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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277PROSITE-ProRule annotation1
Active sitei335PROSITE-ProRule annotation1
Active sitei358PROSITE-ProRule annotation1
Metal bindingi398CalciumBy similarity1
Metal bindingi400CalciumBy similarity1
Metal bindingi447CalciumBy similarity1
Metal bindingi452CalciumBy similarity1

GO - Molecular functioni

  • GTP binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS02263-MONOMER.
BRENDAi2.3.2.13. 2681.
SignaLinkiP21980.
SIGNORiP21980.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase H
Short name:
TGase H
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11778. TGM2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: GOC
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • intrinsic component of plasma membrane Source: CACAO
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7052.
OpenTargetsiENSG00000198959.
PharmGKBiPA36491.

Chemistry databases

ChEMBLiCHEMBL2730.
DrugBankiDB00130. L-Glutamine.

Polymorphism and mutation databases

BioMutaiTGM2.
DMDMi20141877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002137072 – 687Protein-glutamine gamma-glutamyltransferase 2Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei60PhosphoserineCombined sources1
Modified residuei468N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP21980.
PaxDbiP21980.
PeptideAtlasiP21980.
PRIDEiP21980.

PTM databases

iPTMnetiP21980.
PhosphoSitePlusiP21980.
SwissPalmiP21980.

Miscellaneous databases

PMAP-CutDBP21980.

Expressioni

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSG00000198959.
CleanExiHS_TGM2.
ExpressionAtlasiP21980. baseline and differential.
GenevisibleiP21980. HS.

Organism-specific databases

HPAiCAB002598.
HPA021019.
HPA029518.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP13Q128024EBI-727668,EBI-1373806
COL18A1P390602EBI-727668,EBI-2566375
FN1P027513EBI-727668,EBI-1220319
RELAQ042063EBI-727668,EBI-73886
VHLP4033710EBI-727668,EBI-301246

Protein-protein interaction databases

BioGridi112910. 79 interactors.
DIPiDIP-33557N.
IntActiP21980. 52 interactors.
MINTiMINT-88880.
STRINGi9606.ENSP00000355330.

Chemistry databases

BindingDBiP21980.

Structurei

Secondary structure

1687
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi14 – 20Combined sources7
Helixi24 – 26Combined sources3
Beta strandi28 – 30Combined sources3
Beta strandi32 – 34Combined sources3
Beta strandi39 – 48Combined sources10
Turni52 – 54Combined sources3
Beta strandi55 – 66Combined sources12
Turni69 – 72Combined sources4
Beta strandi73 – 79Combined sources7
Beta strandi85 – 87Combined sources3
Beta strandi89 – 95Combined sources7
Beta strandi97 – 105Combined sources9
Beta strandi113 – 123Combined sources11
Beta strandi126 – 138Combined sources13
Helixi153 – 159Combined sources7
Beta strandi164 – 170Combined sources7
Beta strandi172 – 181Combined sources10
Helixi189 – 198Combined sources10
Helixi201 – 205Combined sources5
Helixi207 – 213Combined sources7
Helixi217 – 226Combined sources10
Turni227 – 229Combined sources3
Turni231 – 234Combined sources4
Beta strandi235 – 239Combined sources5
Turni251 – 253Combined sources3
Beta strandi255 – 257Combined sources3
Helixi258 – 266Combined sources9
Turni267 – 269Combined sources3
Beta strandi272 – 275Combined sources4
Helixi277 – 291Combined sources15
Beta strandi295 – 304Combined sources10
Beta strandi306 – 309Combined sources4
Helixi311 – 317Combined sources7
Beta strandi332 – 342Combined sources11
Beta strandi347 – 350Combined sources4
Beta strandi353 – 357Combined sources5
Beta strandi365 – 369Combined sources5
Helixi376 – 380Combined sources5
Turni387 – 389Combined sources3
Helixi390 – 397Combined sources8
Beta strandi400 – 404Combined sources5
Beta strandi412 – 414Combined sources3
Beta strandi419 – 429Combined sources11
Beta strandi433 – 438Combined sources6
Helixi440 – 443Combined sources4
Beta strandi447 – 449Combined sources3
Helixi450 – 460Combined sources11
Turni468 – 471Combined sources4
Beta strandi473 – 478Combined sources6
Beta strandi489 – 497Combined sources9
Beta strandi499 – 501Combined sources3
Beta strandi503 – 514Combined sources12
Beta strandi520 – 534Combined sources15
Beta strandi538 – 546Combined sources9
Helixi548 – 551Combined sources4
Turni552 – 554Combined sources3
Beta strandi560 – 569Combined sources10
Turni570 – 573Combined sources4
Beta strandi574 – 583Combined sources10
Beta strandi590 – 595Combined sources6
Beta strandi598 – 601Combined sources4
Beta strandi603 – 610Combined sources8
Beta strandi613 – 615Combined sources3
Beta strandi619 – 625Combined sources7
Turni627 – 629Combined sources3
Beta strandi634 – 638Combined sources5
Beta strandi647 – 654Combined sources8
Beta strandi658 – 660Combined sources3
Beta strandi662 – 669Combined sources8
Beta strandi671 – 673Combined sources3
Beta strandi676 – 682Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FAUmodel-A1-687[»]
1KV3X-ray2.80A/B/C/D/E/F1-687[»]
2Q3ZX-ray2.00A1-687[»]
3LY6X-ray3.14A/B/C1-687[»]
3S3JX-ray2.25A2-687[»]
3S3PX-ray2.50A2-687[»]
3S3SX-ray2.30A2-687[»]
4PYGX-ray2.80A/B/E1-687[»]
ProteinModelPortaliP21980.
SMRiP21980.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21980.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP21980.
KOiK05625.
OMAiAHITNNT.
OrthoDBiEOG091G030K.
PhylomeDBiP21980.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21980-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY
60 70 80 90 100
EASVDSLTFS VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL
110 120 130 140 150
SLQLTTPANA PIGLYRLSLE ASTGYQGSSF VLGHFILLFN AWCPADAVYL
160 170 180 190 200
DSEEERQEYV LTQQGFIYQG SAKFIKNIPW NFGQFEDGIL DICLILLDVN
210 220 230 240 250
PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGVS
260 270 280 290 300
PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG
360 370 380 390 400
YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD
410 420 430 440 450
VVDWIQQDDG SVHKSINRSL IVGLKISTKS VGRDEREDIT HTYKYPEGSS
460 470 480 490 500
EEREAFTRAN HLNKLAEKEE TGMAMRIRVG QSMNMGSDFD VFAHITNNTA
510 520 530 540 550
EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK SVPLCILYEK
560 570 580 590 600
YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK
610 620 630 640 650
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV
660 670 680
RMDLLPLHMG LHKLVVNFES DKLKAVKGFR NVIIGPA
Length:687
Mass (Da):77,329
Last modified:January 23, 2002 - v2
Checksum:i7DA33FF335DE7B37
GO
Isoform 2 (identifier: P21980-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-548: EKSVPLCILY → GKALCSWSIC
     549-687: Missing.

Show »
Length:548
Mass (Da):61,678
Checksum:i8C2F43A4D1029AC2
GO
Isoform 3 (identifier: P21980-3) [UniParc]FASTAAdd to basket
Also known as: TGH2

The sequence of this isoform differs from the canonical sequence as follows:
     287-349: VLRCLGIPTR...SWMTRPDLQP → GELHAGMWVM...LSNSHPSSGC
     350-687: Missing.

Show »
Length:349
Mass (Da):38,671
Checksum:i37E1EE27C243CCC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → Q in AAA63261 (PubMed:1670766).Curated1
Sequence conflicti186E → Q in AAA63261 (PubMed:1670766).Curated1
Sequence conflicti224V → G in AAA63261 (PubMed:1670766).Curated1
Sequence conflicti533N → T in AAA63261 (PubMed:1670766).Curated1
Sequence conflicti655L → V in AAA63261 (PubMed:1670766).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05255376R → H.1 PublicationCorresponds to variant rs41274720dbSNPEnsembl.1
Natural variantiVAR_055357214R → H.1 PublicationCorresponds to variant rs45530133dbSNPEnsembl.1
Natural variantiVAR_055358324Q → R.1 PublicationCorresponds to variant rs45567334dbSNPEnsembl.1
Natural variantiVAR_037998330M → R in patients with early-onset diabetes type 2; pathological significance unknown. 1 PublicationCorresponds to variant rs141603506dbSNPEnsembl.1
Natural variantiVAR_037999331I → N in patients with early-onset diabetes type 2; pathological significance unknown. 1 Publication1
Natural variantiVAR_055359436R → W.1 PublicationCorresponds to variant rs45629036dbSNPEnsembl.1
Natural variantiVAR_052554536P → S.1 PublicationCorresponds to variant rs45556333dbSNPEnsembl.1
Natural variantiVAR_036554660G → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006413287 – 349VLRCL…PDLQP → GELHAGMWVMSPGRGHEEHW SRNQDIPALVLPPATNTLNA LCGLEPVTTLSGPLSNSHPS SGC in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_006414350 – 687Missing in isoform 3. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_006411539 – 548EKSVPLCILY → GKALCSWSIC in isoform 2. 2 Publications10
Alternative sequenceiVSP_006412549 – 687Missing in isoform 2. 2 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55153 mRNA. Translation: AAA63261.1.
M98478 mRNA. Translation: AAA36739.1.
S81734 mRNA. Translation: AAB36379.1.
AY675221 mRNA. Translation: AAT79353.1.
AK291714 mRNA. Translation: BAF84403.1.
AK314618 mRNA. Translation: BAG37184.1.
DQ523828 Genomic DNA. Translation: ABF47109.1.
AL031651 Genomic DNA. Translation: CAB66115.1.
CH471077 Genomic DNA. Translation: EAW76040.1.
CH471077 Genomic DNA. Translation: EAW76042.1.
CH471077 Genomic DNA. Translation: EAW76044.1.
BC003551 mRNA. Translation: AAH03551.1.
CCDSiCCDS13302.1. [P21980-1]
PIRiA39045.
A44302.
S68092.
RefSeqiNP_001310245.1. NM_001323316.1. [P21980-1]
NP_004604.2. NM_004613.3. [P21980-1]
NP_945189.1. NM_198951.2. [P21980-2]
XP_011527330.1. XM_011529028.1. [P21980-1]
UniGeneiHs.517033.

Genome annotation databases

EnsembliENST00000361475; ENSP00000355330; ENSG00000198959. [P21980-1]
GeneIDi7052.
KEGGihsa:7052.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Tissue transglutaminase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55153 mRNA. Translation: AAA63261.1.
M98478 mRNA. Translation: AAA36739.1.
S81734 mRNA. Translation: AAB36379.1.
AY675221 mRNA. Translation: AAT79353.1.
AK291714 mRNA. Translation: BAF84403.1.
AK314618 mRNA. Translation: BAG37184.1.
DQ523828 Genomic DNA. Translation: ABF47109.1.
AL031651 Genomic DNA. Translation: CAB66115.1.
CH471077 Genomic DNA. Translation: EAW76040.1.
CH471077 Genomic DNA. Translation: EAW76042.1.
CH471077 Genomic DNA. Translation: EAW76044.1.
BC003551 mRNA. Translation: AAH03551.1.
CCDSiCCDS13302.1. [P21980-1]
PIRiA39045.
A44302.
S68092.
RefSeqiNP_001310245.1. NM_001323316.1. [P21980-1]
NP_004604.2. NM_004613.3. [P21980-1]
NP_945189.1. NM_198951.2. [P21980-2]
XP_011527330.1. XM_011529028.1. [P21980-1]
UniGeneiHs.517033.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FAUmodel-A1-687[»]
1KV3X-ray2.80A/B/C/D/E/F1-687[»]
2Q3ZX-ray2.00A1-687[»]
3LY6X-ray3.14A/B/C1-687[»]
3S3JX-ray2.25A2-687[»]
3S3PX-ray2.50A2-687[»]
3S3SX-ray2.30A2-687[»]
4PYGX-ray2.80A/B/E1-687[»]
ProteinModelPortaliP21980.
SMRiP21980.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112910. 79 interactors.
DIPiDIP-33557N.
IntActiP21980. 52 interactors.
MINTiMINT-88880.
STRINGi9606.ENSP00000355330.

Chemistry databases

BindingDBiP21980.
ChEMBLiCHEMBL2730.
DrugBankiDB00130. L-Glutamine.

PTM databases

iPTMnetiP21980.
PhosphoSitePlusiP21980.
SwissPalmiP21980.

Polymorphism and mutation databases

BioMutaiTGM2.
DMDMi20141877.

Proteomic databases

EPDiP21980.
PaxDbiP21980.
PeptideAtlasiP21980.
PRIDEiP21980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361475; ENSP00000355330; ENSG00000198959. [P21980-1]
GeneIDi7052.
KEGGihsa:7052.

Organism-specific databases

CTDi7052.
DisGeNETi7052.
GeneCardsiTGM2.
HGNCiHGNC:11778. TGM2.
HPAiCAB002598.
HPA021019.
HPA029518.
MIMi190196. gene.
neXtProtiNX_P21980.
OpenTargetsiENSG00000198959.
PharmGKBiPA36491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP21980.
KOiK05625.
OMAiAHITNNT.
OrthoDBiEOG091G030K.
PhylomeDBiP21980.
TreeFamiTF324278.

Enzyme and pathway databases

BioCyciZFISH:HS02263-MONOMER.
BRENDAi2.3.2.13. 2681.
SignaLinkiP21980.
SIGNORiP21980.

Miscellaneous databases

ChiTaRSiTGM2. human.
EvolutionaryTraceiP21980.
GeneWikiiTissue_transglutaminase.
GenomeRNAii7052.
PMAP-CutDBP21980.
PROiP21980.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198959.
CleanExiHS_TGM2.
ExpressionAtlasiP21980. baseline and differential.
GenevisibleiP21980. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGM2_HUMAN
AccessioniPrimary (citable) accession number: P21980
Secondary accession number(s): E1P5V9
, Q16436, Q6B838, Q9BTN7, Q9UH35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 189 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.