Reviewed,
UniProtKB/Swiss-Prot P21981 (TGM2_MOUSE)
Last modified
January 19, 2010.
Version 101.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein-glutamine gamma-glutamyltransferase 2 EC=2.3.2.13 Alternative name(s): Tissue transglutaminase TGase C Short name=TGC Short name=TG(C) Transglutaminase-2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 686 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. |
| Catalytic activity | Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3. |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Subunit structure | Monomer. |
| Sequence similarities | Belongs to the transglutaminase superfamily. Transglutaminase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Calcium Metal-binding |
| Molecular function | Acyltransferase Transferase |
| PTM | Acetylation Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | branching involved in salivary gland morphogenesis Inferred from mutant phenotype. Source: MGI positive regulation of cell adhesionInferred from mutant phenotype. Source: UniProtKB salivary gland cavitationInferred from mutant phenotype. Source: MGI |
| Cellular component | cytosol Traceable author statement. Source: UniProtKB proteinaceous extracellular matrixTraceable author statement. Source: UniProtKB |
| Molecular function | GTP binding Ref.2 Non-traceable author statement. Source: UniProtKB acyltransferase activityInferred from electronic annotation. Source: UniProtKB-KW calcium ion bindingNon-traceable author statement. Source: UniProtKB protein-glutamine gamma-glutamyltransferase activityInferred from mutant phenotype. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.8 | ||||||
| Chain | 2 – 686 | 685 | Protein-glutamine gamma-glutamyltransferase 2 | PRO_0000213708 | |||||
Sites | |||||||||
| Active site | 277 | 1 | By similarity | ||||||
| Active site | 335 | 1 | By similarity | ||||||
| Active site | 358 | 1 | By similarity | ||||||
| Metal binding | 398 | 1 | Calcium By similarity | ||||||
| Metal binding | 400 | 1 | Calcium By similarity | ||||||
| Metal binding | 447 | 1 | Calcium By similarity | ||||||
| Metal binding | 452 | 1 | Calcium By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.8 | ||||||
| Modified residue | 219 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 369 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 427 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 32 – 33 | 2 | VL → LV in AAA40420. Ref.1 | ||||||
| Sequence conflict | 51 | 1 | E → Q in AAA40420. Ref.1 | ||||||
| Sequence conflict | 51 | 1 | E → Q in AAD37501. Ref.2 | ||||||
| Sequence conflict | 186 | 1 | E → Q in AAA40420. Ref.1 | ||||||
| Sequence conflict | 226 | 1 | A → D in AAA40420. Ref.1 | ||||||
| Sequence conflict | 325 | 1 | S → T in AAA40420. Ref.1 | ||||||
| Sequence conflict | 357 | 1 | I → L in AAA40420. Ref.1 | ||||||
| Sequence conflict | 357 | 1 | I → L in AAD37501. Ref.2 | ||||||
| Sequence conflict | 396 | 1 | E → K in BAC40899. Ref.4 | ||||||
| Sequence conflict | 408 – 409 | 2 | ED → DE in AAA40420. Ref.1 | ||||||
| Sequence conflict | 415 – 416 | 2 | SI → WM in AAA40420. Ref.1 | ||||||
| Sequence conflict | 421 | 1 | V → I in AAA40420. Ref.1 | ||||||
| Sequence conflict | 481 – 485 | 5 | DSMSM → QYEH in AAA40420. Ref.1 | ||||||
| Sequence conflict | 539 | 1 | N → K in BAE38690. Ref.4 | ||||||
| Sequence conflict | 552 | 1 | G → D in AAA40420. Ref.1 | ||||||
| Sequence conflict | 583 | 1 | L → V in AAA40420. Ref.1 | ||||||
| Sequence conflict | 583 | 1 | L → V in AAD37501. Ref.2 | ||||||
| Sequence conflict | 654 | 1 | F → S in AAA40420. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases." Gentile V., Saydak M., Chiocca E.A., Akande O., Birckbichler P.J., Lee K.N., Stein J.P., Davies P.J.A. J. Biol. Chem. 266:478-483(1991) [PubMed: 1670766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Macrophage. |
| [2] | "Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)." Nanda N., Iismaa S.E., Copeland N.G., Gilbert D.J., Jenkins N., Graham R.M., Sutrave P. Arch. Biochem. Biophys. 366:151-156(1999) [PubMed: 10334875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ. |
| [3] | "Mapping and sequencing of the murine 'tissue' transglutaminase (Tgm2) gene: absence of mutations in MRLlpr/lpr mice." D'Amato M., Iannicola C., Monteriu G., Piacentini M. Cell Death Differ. 6:216-217(1999) [PubMed: 10200571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex, Dendritic cell, Embryonic heart, Heart, Macrophage, Mammary gland and Spleen. |
| [5] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NMRI. Tissue: Mammary tumor. |
| [7] | "Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter." Nagy L., Saydak M., Shipley N., Lu S., Basilion J.P., Yan Z.H., Syka P., Chandraratna R.A.S., Stein J.P., Heyman R.A., Davies P.J.A. J. Biol. Chem. 271:4355-4365(1996) [PubMed: 8626785] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3. Strain: Swiss. |
| [8] | Bienvenut W.V., Serrels B., Brunton V.G., Frame M.C. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-19; 41-74; 158-173; 215-222; 290-327; 550-561; 564-589; 601-609; 634-648 AND 651-671, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic fibroblast. |
| [9] | Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 378-387, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M55154 mRNA. Translation: AAA40420.1. AF114266 mRNA. Translation: AAD37501.1. AF076928 mRNA. Translation: AAC62014.1. AK052912 mRNA. Translation: BAC35200.1. AK080224 mRNA. Translation: BAC37852.1. AK080593 mRNA. Translation: BAC37952.1. AK089481 mRNA. Translation: BAC40899.1. AK143712 mRNA. Translation: BAE25511.1. AK151776 mRNA. Translation: BAE30682.1. AK152152 mRNA. Translation: BAE30987.1. AK152627 mRNA. Translation: BAE31370.1. AK159255 mRNA. Translation: BAE34936.1. AK166302 mRNA. Translation: BAE38690.1. AK168990 mRNA. Translation: BAE40790.1. AK169356 mRNA. Translation: BAE41105.1. AL669824 Genomic DNA. Translation: CAM23188.1. BC016492 mRNA. Translation: AAH16492.1. U24148 Genomic DNA. No translation available. |
| IPI | IPI00126861. |
| PIR | B39045. |
| RefSeq | NP_033399.1. |
| UniGene | Mm.330731 |
3D structure databases | |
| SMR | P21981. Positions 15-686. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P21981. |
PTM databases | |
| PhosphoSite | P21981. |
Proteomic databases | |
| PRIDE | P21981. |
Genome annotation databases | |
| Ensembl | ENSMUST00000103122; ENSMUSP00000099411; ENSMUSG00000037820; Mus musculus. [Genome view] |
| GeneID | 21817. |
| KEGG | mmu:21817. |
Organism-specific databases | |
| CTD | 21817. |
| MGI | MGI:98731. Tgm2. |
Phylogenomic databases | |
| eggNOG | maNOG06398. |
| HOGENOM | HBG444754. |
| HOVERGEN | P21981. |
| InParanoid | P21981. |
| OMA | MAMRIRV. |
| OrthoDB | EOG9B017K. |
| PhylomeDB | P21981. |
Enzyme and pathway databases | |
| BRENDA | 2.3.2.13. 244. |
Gene expression databases | |
| ArrayExpress | P21981. |
| Bgee | P21981. |
| CleanEx | MM_TGM2. |
| Genevestigator | P21981. |
| GermOnline | ENSMUSG00000037820. Mus musculus. |
Family and domain databases | |
| InterPro | IPR008957. Fibronectin_typ-III-like_fold. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002931. Transglutaminase-like. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit. |
| Pfam | PF00927. Transglut_C. 2 hits. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view] |
| SMART | SM00460. TGc. 1 hit. [Graphical view] |
| PROSITE | PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 301224. |
| SOURCE | Search... |
Entry information
| Entry name | TGM2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P21981 Secondary accession number(s): O88901 Q9R1F7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


