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Protein

Contactin-2

Gene

Cntn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonal glycoprotein TAG-1
Axonin-1
Transient axonal glycoprotein 1
Short name:
TAX-1
Gene namesi
Name:Cntn2
Synonyms:Tax1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3821. Cntn2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: RGD
  • plasma membrane Source: BHF-UCL
  • synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 1015985Contactin-2PRO_0000014699Add
BLAST
Propeptidei1016 – 104025Removed in mature formSequence analysisPRO_0000014700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 113PROSITE-ProRule annotation
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 209PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi263 ↔ 308PROSITE-ProRule annotation
Disulfide bondi350 ↔ 397PROSITE-ProRule annotation
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence analysis
Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence analysis
Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence analysis
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence analysis
Glycosylationi920 – 9201N-linked (GlcNAc...)Sequence analysis
Glycosylationi942 – 9421N-linked (GlcNAc...)Sequence analysis
Lipidationi1015 – 10151GPI-anchor amidated alanineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP22063.
PRIDEiP22063.

PTM databases

iPTMnetiP22063.
PhosphoSiteiP22063.
UniCarbKBiP22063.

Expressioni

Tissue specificityi

In neural tissues in embryos, and in adult brain, spinal cord and cerebellum.

Developmental stagei

Transiently expressed on a subset of axons in the developing rat nervous system.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996538.
STRINGi10116.ENSRNOP00000012190.

Structurei

3D structure databases

ProteinModelPortaliP22063.
SMRiP22063. Positions 36-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 13092Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini241 – 32484Ig-like C2-type 3Add
BLAST
Domaini329 – 41385Ig-like C2-type 4Add
BLAST
Domaini419 – 50688Ig-like C2-type 5Add
BLAST
Domaini511 – 60595Ig-like C2-type 6Add
BLAST
Domaini612 – 71099Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini715 – 81298Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini817 – 91397Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini917 – 100892Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi796 – 7983Cell attachment siteSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 6147Gly/Pro-rich

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP22063.
KOiK06760.
PhylomeDBiP22063.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTHARKKAS LLLLVLATVA LVSSPGWSFA QGTPATFGPI FEEQPIGLLF
60 70 80 90 100
PEESAEDQVT LACRARASPP ATYRWKMNGT DMNLEPGSRH QLMGGNLVIM
110 120 130 140 150
SPTKTQDAGV YQCLASNPVG TVVSKEAVLR FGFLQEFSKE ERDPVKTHEG
160 170 180 190 200
WGVMLPCNPP AHYPGLSYRW LLNEFPNFIP TDGRHFVSQT TGNLYIARTN
210 220 230 240 250
ASDLGNYSCL ATSHMDFSTK SVFSKFAQLN LAAEDPRLFA PSIKARFPPE
260 270 280 290 300
TYALVGQQVT LECFAFGNPV PRIKWRKVDG SLSPQWATAE PTLQIPSVSF
310 320 330 340 350
EDEGTYECEA ENSKGRDTVQ GRIIVQAQPE WLKVISDTEA DIGSNLRWGC
360 370 380 390 400
AAAGKPRPMV RWLRNGEPLA SQNRVEVLAG DLRFSKLSLE DSGMYQCVAE
410 420 430 440 450
NKHGTIYASA ELAVQALAPD FRQNPVRRLI PAARGGEISI LCQPRAAPKA
460 470 480 490 500
TILWSKGTEI LGNSTRVTVT SDGTLIIRNI SRSDEGKYTC FAENFMGKAN
510 520 530 540 550
STGILSVRDA TKITLAPSSA DINVGDNLTL QCHASHDPTM DLTFTWTLDD
560 570 580 590 600
FPIDFDKPGG HYRRASAKET IGDLTILNAH VRHGGKYTCM AQTVVDGTSK
610 620 630 640 650
EATVLVRGPP GPPGGVVVRD IGDTTVQLSW SRGFDNHSPI AKYTLQARTP
660 670 680 690 700
PSGKWKQVRT NPVNIEGNAE TAQVLGLMPW MDYEFRVSAS NILGTGEPSG
710 720 730 740 750
PSSKIRTKEA VPSVAPSGLS GGGGAPGELI INWTPVSREY QNGDGFGYLL
760 770 780 790 800
SFRRQGSSSW QTARVPGADA QYFVYGNDSI QPYTPFEVKI RSYNRRGDGP
810 820 830 840 850
ESLTALVYSA EEEPRVAPAK VWAKGSSSSE MNVSWEPVLQ DMNGILLGYE
860 870 880 890 900
IRYWKAGDNE AAADRVRTAG LDTSARVTGL NPNTKYHVTV RAYNRAGTGP
910 920 930 940 950
ASPSADAMTV KPPPRRPPGN ISWTFSSSSL SLKWDPVVPL RNESTVTGYK
960 970 980 990 1000
MLYQNDLHPT PTLHLTSKNW IEIPVPEDIG HALVQIRTTG PGGDGIPAEV
1010 1020 1030 1040
HIVRNGGTSM MVESAAARPA HPGPAFSCMV ILMLAGYQKL
Length:1,040
Mass (Da):113,043
Last modified:August 1, 1991 - v1
Checksum:i6E707EF6614CB4FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31725 mRNA. Translation: AAA42201.1.
PIRiA34695.
RefSeqiNP_037016.1. NM_012884.1.
UniGeneiRn.89910.

Genome annotation databases

GeneIDi25356.
KEGGirno:25356.
UCSCiRGD:3821. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31725 mRNA. Translation: AAA42201.1.
PIRiA34695.
RefSeqiNP_037016.1. NM_012884.1.
UniGeneiRn.89910.

3D structure databases

ProteinModelPortaliP22063.
SMRiP22063. Positions 36-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996538.
STRINGi10116.ENSRNOP00000012190.

PTM databases

iPTMnetiP22063.
PhosphoSiteiP22063.
UniCarbKBiP22063.

Proteomic databases

PaxDbiP22063.
PRIDEiP22063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25356.
KEGGirno:25356.
UCSCiRGD:3821. rat.

Organism-specific databases

CTDi6900.
RGDi3821. Cntn2.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP22063.
KOiK06760.
PhylomeDBiP22063.

Miscellaneous databases

PROiP22063.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN2_RAT
AccessioniPrimary (citable) accession number: P22063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.