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P22023

- KRE5_YEAST

UniProt

P22023 - KRE5_YEAST

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Protein
Killer toxin-resistance protein 5
Gene
KRE5, YOR336W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

GO - Molecular functioni

  1. UDP-glucose:glycoprotein glucosyltransferase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. (1->6)-beta-D-glucan biosynthetic process Source: SGD
  2. UDP-glucosylation Source: GOC
  3. protein glycosylation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33811-MONOMER.
ReactomeiREACT_189184. ER Quality Control Compartment (ERQC).

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer toxin-resistance protein 5
Gene namesi
Name:KRE5
Ordered Locus Names:YOR336W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR336w.
SGDiS000005863. KRE5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 13651348Killer toxin-resistance protein 5
PRO_0000021563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi644 – 6441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi870 – 8701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1091 – 10911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1150 – 11501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1195 – 11951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP22023.
PaxDbiP22023.

Expressioni

Gene expression databases

GenevestigatoriP22023.

Interactioni

Protein-protein interaction databases

BioGridi34719. 71 interactions.
DIPiDIP-5326N.
MINTiMINT-510348.
STRINGi4932.YOR336W.

Structurei

3D structure databases

ProteinModelPortaliP22023.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1362 – 13654Prevents secretion from ER

Sequence similaritiesi

To D.melanogaster UGGG.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000000800.
KOiK11718.
OMAiKLRFVWR.
OrthoDBiEOG7MSMX7.

Family and domain databases

InterProiIPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22023-1 [UniParc]FASTAAdd to Basket

« Hide

MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN     50
LYPLVTGLDD EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM 100
IQHDISSNAE QDDANSSYFV LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD 150
VIQPYDVVIG TNSEAPILIL YGCPTVIDSD FEEFNRNLFM EAMNGEGKFR 200
FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK ILYTVPKEIL 250
VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN 300
NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL 350
TPYNLLTALK TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL 400
QNLQPIKMDL HTIPGFSESV IYFNDIESDP QYDELVNSVQ AFFDKSKFGE 450
LPEIKQNWSE IIFVIDFARL EDSEVKEALG GLVRAVNVVS QGYPQRVGLL 500
PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL SANAKHSKHI 550
PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK 600
ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES 650
VCSERIGYYT KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR 700
IIHVGDISDI WYQLRGSLSQ KDPIGSINTF IDALKLKKVK SHTYKKSGLN 750
QLGLHKWLPD IPLFELQKGS FIALNGRFIH LDQNEVPETE HFEAIIKREA 800
LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ GTHIYNNGID 850
YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS 900
LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD 950
PEVDIEMDVP NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL 1000
ALVDSAGNII DKTTTMKTFG YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD 1050
GHPDFIPSDS LDILSYNPQK IAVKISEEPT HEEEYEEGRN NDTIINIFTI 1100
LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD TLRKSCEYIN 1150
SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL 1200
YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL 1250
EFYSTEPAFL VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL 1300
QLEVPIRFLK GSYKKKLVIN DECVSEWKKK INKFASSPGD EDVPGESVSS 1350
KYQDSDNAAP LHDEL 1365
Length:1,365
Mass (Da):156,477
Last modified:November 1, 1997 - v2
Checksum:iD0F5851175CC0333
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti582 – 5821Missing in AAA34725. 1 Publication
Sequence conflicti780 – 79415HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33556 Genomic DNA. Translation: AAA34725.1.
Z49821 Genomic DNA. Translation: CAA89981.1.
Z75244 Genomic DNA. Translation: CAA99659.1.
BK006948 Genomic DNA. Translation: DAA11097.1.
PIRiS62066. BVBYK5.
RefSeqiNP_014981.1. NM_001183756.1.

Genome annotation databases

EnsemblFungiiYOR336W; YOR336W; YOR336W.
GeneIDi854514.
KEGGisce:YOR336W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33556 Genomic DNA. Translation: AAA34725.1 .
Z49821 Genomic DNA. Translation: CAA89981.1 .
Z75244 Genomic DNA. Translation: CAA99659.1 .
BK006948 Genomic DNA. Translation: DAA11097.1 .
PIRi S62066. BVBYK5.
RefSeqi NP_014981.1. NM_001183756.1.

3D structure databases

ProteinModelPortali P22023.
ModBasei Search...

Protein-protein interaction databases

BioGridi 34719. 71 interactions.
DIPi DIP-5326N.
MINTi MINT-510348.
STRINGi 4932.YOR336W.

Protein family/group databases

CAZyi GT24. Glycosyltransferase Family 24.

Proteomic databases

MaxQBi P22023.
PaxDbi P22023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR336W ; YOR336W ; YOR336W .
GeneIDi 854514.
KEGGi sce:YOR336W.

Organism-specific databases

CYGDi YOR336w.
SGDi S000005863. KRE5.

Phylogenomic databases

eggNOGi NOG320899.
GeneTreei ENSGT00390000004600.
HOGENOMi HOG000000800.
KOi K11718.
OMAi KLRFVWR.
OrthoDBi EOG7MSMX7.

Enzyme and pathway databases

BioCyci YEAST:G3O-33811-MONOMER.
Reactomei REACT_189184. ER Quality Control Compartment (ERQC).

Miscellaneous databases

NextBioi 976873.
PROi P22023.

Gene expression databases

Genevestigatori P22023.

Family and domain databases

InterProi IPR009448. UDP-g_GGtrans.
[Graphical view ]
PANTHERi PTHR11226. PTHR11226. 1 hit.
Pfami PF06427. UDP-g_GGTase. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1-->6)-beta-D-glucan synthesis and normal cell growth."
    Meaden P., Hill K., Wagner J., Slipetz D., Sommer S.S., Bussey H.
    Mol. Cell. Biol. 10:3013-3019(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I."
    Parle-McDermott A.G., Hand N.J., Goulding S.E., Wolfe K.H.
    Yeast 12:999-1004(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKRE5_YEAST
AccessioniPrimary (citable) accession number: P22023
Secondary accession number(s): D6W331, Q12190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 815 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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