Reviewed, UniProtKB/Swiss-Prot P21974 (DCK1_FOWPV)

Names and origin

Protein names

Recommended name:
    Probable deoxycytidine kinase FPV059
      Short name=dCK
    EC=2.7.1.74

Gene names

Ordered Locus Names:	FPV059
ORF Names:	FP26

Organism

Fowlpox virus (FPV)

Taxonomic identifier

10261 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Avipoxvirus

Virus host

Vertebrata [TaxID: 7742]

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NTP + deoxycytidine = NDP + dCMP.
Sequence similarities	Belongs to the DCK/DGK family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW deoxycytidine kinase activity Inferred from electronic annotation. Source: EC phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Probable deoxycytidine kinase FPV059		PRO_0000175093
Regions
	Nucleotide binding	16 – 23	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P21974-1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 4C3B08D885B58CE7	FASTA	219	25,909
	10 20 30 40 50 60 MDSINEFTSK KLSIEGNISS GKTDVLNILR NINNVVSFHD VEDRYTPIEK ELIRKFHENP 70 80 90 100 110 120 SRWSYALQTH YCMKRVRMHL ECFVPSRVNI LERSIFSDRY VFAEAATALG YMDDPEWALY 130 140 150 160 170 180 CKQHDWYTDK LEIQFDGIIY LRTIPESCKE RINEKSITEK NYPNISIDYL KTLHEKHELW 190 200 210 LTQCKKVPVL IIDGEEDFIF DPCAKKKLIN EVTEFINSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a 10.5 kbp HindIII fragment of fowlpox virus: relatedness to the central portion of the vaccinia virus HindIII D region." Tartaglia J., Winslow J., Goebel S.J., Johnson G.P., Taylor J., Paoletti E. J. Gen. Virol. 71:1517-1524(1990) [PubMed: 2165135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FP-1.
[2]	"The genome of fowlpox virus." Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L. J. Virol. 74:3815-3831(2000) [PubMed: 10729156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Fowlpox virus encodes a protein related to human deoxycytidine kinase: further evidence for independent acquisition of genes for enzymes of nucleotide metabolism by different viruses." Koonin E.V., Senkevich T.G. Virus Genes 7:289-295(1993) [PubMed: 8279127] [Abstract] Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X17202 Genomic DNA. Translation: CAA35067.1. AF198100 Genomic DNA. Translation: AAF44403.1.
PIR	D35216.
RefSeq	NP_039022.1.
3D structure databases
HSSP	HSSP built from PDB template 1P5Z based on UniProtKB P27707.
ModBase	Search...
Genome annotation databases
GeneID	1486607.
Enzyme and pathway databases
BRENDA	2.7.1.74. 288568.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. [Graphical view]
PANTHER	PTHR10513. dNK. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCK1_FOWPV

Accession

Primary (citable) accession number: P21974

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)