Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone morphogenetic protein 6

Gene

BMP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

SignaLinkiP22004

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VG-1-R
Short name:
VGR-1
Gene namesi
Name:BMP6
Synonyms:VGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000153162.8
HGNCiHGNC:1073 BMP6
MIMi112266 gene
neXtProtiNX_P22004

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi654
MalaCardsiBMP6
OpenTargetsiENSG00000153162
PharmGKBiPA25383

Chemistry databases

ChEMBLiCHEMBL3286078

Polymorphism and mutation databases

BioMutaiBMP6
DMDMi115076

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003387021 – 374Sequence analysisAdd BLAST354
ChainiPRO_0000033871375 – 513Bone morphogenetic protein 6Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 478By similarity
Disulfide bondi441 ↔ 510By similarity
Disulfide bondi445 ↔ 512By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi477InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP22004
PaxDbiP22004
PeptideAtlasiP22004
PRIDEiP22004

PTM databases

iPTMnetiP22004
PhosphoSitePlusiP22004

Expressioni

Gene expression databases

BgeeiENSG00000153162
CleanExiHS_BMP6
GenevisibleiP22004 HS

Organism-specific databases

HPAiCAB002773
HPA062683

Interactioni

Subunit structurei

Interacts with SOSTDC1.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi107122, 5 interactors
DIPiDIP-5797N
IntActiP22004, 1 interactor
STRINGi9606.ENSP00000283147

Chemistry databases

BindingDBiP22004

Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi411 – 415Combined sources5
Beta strandi418 – 420Combined sources3
Turni421 – 425Combined sources5
Turni427 – 429Combined sources3
Beta strandi430 – 432Combined sources3
Beta strandi434 – 437Combined sources4
Beta strandi440 – 442Combined sources3
Turni451 – 454Combined sources4
Helixi457 – 468Combined sources12
Turni470 – 472Combined sources3
Beta strandi477 – 491Combined sources15
Beta strandi497 – 513Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCWX-ray2.49A/B382-513[»]
2R52X-ray2.50A/B375-513[»]
2R53X-ray2.10A/B411-513[»]
ProteinModelPortaliP22004
SMRiP22004
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22004

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP22004
KOiK16620
OMAiIYKDCVV
OrthoDBiEOG091G0C2J
PhylomeDBiP22004
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP
60 70 80 90 100
GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ
110 120 130 140 150
QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED
160 170 180 190 200
GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL
210 220 230 240 250
TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV
260 270 280 290 300
VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA
310 320 330 340 350
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD
360 370 380 390 400
GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA
410 420 430 440 450
SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN
460 470 480 490 500
AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK
510
KYRNMVVRAC GCH
Length:513
Mass (Da):57,226
Last modified:August 1, 1991 - v1
Checksum:i3F19155B36049278
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047055257R → C. Corresponds to variant dbSNP:rs10458105Ensembl.1
Natural variantiVAR_036200343A → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036201476P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs909733732Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60315 mRNA Translation: AAA36737.1
AL135778 Genomic DNA No translation available.
AL133541 Genomic DNA No translation available.
CCDSiCCDS4503.1
PIRiB39263 BMHU6
RefSeqiNP_001709.1, NM_001718.5
UniGeneiHs.285671

Genome annotation databases

EnsembliENST00000283147; ENSP00000283147; ENSG00000153162
GeneIDi654
KEGGihsa:654
UCSCiuc003mxu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBMP6_HUMAN
AccessioniPrimary (citable) accession number: P22004
Secondary accession number(s): Q5TCP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health