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Protein

Single-stranded-DNA-specific exonuclease RecJ

Gene

recJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:EG10830-MONOMER.
ECOL316407:JW2860-MONOMER.
RETL1328306-WGS:GSTH-1933-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded-DNA-specific exonuclease RecJ (EC:3.1.-.-)
Gene namesi
Name:recJ
Ordered Locus Names:b2892, JW2860
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10830. recJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Single-stranded-DNA-specific exonuclease RecJPRO_0000097228Add
BLAST

Proteomic databases

PaxDbiP21893.
PRIDEiP21893.

Interactioni

Protein-protein interaction databases

BioGridi4262338. 148 interactions.
DIPiDIP-10654N.
IntActiP21893. 24 interactions.
MINTiMINT-1223840.
STRINGi511145.b2892.

Structurei

3D structure databases

ProteinModelPortaliP21893.
SMRiP21893. Positions 70-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecJ family.Curated

Phylogenomic databases

eggNOGiENOG4105C2R. Bacteria.
COG0608. LUCA.
HOGENOMiHOG000018414.
InParanoidiP21893.
KOiK07462.
OMAiNRFDYGY.
PhylomeDBiP21893.

Family and domain databases

InterProiIPR001667. DDH_dom.
IPR003156. DHHA1_dom.
IPR004610. RecJ.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02272. DHHA1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00644. recJ. 1 hit.

Sequencei

Sequence statusi: Complete.

P21893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQIQLRRR EVDETADLPA ELPPLLRRLY ASRGVRSAQE LERSVKGMLP
60 70 80 90 100
WQQLSGVEKA VEILYNAFRE GTRIIVVGDF DADGATSTAL SVLAMRSLGC
110 120 130 140 150
SNIDYLVPNR FEDGYGLSPE VVDQAHARGA QLIVTVDNGI SSHAGVEHAR
160 170 180 190 200
SLGIPVIVTD HHLPGDTLPA AEAIINPNLR DCNFPSKSLA GVGVAFYLML
210 220 230 240 250
ALRTFLRDQG WFDERNIAIP NLAELLDLVA LGTVADVVPL DANNRILTWQ
260 270 280 290 300
GMSRIRAGKC RPGIKALLEV ANRDAQKLAA SDLGFALGPR LNAAGRLDDM
310 320 330 340 350
SVGVALLLCD NIGEARVLAN ELDALNQTRK EIEQGMQIEA LTLCEKLERS
360 370 380 390 400
RDTLPGGLAM YHPEWHQGVV GILASRIKER FHRPVIAFAP AGDGTLKGSG
410 420 430 440 450
RSIQGLHMRD ALERLDTLYP GMMLKFGGHA MAAGLSLEED KFKLFQQRFG
460 470 480 490 500
ELVTEWLDPS LLQGEVVSDG PLSPAEMTME VAQLLRDAGP WGQMFPEPLF
510 520 530 540 550
DGHFRLLQQR LVGERHLKVM VEPVGGGPLL DGIAFNVDTA LWPDNGVREV
560 570
QLAYKLDINE FRGNRSLQII IDNIWPI
Length:577
Mass (Da):63,389
Last modified:November 1, 1997 - v2
Checksum:iCF7724B36D7701DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61Q → H in AAA62789 (PubMed:1987126).Curated
Sequence conflicti20 – 201A → AA in AAA62789 (PubMed:1987126).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54884 Genomic DNA. Translation: AAA62789.1.
U28375 Genomic DNA. Translation: AAA83073.1.
U00096 Genomic DNA. Translation: AAC75930.1.
AP009048 Genomic DNA. Translation: BAE76957.1.
PIRiD65073.
RefSeqiNP_417368.1. NC_000913.3.
WP_000813200.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75930; AAC75930; b2892.
BAE76957; BAE76957; BAE76957.
GeneIDi947367.
KEGGiecj:JW2860.
eco:b2892.
PATRICi32121196. VBIEscCol129921_2986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54884 Genomic DNA. Translation: AAA62789.1.
U28375 Genomic DNA. Translation: AAA83073.1.
U00096 Genomic DNA. Translation: AAC75930.1.
AP009048 Genomic DNA. Translation: BAE76957.1.
PIRiD65073.
RefSeqiNP_417368.1. NC_000913.3.
WP_000813200.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP21893.
SMRiP21893. Positions 70-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262338. 148 interactions.
DIPiDIP-10654N.
IntActiP21893. 24 interactions.
MINTiMINT-1223840.
STRINGi511145.b2892.

Proteomic databases

PaxDbiP21893.
PRIDEiP21893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75930; AAC75930; b2892.
BAE76957; BAE76957; BAE76957.
GeneIDi947367.
KEGGiecj:JW2860.
eco:b2892.
PATRICi32121196. VBIEscCol129921_2986.

Organism-specific databases

EchoBASEiEB0823.
EcoGeneiEG10830. recJ.

Phylogenomic databases

eggNOGiENOG4105C2R. Bacteria.
COG0608. LUCA.
HOGENOMiHOG000018414.
InParanoidiP21893.
KOiK07462.
OMAiNRFDYGY.
PhylomeDBiP21893.

Enzyme and pathway databases

BioCyciEcoCyc:EG10830-MONOMER.
ECOL316407:JW2860-MONOMER.
RETL1328306-WGS:GSTH-1933-MONOMER.

Miscellaneous databases

PROiP21893.

Family and domain databases

InterProiIPR001667. DDH_dom.
IPR003156. DHHA1_dom.
IPR004610. RecJ.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02272. DHHA1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00644. recJ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRECJ_ECOLI
AccessioniPrimary (citable) accession number: P21893
Secondary accession number(s): Q2M9U9, Q46823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.