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Protein

Killer toxin-resistance protein 5

Gene

KRE5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for (1->6)-beta-D-glucan synthesis and normal cell growth.

Miscellaneous

Present with 815 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33811-MONOMER
ReactomeiR-SCE-901032 ER Quality Control Compartment (ERQC)

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

Names & Taxonomyi

Protein namesi
Recommended name:
Killer toxin-resistance protein 5
Gene namesi
Name:KRE5
Ordered Locus Names:YOR336W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR336W
SGDiS000005863 KRE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002156318 – 1365Killer toxin-resistance protein 5Add BLAST1348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1091N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP22023
PaxDbiP22023
PRIDEiP22023

PTM databases

iPTMnetiP22023

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FIG4P428372EBI-9919,EBI-28407

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34719184 interactors.
DIPiDIP-5326N
IntActiP22023 7 interactors.
MINTiP22023
STRINGi4932.YOR336W

Structurei

3D structure databases

ProteinModelPortaliP22023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1362 – 1365Prevents secretion from ER4

Sequence similaritiesi

To D.melanogaster UGGG.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000004600
HOGENOMiHOG000000800
InParanoidiP22023
KOiK11718
OMAiDLKYHIS
OrthoDBiEOG092C04AQ

Family and domain databases

InterProiView protein in InterPro
IPR009448 UDP-g_GGtrans
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF06427 UDP-g_GGTase, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLALVLLL LCAPLRAWTY SLRYGIPESA QVWSILVHLL GDVDNQLLTN
60 70 80 90 100
LYPLVTGLDD EIDIQENLVA LTSNVLRERY DKEDVADLLE LYASLYPMGM
110 120 130 140 150
IQHDISSNAE QDDANSSYFV LNGNRYEKPD DVFYLKSKDL TIQQKVPDVD
160 170 180 190 200
VIQPYDVVIG TNSEAPILIL YGCPTVIDSD FEEFNRNLFM EAMNGEGKFR
210 220 230 240 250
FIWRSTCSLD GKSVEYPLTH PLEITLQNGS RMSSIPQLKK ILYTVPKEIL
260 270 280 290 300
VGADNDDQLH DLEPEELREL DLRVTSLISE FYQYKKDITA TLNFTKSIVN
310 320 330 340 350
NFPLISKQLI KVSSVNKDII TSNEELNSKG FDYNMLGLYI NGQNWKITSL
360 370 380 390 400
TPYNLLTALK TEYQSLLKIT NLLQELEPSK CILDSKFLLN KFSQFSLGKL
410 420 430 440 450
QNLQPIKMDL HTIPGFSESV IYFNDIESDP QYDELVNSVQ AFFDKSKFGE
460 470 480 490 500
LPEIKQNWSE IIFVIDFARL EDSEVKEALG GLVRAVNVVS QGYPQRVGLL
510 520 530 540 550
PFSSDSDKSV VNKIYELKNS TDNLTELKSF LETMLLADGL SANAKHSKHI
560 570 580 590 600
PVPDVFHLLD ELQIDETSII INGEIYPFRK NAWNYLIAKV IKKDTEFIRK
610 620 630 640 650
ELSNSSPKNK QISVRDLLHY KSANLRHNKY TPNYFADSVY SSVNNTALES
660 670 680 690 700
VCSERIGYYT KNEEYNLLHT ITLVDDFGSI HALKRLRNLL HTSFVGVRIR
710 720 730 740 750
IIHVGDISDI WYQLRGSLSQ KDPIGSINTF IDALKLKKVK SHTYKKSGLN
760 770 780 790 800
QLGLHKWLPD IPLFELQKGS FIALNGRFIH LDQNEVPETE HFEAIIKREA
810 820 830 840 850
LRTIDSVFAL DLLFPGFSQE IINPDLIEMI SSILTRLFYQ GTHIYNNGID
860 870 880 890 900
YTTESSLPRM DLSEFFRPNN LTMFEDGKSA SIDLLLILDP LEERTQMILS
910 920 930 940 950
LVEQFRPLKF VNIQVILMPT LELNIVPIRR IYVDDADIVK SITSEDSRSD
960 970 980 990 1000
PEVDIEMDVP NSFIVDNNYR IKKLLIELHS FSSKTVLSTG NIDGMGGVCL
1010 1020 1030 1040 1050
ALVDSAGNII DKTTTMKTFG YGQFHTDKFL KGCYIKSCDS RYTVQSFSTD
1060 1070 1080 1090 1100
GHPDFIPSDS LDILSYNPQK IAVKISEEPT HEEEYEEGRN NDTIINIFTI
1110 1120 1130 1140 1150
LESGPDEEER YMQMILSILS KCPETQKVNF FILDQPFISD TLRKSCEYIN
1160 1170 1180 1190 1200
SSDEMRGNVI FLNYEWPQWL RPQRFSSRRR DVSRFLFLDV LLPQNISKVL
1210 1220 1230 1240 1250
YMSPTEVPLD PFDIFQFQGL KRAPLGLFRM SGDGYWKEGY WEKMLRENNL
1260 1270 1280 1290 1300
EFYSTEPAFL VNLERFRELD AGDKYRIHYQ RISTDAMSLV NIGQDLVNNL
1310 1320 1330 1340 1350
QLEVPIRFLK GSYKKKLVIN DECVSEWKKK INKFASSPGD EDVPGESVSS
1360
KYQDSDNAAP LHDEL
Length:1,365
Mass (Da):156,477
Last modified:November 1, 1997 - v2
Checksum:iD0F5851175CC0333
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti582Missing in AAA34725 (PubMed:2188106).Curated1
Sequence conflicti780 – 794HLDQN…EHFEA → ILIKMKCQKQNISKAK in AAA34725 (PubMed:2188106).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33556 Genomic DNA Translation: AAA34725.1
Z49821 Genomic DNA Translation: CAA89981.1
Z75244 Genomic DNA Translation: CAA99659.1
BK006948 Genomic DNA Translation: DAA11097.1
PIRiS62066 BVBYK5
RefSeqiNP_014981.1, NM_001183756.1

Genome annotation databases

EnsemblFungiiYOR336W; YOR336W; YOR336W
GeneIDi854514
KEGGisce:YOR336W

Similar proteinsi

Entry informationi

Entry nameiKRE5_YEAST
AccessioniPrimary (citable) accession number: P22023
Secondary accession number(s): D6W331, Q12190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome