Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-glucosidase A

Gene

bglA

Organism
Paenibacillus polymyxa (Bacillus polymyxa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

BglA is intracellular and cleaves cellobiose probably through inorganic phosphate mediated hydrolysis.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton donorSequence analysis1
Active sitei352NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BRENDAi3.2.1.21. 683.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Short name:
BGA
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiPaenibacillus polymyxa (Bacillus polymyxa)
Taxonomic identifieri1406 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

Pathology & Biotechi

Chemistry databases

DrugBankiDB04304. Gluconic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638711 – 448Beta-glucosidase AAdd BLAST448

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi349520.PPE_04075.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi11 – 15Combined sources5
Helixi18 – 21Combined sources4
Helixi27 – 29Combined sources3
Helixi34 – 39Combined sources6
Turni42 – 44Combined sources3
Helixi46 – 48Combined sources3
Beta strandi51 – 53Combined sources3
Helixi54 – 56Combined sources3
Helixi57 – 71Combined sources15
Beta strandi74 – 79Combined sources6
Helixi82 – 85Combined sources4
Beta strandi89 – 91Combined sources3
Helixi95 – 110Combined sources16
Beta strandi114 – 122Combined sources9
Helixi126 – 130Combined sources5
Turni131 – 134Combined sources4
Helixi138 – 153Combined sources16
Helixi155 – 157Combined sources3
Beta strandi160 – 165Combined sources6
Helixi167 – 175Combined sources9
Helixi187 – 211Combined sources25
Beta strandi214 – 220Combined sources7
Beta strandi226 – 231Combined sources6
Helixi233 – 246Combined sources14
Helixi248 – 256Combined sources9
Helixi261 – 269Combined sources9
Helixi280 – 284Combined sources5
Beta strandi289 – 294Combined sources6
Beta strandi299 – 303Combined sources5
Turni308 – 311Combined sources4
Beta strandi312 – 314Combined sources3
Helixi331 – 339Combined sources9
Helixi340 – 343Combined sources4
Beta strandi348 – 353Combined sources6
Helixi369 – 387Combined sources19
Beta strandi392 – 398Combined sources7
Helixi406 – 411Combined sources6
Beta strandi416 – 419Combined sources4
Turni421 – 423Combined sources3
Beta strandi426 – 428Combined sources3
Helixi430 – 441Combined sources12
Beta strandi443 – 445Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BGAX-ray2.40A/B/C/D2-448[»]
1BGGX-ray2.30A/B/C/D1-448[»]
1E4IX-ray2.00A2-448[»]
1TR1X-ray2.20A/B/C/D2-448[»]
1UYQX-ray2.20A2-448[»]
ProteinModelPortaliP22073.
SMRiP22073.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22073.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105CS2. Bacteria.
COG2723. LUCA.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFQFPQDF MWGTATAAYQ IEGAYQEDGR GLSIWDTFAH TPGKVFNGDN
60 70 80 90 100
GNVACDSYHR YEEDIRLMKE LGIRTYRFSV SWPRIFPNGD GEVNQEGLDY
110 120 130 140 150
YHRVVDLLND NGIEPFCTLY HWDLPQALQD AGGWGNRRTI QAFVQFAETM
160 170 180 190 200
FREFHGKIQH WLTFNEPWCI AFLSNMLGVH APGLTNLQTA IDVGHHLLVA
210 220 230 240 250
HGLSVRRFRE LGTSGQIGIA PNVSWAVPYS TSEEDKAACA RTISLHSDWF
260 270 280 290 300
LQPIYQGSYP QFLVDWFAEQ GATVPIQDGD MDIIGEPIDM IGINYYSMSV
310 320 330 340 350
NRFNPEAGFL QSEEINMGLP VTDIGWPVES RGLYEVLHYL QKYGNIDIYI
360 370 380 390 400
TENGACINDE VVNGKVQDDR RISYMQQHLV QVHRTIHDGL HVKGYMAWSL
410 420 430 440
LDNFEWAEGY NMRFGMIHVD FRTQVRTPKE SYYWYRNVVS NNWLETRR
Length:448
Mass (Da):51,649
Last modified:August 1, 1991 - v1
Checksum:iD971D2E61B6627C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA. Translation: AAA22263.1.
PIRiJW0037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA. Translation: AAA22263.1.
PIRiJW0037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BGAX-ray2.40A/B/C/D2-448[»]
1BGGX-ray2.30A/B/C/D1-448[»]
1E4IX-ray2.00A2-448[»]
1TR1X-ray2.20A/B/C/D2-448[»]
1UYQX-ray2.20A2-448[»]
ProteinModelPortaliP22073.
SMRiP22073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349520.PPE_04075.

Chemistry databases

DrugBankiDB04304. Gluconic Acid.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CS2. Bacteria.
COG2723. LUCA.

Enzyme and pathway databases

BRENDAi3.2.1.21. 683.

Miscellaneous databases

EvolutionaryTraceiP22073.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGLA_PAEPO
AccessioniPrimary (citable) accession number: P22073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.