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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

KCNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
SIGNORiP22001

Protein family/group databases

TCDBi1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
HGK5
HLK3
HPCN3
Voltage-gated K(+) channel HuKIII
Voltage-gated potassium channel subunit Kv1.3
Gene namesi
Name:KCNA3
Synonyms:HGK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177272.8
HGNCiHGNC:6221 KCNA3
MIMi176263 gene
neXtProtiNX_P22001

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 234CytoplasmicSequence analysisAdd BLAST234
Transmembranei235 – 253Helical; Name=Segment S1Sequence analysisAdd BLAST19
Topological domaini254 – 294ExtracellularSequence analysisAdd BLAST41
Transmembranei295 – 316Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini317 – 327CytoplasmicSequence analysisAdd BLAST11
Transmembranei328 – 348Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini349 – 362ExtracellularSequence analysisAdd BLAST14
Transmembranei363 – 381Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST19
Topological domaini382 – 397CytoplasmicSequence analysisAdd BLAST16
Transmembranei398 – 417Helical; Name=Segment S5Sequence analysisAdd BLAST20
Topological domaini418 – 458ExtracellularSequence analysisAdd BLAST41
Transmembranei459 – 481Helical; Name=Segment S6Sequence analysisAdd BLAST23
Topological domaini482 – 575CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3738
OpenTargetsiENSG00000177272
PharmGKBiPA30021

Chemistry databases

ChEMBLiCHEMBL4633
DrugBankiDB06637 Dalfampridine
GuidetoPHARMACOLOGYi540

Polymorphism and mutation databases

DMDMi215274135

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539771 – 575Potassium voltage-gated channel subfamily A member 3Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi317S-palmitoyl cysteineSequence analysis1
Modified residuei520Phosphoserine; by PKASequence analysis1

Post-translational modificationi

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP22001
PaxDbiP22001
PeptideAtlasiP22001
PRIDEiP22001

PTM databases

iPTMnetiP22001
PhosphoSitePlusiP22001

Expressioni

Gene expression databases

BgeeiENSG00000177272
CleanExiHS_KCNA3
GenevisibleiP22001 HS

Organism-specific databases

HPAiHPA016625

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109941, 16 interactors
DIPiDIP-44822N
IntActiP22001, 3 interactors
MINTiP22001
STRINGi9606.ENSP00000358784

Chemistry databases

BindingDBiP22001

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi105 – 110Combined sources6
Beta strandi113 – 118Combined sources6
Helixi119 – 122Combined sources4
Turni129 – 131Combined sources3
Helixi133 – 136Combined sources4
Helixi137 – 139Combined sources3
Turni142 – 145Combined sources4
Beta strandi146 – 149Combined sources4
Helixi153 – 164Combined sources12
Helixi177 – 186Combined sources10
Helixi191 – 201Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGCX-ray1.20A104-204[»]
ProteinModelPortaliP22001
SMRiP22001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi444 – 449Selectivity filterBy similarity6
Motifi573 – 575PDZ-bindingBy similarity3

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP22001
KOiK04876
OMAiLPRRDFQ
OrthoDBiEOG091G10NU
PhylomeDBiP22001
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004050 K_chnl_volt-dep_Kv1.3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01510 KV13CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

P22001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP
60 70 80 90 100
PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD
110 120 130 140 150
CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD
160 170 180 190 200
RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED
210 220 230 240 250
EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI
260 270 280 290 300
FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET
310 320 330 340 350
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER
360 370 380 390 400
QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL
410 420 430 440 450
LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM
460 470 480 490 500
HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM
510 520 530 540 550
HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG
560 570
NSTATCTTNN NPNSCVNIKK IFTDV
Length:575
Mass (Da):63,842
Last modified:November 25, 2008 - v3
Checksum:i0E98905187A85F48
GO

Sequence cautioni

The sequence AAA36425 differs from that shown. Reason: Frameshift at position 42.Curated
The sequence AAA36425 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA59457 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAA59457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB88073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC31761 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAC31761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72A → G in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti89L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti113L → V in AAA59457 (PubMed:1373731).Curated1
Sequence conflicti143L → V in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti309E → K in AAC31761 (PubMed:7829094).Curated1
Sequence conflicti390T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti471T → S in AAA36425 (PubMed:1986382).Curated1
Sequence conflicti540S → T in AAA36425 (PubMed:1986382).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23499 mRNA Translation: AAC31761.1 Sequence problems.
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56457.1
BC035059 mRNA Translation: AAH35059.2
M55515 Genomic DNA Translation: AAA36425.1 Sequence problems.
M85217 mRNA Translation: AAA59457.1 Sequence problems.
M38217 Genomic DNA Translation: AAB88073.1 Different initiation.
CCDSiCCDS828.2
PIRiA38101
RefSeqiNP_002223.3, NM_002232.4
UniGeneiHs.169948
Hs.619197
Hs.628223

Genome annotation databases

EnsembliENST00000369769; ENSP00000358784; ENSG00000177272
GeneIDi3738
KEGGihsa:3738
UCSCiuc001dzv.3 human

Similar proteinsi

Entry informationi

Entry nameiKCNA3_HUMAN
AccessioniPrimary (citable) accession number: P22001
Secondary accession number(s): Q5VWN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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