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P21913

- SDHB_RAT

UniProt

P21913 - SDHB_RAT

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Sdhb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi95 – 951Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi103 – 1031Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi115 – 1151Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi191 – 1911Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi194 – 1941Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi198 – 1981Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei203 – 2031Ubiquinone; shared with DHSDBy similarity
    Metal bindingi245 – 2451Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi251 – 2511Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi255 – 2551Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: RGD
    7. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. respiratory electron transport chain Source: RGD
    2. succinate metabolic process Source: RGD
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RKP21913.
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:Sdhb
    Synonyms:Sdh1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1308598. Sdhb.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 282252Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000158693Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531N6-acetyllysineBy similarity
    Modified residuei57 – 571N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP21913.
    PRIDEiP21913.

    PTM databases

    PhosphoSiteiP21913.

    Expressioni

    Gene expression databases

    GenevestigatoriP21913.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010593.

    Structurei

    3D structure databases

    ProteinModelPortaliP21913.
    SMRiP21913. Positions 39-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 135802Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 208314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    GeneTreeiENSGT00390000013558.
    HOGENOMiHOG000160590.
    HOVERGENiHBG005483.
    InParanoidiQ0QEZ3.
    KOiK00235.
    OMAiEWRAMSA.
    OrthoDBiEOG7H4DTN.
    PhylomeDBiP21913.
    TreeFamiTF300754.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21913-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVVGVSLK RGFSATALGR VGLQFQACRE AQTAAAAAPR IKTFAIYRWD    50
    PDKAGDKPRM QTYKVDLNKC GPMVLDALIK IKNEIDSTLT FRRSCREGIC 100
    GSCAMNINGG NTLACTRRID TDLGKVSKIY PLPHMYVIKD LVPDLSNFYA 150
    QYKSIEPYLK KKDESQEGKQ QYLQSIEDRE KLDGLYECIL CACCSTSCPS 200
    YWWNGDKYLG PAVLMQAYRW MIDSRDEFTE ERLAKLQDPF SLYRCHTIMN 250
    CTQTCPKGLN PGKAIAEIKK MMATYKEKRA LA 282
    Length:282
    Mass (Da):31,830
    Last modified:September 2, 2008 - v2
    Checksum:i6600EBC8201529A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1243DLG → NLN no nucleotide entry (PubMed:2494655)Curated
    Sequence conflicti153 – 1531K → R no nucleotide entry (PubMed:2494655)Curated
    Sequence conflicti178 – 1781D → E no nucleotide entry (PubMed:2494655)Curated
    Sequence conflicti227 – 2271E → D no nucleotide entry (PubMed:2494655)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473968 Genomic DNA. Translation: EDL80954.1.
    BC158620 mRNA. Translation: AAI58621.1.
    DQ403001 mRNA. Translation: ABD77134.1.
    PIRiB32394.
    RefSeqiNP_001094009.1. NM_001100539.1.
    UniGeneiRn.3902.

    Genome annotation databases

    EnsembliENSRNOT00000010593; ENSRNOP00000010593; ENSRNOG00000007967.
    GeneIDi298596.
    KEGGirno:298596.
    UCSCiRGD:1308598. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473968 Genomic DNA. Translation: EDL80954.1 .
    BC158620 mRNA. Translation: AAI58621.1 .
    DQ403001 mRNA. Translation: ABD77134.1 .
    PIRi B32394.
    RefSeqi NP_001094009.1. NM_001100539.1.
    UniGenei Rn.3902.

    3D structure databases

    ProteinModelPortali P21913.
    SMRi P21913. Positions 39-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010593.

    PTM databases

    PhosphoSitei P21913.

    Proteomic databases

    PaxDbi P21913.
    PRIDEi P21913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010593 ; ENSRNOP00000010593 ; ENSRNOG00000007967 .
    GeneIDi 298596.
    KEGGi rno:298596.
    UCSCi RGD:1308598. rat.

    Organism-specific databases

    CTDi 6390.
    RGDi 1308598. Sdhb.

    Phylogenomic databases

    eggNOGi COG0479.
    GeneTreei ENSGT00390000013558.
    HOGENOMi HOG000160590.
    HOVERGENi HBG005483.
    InParanoidi Q0QEZ3.
    KOi K00235.
    OMAi EWRAMSA.
    OrthoDBi EOG7H4DTN.
    PhylomeDBi P21913.
    TreeFami TF300754.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    Reactomei REACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RK P21913.

    Miscellaneous databases

    NextBioi 644032.
    PROi P21913.

    Gene expression databases

    Genevestigatori P21913.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
      Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-257.
      Tissue: Liver.
    4. "Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species."
      Gould S.J., Subramani S., Scheffler I.E.
      Proc. Natl. Acad. Sci. U.S.A. 86:1934-1938(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-251.
      Tissue: Brain cortex.
    5. Erratum
      Gould S.J., Subramani S., Scheffler I.E.
      Proc. Natl. Acad. Sci. U.S.A. 90:2556-2556(1993)

    Entry informationi

    Entry nameiSDHB_RAT
    AccessioniPrimary (citable) accession number: P21913
    Secondary accession number(s): B0BMZ2, Q0QEZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3