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P21885 (SPEA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine decarboxylase
EC=4.1.1.19
Gene names
Name:speA
Synonyms:cad
Ordered Locus Names:BSU14630
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of agmatine from arginine.

Catalytic activity

L-arginine = agmatine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. Ref.6

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Caution

Was originally (Ref.1) thought to be a lysine decarboxylase and was consequently named cad.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Arginine decarboxylase
PRO_0000201147

Amino acid modifications

Modified residue2261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P21885 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: 1AC7ACAE24F4F6D2

FASTA49053,583
        10         20         30         40         50         60 
MSQHETPLYT GLKKHASRQP VQFHIPGHKK GAGMDPEFRQ FIGENALSID LINIEPLDDL 

        70         80         90        100        110        120 
HAPKGIIKQA QDLAAEAFGA DHTFFSVQGT SGAIMTMVMA VCGPGDKIII PRNVHKSIMT 

       130        140        150        160        170        180 
AIVFSGAVPI FIHPEIDNEL GISHGITLES AKRALTEHPD AKGLLVINPT YFGVAADLKS 

       190        200        210        220        230        240 
IVELAHSFDV PVLVDEAHGV HIHFHDELPL SAMQAGADIA ATSVHKLGGS LTQSSILNMR 

       250        260        270        280        290        300 
EGLVSKDRVQ SILSMLTTTS TSYLLLASLD VARKRLATEG RQLAEETLKL ANQTRDRLNQ 

       310        320        330        340        350        360 
IEGIYCVGSE ILGSKAAYSY DPTKLIISVK SLGLTGHDVE KWLRESFNIE VELSDLYNIL 

       370        380        390        400        410        420 
CIFTPGDSQN DADRLVEALT EIAQQMSEQD VTHQQTEVLL PEIPLLAMTP RDAFYANTEV 

       430        440        450        460        470        480 
IPLKEASGRI IAEFVMVYPP GIPIFIPGEI ITEENISYIF KNLDAGLPVQ GPEDSTLHMI 

       490 
RVIKEQKAIQ

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing the lysine decarboxylase of Bacillus subtilis."
Hemilae H., Koivula T., Paulin L.
Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The ampS-nprE (124 degrees-127 degrees) region of the Bacillus subtilis 168 chromosome: sequencing of a 27 kb segment and identification of several genes in the area."
Winters P., Caldwell R.M., Enfield L., Ferrari E.
Microbiology 142:3033-3037(1996) [PubMed: 8969500] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"Secretory S complex of Bacillus subtilis: sequence analysis and identity to pyruvate dehydrogenase."
Hemilae H.O., Palva A., Paulin L., Arvidson S., Palva I.
J. Bacteriol. 172:5052-5063(1990) [PubMed: 1697575] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-490.
Strain: 168.
[5]"Sequence of a PAL-related lipoprotein from Bacillus subtilis."
Hemilae H.O.
FEMS Microbiol. Lett. 66:37-41(1991) [PubMed: 1936936] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 485-490.
[6]"Characterization of polyamine synthesis pathway in Bacillus subtilis 168."
Sekowska A., Bertin P., Danchin A.
Mol. Microbiol. 29:851-858(1998) [PubMed: 9723923] [Abstract]
Cited for: CHARACTERIZATION OF POLYAMINE PATHWAY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X58433 Genomic DNA. Translation: CAA41337.1.
AF012285 Genomic DNA. Translation: AAC24937.1.
AL009126 Genomic DNA. Translation: CAB13336.1.
M57435 Genomic DNA. Translation: AAA62686.1.
PIRA54546.
RefSeqNP_389346.1. NC_000964.3.

3D structure databases

ProteinModelPortalP21885.
SMRP21885. Positions 1-480.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000428; EBBACP00000000428; EBBACG00000000426.
GeneID936002.
GenomeReviewsGene locus BSU14630 in contig AL009126_GR.
KEGGbsu:BSU14630.
NMPDRfig|224308.1.peg.1465.
PATRIC18974721. VBIBacSub10457_1552.

Organism-specific databases

GenoListBSU14630. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000002042.
HOGENOMHBG634412.
OMATPHAAWQ.
PhylomeDBP21885.
ProtClustDBCLSK873379.

Enzyme and pathway databases

BioCycBSUB:BSU14630-MONOMER.

Family and domain databases

InterProIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.90.100.10. Decarbxylse_C. 1 hit.
G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK01585.
PfamPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMSSF55904. Decarbxylse_C. 1 hit.
SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_BACSU
AccessionPrimary (citable) accession number: P21885
Secondary accession number(s): P26934
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: December 1, 1992
Last modified: January 25, 2012
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents