P21898 (ADH_DROHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:

Adh

Organism

Drosophila heteroneura (Fruit fly)

Taxonomic identifier

32382 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Hawaiian Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Alcohol dehydrogenase		PRO_0000054465
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21898 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: CA245A5FB561A7BD	FASTA	254	27,521
	10 20 30 40 50 60 MVIANSNIIF VAGLGGIGLD TSREIVKSGP KNLVVLDRID NPAAIAELKA LNPKVTITFY 70 80 90 100 110 120 PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDTQI ERTIAVNFTG TVNTTTAIMD 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNSIYQVPV YSASKAAALS FTTSLAKLAH ITGVTVYSIN 190 200 210 220 230 240 PGITKTVLVH KFNSWLNVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR 250 LDAIEWTKHW DSGI

References

[1]	"Rates of DNA change and phylogeny from the DNA sequences of the alcohol dehydrogenase gene for five closely related species of Hawaiian Drosophila." Rowan R.G., Hunt J.A. Mol. Biol. Evol. 8:49-70(1991) [PubMed: 2002765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63287 Genomic DNA. Translation: AAA28351.1.
PIR	A23724.
3D structure databases
ProteinModelPortal	P21898.
SMR	P21898. Positions 1-254.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0012347. Dhet\Adh.
Family and domain databases
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROHE

Accession

Primary (citable) accession number: P21898

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 69 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project