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P21918

- DRD5_HUMAN

UniProt

P21918 - DRD5_HUMAN

Protein

D(1B) dopamine receptor

Gene

DRD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 2 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

    GO - Molecular functioni

    1. dopamine binding Source: UniProtKB
    2. dopamine neurotransmitter receptor activity Source: UniProtKB
    3. dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: BHF-UCL
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    4. associative learning Source: Ensembl
    5. cellular calcium ion homeostasis Source: BHF-UCL
    6. cellular response to catecholamine stimulus Source: BHF-UCL
    7. long term synaptic depression Source: Ensembl
    8. negative regulation of blood pressure Source: Ensembl
    9. negative regulation of NAD(P)H oxidase activity Source: UniProtKB
    10. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
    11. phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
    12. positive regulation of adenylate cyclase activity Source: UniProtKB
    13. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
    14. reactive oxygen species metabolic process Source: UniProtKB
    15. regulation of female receptivity Source: Ensembl
    16. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
    17. response to amphetamine Source: Ensembl
    18. response to cocaine Source: Ensembl
    19. sensitization Source: Ensembl
    20. synaptic transmission Source: UniProtKB
    21. synaptic transmission, dopaminergic Source: UniProtKB
    22. transmission of nerve impulse Source: Ensembl
    23. wound healing Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16968. Dopamine receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(1B) dopamine receptor
    Alternative name(s):
    D(5) dopamine receptor
    D1beta dopamine receptor
    Dopamine D5 receptor
    Gene namesi
    Name:DRD5
    Synonyms:DRD1B, DRD1L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3026. DRD5.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.1 Publication
    Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi7 – 71N → Q: Impairs subcellular location. 1 Publication

    Keywords - Diseasei

    Dystonia

    Organism-specific databases

    MIMi126453. gene+phenotype.
    606798. phenotype.
    Orphaneti93962. Autosomal dominant cervical dystonia.
    93955. Benign essential blepharospasm.
    PharmGKBiPA148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477D(1B) dopamine receptorPRO_0000069405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)1 Publication
    Disulfide bondi113 ↔ 217PROSITE-ProRule annotation
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Lipidationi375 – 3751S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP21918.
    PRIDEiP21918.

    Expressioni

    Tissue specificityi

    Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

    Gene expression databases

    BgeeiP21918.
    CleanExiHS_DRD5.
    GenevestigatoriP21918.

    Organism-specific databases

    HPAiHPA048930.

    Interactioni

    Protein-protein interaction databases

    BioGridi108150. 3 interactions.
    STRINGi9606.ENSP00000306129.

    Structurei

    3D structure databases

    ProteinModelPortaliP21918.
    SMRiP21918. Positions 46-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 7711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 11410ExtracellularSequence Analysis
    Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 22343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 29650CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini321 – 34020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 477117CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10427Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 18022Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24623Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 32024Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei341 – 36020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262978.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP21918.
    KOiK05840.
    OMAiRAENCDS.
    OrthoDBiEOG780RMN.
    PhylomeDBiP21918.
    TreeFamiTF325181.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21918-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL    50
    IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV 100
    AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR 150
    KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW 200
    TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR 250
    IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV 300
    IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA 350
    NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI 400
    VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV 450
    AESVWELDCE GEISLDKITP FTPNGFH 477
    Length:477
    Mass (Da):52,951
    Last modified:March 1, 1992 - v2
    Checksum:iBACCB85E5A72F9CA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621C → S.
    Corresponds to variant rs2227840 [ dbSNP | Ensembl ].
    VAR_029210
    Natural varianti88 – 881L → R.1 Publication
    Corresponds to variant rs6282 [ dbSNP | Ensembl ].
    VAR_011837
    Natural varianti110 – 1101G → E.
    Corresponds to variant rs2227849 [ dbSNP | Ensembl ].
    VAR_029211
    Natural varianti207 – 2071F → V.
    Corresponds to variant rs2227845 [ dbSNP | Ensembl ].
    VAR_029212
    Natural varianti233 – 2331S → N.
    Corresponds to variant rs2227843 [ dbSNP | Ensembl ].
    VAR_029213
    Natural varianti238 – 2381V → I.
    Corresponds to variant rs2227852 [ dbSNP | Ensembl ].
    VAR_024254
    Natural varianti247 – 2471R → H.
    Corresponds to variant rs2227847 [ dbSNP | Ensembl ].
    VAR_029214
    Natural varianti269 – 2691A → V.1 Publication
    Corresponds to variant rs2227842 [ dbSNP | Ensembl ].
    VAR_003458
    Natural varianti286 – 2861A → V.
    Corresponds to variant rs2227850 [ dbSNP | Ensembl ].
    VAR_029215
    Natural varianti297 – 2971T → P.
    Corresponds to variant rs2227851 [ dbSNP | Ensembl ].
    VAR_061217
    Natural varianti330 – 3301P → Q.1 Publication
    Corresponds to variant rs1800762 [ dbSNP | Ensembl ].
    VAR_003459
    Natural varianti351 – 3511N → D.1 Publication
    VAR_003460
    Natural varianti453 – 4531S → C.1 Publication
    VAR_003461

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58454 Genomic DNA. Translation: CAA41360.1.
    M67439 Genomic DNA. Translation: AAA52329.1.
    AY136750 mRNA. Translation: AAN01276.1.
    AK313897 mRNA. Translation: BAG36620.1.
    CH471069 Genomic DNA. Translation: EAW92679.1.
    BC009748 mRNA. Translation: AAH09748.1.
    CCDSiCCDS3405.1.
    PIRiS15080. DYHUD5.
    RefSeqiNP_000789.1. NM_000798.4.
    UniGeneiHs.380681.

    Genome annotation databases

    EnsembliENST00000304374; ENSP00000306129; ENSG00000169676.
    GeneIDi1816.
    KEGGihsa:1816.
    UCSCiuc003gmb.4. human.

    Polymorphism databases

    DMDMi118214.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58454 Genomic DNA. Translation: CAA41360.1 .
    M67439 Genomic DNA. Translation: AAA52329.1 .
    AY136750 mRNA. Translation: AAN01276.1 .
    AK313897 mRNA. Translation: BAG36620.1 .
    CH471069 Genomic DNA. Translation: EAW92679.1 .
    BC009748 mRNA. Translation: AAH09748.1 .
    CCDSi CCDS3405.1.
    PIRi S15080. DYHUD5.
    RefSeqi NP_000789.1. NM_000798.4.
    UniGenei Hs.380681.

    3D structure databases

    ProteinModelPortali P21918.
    SMRi P21918. Positions 46-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108150. 3 interactions.
    STRINGi 9606.ENSP00000306129.

    Chemistry

    BindingDBi P21918.
    ChEMBLi CHEMBL2096905.
    DrugBanki DB00714. Apomorphine.
    DB01038. Carphenazine.
    DB00800. Fenoldopam.
    DB01624. Zuclopenthixol.
    GuidetoPHARMACOLOGYi 218.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 118214.

    Proteomic databases

    PaxDbi P21918.
    PRIDEi P21918.

    Protocols and materials databases

    DNASUi 1816.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304374 ; ENSP00000306129 ; ENSG00000169676 .
    GeneIDi 1816.
    KEGGi hsa:1816.
    UCSCi uc003gmb.4. human.

    Organism-specific databases

    CTDi 1816.
    GeneCardsi GC04P009783.
    H-InvDB HIX0029583.
    HGNCi HGNC:3026. DRD5.
    HPAi HPA048930.
    MIMi 126453. gene+phenotype.
    606798. phenotype.
    neXtProti NX_P21918.
    Orphaneti 93962. Autosomal dominant cervical dystonia.
    93955. Benign essential blepharospasm.
    PharmGKBi PA148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262978.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P21918.
    KOi K05840.
    OMAi RAENCDS.
    OrthoDBi EOG780RMN.
    PhylomeDBi P21918.
    TreeFami TF325181.

    Enzyme and pathway databases

    Reactomei REACT_16968. Dopamine receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Dopamine_receptor_D5.
    GenomeRNAii 1816.
    NextBioi 7405.
    PROi P21918.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21918.
    CleanExi HS_DRD5.
    Genevestigatori P21918.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1."
      Sunahara R.K., Guan H.-C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., van Tol H.H.M., Niznik H.B.
      Nature 350:614-619(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes."
      Grandy D.K., Zhang Y., Bouvier C., Zhou Q.-Y., Johnson R.A., Allen L., Buck K., Bunzow J.R., Salon J., Civelli O.
      Proc. Natl. Acad. Sci. U.S.A. 88:9175-9179(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene."
      Weinshank R.L., Adham N., Macchi M., Olsen M.A., Branchek T.A., Hartig P.R.
      J. Biol. Chem. 266:22427-22435(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Spleen.
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    8. "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells."
      Karpa K.D., Lidow M.S., Pickering M.T., Levenson R., Bergson C.
      Mol. Pharmacol. 56:1071-1078(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-7, MUTAGENESIS OF ASN-7.
    9. "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm."
      Misbahuddin A., Placzek M.R., Chaudhuri K.R., Wood N.W., Bhatia K.P., Warner T.T.
      Neurology 58:124-126(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN BEB.
    10. "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease."
      Sobell J.L., Lind T.J., Sigurdson D.C., Zald D.H., Snitz B.E., Grove W.M., Heston L.L., Sommer S.S.
      Hum. Mol. Genet. 4:507-514(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-269; GLN-330; ASP-351 AND CYS-453.
    11. Cited for: VARIANT ARG-88.

    Entry informationi

    Entry nameiDRD5_HUMAN
    AccessioniPrimary (citable) accession number: P21918
    Secondary accession number(s): B2R9S3, Q8NEQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 164 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3