF
PhylomeDBiP22090
TreeFamiTF300612

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di2.30.30.30, 1 hit
2.40.50.740, 1 hit
HAMAPiMF_00485 Ribosomal_S4e, 1 hit
InterProiView protein in InterPro
IPR032277 40S_S4_C
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR000876 Ribosomal_S4e
IPR013845 Ribosomal_S4e_central_region
IPR038237 Ribosomal_S4e_central_sf
IPR013843 Ribosomal_S4e_N
IPR018199 Ribosomal_S4e_N_CS
IPR002942 S4_RNA-bd
PANTHERiPTHR11581 PTHR11581, 1 hit
PfamiView protein in Pfam
PF16121 40S_S4_C, 1 hit
PF00467 KOW, 1 hit
PF00900 Ribosomal_S4e, 1 hit
PF08071 RS4NT, 1 hit
PIRSFiPIRSF002116 Ribosomal_S4, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667 Ribosomal_S4e_central, 1 hit
SMARTiView protein in SMART
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS00528 RIBOSOMAL_S4E, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

P22090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR
110 120 130 140 150
LVYDTKGRFA VHRITVEEAK YKLCKVRKIT VGVKGIPHLV THDARTIRYP
160 170 180 190 200
DPVIKVNDTV QIDLGTGKII NFIKFDTGNL CMVIGGANLG RVGVITNRER
210 220 230 240 250
HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR GKGIRLTVAE
260
ERDKRLATKQ SSG
Length:263
Mass (Da):29,456
Last modified:January 23, 2007 - v2
Checksum:i3B5D6F1ECFCB120A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58459 mRNA Translation: AAA63256.1
AF041427 Genomic DNA Translation: AAB96967.1
AF116711 mRNA Translation: AAF71131.1
AK292819 mRNA Translation: BAF85508.1
CH471115 Genomic DNA Translation: EAX02771.1
BC010286 mRNA Translation: AAH10286.1
CCDSiCCDS14773.1
PIRiA36338 R3HU4Y
RefSeqiNP_000999.1, NM_001008.3
UniGeneiHs.282376

Genome annotation databases

EnsembliENST00000250784; ENSP00000250784; ENSG00000129824
GeneIDi6192
KEGGihsa:6192
UCSCiuc004fqi.4 human

Similar proteinsi

Entry informationi

Entry nameiRS4Y1_HUMAN
AccessioniPrimary (citable) accession number: P22090
Secondary accession number(s): A8K9V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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