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P22023

- KRE5_YEAST

UniProt

P22023 - KRE5_YEAST

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Protein

Killer toxin-resistance protein 5

Gene

KRE5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

GO - Molecular functioni

  1. UDP-glucose:glycoprotein glucosyltransferase activity Source: SGD

GO - Biological processi

  1. (1->6)-beta-D-glucan biosynthetic process Source: SGD
  2. cell wall organization Source: UniProtKB-KW
  3. protein glycosylation Source: InterPro
  4. UDP-glucosylation Source: GOC
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33811-MONOMER.
ReactomeiREACT_189184. ER Quality Control Compartment (ERQC).

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer toxin-resistance protein 5
Gene namesi
Name:KRE5
Ordered Locus Names:YOR336W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR336w.
SGDiS000005863. KRE5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 13651348Killer toxin-resistance protein 5PRO_0000021563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1091 – 10911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1150 – 11501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1195 – 11951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP22023.
PaxDbiP22023.

Expressioni

Gene expression databases

GenevestigatoriP22023.

Interactioni

Protein-protein interaction databases

BioGridi34719. 71 interactions.
DIPiDIP-5326N.
MINTiMINT-510348.
STRINGi4932.YOR336W.

Structurei

3D structure databases

ProteinModelPortaliP22023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1362 – 13654Prevents secretion from ER

Sequence similaritiesi

To D.melanogaster UGGG.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000000800.
InParanoidiP22023.
KOiK11718.
OMAiKLRFVWR.
OrthoDBiEOG7MSMX7.

Family and domain databases

InterProiIPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22023-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN
60 70 80 90 100
LYPLVTGLDD EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM
110 120 130 140 150
IQHDISSNAE QDDANSSYFV LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD
160 170 180 190 200
VIQPYDVVIG TNSEAPILIL YGCPTVIDSD FEEFNRNLFM EAMNGEGKFR
210 220 230 240 250
FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK ILYTVPKEIL
260 270 280 290 300
VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN
310 320 330 340 350
NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL
360 370 380 390 400
TPYNLLTALK TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL
410 420 430 440 450
QNLQPIKMDL HTIPGFSESV IYFNDIESDP QYDELVNSVQ AFFDKSKFGE
460 470 480 490 500
LPEIKQNWSE IIFVIDFARL EDSEVKEALG GLVRAVNVVS QGYPQRVGLL
510 520 530 540 550
PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL SANAKHSKHI
560 570 580 590 600
PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK
610 620 630 640 650
ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES
660 670 680 690 700
VCSERIGYYT KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR
710 720 730 740 750
IIHVGDISDI WYQLRGSLSQ KDPIGSINTF IDALKLKKVK SHTYKKSGLN
760 770 780 790 800
QLGLHKWLPD IPLFELQKGS FIALNGRFIH LDQNEVPETE HFEAIIKREA
810 820 830 840 850
LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ GTHIYNNGID
860 870 880 890 900
YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS
910 920 930 940 950
LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD
960 970 980 990 1000
PEVDIEMDVP NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL
1010 1020 1030 1040 1050
ALVDSAGNII DKTTTMKTFG YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD
1060 1070 1080 1090 1100
GHPDFIPSDS LDILSYNPQK IAVKISEEPT HEEEYEEGRN NDTIINIFTI
1110 1120 1130 1140 1150
LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD TLRKSCEYIN
1160 1170 1180 1190 1200
SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL
1210 1220 1230 1240 1250
YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL
1260 1270 1280 1290 1300
EFYSTEPAFL VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL
1310 1320 1330 1340 1350
QLEVPIRFLK GSYKKKLVIN DECVSEWKKK INKFASSPGD EDVPGESVSS
1360
KYQDSDNAAP LHDEL
Length:1,365
Mass (Da):156,477
Last modified:November 1, 1997 - v2
Checksum:iD0F5851175CC0333
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti582 – 5821Missing in AAA34725. (PubMed:2188106)Curated
Sequence conflicti780 – 79415HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725. (PubMed:2188106)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33556 Genomic DNA. Translation: AAA34725.1.
Z49821 Genomic DNA. Translation: CAA89981.1.
Z75244 Genomic DNA. Translation: CAA99659.1.
BK006948 Genomic DNA. Translation: DAA11097.1.
PIRiS62066. BVBYK5.
RefSeqiNP_014981.1. NM_001183756.1.

Genome annotation databases

EnsemblFungiiYOR336W; YOR336W; YOR336W.
GeneIDi854514.
KEGGisce:YOR336W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33556 Genomic DNA. Translation: AAA34725.1 .
Z49821 Genomic DNA. Translation: CAA89981.1 .
Z75244 Genomic DNA. Translation: CAA99659.1 .
BK006948 Genomic DNA. Translation: DAA11097.1 .
PIRi S62066. BVBYK5.
RefSeqi NP_014981.1. NM_001183756.1.

3D structure databases

ProteinModelPortali P22023.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34719. 71 interactions.
DIPi DIP-5326N.
MINTi MINT-510348.
STRINGi 4932.YOR336W.

Protein family/group databases

CAZyi GT24. Glycosyltransferase Family 24.

Proteomic databases

MaxQBi P22023.
PaxDbi P22023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR336W ; YOR336W ; YOR336W .
GeneIDi 854514.
KEGGi sce:YOR336W.

Organism-specific databases

CYGDi YOR336w.
SGDi S000005863. KRE5.

Phylogenomic databases

eggNOGi NOG320899.
GeneTreei ENSGT00390000004600.
HOGENOMi HOG000000800.
InParanoidi P22023.
KOi K11718.
OMAi KLRFVWR.
OrthoDBi EOG7MSMX7.

Enzyme and pathway databases

BioCyci YEAST:G3O-33811-MONOMER.
Reactomei REACT_189184. ER Quality Control Compartment (ERQC).

Miscellaneous databases

NextBioi 976873.
PROi P22023.

Gene expression databases

Genevestigatori P22023.

Family and domain databases

InterProi IPR009448. UDP-g_GGtrans.
[Graphical view ]
PANTHERi PTHR11226. PTHR11226. 1 hit.
Pfami PF06427. UDP-g_GGTase. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1-->6)-beta-D-glucan synthesis and normal cell growth."
    Meaden P., Hill K., Wagner J., Slipetz D., Sommer S.S., Bussey H.
    Mol. Cell. Biol. 10:3013-3019(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I."
    Parle-McDermott A.G., Hand N.J., Goulding S.E., Wolfe K.H.
    Yeast 12:999-1004(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKRE5_YEAST
AccessioniPrimary (citable) accession number: P22023
Secondary accession number(s): D6W331, Q12190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 815 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3