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P22090

- RS4Y1_HUMAN

UniProt

P22090 - RS4Y1_HUMAN

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Protein

40S ribosomal protein S4, Y isoform 1

Gene
RPS4Y1, RPS4Y, PRO2646
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. rRNA binding Source: UniProtKB-KW
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. multicellular organismal development Source: UniProtKB
  5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  6. RNA metabolic process Source: Reactome
  7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  8. translation Source: UniProtKB
  9. translational elongation Source: Reactome
  10. translational initiation Source: Reactome
  11. translational termination Source: Reactome
  12. viral life cycle Source: Reactome
  13. viral process Source: Reactome
  14. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, Y isoform 1
Gene namesi
Name:RPS4Y1
Synonyms:RPS4Y
ORF Names:PRO2646
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:10425. RPS4Y1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic small ribosomal subunit Source: UniProtKB
  3. nucleus Source: UniProt
  4. polysome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 26326240S ribosomal protein S4, Y isoform 1UniRule annotationPRO_0000130812Add
BLAST

Proteomic databases

MaxQBiP22090.
PaxDbiP22090.
PRIDEiP22090.

PTM databases

PhosphoSiteiP22090.

Expressioni

Gene expression databases

ArrayExpressiP22090.
BgeeiP22090.
CleanExiHS_RPS4Y1.
GenevestigatoriP22090.

Organism-specific databases

HPAiHPA000857.

Interactioni

Protein-protein interaction databases

BioGridi112106. 6 interactions.
IntActiP22090. 3 interactions.
MINTiMINT-3009664.
STRINGi9606.ENSP00000250784.

Structurei

3D structure databases

ProteinModelPortaliP22090.
SMRiP22090. Positions 1-263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10463S4 RNA-bindingAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1471.
HOGENOMiHOG000231325.
HOVERGENiHBG000935.
InParanoidiP22090.
KOiK02987.
OMAiEAKRIIF.
OrthoDBiEOG77WWD1.
PhylomeDBiP22090.
TreeFamiTF300612.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22090-1 [UniParc]FASTAAdd to Basket

« Hide

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN    50
RLKYALTGDE VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR 100
LVYDTKGRFA VHRITVEEAK YKLCKVRKIT VGVKGIPHLV THDARTIRYP 150
DPVIKVNDTV QIDLGTGKII NFIKFDTGNL CMVIGGANLG RVGVITNRER 200
HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR GKGIRLTVAE 250
ERDKRLATKQ SSG 263
Length:263
Mass (Da):29,456
Last modified:January 23, 2007 - v2
Checksum:i3B5D6F1ECFCB120A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58459 mRNA. Translation: AAA63256.1.
AF041427 Genomic DNA. Translation: AAB96967.1.
AF116711 mRNA. Translation: AAF71131.1.
AK292819 mRNA. Translation: BAF85508.1.
CH471115 Genomic DNA. Translation: EAX02771.1.
BC010286 mRNA. Translation: AAH10286.1.
CCDSiCCDS14773.1.
PIRiA36338. R3HU4Y.
RefSeqiNP_000999.1. NM_001008.3.
UniGeneiHs.282376.

Genome annotation databases

EnsembliENST00000250784; ENSP00000250784; ENSG00000129824.
GeneIDi6192.
KEGGihsa:6192.
UCSCiuc004fqi.3. human.

Polymorphism databases

DMDMi133948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58459 mRNA. Translation: AAA63256.1 .
AF041427 Genomic DNA. Translation: AAB96967.1 .
AF116711 mRNA. Translation: AAF71131.1 .
AK292819 mRNA. Translation: BAF85508.1 .
CH471115 Genomic DNA. Translation: EAX02771.1 .
BC010286 mRNA. Translation: AAH10286.1 .
CCDSi CCDS14773.1.
PIRi A36338. R3HU4Y.
RefSeqi NP_000999.1. NM_001008.3.
UniGenei Hs.282376.

3D structure databases

ProteinModelPortali P22090.
SMRi P22090. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112106. 6 interactions.
IntActi P22090. 3 interactions.
MINTi MINT-3009664.
STRINGi 9606.ENSP00000250784.

PTM databases

PhosphoSitei P22090.

Polymorphism databases

DMDMi 133948.

Proteomic databases

MaxQBi P22090.
PaxDbi P22090.
PRIDEi P22090.

Protocols and materials databases

DNASUi 6192.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250784 ; ENSP00000250784 ; ENSG00000129824 .
GeneIDi 6192.
KEGGi hsa:6192.
UCSCi uc004fqi.3. human.

Organism-specific databases

CTDi 6192.
GeneCardsi GC0YP002709.
HGNCi HGNC:10425. RPS4Y1.
HPAi HPA000857.
MIMi 470000. gene.
neXtProti NX_P22090.
PharmGKBi PA34840.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1471.
HOGENOMi HOG000231325.
HOVERGENi HBG000935.
InParanoidi P22090.
KOi K02987.
OMAi EAKRIIF.
OrthoDBi EOG77WWD1.
PhylomeDBi P22090.
TreeFami TF300612.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS4Y1. human.
GeneWikii RPS4Y1.
GenomeRNAii 6192.
NextBioi 24045.
PROi P22090.
SOURCEi Search...

Gene expression databases

ArrayExpressi P22090.
Bgeei P22090.
CleanExi HS_RPS4Y1.
Genevestigatori P22090.

Family and domain databases

HAMAPi MF_00485. Ribosomal_S4e.
InterProi IPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11581. PTHR11581. 1 hit.
Pfami PF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002116. Ribosomal_S4. 1 hit.
ProDomi PD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
PROSITEi PS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome."
    Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
    Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRS4Y1_HUMAN
AccessioniPrimary (citable) accession number: P22090
Secondary accession number(s): A8K9V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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