Reviewed,
UniProtKB/Swiss-Prot P21879 (IMDH_BACSU)
Last modified
December 15, 2009.
Version 94.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (3) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Inosine-5'-monophosphate dehydrogenase Short name=IMP dehydrogenase Short name=IMPDH Short name=IMPD EC=1.1.1.205 Alternative name(s): Superoxide-inducible protein 12 Short name=SOI12 | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 488 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH. |
| Pathway | Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. |
| Induction | By superoxide. |
| Sequence similarities | Belongs to the IMPDH/GMPR family. Contains 2 CBS domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Domain | CBS domain Repeat |
| Ligand | Metal-binding NAD Potassium |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | IMP dehydrogenase activity Inferred from electronic annotation. Source: EC potassium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 488 | 488 | Inosine-5'-monophosphate dehydrogenase | PRO_0000093691 | |||||
Regions | |||||||||
| Domain | 95 – 153 | 59 | CBS 1 | ||||||
| Domain | 157 – 214 | 58 | CBS 2 | ||||||
| Nucleotide binding | 230 – 253 | 24 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 308 | 1 | Thioimidate intermediate By similarity | ||||||
| Metal binding | 303 | 1 | Potassium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 305 | 1 | Potassium; via carbonyl oxygen By similarity | ||||||
| Binding site | 341 | 1 | IMP By similarity | ||||||
| Binding site | 388 | 1 | IMP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | R → H in CAA39204. Ref.1 | ||||||
| Sequence conflict | 480 – 488 | 9 | KESPNYTIS → VHRNKALPGLFGSHQKKTGF VYDECCQSGFFSSD in CAA39204. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of the Bacillus subtilis IMP dehydrogenase gene." Kanzaki N., Miyagawa K.I. Nucleic Acids Res. 18:6710-6710(1990) [PubMed: 1979163] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [3] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [4] | "First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis." Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M. Electrophoresis 18:1451-1463(1997) [PubMed: 9298659] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-25. Strain: 168 / IS58. |
Cross-references
Sequence databases | |
|---|---|
| X55669 Genomic DNA. Translation: CAA39204.1. D26185 Genomic DNA. Translation: BAA05245.1. AL009126 Genomic DNA. Translation: CAB11785.1. | |
| PIR | DEBSMP. S66039. |
| RefSeq | NP_387890.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 938032. |
| GenomeReviews | Gene locus BSU00090 in contig AL009126_GR. |
| KEGG | bsu:BSU00090. |
| NMPDR | fig|224308.1.peg.9. |
Organism-specific databases | |
| SubtiList | BG10073. guaB. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG298985. |
| OMA | CVGLITV. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.205. 150. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR000644. Cysta_beta_synth_core. IPR005990. IMP_DH. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. IPR018529. IMP_DH_rel. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00571. CBS. 1 hit. PF00478. IMPDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF000130. IMPDH. 1 hit. |
| SMART | SM00116. CBS. 2 hits. [Graphical view] |
| PROSITE | PS51371. CBS. 2 hits. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IMDH_BACSU | ||||||||
| Accession | Primary (citable) accession number: P21879 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
