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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

KCNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: ProtInc
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177272-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
SIGNORiP22001.

Protein family/group databases

TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
HGK5
HLK3
HPCN3
Voltage-gated K(+) channel HuKIII
Voltage-gated potassium channel subunit Kv1.3
Gene namesi
Name:KCNA3
Synonyms:HGK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6221. KCNA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 234CytoplasmicSequence analysisAdd BLAST234
Transmembranei235 – 253Helical; Name=Segment S1Sequence analysisAdd BLAST19
Topological domaini254 – 294ExtracellularSequence analysisAdd BLAST41
Transmembranei295 – 316Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini317 – 327CytoplasmicSequence analysisAdd BLAST11
Transmembranei328 – 348Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini349 – 362ExtracellularSequence analysisAdd BLAST14
Transmembranei363 – 381Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST19
Topological domaini382 – 397CytoplasmicSequence analysisAdd BLAST16
Transmembranei398 – 417Helical; Name=Segment S5Sequence analysisAdd BLAST20
Topological domaini418 – 458ExtracellularSequence analysisAdd BLAST41
Transmembranei459 – 481Helical; Name=Segment S6Sequence analysisAdd BLAST23
Topological domaini482 – 575CytoplasmicSequence analysisAdd BLAST94

GO - Cellular componenti

  • axon Source: Ensembl
  • membrane raft Source: Ensembl
  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3738.
OpenTargetsiENSG00000177272.
PharmGKBiPA30021.

Chemistry databases

ChEMBLiCHEMBL4633.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi540.

Polymorphism and mutation databases

DMDMi215274135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539771 – 575Potassium voltage-gated channel subfamily A member 3Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Lipidationi317S-palmitoyl cysteineSequence analysis1
Modified residuei520Phosphoserine; by PKASequence analysis1

Post-translational modificationi

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP22001.
PaxDbiP22001.
PeptideAtlasiP22001.
PRIDEiP22001.

PTM databases

iPTMnetiP22001.
PhosphoSitePlusiP22001.

Expressioni

Gene expression databases

BgeeiENSG00000177272.
CleanExiHS_KCNA3.
GenevisibleiP22001. HS.

Organism-specific databases

HPAiHPA016625.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi109941. 15 interactors.
DIPiDIP-44822N.
MINTiMINT-1528422.
STRINGi9606.ENSP00000358784.

Chemistry databases

BindingDBiP22001.

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi105 – 110Combined sources6
Beta strandi113 – 118Combined sources6
Helixi119 – 122Combined sources4
Turni129 – 131Combined sources3
Helixi133 – 136Combined sources4
Helixi137 – 139Combined sources3
Turni142 – 145Combined sources4
Beta strandi146 – 149Combined sources4
Helixi153 – 164Combined sources12
Helixi177 – 186Combined sources10
Helixi191 – 201Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGCX-ray1.20A104-204[»]
ProteinModelPortaliP22001.
SMRiP22001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi444 – 449Selectivity filterBy similarity6
Motifi573 – 575PDZ-bindingBy similarity3

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP22001.
KOiK04876.
OMAiKRRMRYF.
OrthoDBiEOG091G10NU.
PhylomeDBiP22001.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004050. K_chnl_volt-dep_Kv1.3.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01510. KV13CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P22001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP
60 70 80 90 100
PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD
110 120 130 140 150
CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD
160 170 180 190 200
RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED
210 220 230 240 250
EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI
260 270 280 290 300
FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET
310 320 330 340 350
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER
360 370 380 390 400
QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL
410 420 430 440 450
LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM
460 470 480 490 500
HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM
510 520 530 540 550
HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG
560 570
NSTATCTTNN NPNSCVNIKK IFTDV
Length:575
Mass (Da):63,842
Last modified:November 25, 2008 - v3
Checksum:i0E98905187A85F48
GO

Sequence cautioni

The sequence AAA36425 differs from that shown. Reason: Frameshift at position 42.Curated
The sequence AAA36425 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA59457 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAA59457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB88073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC31761 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAC31761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72A → G in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti89L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti113L → V in AAA59457 (PubMed:1373731).Curated1
Sequence conflicti143L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti309E → K in AAC31761 (PubMed:7829094).Curated1
Sequence conflicti390T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti471T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti540S → T in AAA36425 (PubMed:1986382).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23499 mRNA. Translation: AAC31761.1. Sequence problems.
AL365361 Genomic DNA. Translation: CAH71983.1.
CH471122 Genomic DNA. Translation: EAW56457.1.
BC035059 mRNA. Translation: AAH35059.2.
M55515 Genomic DNA. Translation: AAA36425.1. Sequence problems.
M85217 mRNA. Translation: AAA59457.1. Sequence problems.
M38217 Genomic DNA. Translation: AAB88073.1. Different initiation.
CCDSiCCDS828.2.
PIRiA38101.
RefSeqiNP_002223.3. NM_002232.4.
UniGeneiHs.169948.
Hs.619197.
Hs.628223.

Genome annotation databases

EnsembliENST00000369769; ENSP00000358784; ENSG00000177272.
GeneIDi3738.
KEGGihsa:3738.
UCSCiuc001dzv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23499 mRNA. Translation: AAC31761.1. Sequence problems.
AL365361 Genomic DNA. Translation: CAH71983.1.
CH471122 Genomic DNA. Translation: EAW56457.1.
BC035059 mRNA. Translation: AAH35059.2.
M55515 Genomic DNA. Translation: AAA36425.1. Sequence problems.
M85217 mRNA. Translation: AAA59457.1. Sequence problems.
M38217 Genomic DNA. Translation: AAB88073.1. Different initiation.
CCDSiCCDS828.2.
PIRiA38101.
RefSeqiNP_002223.3. NM_002232.4.
UniGeneiHs.169948.
Hs.619197.
Hs.628223.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGCX-ray1.20A104-204[»]
ProteinModelPortaliP22001.
SMRiP22001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109941. 15 interactors.
DIPiDIP-44822N.
MINTiMINT-1528422.
STRINGi9606.ENSP00000358784.

Chemistry databases

BindingDBiP22001.
ChEMBLiCHEMBL4633.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi540.

Protein family/group databases

TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiP22001.
PhosphoSitePlusiP22001.

Polymorphism and mutation databases

DMDMi215274135.

Proteomic databases

MaxQBiP22001.
PaxDbiP22001.
PeptideAtlasiP22001.
PRIDEiP22001.

Protocols and materials databases

DNASUi3738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369769; ENSP00000358784; ENSG00000177272.
GeneIDi3738.
KEGGihsa:3738.
UCSCiuc001dzv.3. human.

Organism-specific databases

CTDi3738.
DisGeNETi3738.
GeneCardsiKCNA3.
HGNCiHGNC:6221. KCNA3.
HPAiHPA016625.
MIMi176263. gene.
neXtProtiNX_P22001.
OpenTargetsiENSG00000177272.
PharmGKBiPA30021.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP22001.
KOiK04876.
OMAiKRRMRYF.
OrthoDBiEOG091G10NU.
PhylomeDBiP22001.
TreeFamiTF313103.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177272-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
SIGNORiP22001.

Miscellaneous databases

GeneWikiiKCNA3.
GenomeRNAii3738.
PROiP22001.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177272.
CleanExiHS_KCNA3.
GenevisibleiP22001. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004050. K_chnl_volt-dep_Kv1.3.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01510. KV13CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNA3_HUMAN
AccessioniPrimary (citable) accession number: P22001
Secondary accession number(s): Q5VWN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.