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P21907

- G6PD_ZYMMO

UniProt

P21907 - G6PD_ZYMMO

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461NADPUniRule annotation
    Binding sitei144 – 1441NADPUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Binding sitei212 – 2121SubstrateUniRule annotation
    Binding sitei231 – 2311SubstrateUniRule annotation
    Active sitei236 – 2361Proton acceptorUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:ZMO0367
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Glucose-6-phosphate 1-dehydrogenasePRO_0000068138Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264203.ZMO0367.

    Structurei

    3D structure databases

    ProteinModelPortaliP21907.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiDSIMEAW.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21907-1 [UniParc]FASTAAdd to Basket

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    MTNTVSTMIL FGSTGDLSQR MLLPSLYGLD ADGLLADDLR IVCTSRSEYD    50
    TDGFRDFAEK ALDRFVASDR LNDDAKAKFL NKLFYATVDI TDPTQFGKLA 100
    DLCGPVEKGI AIYLSTAPSL FEGAIAGLKQ AGLAGPTSRL ALEKPLGQDL 150
    ASSDHINDAV LKVFSEKQVY RIDHYLGKET VQNLLTLRFG NALFEPLWNS 200
    KGIDHVQISV AETVGLEGRI GYFDGSGSLR DMVQSHILQL VALVAMEPPA 250
    HMEANAVRDE KVKVFRALRP INNDTVFTHT VTGQYGAGVS GGKEVAGYID 300
    ELGQPSDTET FVAIKAHVDN WRWQGVPFYI RTGKRLPARR SEIVVQFKPV 350
    PHSIFSSSGG ILQPNKLRIV LQPDETIQIS MMVKEPGLDR NGAHMREVWL 400
    DLSLTDVFKD RKRRIAYERL MLDLIEGDAT LFVRRDEVEA QWVWIDGIRE 450
    GWKANSMKPK TYVSGTWGPS TAIALAERDG VTWYD 485
    Length:485
    Mass (Da):53,859
    Last modified:May 1, 1991 - v1
    Checksum:iC326FC605ED92430
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60615 Genomic DNA. Translation: AAA27692.1.
    AF313764 Genomic DNA. Translation: AAG29865.1.
    AE008692 Genomic DNA. Translation: AAV88991.1.
    PIRiB37855.
    RefSeqiYP_008833432.1. NC_022900.1.
    YP_162102.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV88991; AAV88991; ZMO0367.
    GeneIDi17706879.
    3188588.
    KEGGizmi:ZCP4_0905.
    zmo:ZMO0367.
    PATRICi32566068. VBIZymMob102260_0348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60615 Genomic DNA. Translation: AAA27692.1 .
    AF313764 Genomic DNA. Translation: AAG29865.1 .
    AE008692 Genomic DNA. Translation: AAV88991.1 .
    PIRi B37855.
    RefSeqi YP_008833432.1. NC_022900.1.
    YP_162102.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali P21907.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO0367.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV88991 ; AAV88991 ; ZMO0367 .
    GeneIDi 17706879.
    3188588.
    KEGGi zmi:ZCP4_0905.
    zmo:ZMO0367.
    PATRICi 32566068. VBIZymMob102260_0348.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi DSIMEAW.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism."
      Barnell W.O., Yi K.C., Conway T.
      J. Bacteriol. 172:7227-7240(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Ahn J.Y., Kang H.S.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiG6PD_ZYMMO
    AccessioniPrimary (citable) accession number: P21907
    Secondary accession number(s): Q5NQL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3