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Protein

ATP synthase subunit beta, mitochondrial

Gene

atp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi203 – 2108ATPBy similarity

GO - Molecular functioni

  • ADP binding Source: PomBase
  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • mitochondrial ATP synthesis coupled proton transport Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit beta, mitochondrial (EC:3.6.3.14)
Gene namesi
Name:atp2
ORF Names:SPAC222.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC222.12c.
PomBaseiSPAC222.12c. atp2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase, catalytic core Source: PomBase
  • mitochondrial proton-transporting ATP synthase complex Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444Mitochondrion1 PublicationAdd
BLAST
Chaini45 – 525481ATP synthase subunit beta, mitochondrialPRO_0000002453Add
BLAST

Proteomic databases

MaxQBiP22068.
PRIDEiP22068.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi278415. 27 interactions.
MINTiMINT-4687657.

Structurei

3D structure databases

ProteinModelPortaliP22068.
SMRiP22068. Positions 55-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000009605.
InParanoidiP22068.
KOiK02133.
OMAiHDHISEN.
OrthoDBiEOG092C1U90.
PhylomeDBiP22068.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKQALSGI RRFSLATKQS FVKTSYKLPR KSWLNTAKFN TIRYASTEAA
60 70 80 90 100
KHNKGSIKQV IGAVVDCQFE DADSLPSILN ALEVKLPDNK RLVLEVAQHV
110 120 130 140 150
GENTVRTIAM DGTEGLVRGT AVIDTGSPIS IPVGPGTLGR IMNVIGEPVD
160 170 180 190 200
ERGPIKAVKY SPIHADAPSF EEQSTTPEIL ETGIKVVDLL APYARGGKIG
210 220 230 240 250
LFGGAGVGKT VFIQELINNI AKAHGGYSVF TGVGERTREG NDLYREMQET
260 270 280 290 300
GVIKLEGESK AALVFGQMNE PPGARARVAL TGLTVAEYFR DIEGQDVLLF
310 320 330 340 350
IDNIFRFTQA GSEVSALLGR IPSAVGYQPT LATDMGAMQE RITTTKKGSI
360 370 380 390 400
TSVQAVYVPA DDLTDPAPAT TFAHLDATTV LSRSISELGI YPAVDPLDSK
410 420 430 440 450
SRMMDPRILG EEHYNLAGSV QQMLQEYKSL QDIIAILGMD ELSEADKLTV
460 470 480 490 500
ERARKVQRFL SQPFAVAEVF TGIEGRLVSL KDTIRSFKEI LEGKHDSLPE
510 520
SAFYMVGSID DAVKKAEKIA QELAA
Length:525
Mass (Da):56,876
Last modified:August 1, 1991 - v1
Checksum:i32BD77B0B24363F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB60704.1.
PIRiS17211.
RefSeqiNP_593151.1. NM_001018548.2.

Genome annotation databases

EnsemblFungiiSPAC222.12c.1; SPAC222.12c.1:pep; SPAC222.12c.
GeneIDi2541927.
KEGGispo:SPAC222.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB60704.1.
PIRiS17211.
RefSeqiNP_593151.1. NM_001018548.2.

3D structure databases

ProteinModelPortaliP22068.
SMRiP22068. Positions 55-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278415. 27 interactions.
MINTiMINT-4687657.

Proteomic databases

MaxQBiP22068.
PRIDEiP22068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC222.12c.1; SPAC222.12c.1:pep; SPAC222.12c.
GeneIDi2541927.
KEGGispo:SPAC222.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAC222.12c.
PomBaseiSPAC222.12c. atp2.

Phylogenomic databases

HOGENOMiHOG000009605.
InParanoidiP22068.
KOiK02133.
OMAiHDHISEN.
OrthoDBiEOG092C1U90.
PhylomeDBiP22068.

Miscellaneous databases

PROiP22068.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPB_SCHPO
AccessioniPrimary (citable) accession number: P22068
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.