ID   CXB2_RAT                Reviewed;         226 AA.
AC   P21994;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   24-NOV-2009, entry version 81.
DE   RecName: Full=Gap junction beta-2 protein;
DE   AltName: Full=Connexin-26;
DE            Short=Cx26;
GN   Name=Gjb2; Synonyms=Cxn-26;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=90094541; PubMed=2557354; DOI=10.1083/jcb.109.6.3391;
RA   Zhang J.T., Nicholson B.J.;
RT   "Sequence and tissue distribution of a second protein of hepatic gap
RT   junctions, Cx26, as deduced from its cDNA.";
RL   J. Cell Biol. 109:3391-3401(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-18.
RX   MEDLINE=88039049; PubMed=2823143; DOI=10.1038/329732a0;
RA   Nicholson B.J., Dermietzel R., Teplow D., Traub O., Willecke K.,
RA   Revel J.-P.;
RT   "Two homologous protein components of hepatic gap junctions.";
RL   Nature 329:732-734(1987).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Cell junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Liver, kidney, intestine, lung, spleen,
CC       stomach, testis and brain, but not heart and adult skeletal
CC       muscle.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily.
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DR   EMBL; BC078952; AAH78952.1; -; mRNA.
DR   IPI; IPI00208534; -.
DR   PIR; A33646; A33646.
DR   RefSeq; NP_001004099.1; -.
DR   UniGene; Rn.219269; -.
DR   STRING; P21994; -.
DR   Ensembl; ENSRNOT00000011711; ENSRNOP00000011711; ENSRNOG00000008855; Rattus norvegicus.
DR   GeneID; 394266; -.
DR   KEGG; rno:394266; -.
DR   UCSC; NM_001004099; rat.
DR   CTD; 394266; -.
DR   RGD; 728891; Gjb2.
DR   HOVERGEN; P21994; -.
DR   OMA; MYVFYIM; -.
DR   OrthoDB; EOG96T5MW; -.
DR   NextBio; 692713; -.
DR   ArrayExpress; P21994; -.
DR   Genevestigator; P21994; -.
DR   GermOnline; ENSRNOG00000008855; Rattus norvegicus.
DR   GO; GO:0005922; C:connexon complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IDA:RGD.
DR   GO; GO:0005243; F:gap junction channel activity; TAS:RGD.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:RGD.
DR   GO; GO:0030539; P:male genitalia development; IEP:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002268; Connexin26.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR017991; connexins_rgn.
DR   PANTHER; PTHR11984; Connexin; 1.
DR   PANTHER; PTHR11984:SF24; Connexin26; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01139; CONNEXINB2.
DR   SMART; SM00037; CNX; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Direct protein sequencing; Gap junction;
KW   Hearing; Membrane; Transmembrane.
FT   CHAIN         1    226       Gap junction beta-2 protein.
FT                                /FTId=PRO_0000057860.
FT   TOPO_DOM      1     20       Cytoplasmic (Potential).
FT   TRANSMEM     21     40       Potential.
FT   TOPO_DOM     41     75       Extracellular (Potential).
FT   TRANSMEM     76     98       Potential.
FT   TOPO_DOM     99    139       Cytoplasmic (Potential).
FT   TRANSMEM    140    162       Potential.
FT   TOPO_DOM    163    192       Extracellular (Potential).
FT   TRANSMEM    193    215       Potential.
FT   TOPO_DOM    216    226       Cytoplasmic (Potential).
SQ   SEQUENCE   226 AA;  26451 MW;  E36EC95F1B235A0D CRC64;
     MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC
     KNVCYDHYFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH EKKRKFMKGE IKNEFKDIEE
     IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC
     FISRPTEKTV FTVFMISVSG ICILLNITEL CYLFIRYCSG KSKRPV
//