POU domain, class 3, transcription factor 1

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P21952 (PO3F1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 121. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
POU domain, class 3, transcription factor 1

Alternative name(s):
Octamer-binding protein 6
Short name=Oct-6
Octamer-binding transcription factor 6
Short name=OTF-6
POU domain transcription factor SCIP

Gene names

Name:	Pou3f1
Synonyms:	Oct6, Otf-6, Otf6, Scip

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.
Subcellular location	Nucleus.
Tissue specificity	Expressed in embryonal stem cells and in the developing brain.
Sequence similarities	Belongs to the POU transcription factor family. Class-3 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	forebrain development Inferred from mutant phenotype PubMed 19527706. Source: MGI keratinocyte differentiation Inferred from genetic interaction PubMed 9242494. Source: MGI myelination in peripheral nervous system Inferred from genetic interaction PubMed 12782656. Source: MGI
Cellular_component	transcription factor complex Inferred from direct assay PubMed 12782656. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 12782656. Source: MGI RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from sequence orthology PubMed 9632656. Source: MGI RNA polymerase II transcription coactivator activity Inferred from direct assay PubMed 18505825. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 449

449

POU domain, class 3, transcription factor 1

PRO_0000100721

Regions

Domain

245 – 319

POU-specific

DNA binding

337 – 396

Homeobox

Experimental info

Sequence conflict

Missing in CAA40720. Ref.2

Secondary structure

449

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P21952 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 82DD1335A0C4F43C
Show »

FASTA

449

45,324

        10         20         30         40         50         60 
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAERLHA GAAYREVQKL MHHEWLGAGA 

        70         80         90        100        110        120 
GHPVGLAHPQ WLPTGGGGGG DWAGGPHLEH GKAGGGGTGR ADDGGGGGGF HARLVHQGAA 

       130        140        150        160        170        180 
HAGAAWAQGG TAHHLGPAMS PSPGAGGGHQ PQPLGLYAQA AYPGGGGGGL AGMLAAGGGG 

       190        200        210        220        230        240 
AGPGLHHALH EDGHEAQLEP SPPPHLGAHG HAHGHAHAGG LHAAAAHLHP GAGGGGSSVG 

       250        260        270        280        290        300 
EHSDEDAPSS DDLEQFAKQF KQRRIKLGFT QADVGLALGT LYGNVFSQTT ICRFEALQLS 

       310        320        330        340        350        360 
FKNMCKLKPL LNKWLEETDS SSGSPTNLDK IAAQGRKRKK RTSIEVGVKG ALESHFLKCP 

       370        380        390        400        410        420 
KPSAHEITGL ADSLQLEKEV VRVWFCNRRQ KEKRMTPAAG AGHPPMDDVY APGELGPGGG 

       430        440 
SASPPSAPPP PPPAALHHHH HHTLPGSVQ

« Hide

References

[1]	"The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells." Meijer D., Graus A., Kraay R., Langeveld A., Mulder M.P., Grosveld G. Nucleic Acids Res. 18:7357-7365(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Brain.
[2]	"Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain." Suzuki N., Rohdewohld H., Neuman T., Gruss P., Schoeler H.R. EMBO J. 9:3723-3732(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor." Zimmerman E.C., Jones C.M., Fet V., Hogan B.L.M., Magnuson M.A. Nucleic Acids Res. 19:956-956(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Structure and evolution of four POU domain genes expressed in mouse brain." Hara Y., Rovescalli C., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54628 mRNA. Translation: CAA38445.1.
X56959 mRNA. Translation: CAA40280.1.
X57482 mRNA. Translation: CAA40720.1.
M88302 Genomic DNA. Translation: AAA39963.1.

IPI

IPI00129796.

PIR

S30205.

RefSeq

NP_035271.1. NM_011141.2.

UniGene

Mm.297371.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XSD	X-ray	2.05	C	240-402	[»]

ProteinModelPortal

P21952.

SMR

P21952. Positions 247-397.

ModBase

Search...

Protein-protein interaction databases

STRING

10090.ENSMUSP00000100650.

Proteomic databases

PRIDE

P21952.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000053491; ENSMUSP00000137374; ENSMUSG00000090125.

GeneID

18991.

KEGG

mmu:18991.

UCSC

uc029uzh.1. mouse.

Organism-specific databases

CTD

5453.

MGI

MGI:101896. Pou3f1.

Phylogenomic databases

eggNOG

NOG261729.

GeneTree

ENSGT00700000104117.

HOGENOM

HOG000116303.

HOVERGEN

HBG053120.

InParanoid

P21952.

K09365.

OMA

MHHALHE.

OrthoDB

EOG4SQWXT.

Gene expression databases

ArrayExpress

P21952.

Bgee

P21952.

CleanEx

MM_POU3F1.

Genevestigator

P21952.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.
1.10.260.40. 1 hit.

InterPro

IPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]

Pfam

PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]

PIRSF

PIRSF002629. Transcription_factor_POU. 1 hit.

PRINTS

PR00028. POUDOMAIN.

SMART

SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF47413. Lambda_like_DNA. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

295382.

SOURCE

Search...

Entry information

Entry name

PO3F1_MOUSE

Accession

Primary (citable) accession number: P21952

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 29, 2013
This is version 121 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents