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P22004

- BMP6_HUMAN

UniProt

P22004 - BMP6_HUMAN

Protein

Bone morphogenetic protein 6

Gene

BMP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. protein heterodimerization activity Source: MGI

    GO - Biological processi

    1. BMP signaling pathway Source: BHF-UCL
    2. cartilage development Source: UniProtKB-KW
    3. cellular response to mechanical stimulus Source: Ensembl
    4. endochondral ossification Source: Ensembl
    5. eye development Source: Ensembl
    6. growth Source: InterPro
    7. immune response Source: BHF-UCL
    8. inflammatory response Source: Ensembl
    9. kidney development Source: Ensembl
    10. male genitalia development Source: Ensembl
    11. osteoblast differentiation Source: Ensembl
    12. positive regulation of aldosterone biosynthetic process Source: UniProtKB
    13. positive regulation of aldosterone secretion Source: Ensembl
    14. positive regulation of bone mineralization Source: BHF-UCL
    15. positive regulation of chondrocyte differentiation Source: Ensembl
    16. positive regulation of DNA-dependent DNA replication Source: BHF-UCL
    17. positive regulation of endothelial cell differentiation Source: Ensembl
    18. positive regulation of endothelial cell proliferation Source: Ensembl
    19. positive regulation of epithelial cell proliferation Source: BHF-UCL
    20. positive regulation of neuron differentiation Source: Ensembl
    21. positive regulation of osteoblast differentiation Source: BHF-UCL
    22. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    23. positive regulation of protein secretion Source: BHF-UCL
    24. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    25. response to activity Source: Ensembl
    26. response to glucocorticoid Source: Ensembl
    27. response to iron ion Source: Ensembl
    28. response to magnesium ion Source: Ensembl
    29. response to retinoic acid Source: Ensembl
    30. skeletal system development Source: ProtInc
    31. SMAD protein signal transduction Source: UniProtKB
    32. type B pancreatic cell development Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    SignaLinkiP22004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 6
    Short name:
    BMP-6
    Alternative name(s):
    VG-1-related protein
    Short name:
    VG-1-R
    Short name:
    VGR-1
    Gene namesi
    Name:BMP6
    Synonyms:VGR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1073. BMP6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. membrane-bounded vesicle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25383.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 374354Sequence AnalysisPRO_0000033870Add
    BLAST
    Chaini375 – 513139Bone morphogenetic protein 6PRO_0000033871Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi412 ↔ 478By similarity
    Disulfide bondi441 ↔ 510By similarity
    Disulfide bondi445 ↔ 512By similarity
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi477 – 477InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP22004.
    PaxDbiP22004.
    PRIDEiP22004.

    PTM databases

    PhosphoSiteiP22004.

    Expressioni

    Gene expression databases

    ArrayExpressiP22004.
    BgeeiP22004.
    CleanExiHS_BMP6.
    GenevestigatoriP22004.

    Organism-specific databases

    HPAiCAB002773.

    Interactioni

    Subunit structurei

    Interacts with SOSTDC1.By similarity

    Protein-protein interaction databases

    BioGridi107122. 5 interactions.
    DIPiDIP-5797N.
    STRINGi9606.ENSP00000283147.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi411 – 4155
    Beta strandi418 – 4203
    Turni421 – 4255
    Turni427 – 4293
    Beta strandi430 – 4323
    Beta strandi434 – 4374
    Beta strandi440 – 4423
    Turni451 – 4544
    Helixi457 – 46812
    Turni470 – 4723
    Beta strandi477 – 49115
    Beta strandi497 – 51317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QCWX-ray2.49A/B382-513[»]
    2R52X-ray2.50A/B375-513[»]
    2R53X-ray2.10A/B411-513[»]
    ProteinModelPortaliP22004.
    SMRiP22004. Positions 411-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22004.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiP22004.
    KOiK16620.
    OMAiWWGLLCS.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP22004.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22004-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP    50
    GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ 100
    QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED 150
    GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL 200
    TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV 250
    VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA 300
    SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD 350
    GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA 400
    SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN 450
    AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK 500
    KYRNMVVRAC GCH 513
    Length:513
    Mass (Da):57,226
    Last modified:August 1, 1991 - v1
    Checksum:i3F19155B36049278
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti257 – 2571R → C.
    Corresponds to variant rs10458105 [ dbSNP | Ensembl ].
    VAR_047055
    Natural varianti343 – 3431A → D in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036200
    Natural varianti476 – 4761P → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036201

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60315 mRNA. Translation: AAA36737.1.
    AL135778, AL133541 Genomic DNA. Translation: CAI19426.1.
    AL133541, AL135778 Genomic DNA. Translation: CAI19472.1.
    CCDSiCCDS4503.1.
    PIRiB39263. BMHU6.
    RefSeqiNP_001709.1. NM_001718.4.
    UniGeneiHs.285671.

    Genome annotation databases

    EnsembliENST00000283147; ENSP00000283147; ENSG00000153162.
    GeneIDi654.
    KEGGihsa:654.
    UCSCiuc003mxu.4. human.

    Polymorphism databases

    DMDMi115076.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 6 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60315 mRNA. Translation: AAA36737.1 .
    AL135778 , AL133541 Genomic DNA. Translation: CAI19426.1 .
    AL133541 , AL135778 Genomic DNA. Translation: CAI19472.1 .
    CCDSi CCDS4503.1.
    PIRi B39263. BMHU6.
    RefSeqi NP_001709.1. NM_001718.4.
    UniGenei Hs.285671.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QCW X-ray 2.49 A/B 382-513 [» ]
    2R52 X-ray 2.50 A/B 375-513 [» ]
    2R53 X-ray 2.10 A/B 411-513 [» ]
    ProteinModelPortali P22004.
    SMRi P22004. Positions 411-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107122. 5 interactions.
    DIPi DIP-5797N.
    STRINGi 9606.ENSP00000283147.

    PTM databases

    PhosphoSitei P22004.

    Polymorphism databases

    DMDMi 115076.

    Proteomic databases

    MaxQBi P22004.
    PaxDbi P22004.
    PRIDEi P22004.

    Protocols and materials databases

    DNASUi 654.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283147 ; ENSP00000283147 ; ENSG00000153162 .
    GeneIDi 654.
    KEGGi hsa:654.
    UCSCi uc003mxu.4. human.

    Organism-specific databases

    CTDi 654.
    GeneCardsi GC06P007672.
    HGNCi HGNC:1073. BMP6.
    HPAi CAB002773.
    MIMi 112266. gene.
    neXtProti NX_P22004.
    PharmGKBi PA25383.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272883.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi P22004.
    KOi K16620.
    OMAi WWGLLCS.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P22004.
    TreeFami TF316134.

    Enzyme and pathway databases

    SignaLinki P22004.

    Miscellaneous databases

    ChiTaRSi BMP6. human.
    EvolutionaryTracei P22004.
    GeneWikii Bone_morphogenetic_protein_6.
    GenomeRNAii 654.
    NextBioi 2660.
    PROi P22004.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22004.
    Bgeei P22004.
    CleanExi HS_BMP6.
    Genevestigatori P22004.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
      Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
      Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-343 AND LEU-476.
    4. "BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."
      Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S.
      Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 382-513.

    Entry informationi

    Entry nameiBMP6_HUMAN
    AccessioniPrimary (citable) accession number: P22004
    Secondary accession number(s): Q5TCP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3