P22003 (BMP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 5
Short name=BMP-5

Gene names

Name:

BMP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces cartilage and bone formation.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed in the lung and liver.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW growth Inferred from electronic annotation. Source: InterPro ossification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	BMP receptor binding Inferred from physical interaction. Source: MGI cytokine activity Non-traceable author statement. Source: UniProtKB growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Propeptide	31 – 316	286	Potential		PRO_0000033866
	Chain	317 – 454	138	Bone morphogenetic protein 5		PRO_0000033867
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Glycosylation	395	1	N-linked (GlcNAc...) Potential
	Disulfide bond	353 ↔ 419		By similarity
	Disulfide bond	382 ↔ 451		By similarity
	Disulfide bond	386 ↔ 453		By similarity
	Disulfide bond	418		Interchain By similarity
Natural variations
	Natural variant	2	1	H → Y. Corresponds to variant rs9475437 [ dbSNP | Ensembl ].		VAR_047054
	Natural variant	121	1	N → S. Corresponds to variant rs35124644 [ dbSNP | Ensembl ].		VAR_061896

Sequences

	Sequence		Length	Mass (Da)
	P22003 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 631277413CCC22EE	FASTA	454	51,737
	10 20 30 40 50 60 MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 70 80 90 100 110 120 LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 130 140 150 160 170 180 NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 190 200 210 220 230 240 RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 250 260 270 280 290 300 QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 310 320 330 340 350 360 MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 370 380 390 400 410 420 SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 430 440 450 PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone." Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M. Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed: 2263636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Spleen.
+	Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 5 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60314 mRNA. Translation: AAA36736.1. AL133386, AL137178 Genomic DNA. Translation: CAB81657.2. AL137178, AL133386 Genomic DNA. Translation: CAC12765.2. BC027958 mRNA. Translation: AAH27958.1.
IPI	IPI00024886.
PIR	BMHU5. A39263.
RefSeq	NP_066551.1. NM_021073.2.
UniGene	Hs.296648.
3D structure databases
ProteinModelPortal	P22003.
SMR	P22003. Positions 352-454.
ModBase	Search...
Protein-protein interaction databases
STRING	P22003.
PTM databases
PhosphoSite	P22003.
Polymorphism databases
DMDM	115075.
Proteomic databases
PRIDE	P22003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370830; ENSP00000359866; ENSG00000112175.
GeneID	653.
KEGG	hsa:653.
UCSC	uc003pcq.1. human.
Organism-specific databases
CTD	653.
GeneCards	GC06M055667.
H-InvDB	HIX0025072.
HGNC	HGNC:1072. BMP5.
MIM	112265. gene.
neXtProt	NX_P22003.
PharmGKB	PA25382.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10957.
GeneTree	ENSGT00580000081302.
HOGENOM	HBG717159.
HOVERGEN	HBG004860.
InParanoid	P22003.
OMA	YKDRSNS.
OrthoDB	EOG4GB76H.
PhylomeDB	P22003.
Gene expression databases
ArrayExpress	P22003.
Bgee	P22003.
CleanEx	HS_BMP5.
Genevestigator	P22003.
GermOnline	ENSG00000112175. Homo sapiens.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
KO	K04663.
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	2656.
SOURCE	Search...

Entry information

Entry name

BMP5_HUMAN

Accession

Primary (citable) accession number: P22003
Secondary accession number(s): Q9H547, Q9NTM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	January 25, 2012
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.