Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Sdhb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi100Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi103Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi115Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi188Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi191Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi194Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi198Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei203Ubiquinone; shared with DHSDBy similarity1
Metal bindingi245Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi251Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi255Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • respiratory electron transport chain Source: RGD
  • succinate metabolic process Source: RGD
  • tricarboxylic acid cycle Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-71403 Citric acid cycle (TCA cycle)
SABIO-RKiP21913
UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:Sdhb
Synonyms:Sdh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1308598 Sdhb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000015869331 – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP21913
PRIDEiP21913

PTM databases

CarbonylDBiP21913
iPTMnetiP21913
PhosphoSitePlusiP21913
SwissPalmiP21913

Expressioni

Gene expression databases

BgeeiENSRNOG00000007967
GenevisibleiP21913 RN

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

BioGridi255955, 1 interactor
CORUMiP21913
IntActiP21913, 1 interactor
MINTiP21913
STRINGi10116.ENSRNOP00000010593

Structurei

3D structure databases

ProteinModelPortaliP21913
SMRiP21913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 1352Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST80
Domaini178 – 2084Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiP21913
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiP21913
TreeFamiTF300754

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVGVSLK RGFSATALGR VGLQFQACRE AQTAAAAAPR IKTFAIYRWD
60 70 80 90 100
PDKAGDKPRM QTYKVDLNKC GPMVLDALIK IKNEIDSTLT FRRSCREGIC
110 120 130 140 150
GSCAMNINGG NTLACTRRID TDLGKVSKIY PLPHMYVIKD LVPDLSNFYA
160 170 180 190 200
QYKSIEPYLK KKDESQEGKQ QYLQSIEDRE KLDGLYECIL CACCSTSCPS
210 220 230 240 250
YWWNGDKYLG PAVLMQAYRW MIDSRDEFTE ERLAKLQDPF SLYRCHTIMN
260 270 280
CTQTCPKGLN PGKAIAEIKK MMATYKEKRA LA
Length:282
Mass (Da):31,830
Last modified:September 2, 2008 - v2
Checksum:i6600EBC8201529A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122 – 124DLG → NLN no nucleotide entry (PubMed:2494655).Curated3
Sequence conflicti153K → R no nucleotide entry (PubMed:2494655).Curated1
Sequence conflicti178D → E no nucleotide entry (PubMed:2494655).Curated1
Sequence conflicti227E → D no nucleotide entry (PubMed:2494655).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA Translation: EDL80954.1
BC158620 mRNA Translation: AAI58621.1
DQ403001 mRNA Translation: ABD77134.1
PIRiB32394
RefSeqiNP_001094009.1, NM_001100539.1
UniGeneiRn.3902

Genome annotation databases

EnsembliENSRNOT00000010593; ENSRNOP00000010593; ENSRNOG00000007967
GeneIDi298596
KEGGirno:298596
UCSCiRGD:1308598 rat

Entry informationi

Entry nameiSDHB_RAT
AccessioniPrimary (citable) accession number: P21913
Secondary accession number(s): B0BMZ2, Q0QEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health