Reviewed, UniProtKB/Swiss-Prot P21912 (DHSB_HUMAN)

Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    EC=1.3.5.1
Alternative name(s):
    Iron-sulfur subunit of complex II
      Short name=Ip

Gene names

Name:	SDHB
Synonyms:	SDH, SDH1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	Binds 1 2Fe-2S cluster By similarity. Binds 1 3Fe-4S cluster By similarity. Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Involvement in disease	Defects in SDHB are a cause of pheochromocytoma [MIM:171300]. The pheochromocytomas are catecholamine-producing, chromaffin tumors that arise in the adrenal medulla in 90% of cases. In the remaining 10% of cases, they develop in extra-adrenal sympathetic ganglia and may be referred to as "paraganglioma." Pheochromocytoma usually presents with hypertension. Approximately 10% of pheochromocytoma is hereditary. Although pheochromocytoma susceptibility may be associated with germline mutations in the tumor-suppressor genes VHL and NF1 and in the proto-oncogene RET, the genetic basis for most cases of non-syndromic familial pheochromocytoma is unknown. Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.19 Ref.21 Defects in SDHB are the cause of hereditary paragangliomas type 4 (PLG4) [MIM:115310]; also known as familial non-chromaffin paragangliomas type 4. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. PLG4 is characterized by the development of mostly benign, highly vascular, slow growing tumors in the head and neck. In the head and neck region, the carotid body is the largest of all paraganglia and is also the most common site of the tumors. Ref.8 Ref.13 Ref.16 Ref.21 Ref.18 Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Ref.21 Defects in SDHB are a cause of Cowden-like syndrome [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Transit peptide
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Ref.4 Traceable author statement. Source: ProtInc
Cellular component	mitochondrial inner membrane Inferred from Experiment. Source: Reactome
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion
	Chain	29 – 280	252	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial		PRO_0000010355
Regions
	Domain	40 – 133	94	2Fe-2S ferredoxin-type
	Domain	176 – 206	31	4Fe-4S ferredoxin-type
Sites
	Metal binding	93	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	98	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	101	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	113	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	186	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	189	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	192	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	196	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	243	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	249	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	253	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Binding site	201	1	Ubiquinone; shared with DHSD By similarity
Natural variations
	Natural variant	3	1	A → G Found in an individual with features of Cowden-like syndrome and absence of PTEN mutations; associated with increased manganese superoxide dismutase expression; associated with normal reactive oxygen species; associated with a 1.2-fold increase in AKT expression and 1.3-fold change in MAPK expression. dbSNP rs11203289.		VAR_054374
	Natural variant	29	1	A → AQ in pheochromocytoma. Ref.11		VAR_035063
	Natural variant	40	1	K → E Ref.11 Ref.15		VAR_054375
	Natural variant	43	1	A → P in pheochromocytoma. Ref.12		VAR_054376
	Natural variant	46	1	R → G in pheochromocytoma. Ref.11 Ref.12 Ref.14 Ref.16		VAR_035064
	Natural variant	46	1	R → Q in pheochromocytoma and PLG4. Ref.11 Ref.12 Ref.14 Ref.16		VAR_054377
	Natural variant	53	1	G → R in pheochromocytoma. Ref.16		VAR_054378
	Natural variant	65	1	L → H in pheochromocytoma. Ref.14 Ref.16		VAR_054379
	Natural variant	65	1	L → P in pheochromocytoma. Ref.14 Ref.16		VAR_054380
	Natural variant	87	1	L → S in pheochromocytoma. Ref.8 Ref.16		VAR_018517
	Natural variant	100	1	S → F in pheochromocytoma; absence of expression in tumor cells indicating complete loss of SDHB function. Ref.11 Ref.19		VAR_037620
	Natural variant	101	1	C → Y in pheochromocytoma. Ref.11 Ref.16		VAR_035065
	Natural variant	127	1	I → N in pheochromocytoma. Ref.13		VAR_054381
	Natural variant	131	1	P → R in PGL4. Ref.10		VAR_018518
	Natural variant	132	1	H → P in PLG4. Ref.18		VAR_037621
	Natural variant	163	1	S → P Found in two individuals with features of Cowden-like syndrome and absence of PTEN mutations; associated with increased manganese superoxide dismutase function; associated with increased reactive oxygen species; associated with a 2.7-fold change in AKT expression and a 1.7-fold increase in MAPK expression. dbSNP rs33927012.		VAR_054382
	Natural variant	192	1	C → R in pheochromocytoma. Ref.11 Ref.16		VAR_035066
	Natural variant	196	1	C → Y in pheochromocytoma. Ref.11 Ref.16		VAR_035067
	Natural variant	197	1	P → R in PLG4. Ref.8 Ref.13		VAR_017868
	Natural variant	230	1	R → C in pheochromocytoma. Ref.11 Ref.12		VAR_054383
	Natural variant	242	1	R → H in familial malignant paraganglioma and pheochromocytoma, pheochromocytoma and PLG4. Ref.11 Ref.16 Ref.9		VAR_017869
Experimental info
	Sequence conflict	19 – 21	3	GGA → WRT Ref.4
	Sequence conflict	62	1	E → K in AAA81167. Ref.1
	Sequence conflict	67	1	K → NR in AAA80581. Ref.1
	Sequence conflict	151	1	K → R Ref.5
	Sequence conflict	172	1	Q → E Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P21912-1 [UniParc]. Last modified May 2, 2002. Version 3. Checksum: ED12E7C3BA7B6D13	FASTA	280	31,630
	10 20 30 40 50 60 MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD KAGDKPHMQT 70 80 90 100 110 120 YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN 130 140 150 160 170 180 LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL 190 200 210 220 230 240 DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL 250 260 270 280 YRCHTIMNCT RTCPKGLNPG KAIAEIKKMM ATYKEKKASV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase." Au H.C., Ream-Robinson D., Bellew L.A., Broomfield P.L.E., Saghbini M., Scheffler I.E. Gene 159:249-253(1995) [PubMed: 7622059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Liver.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria." Kita K., Oya H., Gennis R.B., Ackrell B.A.C., Kasahara M. Biochem. Biophys. Res. Commun. 166:101-108(1990) [PubMed: 2302193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-280. Tissue: Liver.
[5]	"Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species." Gould S.J., Subramani S., Scheffler I.E. Proc. Natl. Acad. Sci. U.S.A. 86:1934-1938(1989) [PubMed: 2494655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-249. Tissue: Fibroblast.
[6]	Erratum Gould S.J., Subramani S., Scheffler I.E. Proc. Natl. Acad. Sci. U.S.A. 90:2556-2556(1993)
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma." Astuti D., Latif F., Dallol A., Dahia P.L.M., Douglas F., George E., Skoeldberg F., Husebye E.S., Eng C., Maher E.R. Am. J. Hum. Genet. 69:49-54(2001) [PubMed: 11404820] [Abstract] Cited for: VARIANT PLG4 ARG-197, VARIANT PHEOCHROMOCYTOMA SER-87.
[9]	"Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene." Young A.L., Baysal B.E., Deb A., Young W.F. Jr. J. Clin. Endocrinol. Metab. 87:4101-4105(2002) [PubMed: 12213855] [Abstract] Cited for: VARIANT FAMILIAL MALIGNANT PARAGANGLIOMA HIS-242.
[10]	"Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas." Baysal B.E., Willett-Brozick J.E., Lawrence E.C., Drovdlic C.M., Savul S.A., McLeod D.R., Yee H.A., Brackmann D.E., Slattery W.H. III, Myers E.N., Ferrell R.E., Rubinstein W.S. J. Med. Genet. 39:178-183(2002) [PubMed: 11897817] [Abstract] Cited for: VARIANT PGL4 ARG-131.
[11]	"Germ-line mutations in nonsyndromic pheochromocytoma." The Freiburg-Warsaw-Columbus pheochromocytoma study group Neumann H.P.H., Bausch B., McWhinney S.R., Bender B.U., Gimm O., Franke G., Schipper J., Klisch J., Altehoefer C., Zerres K., Januszewicz A., Smith W.M., Munk R., Manz T., Glaesker S., Apel T.W., Treier M., Reineke M. , Walz M.K., Hoang-Vu C., Brauckhoff M., Klein-Franke A., Klose P., Schmidt H., Maier-Woelfle M., Peczkowska M., Szmigielski C., Eng C. N. Engl. J. Med. 346:1459-1466(2002) [PubMed: 12000816] [Abstract] Cited for: VARIANTS PHEOCHROMOCYTOMA GLN-29 INS; GLY-46; TYR-101; ARG-192; TYR-196 AND HIS-242.
[12]	"Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas." Gimenez-Roqueplo A.-P., Favier J., Rustin P., Rieubland C., Crespin M., Nau V., Khau Van Kien P., Corvol P., Plouin P.-F., Jeunemaitre X. Cancer Res. 63:5615-5621(2003) [PubMed: 14500403] [Abstract] Cited for: VARIANTS PHEOCHROMOCYTOMA PRO-43; GLN-46; GLY-46 AND CYS-230.
[13]	"Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility." Astuti D., Hart-Holden N., Latif F., Lalloo F., Black G.C., Lim C., Moran A., Grossman A.B., Hodgson S.V., Freemont A., Ramsden R., Eng C., Evans D.G.R., Maher E.R. Clin. Endocrinol. (Oxf.) 59:728-733(2003) [PubMed: 14974914] [Abstract] Cited for: VARIANT PHEOCHROMOCYTOMA ASN-127, VARIANT PLG4 ARG-197.
[14]	"Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas." Benn D.E., Croxson M.S., Tucker K., Bambach C.P., Richardson A.L., Delbridge L., Pullan P.T., Hammond J., Marsh D.J., Robinson B.G. Oncogene 22:1358-1364(2003) [PubMed: 12618761] [Abstract] Cited for: VARIANTS PHEOCHROMOCYTOMA GLN-46 AND HIS-65.
[15]	"K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma." McDonnell C.M., Benn D.E., Marsh D.J., Robinson B.G., Zacharin M.R. Clin. Endocrinol. (Oxf.) 61:510-514(2004) [PubMed: 15473885] [Abstract] Cited for: VARIANT GLU-40.
[16]	"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations." Neumann H.P.H., Pawlu C., Peczkowska M., Bausch B., McWhinney S.R., Muresan M., Buchta M., Franke G., Klisch J., Bley T.A., Hoegerle S., Boedeker C.C., Opocher G., Schipper J., Januszewicz A., Eng C. JAMA 292:943-951(2004) [PubMed: 15328326] [Abstract] Cited for: VARIANTS PHEOCHROMOCYTOMA GLY-46; GLN-46; ARG-53; PRO-65; SER-87; TYR-101; ARG-192; TYR-196 AND HIS-242, VARIANTS PLG4 GLN-46 AND HIS-242.
[17]	Erratum Neumann H.P.H., Pawlu C., Peczkowska M., Bausch B., McWhinney S.R., Muresan M., Buchta M., Franke G., Klisch J., Bley T.A., Hoegerle S., Boedeker C.C., Opocher G., Schipper J., Januszewicz A., Eng C. JAMA 292:1686-1686(2004)
[18]	"A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas." Maier-Woelfle M., Braendle M., Komminoth P., Saremaslani P., Schmid S., Locher T., Heitz P.U., Krull I., Galeazzi R.L., Schmid C., Perren A. J. Clin. Endocrinol. Metab. 89:362-367(2004) [PubMed: 14715873] [Abstract] Cited for: VARIANT PLG4 PRO-132.
[19]	"Somatic SDHB mutation in an extraadrenal pheochromocytoma." van Nederveen F.H., Korpershoek E., Lenders J.W.M., de Krijger R.R., Dinjens W.N.M. N. Engl. J. Med. 357:306-308(2007) [PubMed: 17634472] [Abstract] Cited for: VARIANT PHEOCHROMOCYTOMA PHE-100.
[20]	"Familial gastrointestinal stromal tumors and germ-line mutations." McWhinney S.R., Pasini B., Stratakis C.A. N. Engl. J. Med. 357:1054-1056(2007) [PubMed: 17804857] [Abstract] Cited for: INVOLVEMENT IN PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA.
[21]	"Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes." Ni Y., Zbuk K.M., Sadler T., Patocs A., Lobo G., Edelman E., Platzer P., Orloff M.S., Waite K.A., Eng C. Am. J. Hum. Genet. 83:261-268(2008) [PubMed: 18678321] [Abstract] Cited for: VARIANTS GLY-3 AND PRO-163, CHARACTERIZATION OF VARIANTS GLY-3 AND PRO-163, INVOLVEMENT IN COWDEN-LIKE DISEASE.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	U17248 mRNA. Translation: AAA81167.1. U17886 , U17296, U17880, U17881, U17882, U17883, U17884, U17885 Genomic DNA. Translation: AAA80581.1. AL049569 Genomic DNA. Translation: CAB96822.1. BC007840 mRNA. Translation: AAH07840.1. D10245 mRNA. Translation: BAA01089.1. M32246 mRNA. Translation: AAA35708.1.
IPI	IPI00294911.
PIR	I38895.
RefSeq	NP_002991.2.
UniGene	Hs.465924
3D structure databases
HSSP	HSSP built from PDB template 1NEK based on UniProtKB P07014.
SMR	P21912. Positions 37-275.
ModBase	Search...
Protein-protein interaction databases
IntAct	P21912. 6 interactions.
Proteomic databases
PeptideAtlas	P21912.
PRIDE	P21912.
Genome annotation databases
Ensembl	ENSG00000117118. Homo sapiens. [Contig view]
GeneID	6390.
KEGG	hsa:6390.
Organism-specific databases
GeneCards	GC01M017217.
H-InvDB	HIX0000179.
HGNC	HGNC:10681. SDHB.
HPA	CAB009822. HPA002867. HPA002868.
MIM	115310. phenotype. 171300. phenotype. 185470. gene. 606864. phenotype. 612359. phenotype.
Orphanet	97286. Carney-Stratakis syndrome. 201. Cowden syndrome. 29072. Hereditary pheochromocytoma-paraganglioma syndrome.
PharmGKB	PA35606.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P21912.
HOVERGEN	P21912.
OMA	P21912. ASIEPWL.
Enzyme and pathway databases
BRENDA	1.3.5.1. 247.
Reactome	REACT_6305. Electron Transport Chain.
Gene expression databases
ArrayExpress	P21912.
Bgee	P21912.
CleanEx	HS_SDHB.
GermOnline	ENSG00000117118. Homo sapiens.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00139. Succinic acid.
NextBio	24824.
SOURCE	Search...

Entry information

Entry name

DHSB_HUMAN

Accession

Primary (citable) accession number: P21912
Secondary accession number(s): Q9NQ12

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 2, 2002
Last modified:	June 16, 2009
This is version 114 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)