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Protein

D(1B) dopamine receptor

Gene

DRD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

GO - Molecular functioni

  • dopamine binding Source: UniProtKB
  • dopamine neurotransmitter receptor activity Source: UniProtKB
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
D1beta dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:DRD5
Synonyms:DRD1B, DRD1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169676.5.
HGNCiHGNC:3026. DRD5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 77CytoplasmicSequence analysisAdd BLAST11
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 114ExtracellularSequence analysis10
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 180Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini181 – 223ExtracellularSequence analysisAdd BLAST43
Transmembranei224 – 246Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini247 – 296CytoplasmicSequence analysisAdd BLAST50
Transmembranei297 – 320Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini321 – 340ExtracellularSequence analysisAdd BLAST20
Transmembranei341 – 360Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini361 – 477CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Benign essential blepharospasm (BEB)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
See also OMIM:606798

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7N → Q: Impairs subcellular location. 1 Publication1

Keywords - Diseasei

Dystonia

Organism-specific databases

DisGeNETi1816.
MalaCardsiDRD5.
MIMi126453. gene+phenotype.
606798. phenotype.
OpenTargetsiENSG00000169676.
Orphaneti93962. Autosomal dominant cervical dystonia.
93955. Benign essential blepharospasm.
PharmGKBiPA148.

Chemistry databases

ChEMBLiCHEMBL1850.
DrugBankiDB00714. Apomorphine.
DB01238. Aripiprazole.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01038. Carphenazine.
DB00477. Chlorpromazine.
DB00568. Cinnarizine.
DB00988. Dopamine.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01186. Pergolide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi218.

Polymorphism and mutation databases

BioMutaiDRD5.
DMDMi118214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694051 – 477D(1B) dopamine receptorAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi113 ↔ 217PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi375S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21918.
PeptideAtlasiP21918.
PRIDEiP21918.

PTM databases

iPTMnetiP21918.

Expressioni

Tissue specificityi

Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

Gene expression databases

BgeeiENSG00000169676.
CleanExiHS_DRD5.
GenevisibleiP21918. HS.

Organism-specific databases

HPAiHPA048930.

Interactioni

Protein-protein interaction databases

BioGridi108150. 3 interactors.
IntActiP21918. 1 interactor.
STRINGi9606.ENSP00000306129.

Chemistry databases

BindingDBiP21918.

Structurei

3D structure databases

ProteinModelPortaliP21918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139331.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21918.
KOiK05840.
OMAiVWELDCE.
OrthoDBiEOG091G06VI.
PhylomeDBiP21918.
TreeFamiTF325181.

Family and domain databases

InterProiView protein in InterPro
IPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR43893:SF8. PTHR43893:SF8. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P21918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL
60 70 80 90 100
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV
110 120 130 140 150
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR
160 170 180 190 200
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW
210 220 230 240 250
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR
260 270 280 290 300
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV
310 320 330 340 350
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA
360 370 380 390 400
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI
410 420 430 440 450
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV
460 470
AESVWELDCE GEISLDKITP FTPNGFH
Length:477
Mass (Da):52,951
Last modified:March 1, 1992 - v2
Checksum:iBACCB85E5A72F9CA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02921062C → S. Corresponds to variant dbSNP:rs2227840Ensembl.1
Natural variantiVAR_01183788L → R1 PublicationCorresponds to variant dbSNP:rs6282Ensembl.1
Natural variantiVAR_029211110G → E. Corresponds to variant dbSNP:rs2227849Ensembl.1
Natural variantiVAR_029212207F → V. Corresponds to variant dbSNP:rs2227845Ensembl.1
Natural variantiVAR_029213233S → N. Corresponds to variant dbSNP:rs2227843Ensembl.1
Natural variantiVAR_024254238V → I. Corresponds to variant dbSNP:rs2227852Ensembl.1
Natural variantiVAR_003458269A → V1 PublicationCorresponds to variant dbSNP:rs538877978Ensembl.1
Natural variantiVAR_029215286A → V. Corresponds to variant dbSNP:rs2227850Ensembl.1
Natural variantiVAR_061217297T → P. Corresponds to variant dbSNP:rs2227851Ensembl.1
Natural variantiVAR_003459330P → Q1 PublicationCorresponds to variant dbSNP:rs1800762Ensembl.1
Natural variantiVAR_003460351N → D1 Publication1
Natural variantiVAR_003461453S → C1 PublicationCorresponds to variant dbSNP:rs776114395Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58454 Genomic DNA. Translation: CAA41360.1.
M67439 Genomic DNA. Translation: AAA52329.1.
AY136750 mRNA. Translation: AAN01276.1.
AK313897 mRNA. Translation: BAG36620.1.
CH471069 Genomic DNA. Translation: EAW92679.1.
BC009748 mRNA. Translation: AAH09748.1.
CCDSiCCDS3405.1.
PIRiS15080. DYHUD5.
RefSeqiNP_000789.1. NM_000798.4.
UniGeneiHs.380681.

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676.
GeneIDi1816.
KEGGihsa:1816.
UCSCiuc003gmb.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDRD5_HUMAN
AccessioniPrimary (citable) accession number: P21918
Secondary accession number(s): B2R9S3, Q8NEQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 1, 1992
Last modified: November 22, 2017
This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families