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P22023

- KRE5_YEAST

UniProt

P22023 - KRE5_YEAST

Protein

Killer toxin-resistance protein 5

Gene

KRE5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

    GO - Molecular functioni

    1. UDP-glucose:glycoprotein glucosyltransferase activity Source: SGD

    GO - Biological processi

    1. (1->6)-beta-D-glucan biosynthetic process Source: SGD
    2. protein glycosylation Source: InterPro
    3. UDP-glucosylation Source: GOC

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33811-MONOMER.
    ReactomeiREACT_189184. ER Quality Control Compartment (ERQC).

    Protein family/group databases

    CAZyiGT24. Glycosyltransferase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer toxin-resistance protein 5
    Gene namesi
    Name:KRE5
    Ordered Locus Names:YOR336W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR336w.
    SGDiS000005863. KRE5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 13651348Killer toxin-resistance protein 5PRO_0000021563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1091 – 10911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1150 – 11501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1195 – 11951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP22023.
    PaxDbiP22023.

    Expressioni

    Gene expression databases

    GenevestigatoriP22023.

    Interactioni

    Protein-protein interaction databases

    BioGridi34719. 71 interactions.
    DIPiDIP-5326N.
    MINTiMINT-510348.
    STRINGi4932.YOR336W.

    Structurei

    3D structure databases

    ProteinModelPortaliP22023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1362 – 13654Prevents secretion from ER

    Sequence similaritiesi

    To D.melanogaster UGGG.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320899.
    GeneTreeiENSGT00390000004600.
    HOGENOMiHOG000000800.
    KOiK11718.
    OMAiKLRFVWR.
    OrthoDBiEOG7MSMX7.

    Family and domain databases

    InterProiIPR009448. UDP-g_GGtrans.
    [Graphical view]
    PANTHERiPTHR11226. PTHR11226. 1 hit.
    PfamiPF06427. UDP-g_GGTase. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22023-1 [UniParc]FASTAAdd to Basket

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    MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN     50
    LYPLVTGLDD EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM 100
    IQHDISSNAE QDDANSSYFV LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD 150
    VIQPYDVVIG TNSEAPILIL YGCPTVIDSD FEEFNRNLFM EAMNGEGKFR 200
    FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK ILYTVPKEIL 250
    VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN 300
    NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL 350
    TPYNLLTALK TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL 400
    QNLQPIKMDL HTIPGFSESV IYFNDIESDP QYDELVNSVQ AFFDKSKFGE 450
    LPEIKQNWSE IIFVIDFARL EDSEVKEALG GLVRAVNVVS QGYPQRVGLL 500
    PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL SANAKHSKHI 550
    PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK 600
    ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES 650
    VCSERIGYYT KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR 700
    IIHVGDISDI WYQLRGSLSQ KDPIGSINTF IDALKLKKVK SHTYKKSGLN 750
    QLGLHKWLPD IPLFELQKGS FIALNGRFIH LDQNEVPETE HFEAIIKREA 800
    LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ GTHIYNNGID 850
    YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS 900
    LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD 950
    PEVDIEMDVP NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL 1000
    ALVDSAGNII DKTTTMKTFG YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD 1050
    GHPDFIPSDS LDILSYNPQK IAVKISEEPT HEEEYEEGRN NDTIINIFTI 1100
    LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD TLRKSCEYIN 1150
    SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL 1200
    YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL 1250
    EFYSTEPAFL VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL 1300
    QLEVPIRFLK GSYKKKLVIN DECVSEWKKK INKFASSPGD EDVPGESVSS 1350
    KYQDSDNAAP LHDEL 1365
    Length:1,365
    Mass (Da):156,477
    Last modified:November 1, 1997 - v2
    Checksum:iD0F5851175CC0333
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti582 – 5821Missing in AAA34725. (PubMed:2188106)Curated
    Sequence conflicti780 – 79415HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725. (PubMed:2188106)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33556 Genomic DNA. Translation: AAA34725.1.
    Z49821 Genomic DNA. Translation: CAA89981.1.
    Z75244 Genomic DNA. Translation: CAA99659.1.
    BK006948 Genomic DNA. Translation: DAA11097.1.
    PIRiS62066. BVBYK5.
    RefSeqiNP_014981.1. NM_001183756.1.

    Genome annotation databases

    EnsemblFungiiYOR336W; YOR336W; YOR336W.
    GeneIDi854514.
    KEGGisce:YOR336W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33556 Genomic DNA. Translation: AAA34725.1 .
    Z49821 Genomic DNA. Translation: CAA89981.1 .
    Z75244 Genomic DNA. Translation: CAA99659.1 .
    BK006948 Genomic DNA. Translation: DAA11097.1 .
    PIRi S62066. BVBYK5.
    RefSeqi NP_014981.1. NM_001183756.1.

    3D structure databases

    ProteinModelPortali P22023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34719. 71 interactions.
    DIPi DIP-5326N.
    MINTi MINT-510348.
    STRINGi 4932.YOR336W.

    Protein family/group databases

    CAZyi GT24. Glycosyltransferase Family 24.

    Proteomic databases

    MaxQBi P22023.
    PaxDbi P22023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR336W ; YOR336W ; YOR336W .
    GeneIDi 854514.
    KEGGi sce:YOR336W.

    Organism-specific databases

    CYGDi YOR336w.
    SGDi S000005863. KRE5.

    Phylogenomic databases

    eggNOGi NOG320899.
    GeneTreei ENSGT00390000004600.
    HOGENOMi HOG000000800.
    KOi K11718.
    OMAi KLRFVWR.
    OrthoDBi EOG7MSMX7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33811-MONOMER.
    Reactomei REACT_189184. ER Quality Control Compartment (ERQC).

    Miscellaneous databases

    NextBioi 976873.
    PROi P22023.

    Gene expression databases

    Genevestigatori P22023.

    Family and domain databases

    InterProi IPR009448. UDP-g_GGtrans.
    [Graphical view ]
    PANTHERi PTHR11226. PTHR11226. 1 hit.
    Pfami PF06427. UDP-g_GGTase. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1-->6)-beta-D-glucan synthesis and normal cell growth."
      Meaden P., Hill K., Wagner J., Slipetz D., Sommer S.S., Bussey H.
      Mol. Cell. Biol. 10:3013-3019(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I."
      Parle-McDermott A.G., Hand N.J., Goulding S.E., Wolfe K.H.
      Yeast 12:999-1004(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKRE5_YEAST
    AccessioniPrimary (citable) accession number: P22023
    Secondary accession number(s): D6W331, Q12190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 815 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3