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P21907

- G6PD_ZYMMO

UniProt

P21907 - G6PD_ZYMMO

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, ZMO0367
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461NADP By similarity
Binding sitei144 – 1441NADP By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei178 – 1781Substrate By similarity
Binding sitei212 – 2121Substrate By similarity
Binding sitei231 – 2311Substrate By similarity
Active sitei236 – 2361Proton acceptor By similarity
Binding sitei334 – 3341Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:ZMO0367
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068138Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO0367.

Structurei

3D structure databases

ProteinModelPortaliP21907.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiDSIMEAW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21907-1 [UniParc]FASTAAdd to Basket

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MTNTVSTMIL FGSTGDLSQR MLLPSLYGLD ADGLLADDLR IVCTSRSEYD    50
TDGFRDFAEK ALDRFVASDR LNDDAKAKFL NKLFYATVDI TDPTQFGKLA 100
DLCGPVEKGI AIYLSTAPSL FEGAIAGLKQ AGLAGPTSRL ALEKPLGQDL 150
ASSDHINDAV LKVFSEKQVY RIDHYLGKET VQNLLTLRFG NALFEPLWNS 200
KGIDHVQISV AETVGLEGRI GYFDGSGSLR DMVQSHILQL VALVAMEPPA 250
HMEANAVRDE KVKVFRALRP INNDTVFTHT VTGQYGAGVS GGKEVAGYID 300
ELGQPSDTET FVAIKAHVDN WRWQGVPFYI RTGKRLPARR SEIVVQFKPV 350
PHSIFSSSGG ILQPNKLRIV LQPDETIQIS MMVKEPGLDR NGAHMREVWL 400
DLSLTDVFKD RKRRIAYERL MLDLIEGDAT LFVRRDEVEA QWVWIDGIRE 450
GWKANSMKPK TYVSGTWGPS TAIALAERDG VTWYD 485
Length:485
Mass (Da):53,859
Last modified:May 1, 1991 - v1
Checksum:iC326FC605ED92430
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60615 Genomic DNA. Translation: AAA27692.1.
AF313764 Genomic DNA. Translation: AAG29865.1.
AE008692 Genomic DNA. Translation: AAV88991.1.
PIRiB37855.
RefSeqiYP_008833432.1. NC_022900.1.
YP_162102.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV88991; AAV88991; ZMO0367.
GeneIDi17706879.
3188588.
KEGGizmi:ZCP4_0905.
zmo:ZMO0367.
PATRICi32566068. VBIZymMob102260_0348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60615 Genomic DNA. Translation: AAA27692.1 .
AF313764 Genomic DNA. Translation: AAG29865.1 .
AE008692 Genomic DNA. Translation: AAV88991.1 .
PIRi B37855.
RefSeqi YP_008833432.1. NC_022900.1.
YP_162102.1. NC_006526.2.

3D structure databases

ProteinModelPortali P21907.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO0367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV88991 ; AAV88991 ; ZMO0367 .
GeneIDi 17706879.
3188588.
KEGGi zmi:ZCP4_0905.
zmo:ZMO0367.
PATRICi 32566068. VBIZymMob102260_0348.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi DSIMEAW.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism."
    Barnell W.O., Yi K.C., Conway T.
    J. Bacteriol. 172:7227-7240(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Ahn J.Y., Kang H.S.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiG6PD_ZYMMO
AccessioniPrimary (citable) accession number: P21907
Secondary accession number(s): Q5NQL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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