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Protein

Bone morphogenetic protein 5

Gene

BMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 5
Short name:
BMP-5
Gene namesi
Name:BMP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1072. BMP5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi653.
OpenTargetsiENSG00000112175.
PharmGKBiPA25382.

Polymorphism and mutation databases

BioMutaiBMP5.
DMDMi115075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000003386631 – 316Sequence analysisAdd BLAST286
ChainiPRO_0000033867317 – 454Bone morphogenetic protein 5Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi353 ↔ 419By similarity
Disulfide bondi382 ↔ 451By similarity
Disulfide bondi386 ↔ 453By similarity
Glycosylationi395N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi418InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22003.
PeptideAtlasiP22003.
PRIDEiP22003.

PTM databases

iPTMnetiP22003.
PhosphoSitePlusiP22003.

Expressioni

Tissue specificityi

Expressed in the lung and liver.

Gene expression databases

BgeeiENSG00000112175.
CleanExiHS_BMP5.
ExpressionAtlasiP22003. baseline and differential.
GenevisibleiP22003. HS.

Organism-specific databases

HPAiCAB033979.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107121. 3 interactors.
IntActiP22003. 1 interactor.
STRINGi9606.ENSP00000359866.

Structurei

3D structure databases

ProteinModelPortaliP22003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP22003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG091G0C2J.
PhylomeDBiP22003.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE
60 70 80 90 100
IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS
110 120 130 140 150
VRASLAEETR GARKGYPASP NGYPRRIQLS RTTPLTTQSP PLASLHDTNF
160 170 180 190 200
LNDADMVMSF VNLVERDKDF SHQRRHYKEF RFDLTQIPHG EAVTAAEFRI
210 220 230 240 250
YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA QALDVGWLVF
260 270 280 290 300
DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF
310 320 330 340 350
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK
360 370 380 390 400
QACKKHELYV SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA
410 420 430 440 450
IVQTLVHLMF PDHVPKPCCA PTKLNAISVL YFDDSSNVIL KKYRNMVVRS

CGCH
Length:454
Mass (Da):51,737
Last modified:August 1, 1991 - v1
Checksum:i631277413CCC22EE
GO
Isoform 2 (identifier: P22003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-405: Missing.

Note: No experimental confirmation available.
Show »
Length:417
Mass (Da):47,670
Checksum:i37F00E6E8AC771DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0470542H → Y.Corresponds to variant rs9475437dbSNPEnsembl.1
Natural variantiVAR_061896121N → S.Corresponds to variant rs35124644dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056841369 – 405Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60314 mRNA. Translation: AAA36736.1.
AK303576 mRNA. Translation: BAG64596.1.
AL133386, AL137178 Genomic DNA. Translation: CAB81657.2.
AL137178, AL133386 Genomic DNA. Translation: CAC12765.2.
BC027958 mRNA. Translation: AAH27958.1.
CCDSiCCDS4958.1. [P22003-1]
PIRiA39263. BMHU5.
RefSeqiNP_001316683.1. NM_001329754.1. [P22003-2]
NP_066551.1. NM_021073.3. [P22003-1]
UniGeneiHs.296648.
Hs.656729.

Genome annotation databases

EnsembliENST00000370830; ENSP00000359866; ENSG00000112175. [P22003-1]
GeneIDi653.
KEGGihsa:653.
UCSCiuc003pcq.4. human. [P22003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 5 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60314 mRNA. Translation: AAA36736.1.
AK303576 mRNA. Translation: BAG64596.1.
AL133386, AL137178 Genomic DNA. Translation: CAB81657.2.
AL137178, AL133386 Genomic DNA. Translation: CAC12765.2.
BC027958 mRNA. Translation: AAH27958.1.
CCDSiCCDS4958.1. [P22003-1]
PIRiA39263. BMHU5.
RefSeqiNP_001316683.1. NM_001329754.1. [P22003-2]
NP_066551.1. NM_021073.3. [P22003-1]
UniGeneiHs.296648.
Hs.656729.

3D structure databases

ProteinModelPortaliP22003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107121. 3 interactors.
IntActiP22003. 1 interactor.
STRINGi9606.ENSP00000359866.

PTM databases

iPTMnetiP22003.
PhosphoSitePlusiP22003.

Polymorphism and mutation databases

BioMutaiBMP5.
DMDMi115075.

Proteomic databases

PaxDbiP22003.
PeptideAtlasiP22003.
PRIDEiP22003.

Protocols and materials databases

DNASUi653.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370830; ENSP00000359866; ENSG00000112175. [P22003-1]
GeneIDi653.
KEGGihsa:653.
UCSCiuc003pcq.4. human. [P22003-1]

Organism-specific databases

CTDi653.
DisGeNETi653.
GeneCardsiBMP5.
HGNCiHGNC:1072. BMP5.
HPAiCAB033979.
MIMi112265. gene.
neXtProtiNX_P22003.
OpenTargetsiENSG00000112175.
PharmGKBiPA25382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP22003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG091G0C2J.
PhylomeDBiP22003.
TreeFamiTF316134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112175-MONOMER.

Miscellaneous databases

GeneWikiiBone_morphogenetic_protein_5.
GenomeRNAii653.
PROiP22003.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112175.
CleanExiHS_BMP5.
ExpressionAtlasiP22003. baseline and differential.
GenevisibleiP22003. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP5_HUMAN
AccessioniPrimary (citable) accession number: P22003
Secondary accession number(s): B4E0Y4, Q9H547, Q9NTM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.