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Protein

Gap junction beta-2 protein

Gene

Gjb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • identical protein binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cell-cell signaling Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to glucagon stimulus Source: RGD
  • cellular response to oxidative stress Source: RGD
  • decidualization Source: RGD
  • epididymis development Source: RGD
  • female pregnancy Source: RGD
  • gap junction assembly Source: RGD
  • inner ear development Source: RGD
  • response to antibiotic Source: RGD
  • response to estradiol Source: RGD
  • response to human chorionic gonadotropin Source: RGD
  • response to ischemia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to progesterone Source: RGD
  • response to retinoic acid Source: RGD
  • sensory perception of sound Source: UniProtKB-KW

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-RNO-190872 Transport of connexons to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-2 protein
Alternative name(s):
Connexin-26
Short name:
Cx26
Gene namesi
Name:Gjb2
Synonyms:Cxn-26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi728891 Gjb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 139CytoplasmicSequence analysisAdd BLAST41
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 215HelicalSequence analysisAdd BLAST23
Topological domaini216 – 226CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578601 – 226Gap junction beta-2 proteinAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 180By similarity
Disulfide bondi60 ↔ 174By similarity
Disulfide bondi64 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP21994
PRIDEiP21994

Expressioni

Tissue specificityi

Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

Gene expression databases

BgeeiENSRNOG00000008855
GenevisibleiP21994 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CnstQ8CBC4-32EBI-2616119,EBI-2615407From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48901N
IntActiP21994, 2 interactors
STRINGi10116.ENSRNOP00000011711

Structurei

3D structure databases

ProteinModelPortaliP21994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP21994
KOiK07621
OMAiRIMILIV
OrthoDBiEOG091G0FKH
PhylomeDBiP21994
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002268 Connexin26
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01139 CONNEXINB2
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P21994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF
160 170 180 190 200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG
210 220
ICILLNITEL CYLFIRYCSG KSKRPV
Length:226
Mass (Da):26,451
Last modified:August 1, 1991 - v1
Checksum:iE36EC95F1B235A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078952 mRNA Translation: AAH78952.1
PIRiA33646
RefSeqiNP_001004099.1, NM_001004099.2
XP_017455254.1, XM_017599765.1
UniGeneiRn.219269

Genome annotation databases

EnsembliENSRNOT00000011711; ENSRNOP00000011711; ENSRNOG00000008855
GeneIDi394266
KEGGirno:394266
UCSCiRGD:728891 rat

Similar proteinsi

Entry informationi

Entry nameiCXB2_RAT
AccessioniPrimary (citable) accession number: P21994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health