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P21952

- PO3F1_MOUSE

UniProt

P21952 - PO3F1_MOUSE

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Protein
POU domain, class 3, transcription factor 1
Gene
Pou3f1, Oct6, Otf-6, Otf6, Scip
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi337 – 39660Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  3. RNA polymerase II transcription coactivator activity Source: UniProtKB
  4. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. Schwann cell development Source: MGI
  2. epidermis development Source: MGI
  3. forebrain development Source: MGI
  4. keratinocyte differentiation Source: MGI
  5. myelination Source: MGI
  6. myelination in peripheral nervous system Source: MGI
  7. positive regulation of gene expression Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. positive regulation of transcription, DNA-templated Source: UniProtKB
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name:
Oct-6
Octamer-binding transcription factor 6
Short name:
OTF-6
POU domain transcription factor SCIP
Gene namesi
Name:Pou3f1
Synonyms:Oct6, Otf-6, Otf6, Scip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101896. Pou3f1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449POU domain, class 3, transcription factor 1
PRO_0000100721Add
BLAST

Proteomic databases

PRIDEiP21952.

Expressioni

Tissue specificityi

Expressed in embryonal stem cells and in the developing brain.

Gene expression databases

BgeeiP21952.
CleanExiMM_POU3F1.
GenevestigatoriP21952.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100650.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi250 – 26617
Helixi271 – 28212
Helixi288 – 2958
Helixi301 – 31818
Helixi346 – 35813
Helixi364 – 37411
Helixi378 – 39215

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XSDX-ray2.05C240-402[»]
ProteinModelPortaliP21952.
SMRiP21952. Positions 247-397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini245 – 31975POU-specific
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00730000110809.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiP21952.
KOiK09365.
OMAiKLMHHEW.
OrthoDBiEOG7DJSMG.
PhylomeDBiP21952.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21952-1 [UniParc]FASTAAdd to Basket

« Hide

MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAERLHA GAAYREVQKL    50
MHHEWLGAGA GHPVGLAHPQ WLPTGGGGGG DWAGGPHLEH GKAGGGGTGR 100
ADDGGGGGGF HARLVHQGAA HAGAAWAQGG TAHHLGPAMS PSPGAGGGHQ 150
PQPLGLYAQA AYPGGGGGGL AGMLAAGGGG AGPGLHHALH EDGHEAQLEP 200
SPPPHLGAHG HAHGHAHAGG LHAAAAHLHP GAGGGGSSVG EHSDEDAPSS 250
DDLEQFAKQF KQRRIKLGFT QADVGLALGT LYGNVFSQTT ICRFEALQLS 300
FKNMCKLKPL LNKWLEETDS SSGSPTNLDK IAAQGRKRKK RTSIEVGVKG 350
ALESHFLKCP KPSAHEITGL ADSLQLEKEV VRVWFCNRRQ KEKRMTPAAG 400
AGHPPMDDVY APGELGPGGG SASPPSAPPP PPPAALHHHH HHTLPGSVQ 449
Length:449
Mass (Da):45,324
Last modified:August 1, 1991 - v1
Checksum:i82DD1335A0C4F43C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351Missing in CAA40720. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54628 mRNA. Translation: CAA38445.1.
X56959 mRNA. Translation: CAA40280.1.
X57482 mRNA. Translation: CAA40720.1.
M88302 Genomic DNA. Translation: AAA39963.1.
CCDSiCCDS57296.1.
PIRiS30205.
RefSeqiNP_035271.1. NM_011141.2.
UniGeneiMm.297371.

Genome annotation databases

EnsembliENSMUST00000053491; ENSMUSP00000137374; ENSMUSG00000090125.
GeneIDi18991.
KEGGimmu:18991.
UCSCiuc029uzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54628 mRNA. Translation: CAA38445.1 .
X56959 mRNA. Translation: CAA40280.1 .
X57482 mRNA. Translation: CAA40720.1 .
M88302 Genomic DNA. Translation: AAA39963.1 .
CCDSi CCDS57296.1.
PIRi S30205.
RefSeqi NP_035271.1. NM_011141.2.
UniGenei Mm.297371.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XSD X-ray 2.05 C 240-402 [» ]
ProteinModelPortali P21952.
SMRi P21952. Positions 247-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000100650.

Proteomic databases

PRIDEi P21952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053491 ; ENSMUSP00000137374 ; ENSMUSG00000090125 .
GeneIDi 18991.
KEGGi mmu:18991.
UCSCi uc029uzh.1. mouse.

Organism-specific databases

CTDi 5453.
MGIi MGI:101896. Pou3f1.

Phylogenomic databases

eggNOGi NOG261729.
GeneTreei ENSGT00730000110809.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi P21952.
KOi K09365.
OMAi KLMHHEW.
OrthoDBi EOG7DJSMG.
PhylomeDBi P21952.
TreeFami TF316413.

Miscellaneous databases

NextBioi 295382.
PROi P21952.
SOURCEi Search...

Gene expression databases

Bgeei P21952.
CleanExi MM_POU3F1.
Genevestigatori P21952.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells."
    Meijer D., Graus A., Kraay R., Langeveld A., Mulder M.P., Grosveld G.
    Nucleic Acids Res. 18:7357-7365(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Brain.
  2. "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain."
    Suzuki N., Rohdewohld H., Neuman T., Gruss P., Schoeler H.R.
    EMBO J. 9:3723-3732(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor."
    Zimmerman E.C., Jones C.M., Fet V., Hogan B.L.M., Magnuson M.A.
    Nucleic Acids Res. 19:956-956(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Structure and evolution of four POU domain genes expressed in mouse brain."
    Hara Y., Rovescalli C., Kim Y., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPO3F1_MOUSE
AccessioniPrimary (citable) accession number: P21952
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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