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Protein

Gap junction beta-2 protein

Gene

Gjb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: RGD

GO - Biological processi

  • cell-cell signaling Source: RGD
  • cellular response to oxidative stress Source: RGD
  • decidualization Source: RGD
  • female pregnancy Source: RGD
  • gap junction assembly Source: Ensembl
  • male genitalia development Source: RGD
  • response to estradiol Source: RGD
  • response to human chorionic gonadotropin Source: RGD
  • response to progesterone Source: RGD
  • sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Hearing

Enzyme and pathway databases

ReactomeiR-RNO-190872. Transport of connexons to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-2 protein
Alternative name(s):
Connexin-26
Short name:
Cx26
Gene namesi
Name:Gjb2
Synonyms:Cxn-26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi728891. Gjb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence analysisAdd
BLAST
Topological domaini99 – 13941CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence analysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21523HelicalSequence analysisAdd
BLAST
Topological domaini216 – 22611CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: RGD
  • connexon complex Source: InterPro
  • cytoplasm Source: RGD
  • gap junction Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Gap junction beta-2 proteinPRO_0000057860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 180By similarity
Disulfide bondi60 ↔ 174By similarity
Disulfide bondi64 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP21994.

Expressioni

Tissue specificityi

Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

Gene expression databases

BgeeiENSRNOG00000008855.
GenevisibleiP21994. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CnstQ8CBC4-32EBI-2616119,EBI-2615407From a different organism.

Protein-protein interaction databases

DIPiDIP-48901N.
IntActiP21994. 1 interaction.
STRINGi10116.ENSRNOP00000011711.

Structurei

3D structure databases

ProteinModelPortaliP21994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP21994.
KOiK07621.
OMAiMYVISAF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP21994.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF
160 170 180 190 200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG
210 220
ICILLNITEL CYLFIRYCSG KSKRPV
Length:226
Mass (Da):26,451
Last modified:August 1, 1991 - v1
Checksum:iE36EC95F1B235A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078952 mRNA. Translation: AAH78952.1.
PIRiA33646.
RefSeqiNP_001004099.1. NM_001004099.1.
UniGeneiRn.219269.

Genome annotation databases

EnsembliENSRNOT00000011711; ENSRNOP00000011711; ENSRNOG00000008855.
GeneIDi394266.
KEGGirno:394266.
UCSCiRGD:728891. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078952 mRNA. Translation: AAH78952.1.
PIRiA33646.
RefSeqiNP_001004099.1. NM_001004099.1.
UniGeneiRn.219269.

3D structure databases

ProteinModelPortaliP21994.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48901N.
IntActiP21994. 1 interaction.
STRINGi10116.ENSRNOP00000011711.

Proteomic databases

PaxDbiP21994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011711; ENSRNOP00000011711; ENSRNOG00000008855.
GeneIDi394266.
KEGGirno:394266.
UCSCiRGD:728891. rat.

Organism-specific databases

CTDi2706.
RGDi728891. Gjb2.

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP21994.
KOiK07621.
OMAiMYVISAF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP21994.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-RNO-190872. Transport of connexons to the plasma membrane.

Miscellaneous databases

PROiP21994.

Gene expression databases

BgeeiENSRNOG00000008855.
GenevisibleiP21994. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXB2_RAT
AccessioniPrimary (citable) accession number: P21994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.