Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 142141Hemoglobin subunit alpha-APRO_0000052605Add
BLAST

Proteomic databases

PRIDEiP21871.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1814Combined sources
Turni19 – 213Combined sources
Helixi22 – 3615Combined sources
Helixi38 – 436Combined sources
Helixi54 – 7219Combined sources
Turni73 – 753Combined sources
Helixi77 – 804Combined sources
Helixi82 – 898Combined sources
Helixi97 – 11317Combined sources
Turni115 – 1173Combined sources
Helixi120 – 13718Combined sources
Helixi138 – 1414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R80X-ray1.44A/C2-142[»]
3DHRX-ray2.00A/C/E/G1-142[»]
3MJUX-ray3.50A2-142[»]
ProteinModelPortaliP21871.
SMRiP21871. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21871.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13822.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSANDKSN VKAVFAKIGG QAGDLGGEAL ERLFITYPQT KTYFPHFDLS
60 70 80 90 100
HGSAQIKGHG KKVAEALVEA ANHIDDIAGA LSKLSDLHAQ KLRVDPVNFK
110 120 130 140
LLGHCFLVVV AVHFPSLLTP EVHASLDKFV LAVGTVLTAK YR
Length:142
Mass (Da):15,273
Last modified:January 23, 2007 - v2
Checksum:iA4CE77962BBE6EFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91S → N in AAA49449 (PubMed:6689309).Curated
Sequence conflicti14 – 207VFAKIGG → IFGKIAA in AAA49449 (PubMed:6689309).Curated
Sequence conflicti16 – 161A → G in BAA19669 (PubMed:9177291).Curated
Sequence conflicti29 – 291A → V in AAA49449 (PubMed:6689309).Curated
Sequence conflicti130 – 1301V → L (PubMed:6689309).Curated
Sequence conflicti131 – 1311L → C (PubMed:9177291).Curated
Sequence conflicti131 – 1311L → C (PubMed:6689309).Curated
Sequence conflicti136 – 1361V → P in AAA49449 (PubMed:6689309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56349 mRNA. Translation: CAA39793.1.
AB001981 Genomic DNA. Translation: BAA19669.1.
K01179 mRNA. Translation: AAA49449.1.
PIRiJC5514.
RefSeqiXP_005508518.1. XM_005508461.1.

Genome annotation databases

GeneIDi102090851.
KEGGiclv:102090851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56349 mRNA. Translation: CAA39793.1.
AB001981 Genomic DNA. Translation: BAA19669.1.
K01179 mRNA. Translation: AAA49449.1.
PIRiJC5514.
RefSeqiXP_005508518.1. XM_005508461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R80X-ray1.44A/C2-142[»]
3DHRX-ray2.00A/C/E/G1-142[»]
3MJUX-ray3.50A2-142[»]
ProteinModelPortaliP21871.
SMRiP21871. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP21871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102090851.
KEGGiclv:102090851.

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13822.

Miscellaneous databases

EvolutionaryTraceiP21871.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete nucleotide sequence of a pigeon alpha-globin cDNA."
    Eguchi Y., Nakashima Y., Oshiro M., Takei H.
    Nucleic Acids Res. 18:7135-7135(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and sequencing of two alpha-globin genes alpha(A) and alpha(D) in pigeon and evidence for embryo-specific expression of the alpha(D)-globin gene."
    Ikehara T., Eguchi Y., Kayo S., Takei H.
    Biochem. Biophys. Res. Commun. 234:450-453(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Primary structure of hemoglobin alpha-chain of Columba livia (gray wild pigeon)."
    Sultana C., Abbasi A., Zaidi Z.H.
    J. Protein Chem. 8:629-646(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
  4. "Nucleotide sequence of the anemic pigeon alpha-globin gene. Structural rearrangements in the cloned cDNA."
    Pletnev A.G., Scobeleva N.A., Frolova L.Y., Kisselev L.L.
    Gene 25:93-100(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-136.

Entry informationi

Entry nameiHBA_COLLI
AccessioniPrimary (citable) accession number: P21871
Secondary accession number(s): O12986, Q91249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.