Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi98Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi101Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi113Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi186Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi189Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi192Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei201Ubiquinone; shared with DHSDBy similarity1
Metal bindingi243Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi249Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi253Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117118-MONOMER.
ZFISH:ENSG00000117118-MONOMER.
BRENDAi1.3.5.1. 2681.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-71403. Citric acid cycle (TCA cycle).
SIGNORiP21912.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDHB
Synonyms:SDH, SDH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10681. SDHB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Pheochromocytoma (PCC)7 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
See also OMIM:171300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03506329A → AQ in PCC. 1 Publication1
Natural variantiVAR_05437643A → P in PCC. 1 Publication1
Natural variantiVAR_03506446R → G in PCC. 3 PublicationsCorresponds to variant rs74315370dbSNPEnsembl.1
Natural variantiVAR_05437746R → Q in PCC and PGL4. 3 PublicationsCorresponds to variant rs772551056dbSNPEnsembl.1
Natural variantiVAR_05437853G → R in PCC. 1 Publication1
Natural variantiVAR_05437965L → H in PCC. 1 Publication1
Natural variantiVAR_05438065L → P in PCC. 1 Publication1
Natural variantiVAR_01851787L → S in PCC. 2 PublicationsCorresponds to variant rs727504457dbSNPEnsembl.1
Natural variantiVAR_037620100S → F in PCC; absence of expression in tumor cells indicating complete loss of SDHB function. 1 PublicationCorresponds to variant rs121917755dbSNPEnsembl.1
Natural variantiVAR_035065101C → Y in PCC. 2 PublicationsCorresponds to variant rs74315371dbSNPEnsembl.1
Natural variantiVAR_054381127I → N in PCC. 1 Publication1
Natural variantiVAR_035066192C → R in PCC. 2 PublicationsCorresponds to variant rs786202732dbSNPEnsembl.1
Natural variantiVAR_035067196C → Y in PCC. 2 Publications1
Natural variantiVAR_054383230R → C in PCC. 1 PublicationCorresponds to variant rs138996609dbSNPEnsembl.1
Natural variantiVAR_017869242R → H in PGL4 and PCC. 3 PublicationsCorresponds to variant rs74315368dbSNPEnsembl.1
Paragangliomas 4 (PGL4)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
See also OMIM:115310
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05437746R → Q in PCC and PGL4. 3 PublicationsCorresponds to variant rs772551056dbSNPEnsembl.1
Natural variantiVAR_018518131P → R in PGL4. 1 Publication1
Natural variantiVAR_037621132H → P in PGL4. 1 PublicationCorresponds to variant rs74315372dbSNPEnsembl.1
Natural variantiVAR_017868197P → R in PGL4. 2 PublicationsCorresponds to variant rs74315367dbSNPEnsembl.1
Natural variantiVAR_017869242R → H in PGL4 and PCC. 3 PublicationsCorresponds to variant rs74315368dbSNPEnsembl.1
Paraganglioma and gastric stromal sarcoma (PGGSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionGastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
See also OMIM:606864
Cowden syndrome 2 (CWS2)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS2 inheritance is autosomal dominant.
See also OMIM:612359
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0543743A → G in CWS2; uncertain pathological significance; associated with increased manganese superoxide dismutase expression and normal levels of reactive oxygen species; associated with a 1.2-fold increase in AKT expression and 1.3-fold change in MAPK expression. 1 PublicationCorresponds to variant rs11203289dbSNPEnsembl.1
Natural variantiVAR_054382163S → P in CWS2; uncertain pathological significance; associated with increased manganese superoxide dismutase function and increased levels of reactive oxygen species; associated with a 2.7-fold change in AKT expression and a 1.7-fold increase in MAPK expression. 1 PublicationCorresponds to variant rs33927012dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6390.
MalaCardsiSDHB.
MIMi115310. phenotype.
171300. phenotype.
606864. phenotype.
612359. phenotype.
OpenTargetsiENSG00000117118.
Orphaneti97286. Carney-Stratakis syndrome.
201. Cowden syndrome.
44890. Gastrointestinal stromal tumor.
29072. Hereditary pheochromocytoma-paraganglioma.
3208. Isolated succinate-CoQ reductase deficiency.
PharmGKBiPA35606.

Chemistry databases

DrugBankiDB00139. Succinic acid.

Polymorphism and mutation databases

BioMutaiSDHB.
DMDMi20455488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionCombined sourcesAdd BLAST28
ChainiPRO_000001035529 – 280Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP21912.
MaxQBiP21912.
PaxDbiP21912.
PeptideAtlasiP21912.
PRIDEiP21912.

2D gel databases

UCD-2DPAGEP21912.

PTM databases

iPTMnetiP21912.
PhosphoSitePlusiP21912.
SwissPalmiP21912.

Expressioni

Gene expression databases

BgeeiENSG00000117118.
CleanExiHS_SDHB.
ExpressionAtlasiP21912. baseline and differential.
GenevisibleiP21912. HS.

Organism-specific databases

HPAiCAB009822.
CAB068233.
CAB068234.
CAB068235.
HPA002868.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.

Binary interactionsi

WithEntry#Exp.IntActNotes
SDHAP310402EBI-1056481,EBI-1057265

Protein-protein interaction databases

BioGridi112291. 102 interactors.
IntActiP21912. 23 interactors.
MINTiMINT-3009566.
STRINGi9606.ENSP00000364649.

Structurei

3D structure databases

ProteinModelPortaliP21912.
SMRiP21912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 1332Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST94
Domaini176 – 2064Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
HOVERGENiHBG005483.
InParanoidiP21912.
KOiK00235.
OMAiIDSHERM.
OrthoDBiEOG091G0EKC.
PhylomeDBiP21912.
TreeFamiTF300754.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD
60 70 80 90 100
KAGDKPHMQT YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS
110 120 130 140 150
CAMNINGGNT LACTRRIDTN LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY
160 170 180 190 200
KSIEPYLKKK DESQEGKQQY LQSIEEREKL DGLYECILCA CCSTSCPSYW
210 220 230 240 250
WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL YRCHTIMNCT
260 270 280
RTCPKGLNPG KAIAEIKKMM ATYKEKKASV
Length:280
Mass (Da):31,630
Last modified:May 2, 2002 - v3
Checksum:iED12E7C3BA7B6D13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 21GGA → WRT in AAA35708 (PubMed:2302193).Curated3
Sequence conflicti19 – 21GGA → WRT in BAA01089 (PubMed:2302193).Curated3
Sequence conflicti62E → K in AAA81167 (PubMed:7622059).Curated1
Sequence conflicti62E → K in AAA35708 (PubMed:2302193).Curated1
Sequence conflicti62E → K in BAA01089 (PubMed:2302193).Curated1
Sequence conflicti67K → NR in AAA80581 (PubMed:7622059).Curated1
Sequence conflicti151K → R no nucleotide entry (PubMed:2494655).Curated1
Sequence conflicti172Q → E no nucleotide entry (PubMed:2494655).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0543743A → G in CWS2; uncertain pathological significance; associated with increased manganese superoxide dismutase expression and normal levels of reactive oxygen species; associated with a 1.2-fold increase in AKT expression and 1.3-fold change in MAPK expression. 1 PublicationCorresponds to variant rs11203289dbSNPEnsembl.1
Natural variantiVAR_03506329A → AQ in PCC. 1 Publication1
Natural variantiVAR_05437540K → E.1 Publication1
Natural variantiVAR_05437643A → P in PCC. 1 Publication1
Natural variantiVAR_03506446R → G in PCC. 3 PublicationsCorresponds to variant rs74315370dbSNPEnsembl.1
Natural variantiVAR_05437746R → Q in PCC and PGL4. 3 PublicationsCorresponds to variant rs772551056dbSNPEnsembl.1
Natural variantiVAR_05437853G → R in PCC. 1 Publication1
Natural variantiVAR_05437965L → H in PCC. 1 Publication1
Natural variantiVAR_05438065L → P in PCC. 1 Publication1
Natural variantiVAR_01851787L → S in PCC. 2 PublicationsCorresponds to variant rs727504457dbSNPEnsembl.1
Natural variantiVAR_037620100S → F in PCC; absence of expression in tumor cells indicating complete loss of SDHB function. 1 PublicationCorresponds to variant rs121917755dbSNPEnsembl.1
Natural variantiVAR_035065101C → Y in PCC. 2 PublicationsCorresponds to variant rs74315371dbSNPEnsembl.1
Natural variantiVAR_054381127I → N in PCC. 1 Publication1
Natural variantiVAR_018518131P → R in PGL4. 1 Publication1
Natural variantiVAR_037621132H → P in PGL4. 1 PublicationCorresponds to variant rs74315372dbSNPEnsembl.1
Natural variantiVAR_054382163S → P in CWS2; uncertain pathological significance; associated with increased manganese superoxide dismutase function and increased levels of reactive oxygen species; associated with a 2.7-fold change in AKT expression and a 1.7-fold increase in MAPK expression. 1 PublicationCorresponds to variant rs33927012dbSNPEnsembl.1
Natural variantiVAR_035066192C → R in PCC. 2 PublicationsCorresponds to variant rs786202732dbSNPEnsembl.1
Natural variantiVAR_035067196C → Y in PCC. 2 Publications1
Natural variantiVAR_017868197P → R in PGL4. 2 PublicationsCorresponds to variant rs74315367dbSNPEnsembl.1
Natural variantiVAR_054383230R → C in PCC. 1 PublicationCorresponds to variant rs138996609dbSNPEnsembl.1
Natural variantiVAR_017869242R → H in PGL4 and PCC. 3 PublicationsCorresponds to variant rs74315368dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17248 mRNA. Translation: AAA81167.1.
U17886
, U17296, U17880, U17881, U17882, U17883, U17884, U17885 Genomic DNA. Translation: AAA80581.1.
AK312056 mRNA. Translation: BAG34992.1.
AL049569 Genomic DNA. Translation: CAB96822.1.
CH471134 Genomic DNA. Translation: EAW94828.1.
BC007840 mRNA. Translation: AAH07840.1.
DQ403007 mRNA. Translation: ABD77140.1.
D10245 mRNA. Translation: BAA01089.1.
M32246 mRNA. Translation: AAA35708.1.
CCDSiCCDS176.1.
PIRiI38895.
RefSeqiNP_002991.2. NM_003000.2.
UniGeneiHs.465924.

Genome annotation databases

EnsembliENST00000375499; ENSP00000364649; ENSG00000117118.
GeneIDi6390.
KEGGihsa:6390.
UCSCiuc001bae.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
TCA Cycle Gene Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17248 mRNA. Translation: AAA81167.1.
U17886
, U17296, U17880, U17881, U17882, U17883, U17884, U17885 Genomic DNA. Translation: AAA80581.1.
AK312056 mRNA. Translation: BAG34992.1.
AL049569 Genomic DNA. Translation: CAB96822.1.
CH471134 Genomic DNA. Translation: EAW94828.1.
BC007840 mRNA. Translation: AAH07840.1.
DQ403007 mRNA. Translation: ABD77140.1.
D10245 mRNA. Translation: BAA01089.1.
M32246 mRNA. Translation: AAA35708.1.
CCDSiCCDS176.1.
PIRiI38895.
RefSeqiNP_002991.2. NM_003000.2.
UniGeneiHs.465924.

3D structure databases

ProteinModelPortaliP21912.
SMRiP21912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112291. 102 interactors.
IntActiP21912. 23 interactors.
MINTiMINT-3009566.
STRINGi9606.ENSP00000364649.

Chemistry databases

DrugBankiDB00139. Succinic acid.

PTM databases

iPTMnetiP21912.
PhosphoSitePlusiP21912.
SwissPalmiP21912.

Polymorphism and mutation databases

BioMutaiSDHB.
DMDMi20455488.

2D gel databases

UCD-2DPAGEP21912.

Proteomic databases

EPDiP21912.
MaxQBiP21912.
PaxDbiP21912.
PeptideAtlasiP21912.
PRIDEiP21912.

Protocols and materials databases

DNASUi6390.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375499; ENSP00000364649; ENSG00000117118.
GeneIDi6390.
KEGGihsa:6390.
UCSCiuc001bae.5. human.

Organism-specific databases

CTDi6390.
DisGeNETi6390.
GeneCardsiSDHB.
GeneReviewsiSDHB.
HGNCiHGNC:10681. SDHB.
HPAiCAB009822.
CAB068233.
CAB068234.
CAB068235.
HPA002868.
MalaCardsiSDHB.
MIMi115310. phenotype.
171300. phenotype.
185470. gene.
606864. phenotype.
612359. phenotype.
neXtProtiNX_P21912.
OpenTargetsiENSG00000117118.
Orphaneti97286. Carney-Stratakis syndrome.
201. Cowden syndrome.
44890. Gastrointestinal stromal tumor.
29072. Hereditary pheochromocytoma-paraganglioma.
3208. Isolated succinate-CoQ reductase deficiency.
PharmGKBiPA35606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
HOVERGENiHBG005483.
InParanoidiP21912.
KOiK00235.
OMAiIDSHERM.
OrthoDBiEOG091G0EKC.
PhylomeDBiP21912.
TreeFamiTF300754.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
BioCyciMetaCyc:ENSG00000117118-MONOMER.
ZFISH:ENSG00000117118-MONOMER.
BRENDAi1.3.5.1. 2681.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-71403. Citric acid cycle (TCA cycle).
SIGNORiP21912.

Miscellaneous databases

ChiTaRSiSDHB. human.
GeneWikiiSDHB.
GenomeRNAii6390.
PROiP21912.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117118.
CleanExiHS_SDHB.
ExpressionAtlasiP21912. baseline and differential.
GenevisibleiP21912. HS.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_HUMAN
AccessioniPrimary (citable) accession number: P21912
Secondary accession number(s): B2R545, Q0QEY7, Q9NQ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 2, 2002
Last modified: November 30, 2016
This is version 195 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.