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Protein

Mast cell carboxypeptidase A

Gene

Cpa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi171Zinc; catalyticBy similarity1
Metal bindingi174Zinc; catalyticBy similarity1
Metal bindingi299Zinc; catalyticBy similarity1
Active sitei373Proton donor/acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.010

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell carboxypeptidase A (EC:3.4.17.1)
Alternative name(s):
Carboxypeptidase A3
R-CPA
RMC-CP
Gene namesi
Name:Cpa3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2390 Cpa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 10By similarity›10
PropeptideiPRO_000000439911 – 104Activation peptideAdd BLAST94
ChainiPRO_0000004400105 – 412Mast cell carboxypeptidase AAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi168 ↔ 181By similarity
Disulfide bondi240 ↔ 263By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP21961
PRIDEiP21961

PTM databases

PhosphoSitePlusiP21961

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014970

Structurei

3D structure databases

ProteinModelPortaliP21961
SMRiP21961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
HOGENOMiHOG000252968
HOVERGENiHBG050815
InParanoidiP21961
KOiK08780
PhylomeDBiP21961

Family and domain databases

Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LMGVIYSTLA IAPVQFDREK VFRVKLQDEK QASILKNLTQ TIELDFWYPD
60 70 80 90 100
AIHDIAVNMT VDFRVTEKES QTIQSTLEQH KMDYEILIND LQEEIDKQFD
110 120 130 140 150
VKEEIAGRHS YAKYNDWNKI VSWTEKMVEK HPEMVSRIKI GSTVEDNPLY
160 170 180 190 200
VLKIGRKDGE RKAIFMDCGI HAREWVSPAF CQWFVYQAAK SYGKNKIMTK
210 220 230 240 250
LLDRMNFYVL PVFNVDGYIW SWTKDRMWRK NRSKNPNSTC IGTDLNRNFD
260 270 280 290 300
VSWDSSPNTD NPCLSVYRGP APESEKETKA VTNFIRSHLN SIKAYITFHS
310 320 330 340 350
YSQMLLFPYG YTIKLPPNHQ DLLKVARIAT DVLSSRYETR YIYGPIASTI
360 370 380 390 400
YKTSGSSLDW AYDLGIKHTF AFELRDKGKS GFLLPESRIK PTCKETMLSV
410
KFIAKYILKH TS
Length:412
Mass (Da):47,944
Last modified:April 13, 2004 - v2
Checksum:iDAB59555FC49137D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti196K → N AA sequence (PubMed:1988052).Curated1
Sequence conflicti237N → S AA sequence (PubMed:1988052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67914 mRNA Translation: AAB48267.1
PIRiA38395
RefSeqiNP_062173.1, NM_019300.1
UniGeneiRn.10700

Genome annotation databases

GeneIDi54242
KEGGirno:54242
UCSCiRGD:2390 rat

Similar proteinsi

Entry informationi

Entry nameiCBPA3_RAT
AccessioniPrimary (citable) accession number: P21961
Secondary accession number(s): P97597
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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