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P22036 (ATMB_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium-transporting ATPase, P-type 1
EC=3.6.3.2
Alternative name(s):
Mg(2+) transport ATPase, P-type 1
Gene names
Name:mgtB
Ordered Locus Names:STM3763
OrganismSalmonella typhimurium
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length908 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates magnesium influx to the cytosol.

Catalytic activity

ATP + H2O + Mg2+(Out) = ADP + phosphate + Mg2+(In).

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Induction

Part of the mgtC/mgtB operon. Induced by low extracellular levels of Mg2+. Ref.3

Disruption phenotype

Decreases Mg2+ influx. Ref.1

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 908908Magnesium-transporting ATPase, P-type 1
PRO_0000046185

Regions

Topological domain1 – 8080Cytoplasmic Ref.4
Transmembrane81 – 10121Helical; Name=1
Topological domain102 – 11312Extracellular Ref.4
Transmembrane114 – 13421Helical; Name=2
Topological domain135 – 293159Cytoplasmic Ref.4
Transmembrane294 – 31421Helical; Name=3
Topological domain315 – 3239Extracellular Ref.4
Transmembrane324 – 34118Helical; Name=4
Topological domain342 – 704363Cytoplasmic Ref.4
Transmembrane705 – 72420Helical; Name=5
Topological domain725 – 7339Extracellular Ref.4
Transmembrane734 – 75320Helical; Name=6
Topological domain754 – 77522Cytoplasmic Ref.4
Transmembrane776 – 79924Helical; Name=7
Topological domain800 – 8089Extracellular Ref.4
Transmembrane809 – 82719Helical; Name=8
Topological domain828 – 84013Cytoplasmic Ref.4
Transmembrane841 – 86020Helical; Name=9
Topological domain861 – 87515Extracellular Ref.4
Transmembrane876 – 89520Helical; Name=10
Topological domain896 – 90813Cytoplasmic Ref.4

Sites

Active site37914-aspartylphosphate intermediate By similarity
Metal binding3371Magnesium Potential
Metal binding6501Magnesium By similarity
Metal binding6541Magnesium By similarity
Metal binding7181Magnesium Potential
Metal binding7431Magnesium Potential
Metal binding7471Magnesium Potential

Experimental info

Sequence conflict7171G → V in AAA72084. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22036 [UniParc].

Last modified January 23, 2002. Version 3.
Checksum: 9C5451BC6E2BA7C2

FASTA908100,387
        10         20         30         40         50         60 
MTDMNIENRK LNRPASENDK QHKKVFPIEA EAFHSPEETL ARLNSHRQGL TIEEASERLK 

        70         80         90        100        110        120 
VYGRNEVAHE QVPPALIQLL QAFNNPFIYV LMALAGVSFI TDYWLPLRRG EETDLTGVLI 

       130        140        150        160        170        180 
ILTMVSLSGL LRFWQEFRTN RAAQALKKMV RTTATVLRRG PGNIGAVQEE IPIEELVPGD 

       190        200        210        220        230        240 
VVFLAAGDLV PADVRLLASR DLFISQSILS GESLPVEKYD VMADVAGKDS EQLPDKDKSL 

       250        260        270        280        290        300 
LDLGNICLMG TNVTSGRAQA VVVATGSRTW FGSLAKSIVG TRTQTAFDRG VNSVSWLLIR 

       310        320        330        340        350        360 
FMLIMVPVVL LINGFSKGDW VEASLFALAV AVGLTPEMLP MIVSSNLAKG AIAMSRRKVI 

       370        380        390        400        410        420 
VKRLNAIQNF GAMDVLCTDK TGTLTQDNIF LEHHLDVSGV KSSRVLMLAW LNSSSQSGAR 

       430        440        450        460        470        480 
NVMDRAILRF GEGRIAPSTK ARFIKRDELP FDFVRRRVSV LVEDAQHGDR CLICKGAVEE 

       490        500        510        520        530        540 
MMMVATHLRE GDRVVALTET RRELLLAKTE DYNAQGFRVL LIATRKLDGS GNNPTLSVED 

       550        560        570        580        590        600 
ETELTIEGML TFLDPPKESA GKAIAALRDN GVAVKVLTGD NPVVTARICL EVGIDTHDIL 

       610        620        630        640        650        660 
TGTQVEAMSD AELASEVEKR AVFARLTPLQ KTRILQALQK NGHTVGFLGD GINDAPALRD 

       670        680        690        700        710        720 
ADVGISVDSA ADIAKESSDI ILLEKDLMVL EEGVIKGRET FGNIIKYLNM TASSNFGNVF 

       730        740        750        760        770        780 
SVLVASAFIP FLPMLAIHLL IQNLMYDISQ LSLPWDKMDK EFLRKPRKWD AKNIGRFMLW 

       790        800        810        820        830        840 
IGPTSSIFDI TTFALMWYVF AANNVEAQAL FQSGWFIEGL LSQTLVVHML RTQKIPFIQS 

       850        860        870        880        890        900 
RATLPVLLTT GLIMAIGIYI PFSPLGAMVG LEPLPLSYFP WLVATLLSYC LVAQGMKRFY 


IKRFGQWF

« Hide

References

« Hide 'large scale' references
[1]"The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase."
Snavely M.D., Miller C.G., Maguire M.E.
J. Biol. Chem. 266:815-823(1991) [PubMed: 1824701] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, PROBABLE OPERON STRUCTURE.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[3]"Magnesium transport in Salmonella typhimurium: mgtA encodes a P-type ATPase and is regulated by Mg2+ in a manner similar to that of the mgtB P-type ATPase."
Tao T., Snavely M.D., Farr S.G., Maguire M.E.
J. Bacteriol. 177:2654-2662(1995) [PubMed: 7751273] [Abstract]
Cited for: INDUCTION, OPERON STRUCTURE.
Strain: LT2.
[4]"Membrane topology of a P-type ATPase. The MgtB magnesium transport protein of Salmonella typhimurium."
Smith D.L., Tao T., Maguire M.E.
J. Biol. Chem. 268:22469-22479(1993) [PubMed: 8226755] [Abstract]
Cited for: TOPOLOGY.
Strain: LT2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M57715 Unassigned DNA. Translation: AAA72084.1.
AE006468 Genomic DNA. Translation: AAL22621.1.
RefSeqNP_462662.1. NC_003197.1.

3D structure databases

ProteinModelPortalP22036.
ModBaseSearch...

Proteomic databases

PRIDEP22036.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1255287.
GenomeReviewsGene locus STM3763 in contig AE006468_GR.
KEGGstm:STM3763.
NMPDRfig|99287.1.peg.3637.
PATRIC32386371. VBISalEnt20916_3981.

Phylogenomic databases

HOGENOMHBG456486.
OMAGYIGFLD.
ProtClustDBPRK15122.

Enzyme and pathway databases

BioCycSTYP99287:STM3763-MONOMER.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR006415. ATPase_P-typ_Mg-translocating.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
KOK01531.
PANTHERPTHR24093:SF62. PTHR24093:SF62. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR01836. MGATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01524. ATPase-IIIB_Mg. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATMB_SALTY
AccessionPrimary (citable) accession number: P22036
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2002
Last modified: January 25, 2012
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents