Alpha-2C adrenergic receptor - Rattus norvegicus (Rat)

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P22086 (ADA2C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Alpha-2C adrenergic receptor

Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name=Alpha-2C adrenoceptor
Short name=Alpha-2CAR

Gene names

Name:

Adra2c

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity by adrenergic receptor signaling pathway Inferred from electronic annotation. Source: Compara activation of protein kinase B activity Inferred from electronic annotation. Source: Compara epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara female pregnancy Inferred from mutant phenotype PubMed 19450576. Source: RGD negative regulation of uterine smooth muscle contraction Inferred from mutant phenotype PubMed 17664026. Source: RGD positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from mutant phenotype PubMed 20862454. Source: RGD regulation of sensory perception of pain Inferred from mutant phenotype PubMed 20007733. Source: RGD
Cellular_component	axon terminus Inferred from direct assay PubMed 12591145. Source: RGD cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	alpha2-adrenergic receptor activity Inferred from mutant phenotype PubMed 12379250. Source: RGD epinephrine binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 458

458

Alpha-2C adrenergic receptor

PRO_0000069107

Regions

Topological domain

1 – 51

Extracellular By similarity

Transmembrane

52 – 76

Helical; Name=1; By similarity

Topological domain

77 – 88

Cytoplasmic By similarity

Transmembrane

89 – 114

Helical; Name=2; By similarity

Topological domain

115 – 124

Extracellular By similarity

Transmembrane

125 – 147

Helical; Name=3; By similarity

Topological domain

148 – 168

Cytoplasmic By similarity

Transmembrane

169 – 191

Helical; Name=4; By similarity

Topological domain

192 – 207

Extracellular By similarity

Transmembrane

208 – 231

Helical; Name=5; By similarity

Topological domain

232 – 379

148

Cytoplasmic By similarity

Transmembrane

380 – 403

Helical; Name=6; By similarity

Topological domain

404 – 416

Extracellular By similarity

Transmembrane

417 – 437

Helical; Name=7; By similarity

Topological domain

438 – 458

Cytoplasmic By similarity

Compositional bias

291 – 305

Arg-rich (basic)

Sites

Site

131

Implicated in ligand binding By similarity

Site

214

Implicated in catechol agonist binding and receptor activation By similarity

Site

218

Implicated in catechol agonist binding and receptor activation By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

124 ↔ 202

By similarity

Experimental info

Sequence conflict

G → R in BAA00700. Ref.4

Sequence conflict

G → A in AAA40634. Ref.1

Sequence conflict

N → T in AAA40634. Ref.1

Sequence conflict

155

Q → E in CAA40861. Ref.2

Sequence conflict

245

S → T in AAA40634. Ref.1

Sequence conflict

252

G → R in AAA42033. Ref.3

Sequence conflict

275

A → R in BAA00700. Ref.4

Sequence conflict

298

L → V in AAA42033. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P22086 [UniParc].

Last modified April 1, 1993. Version 2.
Checksum: 6846C2AF963B33BF
Show »

FASTA

458

49,864

        10         20         30         40         50         60 
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWG PPPGQYSAGA VAGLAAVVGF 

        70         80         90        100        110        120 
LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG 

       130        140        150        160        170        180 
QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA 

       190        200        210        220        230        240 
VISFPPLVSF YRRPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR 

       250        260        270        280        290        300 
TRTLSEKRGP AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR 

       310        320        330        340        350        360 
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE FFLSRRRRAR 

       370        380        390        400        410        420 
SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL YGICREACQL PEPLFKFFFW 

       430        440        450 
IGYCNSSLNP VIYTVFNQDF RRSFKHILFR RRRRGFRQ

« Hide

References

[1]	"Cloning and expression of a rat brain alpha 2B-adrenergic receptor." Flordellis C.S., Handy D.E., Bresnahan M.R., Zannis V.I., Gavras H. Proc. Natl. Acad. Sci. U.S.A. 88:1019-1023(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The rat alpha 2-C4 adrenergic receptor gene encodes a novel pharmacological subtype." Voigt M.M., McCune S.K., Kanterman R.Y., Felder C.C. FEBS Lett. 278:45-50(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype." Lanier S.M., Downing S., Duzic E., Homcy C.J. J. Biol. Chem. 266:10470-10478(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of rat alpha-2-B-adrenergic receptor gene and expression in rat submandibular gland." Saitoh M., Imai A., Shimomura H. Shigaku 80:317-326(1992) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M58316 mRNA. Translation: AAA40634.1. X57659 Genomic DNA. Translation: CAA40861.1. M62371 Genomic DNA. Translation: AAA42033.1. D00819 Genomic DNA. Translation: BAA00700.1.
IPI	IPI00325843.
PIR	A37869. A40392.
RefSeq	NP_612515.1. NM_138506.1.
UniGene	Rn.10297.
3D structure databases
ProteinModelPortal	P22086.
SMR	P22086. Positions 136-167.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000012322.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P22086.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012322; ENSRNOP00000012322; ENSRNOG00000009299.
GeneID	24175.
KEGG	rno:24175.
Organism-specific databases
CTD	152.
RGD	2058. Adra2c.
Phylogenomic databases
eggNOG	NOG249628.
GeneTree	ENSGT00700000104198.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P22086.
KO	K04140.
OMA	CKLNDET.
OrthoDB	EOG4R502W.
Gene expression databases
Genevestigator	P22086.
GermOnline	ENSRNOG00000009299. Rattus norvegicus.
Family and domain databases
InterPro	IPR000735. Adren_rcpt_A2C. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00560. ADRENRGCA2CR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P22086.
ChEMBL	CHEMBL314.
NextBio	602509.

Entry information

Entry name

ADA2C_RAT

Accession

Primary (citable) accession number: P22086

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents