P21974 (DCK1_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidine kinase FPV059
Short name=dCK
EC=2.7.1.74

Gene names

Ordered Locus Names:	FPV059
ORF Names:	FP26

Organism

Fowlpox virus (strain NVSL) (FPV)

Taxonomic identifier

928301 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Avipoxvirus

Virus host

Vertebrata [TaxID: 7742]

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	NTP + deoxycytidine = NDP + dCMP.
Sequence similarities	Belongs to the DCK/DGK family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW deoxycytidine kinase activity Inferred from electronic annotation. Source: EC phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Probable deoxycytidine kinase FPV059		PRO_0000175093
Regions
	Nucleotide binding	16 – 24	9	ATP By similarity
Sites
	Active site	92	1	Proton acceptor Potential
	Binding site	40	1	Substrate By similarity
	Binding site	68	1	Substrate By similarity
	Binding site	93	1	Substrate By similarity
	Binding site	98	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21974 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 4C3B08D885B58CE7	FASTA	219	25,909
	10 20 30 40 50 60 MDSINEFTSK KLSIEGNISS GKTDVLNILR NINNVVSFHD VEDRYTPIEK ELIRKFHENP 70 80 90 100 110 120 SRWSYALQTH YCMKRVRMHL ECFVPSRVNI LERSIFSDRY VFAEAATALG YMDDPEWALY 130 140 150 160 170 180 CKQHDWYTDK LEIQFDGIIY LRTIPESCKE RINEKSITEK NYPNISIDYL KTLHEKHELW 190 200 210 LTQCKKVPVL IIDGEEDFIF DPCAKKKLIN EVTEFINSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a 10.5 kbp HindIII fragment of fowlpox virus: relatedness to the central portion of the vaccinia virus HindIII D region." Tartaglia J., Winslow J., Goebel S.J., Johnson G.P., Taylor J., Paoletti E. J. Gen. Virol. 71:1517-1524(1990) [PubMed: 2165135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FP-1.
[2]	"The genome of fowlpox virus." Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L. J. Virol. 74:3815-3831(2000) [PubMed: 10729156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Fowlpox virus encodes a protein related to human deoxycytidine kinase: further evidence for independent acquisition of genes for enzymes of nucleotide metabolism by different viruses." Koonin E.V., Senkevich T.G. Virus Genes 7:289-295(1993) [PubMed: 8279127] [Abstract] Cited for: DISCUSSION OF SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17202 Genomic DNA. Translation: CAA35067.1. AF198100 Genomic DNA. Translation: AAF44403.1.
PIR	D35216.
RefSeq	NP_039022.1. NC_002188.1.
3D structure databases
ProteinModelPortal	P21974.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1486607.
Phylogenomic databases
ProtClustDB	CLSP2510978.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. [Graphical view]
PANTHER	PTHR10513. dNK. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
PIRSF	PIRSF000705. DNK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCK1_FOWPN

Accession

Primary (citable) accession number: P21974

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	September 21, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program