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Reviewed, UniProtKB/Swiss-Prot P21932 (ADCY3_RAT)

Last modified June 16, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 3
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type III
      Short name=AC-III
    ATP pyrophosphate-lyase 3
    Adenylyl cyclase 3
      Short name=AC3
    Adenylate cyclase, olfactive type
Gene names
Name: Adcy3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length1144 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Cilia of the olfactory epithelium.

Induction

By stimulatory G protein (G(s)), forskolin and ALF4-.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11441144Adenylate cyclase type 3
PRO_0000195689

Regions

Topological domain1 – 7979Cytoplasmic Potential
Transmembrane80 – 10021 Potential
Transmembrane105 – 12521 Potential
Transmembrane139 – 15921 Potential
Transmembrane173 – 19321 Potential
Transmembrane226 – 24621 Potential
Transmembrane381 – 40121 Potential
Topological domain402 – 630229Cytoplasmic Potential
Transmembrane631 – 65121 Potential
Transmembrane662 – 68221 Potential
Transmembrane706 – 72621 Potential
Transmembrane755 – 77521 Potential
Transmembrane777 – 79721 Potential
Transmembrane833 – 85321 Potential
Topological domain854 – 1144291Cytoplasmic Potential

Sites

Metal binding3241Magnesium 1 By similarity
Metal binding3241Magnesium 2 By similarity
Metal binding3251Magnesium 2; via carbonyl oxygen By similarity
Metal binding3681Magnesium 1 By similarity
Metal binding3681Magnesium 2 By similarity

Amino acid modifications

Glycosylation7341N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P21932-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 21098D028DDBAB55

FASTA1,144128,936
        10         20         30         40         50         60 
MTEDQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 

        70         80         90        100        110        120 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGVGLVLDII 

       130        140        150        160        170        180 
LFVLCKKGLL PDRVSRKVVP YLLWLLITAQ IFSYLGLNFS RAHAASDTVG WQAFFVFSFF 

       190        200        210        220        230        240 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 

       250        260        270        280        290        300 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 

       310        320        330        340        350        360 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 

       370        380        390        400        410        420 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 

       430        440        450        460        470        480 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 

       490        500        510        520        530        540 
YLDEKGIETY LIIASKPEVK KTAQNGLNGS ALPNGAPASK PSSPALIETK EPNGSAHASG 

       550        560        570        580        590        600 
STSEEAEEQE AQADNPSFPN PRRRLRLQDL ADRVVDASED EHELNQLLNE ALLERESAQV 

       610        620        630        640        650        660 
VKKRNTFLLT MRFMDPEMET RYSVEKEKQS GAAFSCSCVV LFCTAMVEIL IDPWLMTNYV 

       670        680        690        700        710        720 
TFVVGEVLLL ILTICSMAAI FPRAFPKKLV AFSSWIDRTR WARNTWAMLA IFILVMANVV 

       730        740        750        760        770        780 
DMLSCLQYYM GPYNVTTGIE LDGGCMENPK YYNYVAVLSL IATIMLVQVS HMVKLTLMLL 

       790        800        810        820        830        840 
VTGAVTAINL YAWCPVFDEY DHKRFQEKDS PMVALEKMQV LSTPGLNGTD SRLPLVPSKY 

       850        860        870        880        890        900 
SMTVMMFVMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 

       910        920        930        940        950        960 
ARHFLGSKKR DEELYSQSYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 

       970        980        990       1000       1010       1020 
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFTSSS KEEKSDKERW QHLADLADFA 

      1030       1040       1050       1060       1070       1080 
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 

      1090       1100       1110       1120       1130       1140 
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDRPAAFPN GSSVTLPHQV 


VDNP

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References

[1]"Identification of a specialized adenylyl cyclase that may mediate odorant detection."
Bakalyar H.A., Reed R.R.
Science 250:1403-1406(1990) [PubMed: 2255909] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Olfactory epithelium.

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Cross-references

Sequence databases

M55075 mRNA. Translation: AAA40677.1.
IPIIPI00208332.
PIRA39833.
RefSeqNP_570135.2.
UniGeneRn.87800

3D structure databases

HSSPHSSP built from PDB template 1AB8 based on UniProtKB P26769.
ModBaseSearch...

PTM databases

PhosphoSiteP21932.

Genome annotation databases

EnsemblENSRNOG00000003999. Rattus norvegicus. [Contig view]
GeneID64508.
KEGGrno:64508.

Organism-specific databases

RGD71009. Adcy3.

Phylogenomic databases

HOVERGENP21932.

Enzyme and pathway databases

BRENDA4.6.1.1. 248.

Gene expression databases

ArrayExpressP21932.
GermOnlineENSRNOG00000003999. Rattus norvegicus.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio613282.

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Entry information

Entry nameADCY3_RAT
AccessionPrimary (citable) accession number: P21932
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 16, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents