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Reviewed, UniProtKB/Swiss-Prot P21907 (G6PD_ZYMMO)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Gene names
Name: zwf
Ordered Locus Names: ZMO0367
OrganismZymomonas mobilis [Complete proteome] [HAMAP]
Taxonomic identifier542 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Glucose-6-phosphate 1-dehydrogenase
PRO_0000068138

Sites

Active site2361Proton acceptor By similarity
Binding site141NADP By similarity
Binding site461NADP By similarity
Binding site1741Substrate By similarity
Binding site1781Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P21907-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: C326FC605ED92430

FASTA48553,859
        10         20         30         40         50         60 
MTNTVSTMIL FGSTGDLSQR MLLPSLYGLD ADGLLADDLR IVCTSRSEYD TDGFRDFAEK 

        70         80         90        100        110        120 
ALDRFVASDR LNDDAKAKFL NKLFYATVDI TDPTQFGKLA DLCGPVEKGI AIYLSTAPSL 

       130        140        150        160        170        180 
FEGAIAGLKQ AGLAGPTSRL ALEKPLGQDL ASSDHINDAV LKVFSEKQVY RIDHYLGKET 

       190        200        210        220        230        240 
VQNLLTLRFG NALFEPLWNS KGIDHVQISV AETVGLEGRI GYFDGSGSLR DMVQSHILQL 

       250        260        270        280        290        300 
VALVAMEPPA HMEANAVRDE KVKVFRALRP INNDTVFTHT VTGQYGAGVS GGKEVAGYID 

       310        320        330        340        350        360 
ELGQPSDTET FVAIKAHVDN WRWQGVPFYI RTGKRLPARR SEIVVQFKPV PHSIFSSSGG 

       370        380        390        400        410        420 
ILQPNKLRIV LQPDETIQIS MMVKEPGLDR NGAHMREVWL DLSLTDVFKD RKRRIAYERL 

       430        440        450        460        470        480 
MLDLIEGDAT LFVRRDEVEA QWVWIDGIRE GWKANSMKPK TYVSGTWGPS TAIALAERDG 


VTWYD 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism."
Barnell W.O., Yi K.C., Conway T.
J. Bacteriol. 172:7227-7240(1990) [PubMed: 2254282] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 31821 / ZM4 / CP4.
[2]Ahn J.Y., Kang H.S.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 31821 / ZM4 / CP4.
[3]"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4."
Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. expand/collapse author list , Kang H.L., Lee S.Y., Lee K.J., Kang H.S.
Nat. Biotechnol. 23:63-68(2005) [PubMed: 15592456] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases

M60615 Genomic DNA. Translation: AAA27692.1.
AF313764 Genomic DNA. Translation: AAG29865.1.
AE008692 Genomic DNA. Translation: AAV88991.1.
PIRB37855.
RefSeqYP_162102.1.

3D structure databases

HSSPHSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBaseSearch...

Genome annotation databases

GeneID3188588.
GenomeReviewsGene locus ZMO0367 in contig AE008692_GR.
KEGGzmo:ZMO0367.
NMPDRfig|264203.3.peg.863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP21907.
OMAP21907. LLARDNM.

Enzyme and pathway databases

BioCycZMOB264203:ZMO0367-MON.
BRENDA1.1.1.49. 1658.

Family and domain databases

InterProIPR001282. Glc-6-P_DH.
IPR019796. Glc-6-P_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
ProDomPD001129. G6PD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_ZYMMO
AccessionPrimary (citable) accession number: P21907
Secondary accession number(s): Q5NQL3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents