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P22083

- FUT4_HUMAN

UniProt

P22083 - FUT4_HUMAN

Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

FUT4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

    Pathwayi

    GO - Molecular functioni

    1. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    2. fucosyltransferase activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. fucosylation Source: GOC
    3. L-fucose catabolic process Source: UniProtKB
    4. protein glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
    Alternative name(s):
    ELAM-1 ligand fucosyltransferase
    Fucosyltransferase 4
    Fucosyltransferase IV
    Short name:
    Fuc-TIV
    Short name:
    FucT-IV
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:FUT4
    Synonyms:ELFT, FCT3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:4015. FUT4.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
    Note: Membrane-bound form in trans cisternae of Golgi.

    GO - Cellular componenti

    1. cell periphery Source: Ensembl
    2. cell surface Source: Ensembl
    3. Golgi apparatus Source: UniProtKB
    4. Golgi cisterna membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. membrane Source: ProtInc

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28431.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Alpha-(1,3)-fucosyltransferase 4PRO_0000221100Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP22083.
    PaxDbiP22083.
    PRIDEiP22083.

    PTM databases

    PhosphoSiteiP22083.

    Expressioni

    Gene expression databases

    BgeeiP22083.
    CleanExiHS_FUT4.
    GenevestigatoriP22083.

    Organism-specific databases

    HPAiCAB000014.
    CAB016129.

    Interactioni

    Protein-protein interaction databases

    BioGridi108802. 1 interaction.
    STRINGi9606.ENSP00000351602.

    Structurei

    3D structure databases

    ProteinModelPortaliP22083.
    SMRiP22083. Positions 352-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 147147CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 530358LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei148 – 17225Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283180.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiP22083.
    KOiK07632.
    OMAiCRLRFNI.
    OrthoDBiEOG7Z69C9.
    PhylomeDBiP22083.
    TreeFamiTF316348.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22083-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW    50
    ASWPAHLALA ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL 100
    QHESRCRSST PADAWRAEAA LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP 150
    WTVCVLAAAG LTCTALITYA CWGQLPPLPW ASPTPSRPVG VLLWWEPFGG 200
    RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR DLVKGPPDWP 250
    PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP 300
    SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL 350
    SRKQGLVAWV VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL 400
    LHTVARYKFY LAFENSQHLD YITEKLWRNA LLAGAVPVVL GPDRANYERF 450
    VPRGAFIHVD DFPSASSLAS YLLFLDRNPA VYRRYFHWRR SYAVHITSFW 500
    DEPWCRVCQA VQRAGDRPKS IRNLASWFER 530
    Length:530
    Mass (Da):59,084
    Last modified:April 14, 2009 - v3
    Checksum:iB10C1C3C67BE1562
    GO

    Sequence cautioni

    The sequence AAB20349.1 differs from that shown. Reason: Frameshift at position 114.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121R → P in AAA92977. (PubMed:1716630)Curated
    Sequence conflicti366 – 3661E → D in AAB20349. (PubMed:1718983)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti255 – 2551I → V.
    Corresponds to variant rs2230273 [ dbSNP | Ensembl ].
    VAR_055844

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58596 mRNA. Translation: AAA63172.1.
    M58597 mRNA. Translation: AAA63173.1.
    AP000943 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW66938.1.
    BC136373 mRNA. Translation: AAI36374.1.
    BC136374 mRNA. Translation: AAI36375.1.
    S65161 Genomic DNA. Translation: AAB20349.1. Sequence problems.
    M65030 Genomic DNA. Translation: AAA92977.1.
    CCDSiCCDS8301.1.
    PIRiB36340.
    RefSeqiNP_002024.1. NM_002033.3.
    UniGeneiHs.390420.
    Hs.572064.
    Hs.623098.

    Genome annotation databases

    EnsembliENST00000358752; ENSP00000351602; ENSG00000196371.
    GeneIDi2526.
    KEGGihsa:2526.
    UCSCiuc001pez.3. human.

    Polymorphism databases

    DMDMi226694189.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 4

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58596 mRNA. Translation: AAA63172.1 .
    M58597 mRNA. Translation: AAA63173.1 .
    AP000943 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW66938.1 .
    BC136373 mRNA. Translation: AAI36374.1 .
    BC136374 mRNA. Translation: AAI36375.1 .
    S65161 Genomic DNA. Translation: AAB20349.1 . Sequence problems.
    M65030 Genomic DNA. Translation: AAA92977.1 .
    CCDSi CCDS8301.1.
    PIRi B36340.
    RefSeqi NP_002024.1. NM_002033.3.
    UniGenei Hs.390420.
    Hs.572064.
    Hs.623098.

    3D structure databases

    ProteinModelPortali P22083.
    SMRi P22083. Positions 352-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108802. 1 interaction.
    STRINGi 9606.ENSP00000351602.

    Chemistry

    ChEMBLi CHEMBL4996.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei P22083.

    Polymorphism databases

    DMDMi 226694189.

    Proteomic databases

    MaxQBi P22083.
    PaxDbi P22083.
    PRIDEi P22083.

    Protocols and materials databases

    DNASUi 2526.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358752 ; ENSP00000351602 ; ENSG00000196371 .
    GeneIDi 2526.
    KEGGi hsa:2526.
    UCSCi uc001pez.3. human.

    Organism-specific databases

    CTDi 2526.
    GeneCardsi GC11P094277.
    H-InvDB HIX0036409.
    HGNCi HGNC:4015. FUT4.
    HPAi CAB000014.
    CAB016129.
    MIMi 104230. gene.
    neXtProti NX_P22083.
    PharmGKBi PA28431.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283180.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi P22083.
    KOi K07632.
    OMAi CRLRFNI.
    OrthoDBi EOG7Z69C9.
    PhylomeDBi P22083.
    TreeFami TF316348.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    GenomeRNAii 2526.
    NextBioi 9953.
    PROi P22083.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22083.
    CleanExi HS_FUT4.
    Genevestigatori P22083.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ELFT: a gene that directs the expression of an ELAM-1 ligand."
      Goelz S.E., Hession C., Goff D., Griffiths B., Tizard R., Newman B., Chi-Rosso G., Lobb R.
      Cell 63:1349-1356(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants."
      Kumar R., Potvin B., Muller W.A., Stanley P.
      J. Biol. Chem. 266:21777-21783(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-525.
    6. "Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion."
      Lowe J.B., Kukowska-Latallo J.F., Nair R.P., Larsen R.D., Marks R.M., Macher B.A., Kelly R.J., Ernst L.K.
      J. Biol. Chem. 266:17467-17477(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-530.
      Tissue: Peripheral blood leukocyte.

    Entry informationi

    Entry nameiFUT4_HUMAN
    AccessioniPrimary (citable) accession number: P22083
    Secondary accession number(s): B2RMS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-126 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3