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Protein

ATP synthase subunit s, mitochondrial

Gene

ATP5S

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Magnesium; via carbonyl oxygen1
Metal bindingi93Magnesium1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Short name:
FB
Mitochondrial ATP synthase regulatory component factor B
Gene namesi
Name:ATP5S
Synonyms:ATPW
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000253726 – 200ATP synthase subunit s, mitochondrialAdd BLAST175

Proteomic databases

PaxDbiP22027.
PRIDEiP22027.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015202.

Interactioni

Subunit structurei

Homotetramer. Associates with ATP synthase.1 Publication

Protein-protein interaction databases

DIPiDIP-46291N.
STRINGi9913.ENSBTAP00000020228.

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 35Combined sources10
Helixi39 – 45Combined sources7
Helixi47 – 57Combined sources11
Beta strandi61 – 64Combined sources4
Helixi74 – 76Combined sources3
Beta strandi87 – 94Combined sources8
Helixi99 – 105Combined sources7
Beta strandi113 – 118Combined sources6
Helixi124 – 131Combined sources8
Helixi134 – 139Combined sources6
Beta strandi142 – 147Combined sources6
Helixi153 – 158Combined sources6
Helixi159 – 161Combined sources3
Beta strandi167 – 172Combined sources6
Helixi179 – 189Combined sources11
Beta strandi194 – 198Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZEX-ray1.15A26-200[»]
3E2JX-ray2.90A/B/C/D26-200[»]
3E3ZX-ray1.70A26-200[»]
3E4GX-ray0.96A26-200[»]
ProteinModelPortaliP22027.
SMRiP22027.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22027.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 87LRR 11 PublicationAdd BLAST26
Repeati88 – 116LRR 21 PublicationAdd BLAST29
Repeati117 – 141LRR 31 PublicationAdd BLAST25
Repeati142 – 173LRR 41 PublicationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 61N-terminal domainAdd BLAST61

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3864. Eukaryota.
ENOG4110375. LUCA.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiP22027.
KOiK07554.
OMAiCDIKATK.
OrthoDBiEOG091G0WCB.
TreeFamiTF315274.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026063. ATP_synth_s.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLFGKISQQ LCGLKKLPWS RDSRYFWGWL NAVFNKVDHD RIRDVGPDRA
60 70 80 90 100
ASEWLLRCGA MVRYHGQQRW QKDYNHLPTG PLDKYKIQAI DATDSCIMSI
110 120 130 140 150
GFDHMEGLQY VEKIRLCKCH YIEDGCLERL SQLENLQKSM LEMEIISCGN
160 170 180 190 200
VTDKGIIALH HFRNLKYLFL SDLPGVKEKE KIVQAFKTSL PSLELKLDLK
Length:200
Mass (Da):23,293
Last modified:June 21, 2005 - v2
Checksum:i2C439BE3835E206D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58C → G AA sequence (PubMed:2148527).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26Missing in one third of the chains. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY780292 mRNA. Translation: AAV52866.1.
BC109757 mRNA. Translation: AAI09758.1.
PIRiS13005.
RefSeqiNP_001007813.1. NM_001007812.3.
XP_010807544.1. XM_010809242.2.
UniGeneiBt.13666.

Genome annotation databases

EnsembliENSBTAT00000020228; ENSBTAP00000020228; ENSBTAG00000015202.
GeneIDi493709.
KEGGibta:493709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY780292 mRNA. Translation: AAV52866.1.
BC109757 mRNA. Translation: AAI09758.1.
PIRiS13005.
RefSeqiNP_001007813.1. NM_001007812.3.
XP_010807544.1. XM_010809242.2.
UniGeneiBt.13666.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZEX-ray1.15A26-200[»]
3E2JX-ray2.90A/B/C/D26-200[»]
3E3ZX-ray1.70A26-200[»]
3E4GX-ray0.96A26-200[»]
ProteinModelPortaliP22027.
SMRiP22027.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46291N.
STRINGi9913.ENSBTAP00000020228.

Proteomic databases

PaxDbiP22027.
PRIDEiP22027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020228; ENSBTAP00000020228; ENSBTAG00000015202.
GeneIDi493709.
KEGGibta:493709.

Organism-specific databases

CTDi27109.

Phylogenomic databases

eggNOGiKOG3864. Eukaryota.
ENOG4110375. LUCA.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiP22027.
KOiK07554.
OMAiCDIKATK.
OrthoDBiEOG091G0WCB.
TreeFamiTF315274.

Enzyme and pathway databases

ReactomeiR-BTA-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

EvolutionaryTraceiP22027.

Gene expression databases

BgeeiENSBTAG00000015202.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026063. ATP_synth_s.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5S_BOVIN
AccessioniPrimary (citable) accession number: P22027
Secondary accession number(s): Q32L55, Q5S3X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.