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Protein

Bone morphogenetic protein 6

Gene

BMP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • protein heterodimerization activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153162-MONOMER.
SignaLinkiP22004.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VG-1-R
Short name:
VGR-1
Gene namesi
Name:BMP6
Synonyms:VGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1073. BMP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi654.
OpenTargetsiENSG00000153162.
PharmGKBiPA25383.

Chemistry databases

ChEMBLiCHEMBL3286078.

Polymorphism and mutation databases

BioMutaiBMP6.
DMDMi115076.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003387021 – 374Sequence analysisAdd BLAST354
ChainiPRO_0000033871375 – 513Bone morphogenetic protein 6Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi412 ↔ 478By similarity
Disulfide bondi441 ↔ 510By similarity
Disulfide bondi445 ↔ 512By similarity
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi477InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP22004.
PaxDbiP22004.
PeptideAtlasiP22004.
PRIDEiP22004.

PTM databases

iPTMnetiP22004.
PhosphoSitePlusiP22004.

Expressioni

Gene expression databases

BgeeiENSG00000153162.
CleanExiHS_BMP6.
GenevisibleiP22004. HS.

Organism-specific databases

HPAiCAB002773.

Interactioni

Subunit structurei

Interacts with SOSTDC1.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • protein heterodimerization activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi107122. 4 interactors.
DIPiDIP-5797N.
STRINGi9606.ENSP00000283147.

Chemistry databases

BindingDBiP22004.

Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi411 – 415Combined sources5
Beta strandi418 – 420Combined sources3
Turni421 – 425Combined sources5
Turni427 – 429Combined sources3
Beta strandi430 – 432Combined sources3
Beta strandi434 – 437Combined sources4
Beta strandi440 – 442Combined sources3
Turni451 – 454Combined sources4
Helixi457 – 468Combined sources12
Turni470 – 472Combined sources3
Beta strandi477 – 491Combined sources15
Beta strandi497 – 513Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCWX-ray2.49A/B382-513[»]
2R52X-ray2.50A/B375-513[»]
2R53X-ray2.10A/B411-513[»]
ProteinModelPortaliP22004.
SMRiP22004.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22004.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP22004.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG091G0C2J.
PhylomeDBiP22004.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP
60 70 80 90 100
GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ
110 120 130 140 150
QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED
160 170 180 190 200
GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL
210 220 230 240 250
TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV
260 270 280 290 300
VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA
310 320 330 340 350
SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD
360 370 380 390 400
GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA
410 420 430 440 450
SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN
460 470 480 490 500
AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK
510
KYRNMVVRAC GCH
Length:513
Mass (Da):57,226
Last modified:August 1, 1991 - v1
Checksum:i3F19155B36049278
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047055257R → C.Corresponds to variant rs10458105dbSNPEnsembl.1
Natural variantiVAR_036200343A → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036201476P → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60315 mRNA. Translation: AAA36737.1.
AL135778, AL133541 Genomic DNA. Translation: CAI19426.1.
AL133541, AL135778 Genomic DNA. Translation: CAI19472.1.
CCDSiCCDS4503.1.
PIRiB39263. BMHU6.
RefSeqiNP_001709.1. NM_001718.5.
UniGeneiHs.285671.

Genome annotation databases

EnsembliENST00000283147; ENSP00000283147; ENSG00000153162.
GeneIDi654.
KEGGihsa:654.
UCSCiuc003mxu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 6 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60315 mRNA. Translation: AAA36737.1.
AL135778, AL133541 Genomic DNA. Translation: CAI19426.1.
AL133541, AL135778 Genomic DNA. Translation: CAI19472.1.
CCDSiCCDS4503.1.
PIRiB39263. BMHU6.
RefSeqiNP_001709.1. NM_001718.5.
UniGeneiHs.285671.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCWX-ray2.49A/B382-513[»]
2R52X-ray2.50A/B375-513[»]
2R53X-ray2.10A/B411-513[»]
ProteinModelPortaliP22004.
SMRiP22004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107122. 4 interactors.
DIPiDIP-5797N.
STRINGi9606.ENSP00000283147.

Chemistry databases

BindingDBiP22004.
ChEMBLiCHEMBL3286078.

PTM databases

iPTMnetiP22004.
PhosphoSitePlusiP22004.

Polymorphism and mutation databases

BioMutaiBMP6.
DMDMi115076.

Proteomic databases

MaxQBiP22004.
PaxDbiP22004.
PeptideAtlasiP22004.
PRIDEiP22004.

Protocols and materials databases

DNASUi654.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283147; ENSP00000283147; ENSG00000153162.
GeneIDi654.
KEGGihsa:654.
UCSCiuc003mxu.5. human.

Organism-specific databases

CTDi654.
DisGeNETi654.
GeneCardsiBMP6.
HGNCiHGNC:1073. BMP6.
HPAiCAB002773.
MIMi112266. gene.
neXtProtiNX_P22004.
OpenTargetsiENSG00000153162.
PharmGKBiPA25383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP22004.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG091G0C2J.
PhylomeDBiP22004.
TreeFamiTF316134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153162-MONOMER.
SignaLinkiP22004.

Miscellaneous databases

ChiTaRSiBMP6. human.
EvolutionaryTraceiP22004.
GeneWikiiBone_morphogenetic_protein_6.
GenomeRNAii654.
PROiP22004.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153162.
CleanExiHS_BMP6.
GenevisibleiP22004. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP6_HUMAN
AccessioniPrimary (citable) accession number: P22004
Secondary accession number(s): Q5TCP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.