Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000526052 – 142Hemoglobin subunit alpha-AAdd BLAST141

Proteomic databases

PRIDEiP21871

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Turni19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi54 – 72Combined sources19
Turni73 – 75Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi97 – 113Combined sources17
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Helixi138 – 141Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R80X-ray1.44A/C2-142[»]
3DHRX-ray2.00A/C/E/G1-142[»]
3MJUX-ray3.50A2-142[»]
ProteinModelPortaliP21871
SMRiP21871
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21871

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709
KOiK13822

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSANDKSN VKAVFAKIGG QAGDLGGEAL ERLFITYPQT KTYFPHFDLS
60 70 80 90 100
HGSAQIKGHG KKVAEALVEA ANHIDDIAGA LSKLSDLHAQ KLRVDPVNFK
110 120 130 140
LLGHCFLVVV AVHFPSLLTP EVHASLDKFV LAVGTVLTAK YR
Length:142
Mass (Da):15,273
Last modified:January 23, 2007 - v2
Checksum:iA4CE77962BBE6EFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → N in AAA49449 (PubMed:6689309).Curated1
Sequence conflicti14 – 20VFAKIGG → IFGKIAA in AAA49449 (PubMed:6689309).Curated7
Sequence conflicti16A → G in BAA19669 (PubMed:9177291).Curated1
Sequence conflicti29A → V in AAA49449 (PubMed:6689309).Curated1
Sequence conflicti130V → L (PubMed:6689309).Curated1
Sequence conflicti131L → C (PubMed:9177291).Curated1
Sequence conflicti131L → C (PubMed:6689309).Curated1
Sequence conflicti136V → P in AAA49449 (PubMed:6689309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56349 mRNA Translation: CAA39793.1
AB001981 Genomic DNA Translation: BAA19669.1
K01179 mRNA Translation: AAA49449.1
PIRiJC5514
RefSeqiXP_005508518.1, XM_005508461.1

Genome annotation databases

GeneIDi102090851
KEGGiclv:102090851

Similar proteinsi

Entry informationi

Entry nameiHBA_COLLI
AccessioniPrimary (citable) accession number: P21871
Secondary accession number(s): O12986, Q91249
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health