Reviewed, UniProtKB/Swiss-Prot P21992 (FLAB3_TREPA)

Names and origin

Protein names

Recommended name:
    Flagellar filament 31 kDa core protein
Alternative name(s):
    Class B

Gene names

Name:	flaB3
Ordered Locus Names:	TP_0870

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the core of the flagella.
Subunit structure	The flagellum consists of an outer layer composed of repeating units of flaA around a core that contains several antigenically related polypeptides.
Subcellular location	Periplasmic flagellum. Periplasm.
Sequence similarities	Belongs to the bacterial flagellin family.

Ontologies

Keywords
Cellular component	Bacterial flagellum Periplasm
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	ciliary or flagellar motility Inferred from electronic annotation. Source: InterPro
Cellular component	bacterial-type flagellum filament Inferred from electronic annotation. Source: InterPro periplasmic flagellum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	O83105	2	EBI-1198854,EBI-1198263
	O83204	2	EBI-1198854,EBI-1198866
	O83411	2	EBI-1198854,EBI-1198324
	O83531	2	EBI-1198854,EBI-1198626
	O83637	2	EBI-1198854,EBI-1198342
	O83638	2	EBI-1198854,EBI-1198525
	O83700	2	EBI-1198854,EBI-1198870
	O83709	2	EBI-1198854,EBI-1198665
	O83741	2	EBI-1198854,EBI-1198893
	O83843	2	EBI-1198854,EBI-1198862
	O83913	2	EBI-1198854,EBI-1198847
	O83946	2	EBI-1198854,EBI-1198886
fliW	O83664	2	EBI-1198854,EBI-1198841
glpQ	O30405	2	EBI-1198854,EBI-1198903
gyrA	O83051	2	EBI-1198854,EBI-1198241
mcp4	O52778	2	EBI-1198854,EBI-1198452
mraZ	O83398	2	EBI-1198854,EBI-1198346
nrdB	O83092	2	EBI-1198854,EBI-1198878
TP_0050	O83089	2	EBI-1198854,EBI-1198251
tpl	P45685	2	EBI-1198854,EBI-1198212

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Flagellar filament 31 kDa core protein		PRO_0000182636
Experimental info
	Sequence conflict	251 – 252	2	QQ → HE in CAA45382. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P21992-1 [UniParc]. Last modified December 15, 1998. Version 3. Checksum: CB75EBCFDE8B1244	FASTA	285	31,055
	10 20 30 40 50 60 MIINHNMSAM FAQRQGGING LAIAKNIEKL SSGYRINRAG DDASGLAVSE KMRSQIRGLN 70 80 90 100 110 120 QAGQNIQNGI SFIQATEGYL AETTEIVQRL RELAIQAANG IYSAEDRMQI QVEVSQLVDE 130 140 150 160 170 180 VDRIASQAQF NGMNLLTGRF SRESALGPMQ LHVGANMDQN EKIFINTMTA SALGFFSDEG 190 200 210 220 230 240 TDGSRSISIA TVDGANKVIG TLDSALKEIN KQRADLGAYQ NRFETAYQGI AIAAENLQAA 250 260 270 280 ESRIRDADLA QQMVDYTKNQ ILEQSTMAML AQANTQPQAV LRLMQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and expression of two class B endoflagellar genes of Treponema pallidum subsp. pallidum encoding the 34.5- and 31.0-kilodalton proteins." Champion C.I., Miller J.N., Lovett M.A., Blanco D.R. Infect. Immun. 58:1697-1704(1990) [PubMed: 2187805] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nichols.
[2]	"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.
[3]	"Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenis." Norris S.J., Charon N.W., Cook R.G., Fuentes M.D., Limberger R.J. J. Bacteriol. 170:4072-4082(1988) [PubMed: 3045083] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-30.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X63965 Genomic DNA. Translation: CAA45382.1. AE000520 Genomic DNA. Translation: AAC65835.1.
PIR	A41489.
RefSeq	NP_219305.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P21992. 102 interactions.
Genome annotation databases
GeneID	2611107.
GenomeReviews	Gene locus TP_0870 in contig AE000520_GR.
KEGG	tpa:TP0870.
NMPDR	fig|243276.1.peg.864.
TIGR	TP_0870.
Phylogenomic databases
HOGENOM	P21992.
OMA	ENGSNST
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0870-MON.
Family and domain databases
InterPro	IPR001029. Flagellin_C. IPR001492. Flagellin_N. [Graphical view]
Pfam	PF00700. Flagellin_C. 1 hit. PF00669. Flagellin_N. 1 hit. [Graphical view]
PRINTS	PR00207. FLAGELLIN.
ProtoNet	Search...

Entry information

Entry name

FLAB3_TREPA

Accession

Primary (citable) accession number: P21992
Secondary accession number(s): O83840

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	December 15, 1998
Last modified:	November 24, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)