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Protein

Alpha-2C adrenergic receptor

Gene

Adra2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei131 – 1311Implicated in ligand bindingBy similarity
Sitei214 – 2141Implicated in catechol agonist binding and receptor activationBy similarity
Sitei218 – 2181Implicated in catechol agonist binding and receptor activationBy similarity

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: RGD
  • epinephrine binding Source: Ensembl

GO - Biological processi

  • activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
  • activation of protein kinase B activity Source: Ensembl
  • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
  • female pregnancy Source: RGD
  • negative regulation of uterine smooth muscle contraction Source: RGD
  • platelet activation Source: InterPro
  • positive regulation of neuron differentiation Source: Ensembl
  • positive regulation of vasoconstriction Source: RGD
  • regulation of sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696. Adrenoceptors.
R-RNO-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-RNO-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-418597. G alpha (z) signalling events.
R-RNO-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:Adra2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2058. Adra2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151ExtracellularBy similarityAdd
BLAST
Transmembranei52 – 7625Helical; Name=1By similarityAdd
BLAST
Topological domaini77 – 8812CytoplasmicBy similarityAdd
BLAST
Transmembranei89 – 11426Helical; Name=2By similarityAdd
BLAST
Topological domaini115 – 12410ExtracellularBy similarity
Transmembranei125 – 14723Helical; Name=3By similarityAdd
BLAST
Topological domaini148 – 16821CytoplasmicBy similarityAdd
BLAST
Transmembranei169 – 19123Helical; Name=4By similarityAdd
BLAST
Topological domaini192 – 20716ExtracellularBy similarityAdd
BLAST
Transmembranei208 – 23124Helical; Name=5By similarityAdd
BLAST
Topological domaini232 – 379148CytoplasmicBy similarityAdd
BLAST
Transmembranei380 – 40324Helical; Name=6By similarityAdd
BLAST
Topological domaini404 – 41613ExtracellularBy similarityAdd
BLAST
Transmembranei417 – 43721Helical; Name=7By similarityAdd
BLAST
Topological domaini438 – 45821CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • axon terminus Source: RGD
  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2094111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Alpha-2C adrenergic receptorPRO_0000069107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22086.

PTM databases

PhosphoSiteiP22086.

Expressioni

Gene expression databases

GenevisibleiP22086. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012322.

Chemistry

BindingDBiP22086.

Structurei

3D structure databases

ProteinModelPortaliP22086.
SMRiP22086. Positions 136-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi291 – 30515Arg-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP22086.
KOiK04140.
OMAiQPQCELN.
OrthoDBiEOG7J9VPT.
PhylomeDBiP22086.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWG PPPGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP
260 270 280 290 300
AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR
310 320 330 340 350
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE
360 370 380 390 400
FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL
410 420 430 440 450
YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR

RRRRGFRQ
Length:458
Mass (Da):49,864
Last modified:April 1, 1993 - v2
Checksum:i6846C2AF963B33BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241G → R in BAA00700 (Ref. 4) Curated
Sequence conflicti40 – 401G → A in AAA40634 (PubMed:1704126).Curated
Sequence conflicti69 – 691N → T in AAA40634 (PubMed:1704126).Curated
Sequence conflicti155 – 1551Q → E in CAA40861 (PubMed:1704314).Curated
Sequence conflicti245 – 2451S → T in AAA40634 (PubMed:1704126).Curated
Sequence conflicti252 – 2521G → R in AAA42033 (PubMed:1645350).Curated
Sequence conflicti275 – 2751A → R in BAA00700 (Ref. 4) Curated
Sequence conflicti298 – 2981L → V in AAA42033 (PubMed:1645350).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58316 mRNA. Translation: AAA40634.1.
X57659 Genomic DNA. Translation: CAA40861.1.
M62371 Genomic DNA. Translation: AAA42033.1.
D00819 Genomic DNA. Translation: BAA00700.1.
PIRiA37869.
A40392.
RefSeqiNP_612515.1. NM_138506.1.
UniGeneiRn.10297.

Genome annotation databases

EnsembliENSRNOT00000012322; ENSRNOP00000012322; ENSRNOG00000009299.
GeneIDi24175.
KEGGirno:24175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58316 mRNA. Translation: AAA40634.1.
X57659 Genomic DNA. Translation: CAA40861.1.
M62371 Genomic DNA. Translation: AAA42033.1.
D00819 Genomic DNA. Translation: BAA00700.1.
PIRiA37869.
A40392.
RefSeqiNP_612515.1. NM_138506.1.
UniGeneiRn.10297.

3D structure databases

ProteinModelPortaliP22086.
SMRiP22086. Positions 136-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012322.

Chemistry

BindingDBiP22086.
ChEMBLiCHEMBL2094111.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP22086.

Proteomic databases

PaxDbiP22086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012322; ENSRNOP00000012322; ENSRNOG00000009299.
GeneIDi24175.
KEGGirno:24175.

Organism-specific databases

CTDi152.
RGDi2058. Adra2c.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP22086.
KOiK04140.
OMAiQPQCELN.
OrthoDBiEOG7J9VPT.
PhylomeDBiP22086.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-RNO-390696. Adrenoceptors.
R-RNO-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-RNO-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-418597. G alpha (z) signalling events.
R-RNO-5683826. Surfactant metabolism.

Miscellaneous databases

NextBioi602509.
PROiP22086.

Gene expression databases

GenevisibleiP22086. RN.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The rat alpha 2-C4 adrenergic receptor gene encodes a novel pharmacological subtype."
    Voigt M.M., McCune S.K., Kanterman R.Y., Felder C.C.
    FEBS Lett. 278:45-50(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype."
    Lanier S.M., Downing S., Duzic E., Homcy C.J.
    J. Biol. Chem. 266:10470-10478(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of rat alpha-2-B-adrenergic receptor gene and expression in rat submandibular gland."
    Saitoh M., Imai A., Shimomura H.
    Shigaku 80:317-326(1992)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiADA2C_RAT
AccessioniPrimary (citable) accession number: P22086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.