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P22003 (BMP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 5

Short name=BMP-5
Gene names
Name:BMP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in the lung and liver.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

growth

Inferred from electronic annotation. Source: InterPro

male genitalia development

Inferred from electronic annotation. Source: Ensembl

negative regulation of aldosterone biosynthetic process

Inferred from direct assay PubMed 19584291. Source: BHF-UCL

negative regulation of cell proliferation

Inferred from direct assay PubMed 19584291. Source: BHF-UCL

negative regulation of cortisol biosynthetic process

Inferred from direct assay PubMed 19584291. Source: BHF-UCL

negative regulation of epithelial to mesenchymal transition

Non-traceable author statement PubMed 21319131. Source: BHF-UCL

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Non-traceable author statement PubMed 21319131. Source: BHF-UCL

negative regulation of insulin-like growth factor receptor signaling pathway

Inferred from direct assay PubMed 19584291. Source: BHF-UCL

negative regulation of mononuclear cell migration

Non-traceable author statement PubMed 21319131. Source: BHF-UCL

negative regulation of steroid biosynthetic process

Inferred from direct assay PubMed 19584291. Source: BHF-UCL

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

pattern specification process

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA-dependent DNA replication

Inferred from direct assay PubMed 15516325. Source: BHF-UCL

positive regulation of dendrite development

Inferred from direct assay PubMed 11580864. Source: BHF-UCL

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 11865031. Source: BHF-UCL

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 11580864. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15516325. Source: BHF-UCL

skeletal system development

Non-traceable author statement Ref.1. Source: UniProtKB

type B pancreatic cell development

Inferred from direct assay PubMed 11865031. Source: BHF-UCL

   Cellular_componentextracellular space

Inferred from sequence or structural similarity. Source: BHF-UCL

membrane-bounded vesicle

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionBMP receptor binding

Inferred from physical interaction PubMed 7811286. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Propeptide31 – 316286 Potential
PRO_0000033866
Chain317 – 454138Bone morphogenetic protein 5
PRO_0000033867

Amino acid modifications

Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation3271N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation3951N-linked (GlcNAc...) Potential
Disulfide bond353 ↔ 419 By similarity
Disulfide bond382 ↔ 451 By similarity
Disulfide bond386 ↔ 453 By similarity
Disulfide bond418Interchain By similarity

Natural variations

Natural variant21H → Y.
Corresponds to variant rs9475437 [ dbSNP | Ensembl ].
VAR_047054
Natural variant1211N → S.
Corresponds to variant rs35124644 [ dbSNP | Ensembl ].
VAR_061896

Sequences

Sequence LengthMass (Da)Tools
P22003 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 631277413CCC22EE

FASTA45451,737
        10         20         30         40         50         60 
MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 

        70         80         90        100        110        120 
LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 

       130        140        150        160        170        180 
NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 

       190        200        210        220        230        240 
RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 

       250        260        270        280        290        300 
QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 

       310        320        330        340        350        360 
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 

       370        380        390        400        410        420 
SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 

       430        440        450 
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH 

« Hide

References

« Hide 'large scale' references
[1]"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Spleen.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 5 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60314 mRNA. Translation: AAA36736.1.
AL133386, AL137178 Genomic DNA. Translation: CAB81657.2.
AL137178, AL133386 Genomic DNA. Translation: CAC12765.2.
BC027958 mRNA. Translation: AAH27958.1.
PIRBMHU5. A39263.
RefSeqNP_066551.1. NM_021073.2.
UniGeneHs.296648.

3D structure databases

ProteinModelPortalP22003.
SMRP22003. Positions 352-454.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359866.

PTM databases

PhosphoSiteP22003.

Polymorphism databases

DMDM115075.

Proteomic databases

PaxDbP22003.
PRIDEP22003.

Protocols and materials databases

DNASU653.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370830; ENSP00000359866; ENSG00000112175.
GeneID653.
KEGGhsa:653.
UCSCuc003pcq.3. human.

Organism-specific databases

CTD653.
GeneCardsGC06M055667.
HGNCHGNC:1072. BMP5.
MIM112265. gene.
neXtProtNX_P22003.
PharmGKBPA25382.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272883.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidP22003.
KOK04663.
OMALYNAMAN.
OrthoDBEOG7J9VPQ.
PhylomeDBP22003.
TreeFamTF316134.

Gene expression databases

ArrayExpressP22003.
BgeeP22003.
CleanExHS_BMP5.
GenevestigatorP22003.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBone_morphogenetic_protein_5.
GenomeRNAi653.
NextBio2656.
PROP22003.
SOURCESearch...

Entry information

Entry nameBMP5_HUMAN
AccessionPrimary (citable) accession number: P22003
Secondary accession number(s): Q9H547, Q9NTM5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 16, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM