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Protein

Cartilage matrix protein

Gene

MATN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage matrix protein
Alternative name(s):
Matrilin-1
Gene namesi
Name:MATN1
Synonyms:CMP, CRTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162510.5
HGNCiHGNC:6907 MATN1
MIMi115437 gene
neXtProtiNX_P21941

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4146
OpenTargetsiENSG00000162510
PharmGKBiPA30650

Polymorphism and mutation databases

BioMutaiMATN1
DMDMi115556

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000000749523 – 496Cartilage matrix proteinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 221Sequence analysis
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi234 ↔ 247By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi265 ↔ 452Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21941
PeptideAtlasiP21941
PRIDEiP21941

PTM databases

iPTMnetiP21941
PhosphoSitePlusiP21941

Expressioni

Gene expression databases

BgeeiENSG00000162510
CleanExiHS_MATN1
GenevisibleiP21941 HS

Organism-specific databases

HPAiHPA028580

Interactioni

Subunit structurei

Homotrimer. Interacts with COMP.1 Publication

Protein-protein interaction databases

BioGridi110316, 4 interactors
STRINGi9606.ENSP00000362870

Structurei

3D structure databases

ProteinModelPortaliP21941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 222VWFA 1PROSITE-ProRule annotationAdd BLAST200
Domaini223 – 263EGF-likeAdd BLAST41
Domaini264 – 453VWFA 2PROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili467 – 495Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR75 Eukaryota
ENOG410XSCQ LUCA
GeneTreeiENSGT00910000144060
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiP21941
OMAiYTCACHE
OrthoDBiEOG091G04O4
PhylomeDBiP21941
TreeFamiTF330078

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR030751 Matrilin-1
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44857 PTHR44857, 1 hit
PfamiView protein in Pfam
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50234 VWFA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR
60 70 80 90 100
SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS
110 120 130 140 150
KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI
160 170 180 190 200
VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV
210 220 230 240 250
DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH
260 270 280 290 300
EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ
310 320 330 340 350
IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK
360 370 380 390 400
GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK
410 420 430 440 450
DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK
460 470 480 490
ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV
Length:496
Mass (Da):53,701
Last modified:May 1, 1991 - v1
Checksum:i2D880A8114C7940F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291F → L in AAA63904 (PubMed:2246248).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55682
, M55675, M55676, M55677, M55679, M55680, M55681 Genomic DNA Translation: AAB38702.1
M55683 mRNA Translation: AAA63904.1
AK312949 mRNA Translation: BAG35790.1
AL137857 Genomic DNA No translation available.
CCDSiCCDS336.1
PIRiA37979
RefSeqiNP_002370.1, NM_002379.3
UniGeneiHs.150366

Genome annotation databases

EnsembliENST00000373765; ENSP00000362870; ENSG00000162510
GeneIDi4146
KEGGihsa:4146
UCSCiuc001brz.4 human

Similar proteinsi

Entry informationi

Entry nameiMATN1_HUMAN
AccessioniPrimary (citable) accession number: P21941
Secondary accession number(s): B2R7E3, Q5TBB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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