SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21958

- TAP1_MOUSE

UniProt

P21958 - TAP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Antigen peptide transporter 1
Gene
Tap1, Abcb2, Ham-1, Ham1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  4. MHC class I protein binding Source: MGI
  5. peptide transporter activity Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class I Source: Ensembl
  2. cytosol to ER transport Source: Ensembl
  3. defense response Source: MGI
  4. intracellular transport of viral protein in host cell Source: Ensembl
  5. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197102. ER-Phagosome pathway.
REACT_199105. ER-Phagosome pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Histocompatibility antigen modifier 1
Peptide transporter TAP1
Gene namesi
Name:Tap1
Synonyms:Abcb2, Ham-1, Ham1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:98483. Tap1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: The transmembrane segments seem to form a pore in the membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei12 – 3221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini33 – 364Lumenal Reviewed prediction
Transmembranei37 – 5923Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini60 – 689Cytoplasmic Reviewed prediction
Transmembranei69 – 8921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini90 – 10920Lumenal Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini131 – 16232Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini184 – 20320Lumenal Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini225 – 27450Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei275 – 29521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini296 – 3049Lumenal Reviewed prediction
Transmembranei305 – 32521Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini326 – 39469Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini416 – 4194Lumenal Reviewed prediction
Transmembranei420 – 44021Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini441 – 724284Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: Ensembl
  2. integral component of membrane Source: RefGenome
  3. mitochondrion Source: MGI
  4. phagocytic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Antigen peptide transporter 1
PRO_0000093327Add
BLAST

Proteomic databases

MaxQBiP21958.
PaxDbiP21958.
PRIDEiP21958.

PTM databases

PhosphoSiteiP21958.

Expressioni

Gene expression databases

ArrayExpressiP21958.
BgeeiP21958.
GenevestigatoriP21958.

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2. Interacts with PSMB5 and PSMB8 By similarity.

Protein-protein interaction databases

BioGridi203966. 1 interaction.
IntActiP21958. 2 interactions.
MINTiMINT-4136864.

Structurei

3D structure databases

ProteinModelPortaliP21958.
SMRiP21958. Positions 151-718.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini163 – 446284ABC transmembrane type-1
Add
BLAST
Domaini479 – 718240ABC transporter
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni351 – 39646Involved in peptide-binding site By similarity
Add
BLAST
Regioni429 – 46335Involved in peptide-binding site By similarity
Add
BLAST

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2 By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ62427.
KOiK05653.
OMAiCLGSEIR.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP21958.
TreeFamiTF105197.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01896. TAP1PROTEIN.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21958-1 [UniParc]FASTAAdd to Basket

« Hide

MAAHVWLAAA LLLLVDWLLL RPMLPGIFSL LVPEVPLLRV WVVGLSRWAI    50
LGLGVRGVLG VTAGAHGWLA ALQPLVAALS LALPGLALFR ELAAWGTLRE 100
GDSAGLLYWN SRPDAFAISY VAALPAAALW HKLGSLWAPS GNRDAGDMLC 150
RMLGFLGPKK RRLYLVLVLL ILSCLGEMAI PFFTGRITDW ILQDKTVPSF 200
TRNIWLMSIL TIASTALEFA SDGIYNITMG HMHGRVHREV FRAVLRQETG 250
FFLKNPAGSI TSRVTEDTAN VCESISGTLS LLLWYLGRAL CLLVFMFWGS 300
PYLTLVTLIN LPLLFLLPKK LGKVHQSLAV KVQESLAKST QVALEALSAM 350
PTVRSFANEE GEAQKFRQKL EEMKTLNKKE ALAYVAEVWT TSVSGMLLKV 400
GILYLGGQLV IRGAVSSGNL VSFVLYQLQF TQAVQVLLSL YPSMQKAVGS 450
SEKIFEYLDR TPCSPLSGSL APSNMKGLVE FQDVSFAYPN QPKVQVLQGL 500
TFTLHPGTVT ALVGPNGSGK STVAALLQNL YQPTGGQLLL DGQCLVQYDH 550
HYLHTQVAAV GQEPLLFGRS FRENIAYGLN RTPTMEEITA VAVESGAHDF 600
ISGFPQGYDT EVGETGNQLS GGQRQAVALA RALIRKPLLL ILDDATSALD 650
AGNQLRVQRL LYESPKRASR TVLLITQQLS LAEQAHHILF LREGSVGEQG 700
THLQLMKRGG CYRAMVEALA APAD 724
Length:724
Mass (Da):78,864
Last modified:June 28, 2011 - v3
Checksum:iA08E40F9F5FBAE9D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771G → D in AAB41962. 1 Publication
Sequence conflicti277 – 2771G → D in AAA39570. 1 Publication
Sequence conflicti277 – 2771G → D in CAA42178. 1 Publication
Sequence conflicti355 – 3551S → Q in CAA42178. 1 Publication
Sequence conflicti414 – 4141A → T in AAB41962. 1 Publication
Sequence conflicti414 – 4141A → T in AAA39570. 1 Publication
Sequence conflicti414 – 4141A → T in CAA42178. 1 Publication
Sequence conflicti481 – 4811F → L in CAA42178. 1 Publication
Sequence conflicti544 – 5441C → R in AAB41962. 1 Publication
Sequence conflicti544 – 5441C → R in AAA39570. 1 Publication
Sequence conflicti544 – 5441C → R in CAA42178. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60018 mRNA. Translation: AAB41962.1.
U60019 mRNA. Translation: AAB41963.1.
AK162731 mRNA. Translation: BAE37041.1.
AF027865 Genomic DNA. Translation: AAB81534.1.
CH466660 Genomic DNA. Translation: EDL10260.1.
M55637 mRNA. Translation: AAA39570.1.
X59615 mRNA. Translation: CAA42178.1.
CCDSiCCDS28643.1.
PIRiA37779.
JC2020.
RefSeqiNP_038711.2. NM_013683.2.
UniGeneiMm.482076.

Genome annotation databases

EnsembliENSMUST00000170086; ENSMUSP00000128401; ENSMUSG00000037321.
GeneIDi21354.
KEGGimmu:21354.
UCSCiuc008cbu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60018 mRNA. Translation: AAB41962.1 .
U60019 mRNA. Translation: AAB41963.1 .
AK162731 mRNA. Translation: BAE37041.1 .
AF027865 Genomic DNA. Translation: AAB81534.1 .
CH466660 Genomic DNA. Translation: EDL10260.1 .
M55637 mRNA. Translation: AAA39570.1 .
X59615 mRNA. Translation: CAA42178.1 .
CCDSi CCDS28643.1.
PIRi A37779.
JC2020.
RefSeqi NP_038711.2. NM_013683.2.
UniGenei Mm.482076.

3D structure databases

ProteinModelPortali P21958.
SMRi P21958. Positions 151-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203966. 1 interaction.
IntActi P21958. 2 interactions.
MINTi MINT-4136864.

PTM databases

PhosphoSitei P21958.

Proteomic databases

MaxQBi P21958.
PaxDbi P21958.
PRIDEi P21958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170086 ; ENSMUSP00000128401 ; ENSMUSG00000037321 .
GeneIDi 21354.
KEGGi mmu:21354.
UCSCi uc008cbu.2. mouse.

Organism-specific databases

CTDi 6890.
MGIi MGI:98483. Tap1.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00550000074497.
HOVERGENi HBG008358.
InParanoidi Q62427.
KOi K05653.
OMAi CLGSEIR.
OrthoDBi EOG7Z3F4H.
PhylomeDBi P21958.
TreeFami TF105197.

Enzyme and pathway databases

Reactomei REACT_197102. ER-Phagosome pathway.
REACT_199105. ER-Phagosome pathway.

Miscellaneous databases

NextBioi 300552.
PROi P21958.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21958.
Bgeei P21958.
Genevestigatori P21958.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
PRINTSi PR01896. TAP1PROTEIN.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsi TIGR00958. 3a01208. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Allelic variation in the mouse Tap-1 and Tap-2 transporter genes."
    Marusina K., Iyer M., Monaco J.J.
    J. Immunol. 158:5251-5256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WEHI-3.
    Tissue: T-cell lymphoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Transport protein genes in the murine MHC: possible implications for antigen processing."
    Monaco J.J., Cho S., Attaya M.
    Science 250:1723-1726(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 148-724.
  6. Sun X.Y., Zhou J., Frazer I.
    Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 148-724.
    Strain: BALB/c.

Entry informationi

Entry nameiTAP1_MOUSE
AccessioniPrimary (citable) accession number: P21958
Secondary accession number(s): Q62427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi