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P22004 (BMP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 6

Short name=BMP-6
Alternative name(s):
VG-1-related protein
Short name=VG-1-R
Short name=VGR-1
Gene names
Name:BMP6
Synonyms:VGR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces cartilage and bone formation.

Subunit structure

Interacts with SOSTDC1 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 18436533. Source: BHF-UCL

SMAD protein signal transduction

Inferred from direct assay PubMed 17244894. Source: UniProtKB

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from electronic annotation. Source: Ensembl

eye development

Inferred from electronic annotation. Source: Ensembl

growth

Inferred from electronic annotation. Source: InterPro

immune response

Inferred from mutant phenotype PubMed 16886151. Source: BHF-UCL

inflammatory response

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA-dependent DNA replication

Non-traceable author statement PubMed 15516325. Source: BHF-UCL

positive regulation of aldosterone biosynthetic process

Inferred from direct assay PubMed 16527843. Source: UniProtKB

positive regulation of aldosterone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from direct assay PubMed 18436533. Source: BHF-UCL

positive regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 11865031. Source: BHF-UCL

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from direct assay PubMed 18436533. Source: BHF-UCL

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 17244894. Source: UniProtKB

positive regulation of protein secretion

Non-traceable author statement PubMed 15516325. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16527843. Source: UniProtKB

response to activity

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to iron ion

Inferred from electronic annotation. Source: Ensembl

response to magnesium ion

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Traceable author statement PubMed 8089189. Source: ProtInc

type B pancreatic cell development

Inferred from direct assay PubMed 11865031. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionBMP receptor binding

Inferred from physical interaction PubMed 7811286. Source: MGI

protein heterodimerization activity

Inferred from direct assay PubMed 7811286. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 374354 Potential
PRO_0000033870
Chain375 – 513139Bone morphogenetic protein 6
PRO_0000033871

Amino acid modifications

Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3861N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4541N-linked (GlcNAc...) Potential
Disulfide bond412 ↔ 478 By similarity
Disulfide bond441 ↔ 510 By similarity
Disulfide bond445 ↔ 512 By similarity
Disulfide bond477Interchain By similarity

Natural variations

Natural variant2571R → C.
Corresponds to variant rs10458105 [ dbSNP | Ensembl ].
VAR_047055
Natural variant3431A → D in a colorectal cancer sample; somatic mutation. Ref.3
VAR_036200
Natural variant4761P → L in a colorectal cancer sample; somatic mutation. Ref.3
VAR_036201

Secondary structure

...................... 513
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22004 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 3F19155B36049278

FASTA51357,226
        10         20         30         40         50         60 
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP 

        70         80         90        100        110        120 
QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP 

       130        140        150        160        170        180 
RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH 

       190        200        210        220        230        240 
PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF 

       250        260        270        280        290        300 
NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA 

       310        320        330        340        350        360 
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV 

       370        380        390        400        410        420 
AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS 

       430        440        450        460        470        480 
FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP 

       490        500        510 
TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH 

« Hide

References

« Hide 'large scale' references
[1]"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-343 AND LEU-476.
[4]"BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."
Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S.
Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 382-513.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 6 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60315 mRNA. Translation: AAA36737.1.
AL135778, AL133541 Genomic DNA. Translation: CAI19426.1.
AL133541, AL135778 Genomic DNA. Translation: CAI19472.1.
CCDSCCDS4503.1.
PIRBMHU6. B39263.
RefSeqNP_001709.1. NM_001718.4.
UniGeneHs.285671.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QCWX-ray2.49A/B382-513[»]
2R52X-ray2.50A/B375-513[»]
2R53X-ray2.10A/B411-513[»]
ProteinModelPortalP22004.
SMRP22004. Positions 411-513.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107122. 5 interactions.
DIPDIP-5797N.
STRING9606.ENSP00000283147.

PTM databases

PhosphoSiteP22004.

Polymorphism databases

DMDM115076.

Proteomic databases

MaxQBP22004.
PaxDbP22004.
PRIDEP22004.

Protocols and materials databases

DNASU654.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283147; ENSP00000283147; ENSG00000153162.
GeneID654.
KEGGhsa:654.
UCSCuc003mxu.4. human.

Organism-specific databases

CTD654.
GeneCardsGC06P007672.
HGNCHGNC:1073. BMP6.
HPACAB002773.
MIM112266. gene.
neXtProtNX_P22004.
PharmGKBPA25383.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272883.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidP22004.
KOK16620.
OMAWWGLLCS.
OrthoDBEOG7J9VPQ.
PhylomeDBP22004.
TreeFamTF316134.

Enzyme and pathway databases

SignaLinkP22004.

Gene expression databases

ArrayExpressP22004.
BgeeP22004.
CleanExHS_BMP6.
GenevestigatorP22004.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBMP6. human.
EvolutionaryTraceP22004.
GeneWikiBone_morphogenetic_protein_6.
GenomeRNAi654.
NextBio2660.
PROP22004.
SOURCESearch...

Entry information

Entry nameBMP6_HUMAN
AccessionPrimary (citable) accession number: P22004
Secondary accession number(s): Q5TCP3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM