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P21918

- DRD5_HUMAN

UniProt

P21918 - DRD5_HUMAN

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Protein
D(1B) dopamine receptor
Gene
DRD5, DRD1B, DRD1L2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

GO - Molecular functioni

  1. dopamine binding Source: UniProtKB
  2. dopamine neurotransmitter receptor activity Source: UniProtKB
  3. dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. activation of adenylate cyclase activity Source: BHF-UCL
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
  4. associative learning Source: Ensembl
  5. cellular calcium ion homeostasis Source: BHF-UCL
  6. cellular response to catecholamine stimulus Source: BHF-UCL
  7. long term synaptic depression Source: Ensembl
  8. negative regulation of NAD(P)H oxidase activity Source: UniProtKB
  9. negative regulation of blood pressure Source: Ensembl
  10. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  11. phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
  12. positive regulation of adenylate cyclase activity Source: UniProtKB
  13. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  14. reactive oxygen species metabolic process Source: UniProtKB
  15. regulation of female receptivity Source: Ensembl
  16. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
  17. response to amphetamine Source: Ensembl
  18. response to cocaine Source: Ensembl
  19. sensitization Source: Ensembl
  20. synaptic transmission Source: UniProtKB
  21. synaptic transmission, dopaminergic Source: UniProtKB
  22. transmission of nerve impulse Source: Ensembl
  23. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
D1beta dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:DRD5
Synonyms:DRD1B, DRD1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:3026. DRD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed prediction
Add
BLAST
Transmembranei40 – 6627Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini67 – 7711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei78 – 10427Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini105 – 11410Extracellular Reviewed prediction
Transmembranei115 – 13622Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini137 – 15822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei159 – 18022Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini181 – 22343Extracellular Reviewed prediction
Add
BLAST
Transmembranei224 – 24623Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini247 – 29650Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei297 – 32024Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini321 – 34020Extracellular Reviewed prediction
Add
BLAST
Transmembranei341 – 36020Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini361 – 477117Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi7 – 71N → Q: Impairs subcellular location. 1 Publication

Keywords - Diseasei

Dystonia

Organism-specific databases

MIMi126453. gene+phenotype.
606798. phenotype.
Orphaneti93962. Autosomal dominant cervical dystonia.
93955. Benign essential blepharospasm.
PharmGKBiPA148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477D(1B) dopamine receptor
PRO_0000069405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)1 Publication
Disulfide bondi113 ↔ 217 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Lipidationi375 – 3751S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21918.
PRIDEiP21918.

Expressioni

Tissue specificityi

Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

Gene expression databases

BgeeiP21918.
CleanExiHS_DRD5.
GenevestigatoriP21918.

Organism-specific databases

HPAiHPA048930.

Interactioni

Protein-protein interaction databases

BioGridi108150. 3 interactions.
STRINGi9606.ENSP00000306129.

Structurei

3D structure databases

ProteinModelPortaliP21918.
SMRiP21918. Positions 46-374.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21918.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiP21918.
TreeFamiTF325181.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21918-1 [UniParc]FASTAAdd to Basket

« Hide

MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL    50
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV 100
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR 150
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW 200
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR 250
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV 300
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA 350
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI 400
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV 450
AESVWELDCE GEISLDKITP FTPNGFH 477
Length:477
Mass (Da):52,951
Last modified:March 1, 1992 - v2
Checksum:iBACCB85E5A72F9CA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621C → S.
Corresponds to variant rs2227840 [ dbSNP | Ensembl ].
VAR_029210
Natural varianti88 – 881L → R.1 Publication
Corresponds to variant rs6282 [ dbSNP | Ensembl ].
VAR_011837
Natural varianti110 – 1101G → E.
Corresponds to variant rs2227849 [ dbSNP | Ensembl ].
VAR_029211
Natural varianti207 – 2071F → V.
Corresponds to variant rs2227845 [ dbSNP | Ensembl ].
VAR_029212
Natural varianti233 – 2331S → N.
Corresponds to variant rs2227843 [ dbSNP | Ensembl ].
VAR_029213
Natural varianti238 – 2381V → I.
Corresponds to variant rs2227852 [ dbSNP | Ensembl ].
VAR_024254
Natural varianti247 – 2471R → H.
Corresponds to variant rs2227847 [ dbSNP | Ensembl ].
VAR_029214
Natural varianti269 – 2691A → V.1 Publication
Corresponds to variant rs2227842 [ dbSNP | Ensembl ].
VAR_003458
Natural varianti286 – 2861A → V.
Corresponds to variant rs2227850 [ dbSNP | Ensembl ].
VAR_029215
Natural varianti297 – 2971T → P.
Corresponds to variant rs2227851 [ dbSNP | Ensembl ].
VAR_061217
Natural varianti330 – 3301P → Q.1 Publication
Corresponds to variant rs1800762 [ dbSNP | Ensembl ].
VAR_003459
Natural varianti351 – 3511N → D.1 Publication
VAR_003460
Natural varianti453 – 4531S → C.1 Publication
VAR_003461

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58454 Genomic DNA. Translation: CAA41360.1.
M67439 Genomic DNA. Translation: AAA52329.1.
AY136750 mRNA. Translation: AAN01276.1.
AK313897 mRNA. Translation: BAG36620.1.
CH471069 Genomic DNA. Translation: EAW92679.1.
BC009748 mRNA. Translation: AAH09748.1.
CCDSiCCDS3405.1.
PIRiS15080. DYHUD5.
RefSeqiNP_000789.1. NM_000798.4.
UniGeneiHs.380681.

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676.
GeneIDi1816.
KEGGihsa:1816.
UCSCiuc003gmb.4. human.

Polymorphism databases

DMDMi118214.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58454 Genomic DNA. Translation: CAA41360.1 .
M67439 Genomic DNA. Translation: AAA52329.1 .
AY136750 mRNA. Translation: AAN01276.1 .
AK313897 mRNA. Translation: BAG36620.1 .
CH471069 Genomic DNA. Translation: EAW92679.1 .
BC009748 mRNA. Translation: AAH09748.1 .
CCDSi CCDS3405.1.
PIRi S15080. DYHUD5.
RefSeqi NP_000789.1. NM_000798.4.
UniGenei Hs.380681.

3D structure databases

ProteinModelPortali P21918.
SMRi P21918. Positions 46-374.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108150. 3 interactions.
STRINGi 9606.ENSP00000306129.

Chemistry

BindingDBi P21918.
ChEMBLi CHEMBL2096905.
DrugBanki DB00714. Apomorphine.
DB01038. Carphenazine.
DB00800. Fenoldopam.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi 218.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 118214.

Proteomic databases

PaxDbi P21918.
PRIDEi P21918.

Protocols and materials databases

DNASUi 1816.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304374 ; ENSP00000306129 ; ENSG00000169676 .
GeneIDi 1816.
KEGGi hsa:1816.
UCSCi uc003gmb.4. human.

Organism-specific databases

CTDi 1816.
GeneCardsi GC04P009783.
H-InvDB HIX0029583.
HGNCi HGNC:3026. DRD5.
HPAi HPA048930.
MIMi 126453. gene+phenotype.
606798. phenotype.
neXtProti NX_P21918.
Orphaneti 93962. Autosomal dominant cervical dystonia.
93955. Benign essential blepharospasm.
PharmGKBi PA148.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262978.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P21918.
KOi K05840.
OMAi RAENCDS.
OrthoDBi EOG780RMN.
PhylomeDBi P21918.
TreeFami TF325181.

Enzyme and pathway databases

Reactomei REACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Dopamine_receptor_D5.
GenomeRNAii 1816.
NextBioi 7405.
PROi P21918.
SOURCEi Search...

Gene expression databases

Bgeei P21918.
CleanExi HS_DRD5.
Genevestigatori P21918.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1."
    Sunahara R.K., Guan H.-C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., van Tol H.H.M., Niznik H.B.
    Nature 350:614-619(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes."
    Grandy D.K., Zhang Y., Bouvier C., Zhou Q.-Y., Johnson R.A., Allen L., Buck K., Bunzow J.R., Salon J., Civelli O.
    Proc. Natl. Acad. Sci. U.S.A. 88:9175-9179(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene."
    Weinshank R.L., Adham N., Macchi M., Olsen M.A., Branchek T.A., Hartig P.R.
    J. Biol. Chem. 266:22427-22435(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  8. "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells."
    Karpa K.D., Lidow M.S., Pickering M.T., Levenson R., Bergson C.
    Mol. Pharmacol. 56:1071-1078(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-7, MUTAGENESIS OF ASN-7.
  9. "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm."
    Misbahuddin A., Placzek M.R., Chaudhuri K.R., Wood N.W., Bhatia K.P., Warner T.T.
    Neurology 58:124-126(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BEB.
  10. "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease."
    Sobell J.L., Lind T.J., Sigurdson D.C., Zald D.H., Snitz B.E., Grove W.M., Heston L.L., Sommer S.S.
    Hum. Mol. Genet. 4:507-514(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-269; GLN-330; ASP-351 AND CYS-453.
  11. Cited for: VARIANT ARG-88.

Entry informationi

Entry nameiDRD5_HUMAN
AccessioniPrimary (citable) accession number: P21918
Secondary accession number(s): B2R9S3, Q8NEQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 1, 1992
Last modified: September 3, 2014
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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