P22090 (RS4Y1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S4, Y isoform 1

Gene names

Name:	RPS4Y1
Synonyms:	RPS4Y
ORF Names:	PRO2646

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S4e family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome multicellular organismal development Inferred from mutant phenotype PubMed 8358435. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Non-traceable author statement PubMed 8358435. Source: UniProtKB polysome Inferred from direct assay PubMed 8139551. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from mutant phenotype PubMed 8358435. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	40S ribosomal protein S4, Y isoform 1 HAMAP-Rule MF_00485		PRO_0000130812
Regions
	Domain	42 – 104	63	S4 RNA-binding

Sequences

	Sequence		Length	Mass (Da)
	P22090 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 3B5D6F1ECFCB120A	FASTA	263	29,456
	10 20 30 40 50 60 MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE 70 80 90 100 110 120 VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK 130 140 150 160 170 180 YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL 190 200 210 220 230 240 CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR 250 260 GKGIRLTVAE ERDKRLATKQ SSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome." Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C. Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal liver.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M58459 mRNA. Translation: AAA63256.1. AF041427 Genomic DNA. Translation: AAB96967.1. AF116711 mRNA. Translation: AAF71131.1. AK292819 mRNA. Translation: BAF85508.1. CH471115 Genomic DNA. Translation: EAX02771.1. BC010286 mRNA. Translation: AAH10286.1.
IPI	IPI00302740.
PIR	R3HU4Y. A36338.
RefSeq	NP_000999.1. NM_001008.3.
UniGene	Hs.282376.
3D structure databases
ProteinModelPortal	P22090.
ModBase	Search...
Protein-protein interaction databases
IntAct	P22090. 1 interaction.
STRING	9606.ENSP00000250784.
PTM databases
PhosphoSite	P22090.
Polymorphism databases
DMDM	133948.
Proteomic databases
PaxDb	P22090.
PRIDE	P22090.
Protocols and materials databases
DNASU	6192.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000250784; ENSP00000250784; ENSG00000129824.
GeneID	6192.
KEGG	hsa:6192.
UCSC	uc004fqi.3. human.
Organism-specific databases
CTD	6192.
GeneCards	GC0YP002709.
HGNC	HGNC:10425. RPS4Y1.
HPA	HPA000857.
MIM	470000. gene.
neXtProt	NX_P22090.
PharmGKB	PA34840.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1471.
HOGENOM	HOG000231325.
HOVERGEN	HBG000935.
InParanoid	P22090.
KO	K02987.
OMA	DKRLATK.
OrthoDB	EOG42BXBF.
PhylomeDB	P22090.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P22090.
Bgee	P22090.
CleanEx	HS_RPS4Y1.
Genevestigator	P22090.
GermOnline	ENSG00000129824. Homo sapiens.
Family and domain databases
HAMAP	MF_00485. Ribosomal_S4e.
InterPro	IPR005824. KOW. IPR000876. Ribosomal_S4e. IPR013845. Ribosomal_S4e_central. IPR013843. Ribosomal_S4e_N. IPR018199. Ribosomal_S4e_N_CS. IPR002942. S4_RNA-bd. [Graphical view]
PANTHER	PTHR11581. PTHR11581. 1 hit.
Pfam	PF00467. KOW. 1 hit. PF00900. Ribosomal_S4e. 1 hit. PF08071. RS4NT. 1 hit. PF01479. S4. 1 hit. [Graphical view]
PIRSF	PIRSF002116. Ribosomal_S4. 1 hit.
ProDom	PD002667. Ribosomal_S4e_central. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00363. S4. 1 hit. [Graphical view]
PROSITE	PS00528. RIBOSOMAL_S4E. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS4Y1. human.
GenomeRNAi	6192.
NextBio	24045.
SOURCE	Search...

Entry information

Entry name

RS4Y1_HUMAN

Accession

Primary (citable) accession number: P22090
Secondary accession number(s): A8K9V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.