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P22023 (KRE5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer toxin-resistance protein 5
Gene names
Name:KRE5
Ordered Locus Names:YOR336W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

Subcellular location

Endoplasmic reticulum lumen.

Miscellaneous

Present with 815 molecules/cell in log phase SD medium.

Sequence similarities

To D.melanogaster UGGG.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 13651348Killer toxin-resistance protein 5
PRO_0000021563

Regions

Motif1362 – 13654Prevents secretion from ER

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation6441N-linked (GlcNAc...) Potential
Glycosylation8701N-linked (GlcNAc...) Potential
Glycosylation10911N-linked (GlcNAc...) Potential
Glycosylation11501N-linked (GlcNAc...) Potential
Glycosylation11951N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5821Missing in AAA34725. Ref.1
Sequence conflict780 – 79415HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22023 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D0F5851175CC0333

FASTA1,365156,477
        10         20         30         40         50         60 
MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN LYPLVTGLDD 

        70         80         90        100        110        120 
EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM IQHDISSNAE QDDANSSYFV 

       130        140        150        160        170        180 
LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD VIQPYDVVIG TNSEAPILIL YGCPTVIDSD 

       190        200        210        220        230        240 
FEEFNRNLFM EAMNGEGKFR FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK 

       250        260        270        280        290        300 
ILYTVPKEIL VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN 

       310        320        330        340        350        360 
NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL TPYNLLTALK 

       370        380        390        400        410        420 
TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL QNLQPIKMDL HTIPGFSESV 

       430        440        450        460        470        480 
IYFNDIESDP QYDELVNSVQ AFFDKSKFGE LPEIKQNWSE IIFVIDFARL EDSEVKEALG 

       490        500        510        520        530        540 
GLVRAVNVVS QGYPQRVGLL PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL 

       550        560        570        580        590        600 
SANAKHSKHI PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK 

       610        620        630        640        650        660 
ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES VCSERIGYYT 

       670        680        690        700        710        720 
KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR IIHVGDISDI WYQLRGSLSQ 

       730        740        750        760        770        780 
KDPIGSINTF IDALKLKKVK SHTYKKSGLN QLGLHKWLPD IPLFELQKGS FIALNGRFIH 

       790        800        810        820        830        840 
LDQNEVPETE HFEAIIKREA LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ 

       850        860        870        880        890        900 
GTHIYNNGID YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS 

       910        920        930        940        950        960 
LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD PEVDIEMDVP 

       970        980        990       1000       1010       1020 
NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL ALVDSAGNII DKTTTMKTFG 

      1030       1040       1050       1060       1070       1080 
YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD GHPDFIPSDS LDILSYNPQK IAVKISEEPT 

      1090       1100       1110       1120       1130       1140 
HEEEYEEGRN NDTIINIFTI LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD 

      1150       1160       1170       1180       1190       1200 
TLRKSCEYIN SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL 

      1210       1220       1230       1240       1250       1260 
YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL EFYSTEPAFL 

      1270       1280       1290       1300       1310       1320 
VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL QLEVPIRFLK GSYKKKLVIN 

      1330       1340       1350       1360 
DECVSEWKKK INKFASSPGD EDVPGESVSS KYQDSDNAAP LHDEL 

« Hide

References

« Hide 'large scale' references
[1]"The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1-->6)-beta-D-glucan synthesis and normal cell growth."
Meaden P., Hill K., Wagner J., Slipetz D., Sommer S.S., Bussey H.
Mol. Cell. Biol. 10:3013-3019(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I."
Parle-McDermott A.G., Hand N.J., Goulding S.E., Wolfe K.H.
Yeast 12:999-1004(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33556 Genomic DNA. Translation: AAA34725.1.
Z49821 Genomic DNA. Translation: CAA89981.1.
Z75244 Genomic DNA. Translation: CAA99659.1.
BK006948 Genomic DNA. Translation: DAA11097.1.
PIRBVBYK5. S62066.
RefSeqNP_014981.1. NM_001183756.1.

3D structure databases

ProteinModelPortalP22023.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34719. 71 interactions.
DIPDIP-5326N.
MINTMINT-510348.
STRING4932.YOR336W.

Protein family/group databases

CAZyGT24. Glycosyltransferase Family 24.

Proteomic databases

MaxQBP22023.
PaxDbP22023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR336W; YOR336W; YOR336W.
GeneID854514.
KEGGsce:YOR336W.

Organism-specific databases

CYGDYOR336w.
SGDS000005863. KRE5.

Phylogenomic databases

eggNOGNOG320899.
GeneTreeENSGT00390000004600.
HOGENOMHOG000000800.
KOK11718.
OMAKLRFVWR.
OrthoDBEOG7MSMX7.

Enzyme and pathway databases

BioCycYEAST:G3O-33811-MONOMER.

Gene expression databases

GenevestigatorP22023.

Family and domain databases

InterProIPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERPTHR11226. PTHR11226. 1 hit.
PfamPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio976873.
PROP22023.

Entry information

Entry nameKRE5_YEAST
AccessionPrimary (citable) accession number: P22023
Secondary accession number(s): D6W331, Q12190
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD