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Protein

D(1B) dopamine receptor

Gene

DRD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.1 Publication

GO - Molecular functioni

  1. dopamine binding Source: UniProtKB
  2. dopamine neurotransmitter receptor activity Source: UniProtKB
  3. dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
  4. G-protein coupled amine receptor activity Source: GO_Central

GO - Biological processi

  1. activation of adenylate cyclase activity Source: BHF-UCL
  2. adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  4. associative learning Source: Ensembl
  5. cellular calcium ion homeostasis Source: BHF-UCL
  6. cellular response to catecholamine stimulus Source: BHF-UCL
  7. learning Source: GO_Central
  8. long term synaptic depression Source: Ensembl
  9. negative regulation of blood pressure Source: Ensembl
  10. negative regulation of NAD(P)H oxidase activity Source: UniProtKB
  11. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  12. phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
  13. positive regulation of adenylate cyclase activity Source: UniProtKB
  14. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: GO_Central
  15. reactive oxygen species metabolic process Source: UniProtKB
  16. regulation of female receptivity Source: Ensembl
  17. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
  18. response to amphetamine Source: Ensembl
  19. response to cocaine Source: Ensembl
  20. sensitization Source: Ensembl
  21. sensory perception of chemical stimulus Source: GO_Central
  22. synaptic transmission Source: UniProtKB
  23. synaptic transmission, dopaminergic Source: UniProtKB
  24. transmission of nerve impulse Source: Ensembl
  25. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
D1beta dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:DRD5
Synonyms:DRD1B, DRD1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:3026. DRD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 7711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei78 – 10427Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 11410ExtracellularSequence Analysis
Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 18022Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini181 – 22343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei224 – 24623Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini247 – 29650CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei297 – 32024Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini321 – 34020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei341 – 36020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini361 – 477117CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Benign essential blepharospasm (BEB)1 Publication

Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Disease descriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.

See also OMIM:606798

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi7 – 71N → Q: Impairs subcellular location. 1 Publication

Keywords - Diseasei

Dystonia

Organism-specific databases

MIMi126453. gene+phenotype.
606798. phenotype.
Orphaneti93962. Autosomal dominant cervical dystonia.
93955. Benign essential blepharospasm.
PharmGKBiPA148.

Chemistry

DrugBankiDB00714. Apomorphine.
DB01238. Aripiprazole.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB00568. Cinnarizine.
DB00988. Dopamine.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01186. Pergolide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.

Polymorphism and mutation databases

BioMutaiDRD5.
DMDMi118214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477D(1B) dopamine receptorPRO_0000069405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)1 Publication
Disulfide bondi113 ↔ 217PROSITE-ProRule annotation
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Lipidationi375 – 3751S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21918.
PRIDEiP21918.

Expressioni

Tissue specificityi

Neuron-specific, localized primarily within limbic regions of the brain.1 Publication

Gene expression databases

BgeeiP21918.
CleanExiHS_DRD5.
GenevestigatoriP21918.

Organism-specific databases

HPAiHPA048930.

Interactioni

Protein-protein interaction databases

BioGridi108150. 3 interactions.
STRINGi9606.ENSP00000306129.

Structurei

3D structure databases

ProteinModelPortaliP21918.
SMRiP21918. Positions 46-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21918.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiP21918.
TreeFamiTF325181.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL
60 70 80 90 100
IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV
110 120 130 140 150
AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR
160 170 180 190 200
KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW
210 220 230 240 250
TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR
260 270 280 290 300
IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV
310 320 330 340 350
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA
360 370 380 390 400
NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI
410 420 430 440 450
VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV
460 470
AESVWELDCE GEISLDKITP FTPNGFH
Length:477
Mass (Da):52,951
Last modified:March 1, 1992 - v2
Checksum:iBACCB85E5A72F9CA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621C → S.
Corresponds to variant rs2227840 [ dbSNP | Ensembl ].
VAR_029210
Natural varianti88 – 881L → R.1 Publication
Corresponds to variant rs6282 [ dbSNP | Ensembl ].
VAR_011837
Natural varianti110 – 1101G → E.
Corresponds to variant rs2227849 [ dbSNP | Ensembl ].
VAR_029211
Natural varianti207 – 2071F → V.
Corresponds to variant rs2227845 [ dbSNP | Ensembl ].
VAR_029212
Natural varianti233 – 2331S → N.
Corresponds to variant rs2227843 [ dbSNP | Ensembl ].
VAR_029213
Natural varianti238 – 2381V → I.
Corresponds to variant rs2227852 [ dbSNP | Ensembl ].
VAR_024254
Natural varianti247 – 2471R → H.
Corresponds to variant rs2227847 [ dbSNP | Ensembl ].
VAR_029214
Natural varianti269 – 2691A → V.1 Publication
Corresponds to variant rs2227842 [ dbSNP | Ensembl ].
VAR_003458
Natural varianti286 – 2861A → V.
Corresponds to variant rs2227850 [ dbSNP | Ensembl ].
VAR_029215
Natural varianti297 – 2971T → P.
Corresponds to variant rs2227851 [ dbSNP | Ensembl ].
VAR_061217
Natural varianti330 – 3301P → Q.1 Publication
Corresponds to variant rs1800762 [ dbSNP | Ensembl ].
VAR_003459
Natural varianti351 – 3511N → D.1 Publication
VAR_003460
Natural varianti453 – 4531S → C.1 Publication
VAR_003461

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58454 Genomic DNA. Translation: CAA41360.1.
M67439 Genomic DNA. Translation: AAA52329.1.
AY136750 mRNA. Translation: AAN01276.1.
AK313897 mRNA. Translation: BAG36620.1.
CH471069 Genomic DNA. Translation: EAW92679.1.
BC009748 mRNA. Translation: AAH09748.1.
CCDSiCCDS3405.1.
PIRiS15080. DYHUD5.
RefSeqiNP_000789.1. NM_000798.4.
UniGeneiHs.380681.

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676.
GeneIDi1816.
KEGGihsa:1816.
UCSCiuc003gmb.4. human.

Polymorphism and mutation databases

BioMutaiDRD5.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58454 Genomic DNA. Translation: CAA41360.1.
M67439 Genomic DNA. Translation: AAA52329.1.
AY136750 mRNA. Translation: AAN01276.1.
AK313897 mRNA. Translation: BAG36620.1.
CH471069 Genomic DNA. Translation: EAW92679.1.
BC009748 mRNA. Translation: AAH09748.1.
CCDSiCCDS3405.1.
PIRiS15080. DYHUD5.
RefSeqiNP_000789.1. NM_000798.4.
UniGeneiHs.380681.

3D structure databases

ProteinModelPortaliP21918.
SMRiP21918. Positions 46-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108150. 3 interactions.
STRINGi9606.ENSP00000306129.

Chemistry

BindingDBiP21918.
ChEMBLiCHEMBL2096905.
DrugBankiDB00714. Apomorphine.
DB01238. Aripiprazole.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB00568. Cinnarizine.
DB00988. Dopamine.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01186. Pergolide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi218.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiDRD5.
DMDMi118214.

Proteomic databases

PaxDbiP21918.
PRIDEiP21918.

Protocols and materials databases

DNASUi1816.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304374; ENSP00000306129; ENSG00000169676.
GeneIDi1816.
KEGGihsa:1816.
UCSCiuc003gmb.4. human.

Organism-specific databases

CTDi1816.
GeneCardsiGC04P009783.
H-InvDBHIX0029583.
HGNCiHGNC:3026. DRD5.
HPAiHPA048930.
MIMi126453. gene+phenotype.
606798. phenotype.
neXtProtiNX_P21918.
Orphaneti93962. Autosomal dominant cervical dystonia.
93955. Benign essential blepharospasm.
PharmGKBiPA148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21918.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiP21918.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiDopamine_receptor_D5.
GenomeRNAii1816.
NextBioi7405.
PROiP21918.
SOURCEiSearch...

Gene expression databases

BgeeiP21918.
CleanExiHS_DRD5.
GenevestigatoriP21918.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1."
    Sunahara R.K., Guan H.-C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., van Tol H.H.M., Niznik H.B.
    Nature 350:614-619(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes."
    Grandy D.K., Zhang Y., Bouvier C., Zhou Q.-Y., Johnson R.A., Allen L., Buck K., Bunzow J.R., Salon J., Civelli O.
    Proc. Natl. Acad. Sci. U.S.A. 88:9175-9179(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene."
    Weinshank R.L., Adham N., Macchi M., Olsen M.A., Branchek T.A., Hartig P.R.
    J. Biol. Chem. 266:22427-22435(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  8. "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells."
    Karpa K.D., Lidow M.S., Pickering M.T., Levenson R., Bergson C.
    Mol. Pharmacol. 56:1071-1078(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-7, MUTAGENESIS OF ASN-7.
  9. "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm."
    Misbahuddin A., Placzek M.R., Chaudhuri K.R., Wood N.W., Bhatia K.P., Warner T.T.
    Neurology 58:124-126(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BEB.
  10. "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease."
    Sobell J.L., Lind T.J., Sigurdson D.C., Zald D.H., Snitz B.E., Grove W.M., Heston L.L., Sommer S.S.
    Hum. Mol. Genet. 4:507-514(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-269; GLN-330; ASP-351 AND CYS-453.
  11. Cited for: VARIANT ARG-88.

Entry informationi

Entry nameiDRD5_HUMAN
AccessioniPrimary (citable) accession number: P21918
Secondary accession number(s): B2R9S3, Q8NEQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 1, 1992
Last modified: April 29, 2015
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.