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P22079

- PERL_HUMAN

UniProt

P22079 - PERL_HUMAN

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Protein

Lactoperoxidase

Gene

LPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May contribute to airway host defense against infection.1 Publication

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Binds 1 calcium ion per heterodimer.PROSITE-ProRule annotation
Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251Heme (covalent; via 2 links)By similarity
Active sitei226 – 2261Proton acceptorPROSITE-ProRule annotation
Metal bindingi227 – 2271CalciumPROSITE-ProRule annotation
Metal bindingi301 – 3011CalciumPROSITE-ProRule annotation
Metal bindingi303 – 3031Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi305 – 3051CalciumPROSITE-ProRule annotation
Metal bindingi307 – 3071CalciumPROSITE-ProRule annotation
Sitei372 – 3721Transition state stabilizerPROSITE-ProRule annotation
Binding sitei375 – 3751Heme (covalent; via 2 links)By similarity
Metal bindingi468 – 4681Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. thiocyanate peroxidase activity Source: UniProt

GO - Biological processi

  1. defense response to bacterium Source: UniProt
  2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
  3. hydrogen peroxide catabolic process Source: UniProtKB-KW
  4. response to oxidative stress Source: UniProtKB
  5. thiocyanate metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3316. HsLPO.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoperoxidase (EC:1.11.1.7)
Short name:
LPO
Alternative name(s):
Salivary peroxidase
Short name:
SPO
Gene namesi
Name:LPO
Synonyms:SAPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6678. LPO.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProt
  2. cytoplasm Source: Ensembl
  3. extracellular space Source: UniProt
  4. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 10074By similarityPRO_0000023649Add
BLAST
Chaini101 – 712612LactoperoxidasePRO_0000023650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi132 ↔ 145PROSITE-ProRule annotation
Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication
Disulfide bondi246 ↔ 256PROSITE-ProRule annotation
Disulfide bondi250 ↔ 274PROSITE-ProRule annotation
Modified residuei315 – 3151PhosphoserineBy similarity
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi354 ↔ 365PROSITE-ProRule annotation
Glycosylationi358 – 3581N-linked (GlcNAc...)2 Publications
Disulfide bondi573 ↔ 630PROSITE-ProRule annotation
Disulfide bondi671 ↔ 696PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP22079.
PeptideAtlasiP22079.
PRIDEiP22079.

PTM databases

PhosphoSiteiP22079.

Expressioni

Tissue specificityi

Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.1 Publication

Gene expression databases

BgeeiP22079.
CleanExiHS_LPO.
ExpressionAtlasiP22079. baseline and differential.
GenevestigatoriP22079.

Organism-specific databases

HPAiHPA028688.

Interactioni

Protein-protein interaction databases

BioGridi110207. 1 interaction.
STRINGi9606.ENSP00000262290.

Structurei

3D structure databases

ProteinModelPortaliP22079.
SMRiP22079. Positions 130-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG262194.
GeneTreeiENSGT00550000074325.
HOGENOMiHOG000016084.
HOVERGENiHBG000071.
InParanoidiP22079.
KOiK12550.
OMAiSPWASVK.
OrthoDBiEOG7M0NQW.
PhylomeDBiP22079.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR029587. LPO.
[Graphical view]
PANTHERiPTHR11475:SF53. PTHR11475:SF53. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P22079-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL
60 70 80 90 100
DSRTRLKTAM SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ
110 120 130 140 150
KASLTNVTDP SLDLTSLSLE VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK
160 170 180 190 200
PALGAANRAL ARWLPAEYED GLSLPFGWTP GKTRNGFPLP LAREVSNKIV
210 220 230 240 250
GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE YSKAQCDEYC
260 270 280 290 300
IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL
310 320 330 340 350
TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK
360 370 380 390 400
PSPCEFINTT ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL
410 420 430 440 450
NPQWDGEKLY QEARKILGAF VQIITFRDYL PILLGDHMQK WIPPYQGYSE
460 470 480 490 500
SVDPRISNVF TFAFRFGHLE VPSSMFRLDE NYQPWGPEPE LPLHTLFFNT
510 520 530 540 550
WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ PTHRIHGFDL
560 570 580 590 600
AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL
610 620 630 640 650
YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP
660 670 680 690 700
GVFTNEQKDS LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID
710
KLDLSPWASV KN
Length:712
Mass (Da):80,288
Last modified:January 24, 2001 - v2
Checksum:iBC7AA410997198C0
GO
Isoform 2 (identifier: P22079-2) [UniParc]FASTAAdd to Basket

Also known as: V3

The sequence of this isoform differs from the canonical sequence as follows:
     26-108: Missing.

Show »
Length:629
Mass (Da):70,984
Checksum:i8A8BBBB5E48C8BBD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551N → S in ABQ53140. (PubMed:19059195)Curated
Sequence conflicti678 – 6781K → M in ABQ53140. (PubMed:19059195)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051T → I.1 Publication
Corresponds to variant rs8178318 [ dbSNP | Ensembl ].
VAR_018809
Natural varianti244 – 2441A → T.1 Publication
Corresponds to variant rs8178338 [ dbSNP | Ensembl ].
VAR_018810
Natural varianti414 – 4141R → Q.1 Publication
Corresponds to variant rs8178355 [ dbSNP | Ensembl ].
VAR_018811
Natural varianti421 – 4211V → M.3 Publications
Corresponds to variant rs2301870 [ dbSNP | Ensembl ].
VAR_018812
Natural varianti514 – 5141R → Q.1 Publication
Corresponds to variant rs8178401 [ dbSNP | Ensembl ].
VAR_018813
Natural varianti614 – 6141I → T.1 Publication
Corresponds to variant rs8178408 [ dbSNP | Ensembl ].
VAR_018814
Natural varianti700 – 7001D → N.1 Publication
Corresponds to variant rs8178412 [ dbSNP | Ensembl ].
VAR_018815

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 10883Missing in isoform 2. CuratedVSP_044473Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39573 mRNA. Translation: AAC50717.1.
EF579964 mRNA. Translation: ABQ53140.1.
AY324876 Genomic DNA. Translation: AAP72968.1.
AC004687 Genomic DNA. No translation available.
AC005962 Genomic DNA. No translation available.
BC107166 mRNA. Translation: AAI07167.1.
BC107167 mRNA. Translation: AAI07168.1.
M58151 mRNA. Translation: AAA63213.1.
CCDSiCCDS32689.1. [P22079-1]
CCDS54149.1. [P22079-2]
PIRiJC4935.
RefSeqiNP_001153574.1. NM_001160102.1. [P22079-2]
NP_006142.1. NM_006151.2. [P22079-1]
UniGeneiHs.234742.

Genome annotation databases

EnsembliENST00000262290; ENSP00000262290; ENSG00000167419. [P22079-1]
ENST00000421678; ENSP00000400245; ENSG00000167419. [P22079-2]
ENST00000582328; ENSP00000464636; ENSG00000167419. [P22079-2]
GeneIDi4025.
KEGGihsa:4025.
UCSCiuc002ivt.3. human. [P22079-1]
uc010dcp.3. human. [P22079-2]

Polymorphism databases

DMDMi12643419.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39573 mRNA. Translation: AAC50717.1 .
EF579964 mRNA. Translation: ABQ53140.1 .
AY324876 Genomic DNA. Translation: AAP72968.1 .
AC004687 Genomic DNA. No translation available.
AC005962 Genomic DNA. No translation available.
BC107166 mRNA. Translation: AAI07167.1 .
BC107167 mRNA. Translation: AAI07168.1 .
M58151 mRNA. Translation: AAA63213.1 .
CCDSi CCDS32689.1. [P22079-1 ]
CCDS54149.1. [P22079-2 ]
PIRi JC4935.
RefSeqi NP_001153574.1. NM_001160102.1. [P22079-2 ]
NP_006142.1. NM_006151.2. [P22079-1 ]
UniGenei Hs.234742.

3D structure databases

ProteinModelPortali P22079.
SMRi P22079. Positions 130-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110207. 1 interaction.
STRINGi 9606.ENSP00000262290.

Chemistry

BindingDBi P22079.
ChEMBLi CHEMBL5898.

Protein family/group databases

PeroxiBasei 3316. HsLPO.

PTM databases

PhosphoSitei P22079.

Polymorphism databases

DMDMi 12643419.

Proteomic databases

PaxDbi P22079.
PeptideAtlasi P22079.
PRIDEi P22079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262290 ; ENSP00000262290 ; ENSG00000167419 . [P22079-1 ]
ENST00000421678 ; ENSP00000400245 ; ENSG00000167419 . [P22079-2 ]
ENST00000582328 ; ENSP00000464636 ; ENSG00000167419 . [P22079-2 ]
GeneIDi 4025.
KEGGi hsa:4025.
UCSCi uc002ivt.3. human. [P22079-1 ]
uc010dcp.3. human. [P22079-2 ]

Organism-specific databases

CTDi 4025.
GeneCardsi GC17P056315.
HGNCi HGNC:6678. LPO.
HPAi HPA028688.
MIMi 150205. gene.
170990. gene.
neXtProti NX_P22079.
PharmGKBi PA30439.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262194.
GeneTreei ENSGT00550000074325.
HOGENOMi HOG000016084.
HOVERGENi HBG000071.
InParanoidi P22079.
KOi K12550.
OMAi SPWASVK.
OrthoDBi EOG7M0NQW.
PhylomeDBi P22079.
TreeFami TF314316.

Miscellaneous databases

ChiTaRSi LPO. human.
GeneWikii Lactoperoxidase.
GenomeRNAii 4025.
NextBioi 15782.
PROi P22079.
SOURCEi Search...

Gene expression databases

Bgeei P22079.
CleanExi HS_LPO.
ExpressionAtlasi P22079. baseline and differential.
Genevestigatori P22079.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
InterProi IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR029587. LPO.
[Graphical view ]
PANTHERi PTHR11475:SF53. PTHR11475:SF53. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA."
    Kiser C., Caterina J., Engler J.A., Rahemtulla B., Rahemtulla F.
    Gene 173:261-264(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Submandibular gland.
  2. "Molecular heterogeneity and alternative splicing of human lactoperoxidase."
    Fragoso M.A., Torbati A., Fregien N., Conner G.E.
    Arch. Biochem. Biophys. 482:52-57(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-421, ALTERNATIVE SPLICING.
  3. NIEHS SNPs program
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-105; THR-244; GLN-414; MET-421; GLN-514; THR-614 AND ASN-700.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Molecular cloning of cDNAs encoding bovine and human lactoperoxidase."
    Dull T.J., Uyeda C., Strosberg A.D., Nedwin G., Seilhamer J.J.
    DNA Cell Biol. 9:499-509(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-712, VARIANT MET-421.
  7. Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212 AND ASN-358.
    Tissue: Saliva.
  9. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-358.
    Tissue: Milk.

Entry informationi

Entry nameiPERL_HUMAN
AccessioniPrimary (citable) accession number: P22079
Secondary accession number(s): A5JUY4
, E7EMJ3, Q13408, Q3KNQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 24, 2001
Last modified: October 29, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3