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P22003

- BMP5_HUMAN

UniProt

P22003 - BMP5_HUMAN

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Protein

Bone morphogenetic protein 5

Gene

BMP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  1. BMP receptor binding Source: MGI

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. growth Source: InterPro
  3. male genitalia development Source: Ensembl
  4. negative regulation of aldosterone biosynthetic process Source: BHF-UCL
  5. negative regulation of cell proliferation Source: BHF-UCL
  6. negative regulation of cortisol biosynthetic process Source: BHF-UCL
  7. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
  8. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  9. negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
  10. negative regulation of mononuclear cell migration Source: BHF-UCL
  11. negative regulation of steroid biosynthetic process Source: BHF-UCL
  12. ossification Source: UniProtKB-KW
  13. pattern specification process Source: Ensembl
  14. positive regulation of dendrite development Source: BHF-UCL
  15. positive regulation of DNA-dependent DNA replication Source: BHF-UCL
  16. positive regulation of epithelial cell proliferation Source: BHF-UCL
  17. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  18. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  19. skeletal system development Source: UniProtKB
  20. type B pancreatic cell development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 5
Short name:
BMP-5
Gene namesi
Name:BMP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1072. BMP5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. membrane-bounded vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Propeptidei31 – 316286Sequence AnalysisPRO_0000033866Add
BLAST
Chaini317 – 454138Bone morphogenetic protein 5PRO_0000033867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi353 ↔ 419By similarity
Disulfide bondi382 ↔ 451By similarity
Disulfide bondi386 ↔ 453By similarity
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi418 – 418InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22003.
PRIDEiP22003.

PTM databases

PhosphoSiteiP22003.

Expressioni

Tissue specificityi

Expressed in the lung and liver.

Gene expression databases

BgeeiP22003.
CleanExiHS_BMP5.
ExpressionAtlasiP22003. baseline and differential.
GenevestigatoriP22003.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000359866.

Structurei

3D structure databases

ProteinModelPortaliP22003.
SMRiP22003. Positions 352-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP22003.
KOiK04663.
OMAiLYNAMAN.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP22003.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P22003-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE
60 70 80 90 100
IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS
110 120 130 140 150
VRASLAEETR GARKGYPASP NGYPRRIQLS RTTPLTTQSP PLASLHDTNF
160 170 180 190 200
LNDADMVMSF VNLVERDKDF SHQRRHYKEF RFDLTQIPHG EAVTAAEFRI
210 220 230 240 250
YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA QALDVGWLVF
260 270 280 290 300
DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF
310 320 330 340 350
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK
360 370 380 390 400
QACKKHELYV SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA
410 420 430 440 450
IVQTLVHLMF PDHVPKPCCA PTKLNAISVL YFDDSSNVIL KKYRNMVVRS

CGCH
Length:454
Mass (Da):51,737
Last modified:August 1, 1991 - v1
Checksum:i631277413CCC22EE
GO
Isoform 2 (identifier: P22003-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-405: Missing.

Note: No experimental confirmation available

Show »
Length:417
Mass (Da):47,670
Checksum:i37F00E6E8AC771DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21H → Y.
Corresponds to variant rs9475437 [ dbSNP | Ensembl ].
VAR_047054
Natural varianti121 – 1211N → S.
Corresponds to variant rs35124644 [ dbSNP | Ensembl ].
VAR_061896

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 40537Missing in isoform 2. 1 PublicationVSP_056841Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60314 mRNA. Translation: AAA36736.1.
AK303576 mRNA. Translation: BAG64596.1.
AL133386, AL137178 Genomic DNA. Translation: CAB81657.2.
AL137178, AL133386 Genomic DNA. Translation: CAC12765.2.
BC027958 mRNA. Translation: AAH27958.1.
CCDSiCCDS4958.1.
PIRiA39263. BMHU5.
RefSeqiNP_066551.1. NM_021073.2.
UniGeneiHs.296648.

Genome annotation databases

EnsembliENST00000370830; ENSP00000359866; ENSG00000112175. [P22003-1]
GeneIDi653.
KEGGihsa:653.
UCSCiuc003pcq.3. human. [P22003-1]

Polymorphism databases

DMDMi115075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 5 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60314 mRNA. Translation: AAA36736.1 .
AK303576 mRNA. Translation: BAG64596.1 .
AL133386 , AL137178 Genomic DNA. Translation: CAB81657.2 .
AL137178 , AL133386 Genomic DNA. Translation: CAC12765.2 .
BC027958 mRNA. Translation: AAH27958.1 .
CCDSi CCDS4958.1.
PIRi A39263. BMHU5.
RefSeqi NP_066551.1. NM_021073.2.
UniGenei Hs.296648.

3D structure databases

ProteinModelPortali P22003.
SMRi P22003. Positions 352-454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359866.

PTM databases

PhosphoSitei P22003.

Polymorphism databases

DMDMi 115075.

Proteomic databases

PaxDbi P22003.
PRIDEi P22003.

Protocols and materials databases

DNASUi 653.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370830 ; ENSP00000359866 ; ENSG00000112175 . [P22003-1 ]
GeneIDi 653.
KEGGi hsa:653.
UCSCi uc003pcq.3. human. [P22003-1 ]

Organism-specific databases

CTDi 653.
GeneCardsi GC06M055667.
HGNCi HGNC:1072. BMP5.
MIMi 112265. gene.
neXtProti NX_P22003.
PharmGKBi PA25382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272883.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P22003.
KOi K04663.
OMAi LYNAMAN.
OrthoDBi EOG7J9VPQ.
PhylomeDBi P22003.
TreeFami TF316134.

Miscellaneous databases

GeneWikii Bone_morphogenetic_protein_5.
GenomeRNAii 653.
NextBioi 2656.
PROi P22003.
SOURCEi Search...

Gene expression databases

Bgeei P22003.
CleanExi HS_BMP5.
ExpressionAtlasi P22003. baseline and differential.
Genevestigatori P22003.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
    Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
    Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Bone.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiBMP5_HUMAN
AccessioniPrimary (citable) accession number: P22003
Secondary accession number(s): B4E0Y4, Q9H547, Q9NTM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 26, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3