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P21927

- CHLE_RABIT

UniProt

P21927 - CHLE_RABIT

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Protein

Cholinesterase

Gene
BCHE
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters By similarity.

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei205 – 2051Acyl-ester intermediate By similarity
Active sitei332 – 3321Charge relay system By similarity
Active sitei445 – 4451Charge relay system By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB
  2. cholinesterase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
Pseudocholinesterase
Gene namesi
Name:BCHE
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 88 Reviewed prediction
Chaini9 – 581573CholinesterasePRO_0000008616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi72 ↔ 99 By similarity
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Modified residuei205 – 2051Phosphoserine By similarity
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi259 ↔ 270 By similarity
Glycosylationi263 – 2631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi407 ↔ 526 By similarity
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi578 – 578Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Present in most cells except erythrocytes.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006971.

Structurei

3D structure databases

ProteinModelPortaliP21927.
SMRiP21927. Positions 11-541, 543-572.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21927-1 [UniParc]FASTAAdd to Basket

« Hide

MVTRSSHTED VIITTKNGRI RGINLPVFGG TVTAFLGIPY AQPPLGRLRF    50
KKPQSLTKWS DIWNATKYAN SCCQNIDQSF PGFHGSEMWN PNTDLSEDCL 100
YLNVWIPTPK PKNATVMIWI YGGGFQTGTS SLQVYDGKFL TRVERVIVVS 150
MNYRVGALGF LALPGNPEAP GNMGLFDQQL ALQWVQKNIA AFGGNPKSVT 200
LFGESAGAAS VSLHLLSPRS HPLFTRAILQ SGSSNAPWEV MSLHEARNRT 250
LTLAKFVGCS TENETEIIKC LRNKDAQEIL LNEVFVVPFD SLLSVNFGPT 300
VDGDFLTDMP DTLLQLGQLK KTQILVGVNK DEGTAFLVYG APGFSKDNTS 350
IITRKEFQEG LKIFFPGVSE FGKESILFHY TDWVDEQRPE NYREALDDVV 400
GDYNFICPAL EFTKKFSEWG NNAFFYYFEH RSSKLPWPEW MGVMHGYEIE 450
FVFGLPLERR VNYTKAEEIL SRSIMKRWAN FAKYGNPNGT QNNSTRWPVF 500
KSTEQKYLTL NTESPRIYTK LRAQQCRFWT LFFPKVLEMT GNIDEAEQEW 550
KAGFHRWNNY MMAWKNHFND YTSKKERCAG F 581
Length:581
Mass (Da):66,156
Last modified:May 1, 1991 - v1
Checksum:iFE8B199E7B32EB0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52090, X52091, X52092 Genomic DNA. Translation: CAA36308.1.
M62779 Genomic DNA. Translation: AAA31169.1.
PIRiS10255. C39768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52090 , X52091 , X52092 Genomic DNA. Translation: CAA36308.1 .
M62779 Genomic DNA. Translation: AAA31169.1 .
PIRi S10255. C39768.

3D structure databases

ProteinModelPortali P21927.
SMRi P21927. Positions 11-541, 543-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000006971.

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2272.
HOGENOMi HOG000091866.
HOVERGENi HBG008839.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
ProDomi PD415333. AChE_tetra. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of rabbit butyrylcholinesterase."
    Jbilo O., Roudani S., Chatonnet A.
    Nucleic Acids Res. 18:3990-3990(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: New Zealand.
  2. "Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates."
    Arpagaus M., Chatonnet A., Masson P., Newton M., Vaughan T.A., Bartels C.F., Nogueira C.P., la Du B.N., Lockridge O.
    J. Biol. Chem. 266:6966-6974(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-215.
    Tissue: Liver.

Entry informationi

Entry nameiCHLE_RABIT
AccessioniPrimary (citable) accession number: P21927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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