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P22083 (FUT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-(1,3)-fucosyltransferase 4

EC=2.4.1.-
Alternative name(s):
ELAM-1 ligand fucosyltransferase
Fucosyltransferase 4
Fucosyltransferase IV
Short name=Fuc-TIV
Short name=FucT-IV
Galactoside 3-L-fucosyltransferase
Gene names
Name:FUT4
Synonyms:ELFT, FCT3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Caution

It is uncertain whether Met-1 or Met-126 is the initiator.

Sequence caution

The sequence AAB20349.1 differs from that shown. Reason: Frameshift at position 114.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Alpha-(1,3)-fucosyltransferase 4
PRO_0000221100

Regions

Topological domain1 – 147147Cytoplasmic Potential
Transmembrane148 – 17225Helical; Signal-anchor for type II membrane protein; Potential
Topological domain173 – 530358Lumenal Potential

Amino acid modifications

Glycosylation2161N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential

Natural variations

Natural variant2551I → V.
Corresponds to variant rs2230273 [ dbSNP | Ensembl ].
VAR_055844

Experimental info

Sequence conflict2121R → P in AAA92977. Ref.6
Sequence conflict3661E → D in AAB20349. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P22083 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: B10C1C3C67BE1562

FASTA53059,084
        10         20         30         40         50         60 
MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW ASWPAHLALA 

        70         80         90        100        110        120 
ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL QHESRCRSST PADAWRAEAA 

       130        140        150        160        170        180 
LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP WTVCVLAAAG LTCTALITYA CWGQLPPLPW 

       190        200        210        220        230        240 
ASPTPSRPVG VLLWWEPFGG RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR 

       250        260        270        280        290        300 
DLVKGPPDWP PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP 

       310        320        330        340        350        360 
SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL SRKQGLVAWV 

       370        380        390        400        410        420 
VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL LHTVARYKFY LAFENSQHLD 

       430        440        450        460        470        480 
YITEKLWRNA LLAGAVPVVL GPDRANYERF VPRGAFIHVD DFPSASSLAS YLLFLDRNPA 

       490        500        510        520        530 
VYRRYFHWRR SYAVHITSFW DEPWCRVCQA VQRAGDRPKS IRNLASWFER 

« Hide

References

« Hide 'large scale' references
[1]"ELFT: a gene that directs the expression of an ELAM-1 ligand."
Goelz S.E., Hession C., Goff D., Griffiths B., Tizard R., Newman B., Chi-Rosso G., Lobb R.
Cell 63:1349-1356(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants."
Kumar R., Potvin B., Muller W.A., Stanley P.
J. Biol. Chem. 266:21777-21783(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-525.
[6]"Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion."
Lowe J.B., Kukowska-Latallo J.F., Nair R.P., Larsen R.D., Marks R.M., Macher B.A., Kelly R.J., Ernst L.K.
J. Biol. Chem. 266:17467-17477(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-530.
Tissue: Peripheral blood leukocyte.
+Additional computationally mapped references.

Web resources

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Fucosyltransferase 4

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58596 mRNA. Translation: AAA63172.1.
M58597 mRNA. Translation: AAA63173.1.
AP000943 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66938.1.
BC136373 mRNA. Translation: AAI36374.1.
BC136374 mRNA. Translation: AAI36375.1.
S65161 Genomic DNA. Translation: AAB20349.1. Sequence problems.
M65030 Genomic DNA. Translation: AAA92977.1.
PIRB36340.
RefSeqNP_002024.1. NM_002033.3.
UniGeneHs.390420.
Hs.572064.
Hs.623098.

3D structure databases

ProteinModelPortalP22083.
SMRP22083. Positions 352-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108802. 1 interaction.
STRING9606.ENSP00000351602.

Chemistry

ChEMBLCHEMBL4996.

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSiteP22083.

Polymorphism databases

DMDM226694189.

Proteomic databases

PaxDbP22083.
PRIDEP22083.

Protocols and materials databases

DNASU2526.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358752; ENSP00000351602; ENSG00000196371.
GeneID2526.
KEGGhsa:2526.
UCSCuc001pez.3. human.

Organism-specific databases

CTD2526.
GeneCardsGC11P094277.
H-InvDBHIX0036409.
HGNCHGNC:4015. FUT4.
HPACAB000014.
CAB016129.
MIM104230. gene.
neXtProtNX_P22083.
PharmGKBPA28431.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283180.
HOGENOMHOG000045583.
HOVERGENHBG000274.
InParanoidP22083.
KOK07632.
OMACRLRFNI.
OrthoDBEOG7Z69C9.
PhylomeDBP22083.
TreeFamTF316348.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

BgeeP22083.
CleanExHS_FUT4.
GenevestigatorP22083.

Family and domain databases

InterProIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. PTHR11929. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2526.
NextBio9953.
PROP22083.
SOURCESearch...

Entry information

Entry nameFUT4_HUMAN
AccessionPrimary (citable) accession number: P22083
Secondary accession number(s): B2RMS0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM