P21908 (GLK_ZYMMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	ZMO0369

Organism

Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) [Complete proteome] [HAMAP]

Taxonomic identifier

264203 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Zymomonas › Zymomonas mobilis › Zymomonas mobilis subsp. mobilis

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Glucokinase HAMAP-Rule MF_00524		PRO_0000215147
Regions
	Nucleotide binding	6 – 11	6	ATP Potential
Experimental info
	Sequence conflict	258	1	A → R Ref.1
	Sequence conflict	258	1	A → R Ref.2
	Sequence conflict	313 – 324	12	AAAYA…YSEVE → QLPMPTNILKLNNIF Ref.1
	Sequence conflict	313 – 324	12	AAAYA…YSEVE → QLPMPTNILKLNNIF Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P21908 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: BAAC13AAB6DB8716	FASTA	324	34,897
	10 20 30 40 50 60 MEIVAIDIGG THARFSIAEV SNGRVLSLGE ETTFKTAEHA SLQLAWERFG EKLGRPLPRA 70 80 90 100 110 120 AAIAWAGPVH GEVLKLTNNP WVLRPATLNE KLDIDTHVLI NDFGAVAHAV AHMDSSYLDH 130 140 150 160 170 180 ICGPDEALPS DGVITILGPG TGLGVAHLLR TEGRYFVIET EGGHIDFAPL DRLEDKILAR 190 200 210 220 230 240 LRERFRRVSI ERIISGPGLG NIYEALAAIE GVPFSLLDDI KLWQMALEGK DNLAEAALDR 250 260 270 280 290 300 FCLSLGAIAG DLALAQGATS VVIGGGVGLR IASHLPESGF RQRFVSKGRF ERVMSKIPVK 310 320 LITYPQPGLL GAAAAYANKY SEVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism." Barnell W.O., Yi K.C., Conway T. J. Bacteriol. 172:7227-7240(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.
[2]	Ahn J.Y., Kang H.S. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.
[3]	"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4." Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. , Kang H.L., Lee S.Y., Lee K.J., Kang H.S. Nat. Biotechnol. 23:63-68(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60615 Genomic DNA. Translation: AAA27694.1. AF313764 Genomic DNA. Translation: AAG29867.1. AE008692 Genomic DNA. Translation: AAV88993.1.
PIR	D37855.
RefSeq	YP_162104.1. NC_006526.2.
3D structure databases
ProteinModelPortal	P21908.
ModBase	Search...
Protein-protein interaction databases
STRING	264203.ZMO0369.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV88993; AAV88993; ZMO0369.
GeneID	3188599.
KEGG	zmo:ZMO0369.
PATRIC	32566072. VBIZymMob102260_0350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	IAPRIAH.
ProtClustDB	CLSK933036.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_ZYMMO

Accession

Primary (citable) accession number: P21908
Secondary accession number(s): Q5NQL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program