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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000526052 – 142Hemoglobin subunit alpha-AAdd BLAST141

Proteomic databases

PRIDEiP21871.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Turni19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi54 – 72Combined sources19
Turni73 – 75Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi97 – 113Combined sources17
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Helixi138 – 141Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R80X-ray1.44A/C2-142[»]
3DHRX-ray2.00A/C/E/G1-142[»]
3MJUX-ray3.50A2-142[»]
ProteinModelPortaliP21871.
SMRiP21871.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21871.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13822.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSANDKSN VKAVFAKIGG QAGDLGGEAL ERLFITYPQT KTYFPHFDLS
60 70 80 90 100
HGSAQIKGHG KKVAEALVEA ANHIDDIAGA LSKLSDLHAQ KLRVDPVNFK
110 120 130 140
LLGHCFLVVV AVHFPSLLTP EVHASLDKFV LAVGTVLTAK YR
Length:142
Mass (Da):15,273
Last modified:January 23, 2007 - v2
Checksum:iA4CE77962BBE6EFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → N in AAA49449 (PubMed:6689309).Curated1
Sequence conflicti14 – 20VFAKIGG → IFGKIAA in AAA49449 (PubMed:6689309).Curated7
Sequence conflicti16A → G in BAA19669 (PubMed:9177291).Curated1
Sequence conflicti29A → V in AAA49449 (PubMed:6689309).Curated1
Sequence conflicti130V → L (PubMed:6689309).Curated1
Sequence conflicti131L → C (PubMed:9177291).Curated1
Sequence conflicti131L → C (PubMed:6689309).Curated1
Sequence conflicti136V → P in AAA49449 (PubMed:6689309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56349 mRNA. Translation: CAA39793.1.
AB001981 Genomic DNA. Translation: BAA19669.1.
K01179 mRNA. Translation: AAA49449.1.
PIRiJC5514.
RefSeqiXP_005508518.1. XM_005508461.1.

Genome annotation databases

GeneIDi102090851.
KEGGiclv:102090851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56349 mRNA. Translation: CAA39793.1.
AB001981 Genomic DNA. Translation: BAA19669.1.
K01179 mRNA. Translation: AAA49449.1.
PIRiJC5514.
RefSeqiXP_005508518.1. XM_005508461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R80X-ray1.44A/C2-142[»]
3DHRX-ray2.00A/C/E/G1-142[»]
3MJUX-ray3.50A2-142[»]
ProteinModelPortaliP21871.
SMRiP21871.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP21871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102090851.
KEGGiclv:102090851.

Phylogenomic databases

HOVERGENiHBG009709.
KOiK13822.

Miscellaneous databases

EvolutionaryTraceiP21871.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_COLLI
AccessioniPrimary (citable) accession number: P21871
Secondary accession number(s): O12986, Q91249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.