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Protein

Cartilage matrix protein

Gene

MATN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162510-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage matrix protein
Alternative name(s):
Matrilin-1
Gene namesi
Name:MATN1
Synonyms:CMP, CRTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6907. MATN1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4146.
OpenTargetsiENSG00000162510.
PharmGKBiPA30650.

Polymorphism and mutation databases

BioMutaiMATN1.
DMDMi115556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000000749523 – 496Cartilage matrix proteinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 221Sequence analysis
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi234 ↔ 247By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi265 ↔ 452Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21941.
PeptideAtlasiP21941.
PRIDEiP21941.

PTM databases

iPTMnetiP21941.
PhosphoSitePlusiP21941.

Expressioni

Gene expression databases

BgeeiENSG00000162510.
CleanExiHS_MATN1.
GenevisibleiP21941. HS.

Organism-specific databases

HPAiHPA028580.

Interactioni

Subunit structurei

Homotrimer. Interacts with COMP.1 Publication

Protein-protein interaction databases

BioGridi110316. 4 interactors.
STRINGi9606.ENSP00000362870.

Structurei

3D structure databases

ProteinModelPortaliP21941.
SMRiP21941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 222VWFA 1PROSITE-ProRule annotationAdd BLAST200
Domaini223 – 263EGF-likeAdd BLAST41
Domaini264 – 453VWFA 2PROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili467 – 495Sequence analysisAdd BLAST29

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR75. Eukaryota.
ENOG410XSCQ. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiP21941.
OMAiQIASEPQ.
OrthoDBiEOG091G04O4.
PhylomeDBiP21941.
TreeFamiTF330078.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR030751. Matrilin-1.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF91. PTHR11132:SF91. 1 hit.
PfamiPF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR
60 70 80 90 100
SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS
110 120 130 140 150
KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI
160 170 180 190 200
VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV
210 220 230 240 250
DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH
260 270 280 290 300
EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ
310 320 330 340 350
IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK
360 370 380 390 400
GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK
410 420 430 440 450
DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK
460 470 480 490
ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV
Length:496
Mass (Da):53,701
Last modified:May 1, 1991 - v1
Checksum:i2D880A8114C7940F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291F → L in AAA63904 (PubMed:2246248).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55682
, M55675, M55676, M55677, M55679, M55680, M55681 Genomic DNA. Translation: AAB38702.1.
M55683 mRNA. Translation: AAA63904.1.
AK312949 mRNA. Translation: BAG35790.1.
AL137857 Genomic DNA. Translation: CAI19322.1.
CCDSiCCDS336.1.
PIRiA37979.
RefSeqiNP_002370.1. NM_002379.3.
UniGeneiHs.150366.

Genome annotation databases

EnsembliENST00000373765; ENSP00000362870; ENSG00000162510.
GeneIDi4146.
KEGGihsa:4146.
UCSCiuc001brz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55682
, M55675, M55676, M55677, M55679, M55680, M55681 Genomic DNA. Translation: AAB38702.1.
M55683 mRNA. Translation: AAA63904.1.
AK312949 mRNA. Translation: BAG35790.1.
AL137857 Genomic DNA. Translation: CAI19322.1.
CCDSiCCDS336.1.
PIRiA37979.
RefSeqiNP_002370.1. NM_002379.3.
UniGeneiHs.150366.

3D structure databases

ProteinModelPortaliP21941.
SMRiP21941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110316. 4 interactors.
STRINGi9606.ENSP00000362870.

PTM databases

iPTMnetiP21941.
PhosphoSitePlusiP21941.

Polymorphism and mutation databases

BioMutaiMATN1.
DMDMi115556.

Proteomic databases

PaxDbiP21941.
PeptideAtlasiP21941.
PRIDEiP21941.

Protocols and materials databases

DNASUi4146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373765; ENSP00000362870; ENSG00000162510.
GeneIDi4146.
KEGGihsa:4146.
UCSCiuc001brz.4. human.

Organism-specific databases

CTDi4146.
DisGeNETi4146.
GeneCardsiMATN1.
H-InvDBHIX0000347.
HIX0028643.
HIX0029177.
HGNCiHGNC:6907. MATN1.
HPAiHPA028580.
MIMi115437. gene.
neXtProtiNX_P21941.
OpenTargetsiENSG00000162510.
PharmGKBiPA30650.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR75. Eukaryota.
ENOG410XSCQ. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiP21941.
OMAiQIASEPQ.
OrthoDBiEOG091G04O4.
PhylomeDBiP21941.
TreeFamiTF330078.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162510-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.

Miscellaneous databases

GeneWikiiMATN1.
GenomeRNAii4146.
PROiP21941.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162510.
CleanExiHS_MATN1.
GenevisibleiP21941. HS.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR030751. Matrilin-1.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF91. PTHR11132:SF91. 1 hit.
PfamiPF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATN1_HUMAN
AccessioniPrimary (citable) accession number: P21941
Secondary accession number(s): B2R7E3, Q5TBB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.