##gff-version 3
P22004	UniProtKB	Signal peptide	1	20	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Propeptide	21	374	.	.	.	ID=PRO_0000033870;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Chain	375	513	.	.	.	ID=PRO_0000033871;Note=Bone morphogenetic protein 6	
P22004	UniProtKB	Region	38	66	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Region	89	131	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Region	145	200	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Region	373	398	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Compositional bias	103	121	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Compositional bias	160	174	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Compositional bias	382	398	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P22004	UniProtKB	Glycosylation	241	241	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Glycosylation	269	269	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Glycosylation	386	386	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Glycosylation	404	404	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P22004	UniProtKB	Glycosylation	454	454	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:18070108;Dbxref=PMID:18070108	
P22004	UniProtKB	Disulfide bond	412	478	.	.	.	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18070108,ECO:0000269|PubMed:31019025;Dbxref=PMID:18070108,PMID:31019025	
P22004	UniProtKB	Disulfide bond	441	510	.	.	.	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18070108,ECO:0000269|PubMed:31019025;Dbxref=PMID:18070108,PMID:31019025	
P22004	UniProtKB	Disulfide bond	445	512	.	.	.	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18070108,ECO:0000269|PubMed:31019025;Dbxref=PMID:18070108,PMID:31019025	
P22004	UniProtKB	Disulfide bond	477	477	.	.	.	Note=Interchain;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18070108,ECO:0000269|PubMed:31019025;Dbxref=PMID:18070108,PMID:31019025	
P22004	UniProtKB	Natural variant	95	95	.	.	.	ID=VAR_087884;Note=In IO%3B associated with disease susceptibility%3B some patients also carry a HFE variant%3B decreased function in positive regulation of SMAD protein signal transduction%3B results in partial activation of hepcidin expression%3B affects post-translational processing resulting in reduced amount of the mature form%3B results in impaired secretion. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26582087,ECO:0000269|PubMed:27591421;Dbxref=dbSNP:rs199518216,PMID:26582087,PMID:27591421	
P22004	UniProtKB	Natural variant	96	96	.	.	.	ID=VAR_087885;Note=In IO%3B associated with disease susceptibility%3B some patients also carry a HFE variant%3B decreased function in positive regulation of SMAD protein signal transduction%3B results in partial activation of hepcidin expression%3B affects post-translational processing resulting in reduced amount of the mature form%3B results in impaired secretion. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26582087,ECO:0000269|PubMed:27590690,ECO:0000269|PubMed:28335084,ECO:0000269|PubMed:31640930;Dbxref=dbSNP:rs200573175,PMID:26582087,PMID:27590690,PMID:28335084,PMID:31640930	
P22004	UniProtKB	Natural variant	112	112	.	.	.	ID=VAR_087886;Note=In IO%3B associated with disease susceptibility. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28335084;Dbxref=dbSNP:rs201486498,PMID:28335084	
P22004	UniProtKB	Natural variant	113	113	.	.	.	ID=VAR_087887;Note=In IO%3B associated with disease susceptibility%3B some patients also carry a HFE variant%3B decreased function in positive regulation of SMAD protein signal transduction%3B results in partial activation of hepcidin expression%3B affects post-translational processing resulting in reduced amount of the mature form%3B results in impaired secretion. Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26582087,ECO:0000269|PubMed:27591421,ECO:0000269|PubMed:31640930;Dbxref=dbSNP:rs7745236,PMID:26582087,PMID:27591421,PMID:31640930	
P22004	UniProtKB	Natural variant	158	513	.	.	.	ID=VAR_087888;Note=In IO%3B associated with disease susceptibility. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32464486;Dbxref=PMID:32464486	
P22004	UniProtKB	Natural variant	257	257	.	.	.	ID=VAR_047055;Note=R->C;Dbxref=dbSNP:rs10458105	
P22004	UniProtKB	Natural variant	257	257	.	.	.	ID=VAR_087889;Note=In IO%3B associated with disease susceptibility. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28335084,ECO:0000269|PubMed:32464486;Dbxref=dbSNP:rs148916269,PMID:28335084,PMID:32464486	
P22004	UniProtKB	Natural variant	343	343	.	.	.	ID=VAR_036200;Note=In a colorectal cancer sample%3B somatic mutation. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
P22004	UniProtKB	Natural variant	394	394	.	.	.	ID=VAR_087890;Note=In IO%3B associated with disease susceptibility%3B results in decreased activation of hepcidin expression in cultured liver cells. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:32464486,ECO:0000269|PubMed:34037557;Dbxref=dbSNP:rs142167481,PMID:32464486,PMID:34037557	
P22004	UniProtKB	Natural variant	476	476	.	.	.	ID=VAR_036201;Note=In a colorectal cancer sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs909733732,PMID:16959974	
P22004	UniProtKB	Beta strand	411	415	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	418	420	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Turn	421	425	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Turn	427	429	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	430	432	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	434	437	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	440	442	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Turn	451	454	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Helix	457	468	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Turn	470	472	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	477	491	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53	
P22004	UniProtKB	Beta strand	497	513	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2R53