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P22003

- BMP5_HUMAN

UniProt

P22003 - BMP5_HUMAN

Protein

Bone morphogenetic protein 5

Gene

BMP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. growth Source: InterPro
    3. male genitalia development Source: Ensembl
    4. negative regulation of aldosterone biosynthetic process Source: BHF-UCL
    5. negative regulation of cell proliferation Source: BHF-UCL
    6. negative regulation of cortisol biosynthetic process Source: BHF-UCL
    7. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
    8. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    9. negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
    10. negative regulation of mononuclear cell migration Source: BHF-UCL
    11. negative regulation of steroid biosynthetic process Source: BHF-UCL
    12. ossification Source: UniProtKB-KW
    13. pattern specification process Source: Ensembl
    14. positive regulation of dendrite development Source: BHF-UCL
    15. positive regulation of DNA-dependent DNA replication Source: BHF-UCL
    16. positive regulation of epithelial cell proliferation Source: BHF-UCL
    17. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    18. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    19. skeletal system development Source: UniProtKB
    20. type B pancreatic cell development Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 5
    Short name:
    BMP-5
    Gene namesi
    Name:BMP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1072. BMP5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL
    2. membrane-bounded vesicle Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Propeptidei31 – 316286Sequence AnalysisPRO_0000033866Add
    BLAST
    Chaini317 – 454138Bone morphogenetic protein 5PRO_0000033867Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi353 ↔ 419By similarity
    Disulfide bondi382 ↔ 451By similarity
    Disulfide bondi386 ↔ 453By similarity
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi418 – 418InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP22003.
    PRIDEiP22003.

    PTM databases

    PhosphoSiteiP22003.

    Expressioni

    Tissue specificityi

    Expressed in the lung and liver.

    Gene expression databases

    ArrayExpressiP22003.
    BgeeiP22003.
    CleanExiHS_BMP5.
    GenevestigatoriP22003.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359866.

    Structurei

    3D structure databases

    ProteinModelPortaliP22003.
    SMRiP22003. Positions 352-454.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiP22003.
    KOiK04663.
    OMAiLYNAMAN.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP22003.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22003-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE    50
    IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS 100
    VRASLAEETR GARKGYPASP NGYPRRIQLS RTTPLTTQSP PLASLHDTNF 150
    LNDADMVMSF VNLVERDKDF SHQRRHYKEF RFDLTQIPHG EAVTAAEFRI 200
    YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA QALDVGWLVF 250
    DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 300
    MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK 350
    QACKKHELYV SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA 400
    IVQTLVHLMF PDHVPKPCCA PTKLNAISVL YFDDSSNVIL KKYRNMVVRS 450
    CGCH 454
    Length:454
    Mass (Da):51,737
    Last modified:August 1, 1991 - v1
    Checksum:i631277413CCC22EE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21H → Y.
    Corresponds to variant rs9475437 [ dbSNP | Ensembl ].
    VAR_047054
    Natural varianti121 – 1211N → S.
    Corresponds to variant rs35124644 [ dbSNP | Ensembl ].
    VAR_061896

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60314 mRNA. Translation: AAA36736.1.
    AL133386, AL137178 Genomic DNA. Translation: CAB81657.2.
    AL137178, AL133386 Genomic DNA. Translation: CAC12765.2.
    BC027958 mRNA. Translation: AAH27958.1.
    CCDSiCCDS4958.1.
    PIRiA39263. BMHU5.
    RefSeqiNP_066551.1. NM_021073.2.
    UniGeneiHs.296648.

    Genome annotation databases

    EnsembliENST00000370830; ENSP00000359866; ENSG00000112175.
    GeneIDi653.
    KEGGihsa:653.
    UCSCiuc003pcq.3. human.

    Polymorphism databases

    DMDMi115075.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 5 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60314 mRNA. Translation: AAA36736.1 .
    AL133386 , AL137178 Genomic DNA. Translation: CAB81657.2 .
    AL137178 , AL133386 Genomic DNA. Translation: CAC12765.2 .
    BC027958 mRNA. Translation: AAH27958.1 .
    CCDSi CCDS4958.1.
    PIRi A39263. BMHU5.
    RefSeqi NP_066551.1. NM_021073.2.
    UniGenei Hs.296648.

    3D structure databases

    ProteinModelPortali P22003.
    SMRi P22003. Positions 352-454.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359866.

    PTM databases

    PhosphoSitei P22003.

    Polymorphism databases

    DMDMi 115075.

    Proteomic databases

    PaxDbi P22003.
    PRIDEi P22003.

    Protocols and materials databases

    DNASUi 653.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370830 ; ENSP00000359866 ; ENSG00000112175 .
    GeneIDi 653.
    KEGGi hsa:653.
    UCSCi uc003pcq.3. human.

    Organism-specific databases

    CTDi 653.
    GeneCardsi GC06M055667.
    HGNCi HGNC:1072. BMP5.
    MIMi 112265. gene.
    neXtProti NX_P22003.
    PharmGKBi PA25382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272883.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi P22003.
    KOi K04663.
    OMAi LYNAMAN.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P22003.
    TreeFami TF316134.

    Miscellaneous databases

    GeneWikii Bone_morphogenetic_protein_5.
    GenomeRNAii 653.
    NextBioi 2656.
    PROi P22003.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22003.
    Bgeei P22003.
    CleanExi HS_BMP5.
    Genevestigatori P22003.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
      Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
      Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Spleen.

    Entry informationi

    Entry nameiBMP5_HUMAN
    AccessioniPrimary (citable) accession number: P22003
    Secondary accession number(s): Q9H547, Q9NTM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3