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Protein

KDP operon transcriptional regulatory protein KdpE

Gene

kdpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi126 – 225OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:KDPE-MONOMER.
ECOL316407:JW5096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
KDP operon transcriptional regulatory protein KdpE
Gene namesi
Name:kdpE
Ordered Locus Names:b0694, JW5096
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10517. kdpE.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811131 – 225KDP operon transcriptional regulatory protein KdpEAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei524-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by KdpD.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21866.
PRIDEiP21866.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
kdpDP218655EBI-6403634,EBI-1123100
rstAP521082EBI-6403634,EBI-558990

Protein-protein interaction databases

BioGridi4259924. 3 interactors.
DIPiDIP-10063N.
IntActiP21866. 2 interactors.
STRINGi511145.b0694.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi11 – 22Combined sources12
Turni23 – 25Combined sources3
Beta strandi27 – 33Combined sources7
Helixi34 – 44Combined sources11
Beta strandi47 – 55Combined sources9
Beta strandi56 – 58Combined sources3
Helixi60 – 68Combined sources9
Beta strandi75 – 80Combined sources6
Helixi84 – 93Combined sources10
Beta strandi96 – 102Combined sources7
Helixi105 – 119Combined sources15
Beta strandi127 – 130Combined sources4
Beta strandi135 – 137Combined sources3
Turni138 – 141Combined sources4
Beta strandi142 – 145Combined sources4
Beta strandi148 – 150Combined sources3
Helixi154 – 165Combined sources12
Turni166 – 168Combined sources3
Beta strandi170 – 172Combined sources3
Helixi173 – 180Combined sources8
Beta strandi182 – 184Combined sources3
Helixi189 – 203Combined sources15
Beta strandi211 – 216Combined sources6
Turni217 – 219Combined sources3
Beta strandi220 – 223Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZH2X-ray2.00A/B1-121[»]
1ZH4X-ray2.20A/B1-121[»]
3ZQ7X-ray2.52A124-225[»]
4KFCX-ray2.53A/B3-225[»]
4KNYX-ray2.94A/B3-225[»]
4L85X-ray2.20A/B/C3-121[»]
ProteinModelPortaliP21866.
SMRiP21866.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21866.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EEX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP21866.
KOiK07667.
OMAiLEGEGCR.
PhylomeDBiP21866.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVLIVEDE QAIRRFLRTA LEGDGMRVFE AETLQRGLLE AATRKPDLII
60 70 80 90 100
LDLGLPDGDG IEFIRDLRQW SAVPVIVLSA RSEESDKIAA LDAGADDYLS
110 120 130 140 150
KPFGIGELQA RLRVALRRHS ATTAPDPLVK FSDVTVDLAA RVIHRGEEEV
160 170 180 190 200
HLTPIEFRLL AVLLNNAGKV LTQRQLLNQV WGPNAVEHSH YLRIYMGHLR
210 220
QKLEQDPARP RHFITETGIG YRFML
Length:225
Mass (Da):25,362
Last modified:November 1, 1997 - v3
Checksum:i6C2D029F82706F6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160 – 176LAVLL…TQRQL → AGRCSTMPEKYSPSGPV in AAA24042 (PubMed:1532388).CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36066 Genomic DNA. Translation: AAA24042.1.
U00096 Genomic DNA. Translation: AAC73788.1.
AP009048 Genomic DNA. Translation: BAA35351.2.
PIRiE64804.
RefSeqiNP_415222.1. NC_000913.3.
WP_000186076.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiAAC73788; AAC73788; b0694.
BAA35351; BAA35351; BAA35351.
GeneIDi945302.
KEGGiecj:JW5096.
eco:b0694.
PATRICi32116583. VBIEscCol129921_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36066 Genomic DNA. Translation: AAA24042.1.
U00096 Genomic DNA. Translation: AAC73788.1.
AP009048 Genomic DNA. Translation: BAA35351.2.
PIRiE64804.
RefSeqiNP_415222.1. NC_000913.3.
WP_000186076.1. NZ_CP014272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZH2X-ray2.00A/B1-121[»]
1ZH4X-ray2.20A/B1-121[»]
3ZQ7X-ray2.52A124-225[»]
4KFCX-ray2.53A/B3-225[»]
4KNYX-ray2.94A/B3-225[»]
4L85X-ray2.20A/B/C3-121[»]
ProteinModelPortaliP21866.
SMRiP21866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259924. 3 interactors.
DIPiDIP-10063N.
IntActiP21866. 2 interactors.
STRINGi511145.b0694.

Proteomic databases

PaxDbiP21866.
PRIDEiP21866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73788; AAC73788; b0694.
BAA35351; BAA35351; BAA35351.
GeneIDi945302.
KEGGiecj:JW5096.
eco:b0694.
PATRICi32116583. VBIEscCol129921_0724.

Organism-specific databases

EchoBASEiEB0512.
EcoGeneiEG10517. kdpE.

Phylogenomic databases

eggNOGiENOG4105EEX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP21866.
KOiK07667.
OMAiLEGEGCR.
PhylomeDBiP21866.

Enzyme and pathway databases

BioCyciEcoCyc:KDPE-MONOMER.
ECOL316407:JW5096-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP21866.
PROiP21866.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDPE_ECOLI
AccessioniPrimary (citable) accession number: P21866
Secondary accession number(s): P75739, P76822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.