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P21952

- PO3F1_MOUSE

UniProt

P21952 - PO3F1_MOUSE

Protein

POU domain, class 3, transcription factor 1

Gene

Pou3f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi337 – 39660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    3. RNA polymerase II transcription coactivator activity Source: UniProtKB
    4. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. epidermis development Source: MGI
    2. forebrain development Source: MGI
    3. keratinocyte differentiation Source: MGI
    4. myelination Source: MGI
    5. myelination in peripheral nervous system Source: MGI
    6. positive regulation of gene expression Source: UniProtKB
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    9. Schwann cell development Source: MGI
    10. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 1
    Alternative name(s):
    Octamer-binding protein 6
    Short name:
    Oct-6
    Octamer-binding transcription factor 6
    Short name:
    OTF-6
    POU domain transcription factor SCIP
    Gene namesi
    Name:Pou3f1
    Synonyms:Oct6, Otf-6, Otf6, Scip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:101896. Pou3f1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449POU domain, class 3, transcription factor 1PRO_0000100721Add
    BLAST

    Proteomic databases

    PRIDEiP21952.

    Expressioni

    Tissue specificityi

    Expressed in embryonal stem cells and in the developing brain.

    Gene expression databases

    BgeeiP21952.
    CleanExiMM_POU3F1.
    GenevestigatoriP21952.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000100650.

    Structurei

    Secondary structure

    1
    449
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi250 – 26617
    Helixi271 – 28212
    Helixi288 – 2958
    Helixi301 – 31818
    Helixi346 – 35813
    Helixi364 – 37411
    Helixi378 – 39215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XSDX-ray2.05C240-402[»]
    ProteinModelPortaliP21952.
    SMRiP21952. Positions 247-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini245 – 31975POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP21952.
    KOiK09365.
    OMAiKLMHHEW.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP21952.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21952-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAERLHA GAAYREVQKL    50
    MHHEWLGAGA GHPVGLAHPQ WLPTGGGGGG DWAGGPHLEH GKAGGGGTGR 100
    ADDGGGGGGF HARLVHQGAA HAGAAWAQGG TAHHLGPAMS PSPGAGGGHQ 150
    PQPLGLYAQA AYPGGGGGGL AGMLAAGGGG AGPGLHHALH EDGHEAQLEP 200
    SPPPHLGAHG HAHGHAHAGG LHAAAAHLHP GAGGGGSSVG EHSDEDAPSS 250
    DDLEQFAKQF KQRRIKLGFT QADVGLALGT LYGNVFSQTT ICRFEALQLS 300
    FKNMCKLKPL LNKWLEETDS SSGSPTNLDK IAAQGRKRKK RTSIEVGVKG 350
    ALESHFLKCP KPSAHEITGL ADSLQLEKEV VRVWFCNRRQ KEKRMTPAAG 400
    AGHPPMDDVY APGELGPGGG SASPPSAPPP PPPAALHHHH HHTLPGSVQ 449
    Length:449
    Mass (Da):45,324
    Last modified:August 1, 1991 - v1
    Checksum:i82DD1335A0C4F43C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351Missing in CAA40720. (PubMed:1976514)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54628 mRNA. Translation: CAA38445.1.
    X56959 mRNA. Translation: CAA40280.1.
    X57482 mRNA. Translation: CAA40720.1.
    M88302 Genomic DNA. Translation: AAA39963.1.
    CCDSiCCDS57296.1.
    PIRiS30205.
    RefSeqiNP_035271.1. NM_011141.2.
    UniGeneiMm.297371.

    Genome annotation databases

    EnsembliENSMUST00000053491; ENSMUSP00000137374; ENSMUSG00000090125.
    GeneIDi18991.
    KEGGimmu:18991.
    UCSCiuc029uzh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54628 mRNA. Translation: CAA38445.1 .
    X56959 mRNA. Translation: CAA40280.1 .
    X57482 mRNA. Translation: CAA40720.1 .
    M88302 Genomic DNA. Translation: AAA39963.1 .
    CCDSi CCDS57296.1.
    PIRi S30205.
    RefSeqi NP_035271.1. NM_011141.2.
    UniGenei Mm.297371.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XSD X-ray 2.05 C 240-402 [» ]
    ProteinModelPortali P21952.
    SMRi P21952. Positions 247-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000100650.

    Proteomic databases

    PRIDEi P21952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053491 ; ENSMUSP00000137374 ; ENSMUSG00000090125 .
    GeneIDi 18991.
    KEGGi mmu:18991.
    UCSCi uc029uzh.1. mouse.

    Organism-specific databases

    CTDi 5453.
    MGIi MGI:101896. Pou3f1.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P21952.
    KOi K09365.
    OMAi KLMHHEW.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P21952.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295382.
    PROi P21952.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21952.
    CleanExi MM_POU3F1.
    Genevestigatori P21952.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells."
      Meijer D., Graus A., Kraay R., Langeveld A., Mulder M.P., Grosveld G.
      Nucleic Acids Res. 18:7357-7365(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Brain.
    2. "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain."
      Suzuki N., Rohdewohld H., Neuman T., Gruss P., Schoeler H.R.
      EMBO J. 9:3723-3732(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor."
      Zimmerman E.C., Jones C.M., Fet V., Hogan B.L.M., Magnuson M.A.
      Nucleic Acids Res. 19:956-956(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Structure and evolution of four POU domain genes expressed in mouse brain."
      Hara Y., Rovescalli C., Kim Y., Nirenberg M.
      Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPO3F1_MOUSE
    AccessioniPrimary (citable) accession number: P21952
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3