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P22073

- BGLA_PAEPO

UniProt

P22073 - BGLA_PAEPO

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Protein

Beta-glucosidase A

Gene

bglA

Organism
Paenibacillus polymyxa (Bacillus polymyxa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

BglA is intracellular and cleaves cellobiose probably through inorganic phosphate mediated hydrolysis.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Proton donorSequence Analysis
Active sitei352 – 3521NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Short name:
BGA
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiPaenibacillus polymyxa (Bacillus polymyxa)
Taxonomic identifieri1406 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Beta-glucosidase APRO_0000063871Add
BLAST

Interactioni

Subunit structurei

Homooctamer.

Structurei

Secondary structure

1
448
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi11 – 155Combined sources
Helixi18 – 214Combined sources
Helixi27 – 293Combined sources
Helixi34 – 396Combined sources
Turni42 – 443Combined sources
Helixi46 – 483Combined sources
Beta strandi51 – 533Combined sources
Helixi54 – 563Combined sources
Helixi57 – 7115Combined sources
Beta strandi74 – 796Combined sources
Helixi82 – 854Combined sources
Beta strandi89 – 913Combined sources
Helixi95 – 11016Combined sources
Beta strandi114 – 1229Combined sources
Helixi126 – 1305Combined sources
Turni131 – 1344Combined sources
Helixi138 – 15316Combined sources
Helixi155 – 1573Combined sources
Beta strandi160 – 1656Combined sources
Helixi167 – 1759Combined sources
Helixi187 – 21125Combined sources
Beta strandi214 – 2207Combined sources
Beta strandi226 – 2316Combined sources
Helixi233 – 24614Combined sources
Helixi248 – 2569Combined sources
Helixi261 – 2699Combined sources
Helixi280 – 2845Combined sources
Beta strandi289 – 2946Combined sources
Beta strandi299 – 3035Combined sources
Turni308 – 3114Combined sources
Beta strandi312 – 3143Combined sources
Helixi331 – 3399Combined sources
Helixi340 – 3434Combined sources
Beta strandi348 – 3536Combined sources
Helixi369 – 38719Combined sources
Beta strandi392 – 3987Combined sources
Helixi406 – 4116Combined sources
Beta strandi416 – 4194Combined sources
Turni421 – 4233Combined sources
Beta strandi426 – 4283Combined sources
Helixi430 – 44112Combined sources
Beta strandi443 – 4453Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BGAX-ray2.40A/B/C/D2-448[»]
1BGGX-ray2.30A/B/C/D1-448[»]
1E4IX-ray2.00A2-448[»]
1TR1X-ray2.20A/B/C/D2-448[»]
1UYQX-ray2.20A2-448[»]
ProteinModelPortaliP22073.
SMRiP22073. Positions 2-448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22073.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIFQFPQDF MWGTATAAYQ IEGAYQEDGR GLSIWDTFAH TPGKVFNGDN
60 70 80 90 100
GNVACDSYHR YEEDIRLMKE LGIRTYRFSV SWPRIFPNGD GEVNQEGLDY
110 120 130 140 150
YHRVVDLLND NGIEPFCTLY HWDLPQALQD AGGWGNRRTI QAFVQFAETM
160 170 180 190 200
FREFHGKIQH WLTFNEPWCI AFLSNMLGVH APGLTNLQTA IDVGHHLLVA
210 220 230 240 250
HGLSVRRFRE LGTSGQIGIA PNVSWAVPYS TSEEDKAACA RTISLHSDWF
260 270 280 290 300
LQPIYQGSYP QFLVDWFAEQ GATVPIQDGD MDIIGEPIDM IGINYYSMSV
310 320 330 340 350
NRFNPEAGFL QSEEINMGLP VTDIGWPVES RGLYEVLHYL QKYGNIDIYI
360 370 380 390 400
TENGACINDE VVNGKVQDDR RISYMQQHLV QVHRTIHDGL HVKGYMAWSL
410 420 430 440
LDNFEWAEGY NMRFGMIHVD FRTQVRTPKE SYYWYRNVVS NNWLETRR
Length:448
Mass (Da):51,649
Last modified:August 1, 1991 - v1
Checksum:iD971D2E61B6627C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA. Translation: AAA22263.1.
PIRiJW0037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60210 Genomic DNA. Translation: AAA22263.1 .
PIRi JW0037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BGA X-ray 2.40 A/B/C/D 2-448 [» ]
1BGG X-ray 2.30 A/B/C/D 1-448 [» ]
1E4I X-ray 2.00 A 2-448 [» ]
1TR1 X-ray 2.20 A/B/C/D 2-448 [» ]
1UYQ X-ray 2.20 A 2-448 [» ]
ProteinModelPortali P22073.
SMRi P22073. Positions 2-448.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P22073.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences and homology analysis of two genes encoding beta-glucosidases from Bacillus polymyxa."
    Gonzalez-Candelas L., Ramon D., Polaina J.
    Gene 95:31-38(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Crystal structure of beta-glucosidase A from Bacillus polymyxa: insights into the catalytic activity in family 1 glycosyl hydrolases."
    Sanz-Aparicio J., Hermoso J.A., Martinez-Ripoll M., Lequerica J.L., Polaina J.
    J. Mol. Biol. 275:491-502(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    Strain: ATCC 842 / DSM 36 / JCM 2507 / NBRC 15309 / NCIMB 8158 / NCTC 10343 / NRRL B-4317 / VKM B-514.

Entry informationi

Entry nameiBGLA_PAEPO
AccessioniPrimary (citable) accession number: P22073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3