UniProtKB - P22082 (SNF2_YEAST)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Transcription regulatory protein SNF2
Gene
SNF2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in transcriptional activation. Catalytic component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Miscellaneous
Present with 217 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 792 – 799 | ATPPROSITE-ProRule annotation | 8 | |
DNA bindingi | 1446 – 1456 | A.T hook 1Add BLAST | 11 | |
DNA bindingi | 1502 – 1513 | A.T hook 2Add BLAST | 12 | |
DNA bindingi | 1516 – 1526 | A.T hook 3Add BLAST | 11 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA-dependent ATPase activity Source: SGD
- helicase activity Source: UniProtKB-KW
- lysine-acetylated histone binding Source: SGD
- nucleosomal DNA binding Source: SGD
- rDNA binding Source: SGD
- RNA polymerase II activating transcription factor binding Source: SGD
GO - Biological processi
- ATP-dependent chromatin remodeling Source: SGD
- cellular alcohol catabolic process Source: SGD
- chromatin remodeling Source: SGD
- DNA-dependent DNA replication Source: SGD
- double-strand break repair Source: SGD
- nucleosome mobilization Source: SGD
- positive regulation of cell adhesion involved in single-species biofilm formation Source: SGD
- positive regulation of invasive growth in response to glucose limitation Source: SGD
- positive regulation of mating type switching Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation Source: SGD
- strand invasion Source: SGD
- sucrose catabolic process Source: SGD
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-33775-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription regulatory protein SNF2 (EC:3.6.4.-)Alternative name(s): ATP-dependent helicase SNF2 Regulatory protein GAM1 Regulatory protein SWI2 SWI/SNF complex component SNF2 Transcription factor TYE3 |
Gene namesi | Name:SNF2 Synonyms:GAM1, RIC1, SWI2, TYE3 Ordered Locus Names:YOR290C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOR290C. |
SGDi | S000005816. SNF2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074358 | 1 – 1703 | Transcription regulatory protein SNF2Add BLAST | 1703 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 543 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 716 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1340 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P22082. |
PaxDbi | P22082. |
PRIDEi | P22082. |
PTM databases
iPTMneti | P22082. |
Interactioni
Subunit structurei
Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
Binary interactionsi
GO - Molecular functioni
- lysine-acetylated histone binding Source: SGD
- RNA polymerase II activating transcription factor binding Source: SGD
Protein-protein interaction databases
BioGridi | 34678. 233 interactors. |
DIPi | DIP-1150N. |
IntActi | P22082. 52 interactors. |
MINTi | P22082. |
STRINGi | 4932.YOR290C. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 593 – 657 | Combined sources | 65 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4I6M | X-ray | 2.80 | C | 575-667 | [»] | |
5X0X | electron microscopy | 3.97 | O | 666-1400 | [»] | |
5X0Y | electron microscopy | 3.97 | O | 666-1400 | [»] | |
ProteinModelPortali | P22082. | |||||
SMRi | P22082. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 247 – 282 | QLQPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 588 – 661 | HSAPROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 779 – 944 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 1091 – 1254 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 164 | |
Domaini | 1568 – 1638 | BromoPROSITE-ProRule annotationAdd BLAST | 71 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 894 – 897 | DEGH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 68 | Gln-richAdd BLAST | 14 | |
Compositional biasi | 207 – 239 | Ala/Gln-richAdd BLAST | 33 |
Keywords - Domaini
Bromodomain, RepeatPhylogenomic databases
GeneTreei | ENSGT00910000145744. |
HOGENOMi | HOG000172362. |
InParanoidi | P22082. |
KOi | K11786. |
OMAi | HNQTAKE. |
OrthoDBi | EOG092C1YH4. |
Family and domain databases
CDDi | cd00079. HELICc. 1 hit. |
Gene3Di | 1.20.920.10. 1 hit. |
InterProi | View protein in InterPro IPR017956. AT_hook_DNA-bd_motif. IPR001487. Bromodomain. IPR036427. Bromodomain-like_sf. IPR018359. Bromodomain_CS. IPR014978. Gln-Leu-Gln_QLQ. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR014012. HSA_dom. IPR027417. P-loop_NTPase. IPR029295. SnAC. IPR000330. SNF2_N. |
Pfami | View protein in Pfam PF00439. Bromodomain. 1 hit. PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF08880. QLQ. 1 hit. PF14619. SnAC. 1 hit. PF00176. SNF2_N. 1 hit. |
PRINTSi | PR00503. BROMODOMAIN. |
SMARTi | View protein in SMART SM00384. AT_hook. 2 hits. SM00297. BROMO. 1 hit. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00951. QLQ. 1 hit. SM01314. SnAC. 1 hit. |
SUPFAMi | SSF47370. SSF47370. 1 hit. SSF52540. SSF52540. 2 hits. |
PROSITEi | View protein in PROSITE PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. PS51666. QLQ. 1 hit. |
i Sequence
Sequence statusi: Complete.
P22082-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIPQRQFSN EEVNRCYLRW QHLRNEHGMN APSVPEFIYL TKVLQFAAKQ
60 70 80 90 100
RQELQMQRQQ QGISGSQQNI VPNSSDQAEL PNNASSHISA SASPHLAPNM
110 120 130 140 150
QLNGNETFST SAHQSPIMQT QMPLNSNGGN NMLPQRQSSV GSLNATNFSP
160 170 180 190 200
TPANNGENAA EKPDNSNHNN LNLNNSELQP QNRSLQEHNI QDSNVMPGSQ
210 220 230 240 250
INSPMPQQAQ MQQAQFQAQQ AQQAQQAQQA QQAQARLQQG RRLPMTMFTA
260 270 280 290 300
EQSELLKAQI TSLKCLVNRK PIPFEFQAVI QKSINHPPDF KRMLLSLSEF
310 320 330 340 350
ARRRQPTDQN NQSNLNGGNN TQQPGTNSHY NNTNTDNVSG LTRNAPLDSK
360 370 380 390 400
DENFASVSPA GPSSVHNAKN GTLDKNSQTV SGTPITQTES KKEENETISN
410 420 430 440 450
VAKTAPNSNK THTEQNNPPK PQKPVPLNVL QDQYKEGIKV VDIDDPDMMV
460 470 480 490 500
DSFTMPNISH SNIDYQTLLA NSDHAKFTIE PGVLPVGIDT HTATDIYQTL
510 520 530 540 550
IALNLDTTVN DCLDKLLNDE CTESTRENAL YDYYALQLLP LQKAVRGHVL
560 570 580 590 600
QFEWHQNSLL TNTHPNFLSK IRNINVQDAL LTNQLYKNHE LLKLERKKTE
610 620 630 640 650
AVARLKSMNK SAINQYNRRQ DKKNKRLKFG HRLIATHTNL ERDEQKRAEK
660 670 680 690 700
KAKERLQALK ANDEEAYIKL LDQTKDTRIT HLLRQTNAFL DSLTRAVKDQ
710 720 730 740 750
QKYTKEMIDS HIKEASEEVD DLSMVPKMKD EEYDDDDDNS NVDYYNVAHR
760 770 780 790 800
IKEDIKKQPS ILVGGTLKDY QIKGLQWMVS LFNNHLNGIL ADEMGLGKTI
810 820 830 840 850
QTISLLTYLY EMKNIRGPYL VIVPLSTLSN WSSEFAKWAP TLRTISFKGS
860 870 880 890 900
PNERKAKQAK IRAGEFDVVL TTFEYIIKER ALLSKVKWVH MIIDEGHRMK
910 920 930 940 950
NAQSKLSLTL NTHYHADYRL ILTGTPLQNN LPELWALLNF VLPKIFNSVK
960 970 980 990 1000
SFDEWFNTPF ANTGGQDKIE LSEEETLLVI RRLHKVLRPF LLRRLKKDVE
1010 1020 1030 1040 1050
KELPDKVEKV VKCKMSALQQ IMYQQMLKYR RLFIGDQNNK KMVGLRGFNN
1060 1070 1080 1090 1100
QIMQLKKICN HPFVFEEVED QINPTRETND DIWRVAGKFE LLDRILPKLK
1110 1120 1130 1140 1150
ATGHRVLIFF QMTQIMDIME DFLRYINIKY LRLDGHTKSD ERSELLRLFN
1160 1170 1180 1190 1200
APDSEYLCFI LSTRAGGLGL NLQTADTVII FDTDWNPHQD LQAQDRAHRI
1210 1220 1230 1240 1250
GQKNEVRILR LITTNSVEEV ILERAYKKLD IDGKVIQAGK FDNKSTSEEQ
1260 1270 1280 1290 1300
EALLRSLLDA EEERRKKRES GVEEEEELKD SEINEILARN DEEMAVLTRM
1310 1320 1330 1340 1350
DEDRSKKEEE LGVKSRLLEK SELPDIYSRD IGAELKREES ESAAVYNGRG
1360 1370 1380 1390 1400
ARERKTATYN DNMSEEQWLR QFEVSDDEKN DKQARKQRTK KEDKSEAIDG
1410 1420 1430 1440 1450
NGEIKGENID ADNDGPRINN ISAEDRADTD LAMNDDDFLS KKRKAGRPRG
1460 1470 1480 1490 1500
RPKKVKLEGS ENSEPPALES SPVTGDNSPS EDFMDIPKPR TAGKTSVKSA
1510 1520 1530 1540 1550
RTSTRGRGRG RGRGRGRGRG RGRPPKARNG LDYVRTPAAA TSPIDIREKV
1560 1570 1580 1590 1600
AKQALDLYHF ALNYENEAGR KLSDIFLSKP SKALYPDYYM IIKYPVAFDN
1610 1620 1630 1640 1650
INTHIETLAY NSLKETLQDF HLIFSNARIY NTEGSVVYED SLELEKVVTK
1660 1670 1680 1690 1700
KYCEIMGDNS QLDFTEFDEQ YGTRPLVLPP VVTSSVAESF TDEADSSMTE
ASV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61703 Genomic DNA. Translation: AAA35059.1. X57837 Genomic DNA. Translation: CAA40969.1. D90459 Genomic DNA. Translation: BAA14423.1. X89633 Genomic DNA. Translation: CAA61793.1. Z75198 Genomic DNA. Translation: CAA99517.1. Z75199 Genomic DNA. Translation: CAA99519.1. BK006948 Genomic DNA. Translation: DAA11054.1. |
PIRi | S15047. |
RefSeqi | NP_014933.3. NM_001183709.3. |
Genome annotation databases
EnsemblFungii | YOR290C; YOR290C; YOR290C. |
GeneIDi | 854465. |
KEGGi | sce:YOR290C. |
Similar proteinsi
Entry informationi
Entry namei | SNF2_YEAST | |
Accessioni | P22082Primary (citable) accession number: P22082 Secondary accession number(s): D6W2Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | March 28, 2018 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |