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P21866 (KDPE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KDP operon transcriptional regulatory protein KdpE
Gene names
Name:kdpE
Ordered Locus Names:b0694, JW5096
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Ref.1

Subcellular location

Cytoplasm Ref.1.

Post-translational modification

Phosphorylated by KdpD Probable.

Sequence similarities

Contains 1 response regulatory domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225KDP operon transcriptional regulatory protein KdpE
PRO_0000081113

Regions

Domain1 – 116116Response regulatory

Amino acid modifications

Modified residue5214-aspartylphosphate By similarity

Experimental info

Sequence conflict160 – 17617LAVLL…TQRQL → AGRCSTMPEKYSPSGPV in AAA24042. Ref.1

Secondary structure

............................................ 225
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21866 [UniParc].

Last modified November 1, 1997. Version 3.
Checksum: 6C2D029F82706F6D

FASTA22525,362
        10         20         30         40         50         60 
MTNVLIVEDE QAIRRFLRTA LEGDGMRVFE AETLQRGLLE AATRKPDLII LDLGLPDGDG 

        70         80         90        100        110        120 
IEFIRDLRQW SAVPVIVLSA RSEESDKIAA LDAGADDYLS KPFGIGELQA RLRVALRRHS 

       130        140        150        160        170        180 
ATTAPDPLVK FSDVTVDLAA RVIHRGEEEV HLTPIEFRLL AVLLNNAGKV LTQRQLLNQV 

       190        200        210        220 
WGPNAVEHSH YLRIYMGHLR QKLEQDPARP RHFITETGIG YRFML 

« Hide

References

« Hide 'large scale' references
[1]"KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor-effector class of regulators."
Walderhaug M.O., Polarek J.W., Voelkner P., Daniel J.M., Hesse J.E., Altendorf K., Epstein W.
J. Bacteriol. 174:2152-2159(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
Strain: K12.
[2]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Escherichia coli proteome analysis using the gene-protein database."
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY 2D-GEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36066 Genomic DNA. Translation: AAA24042.1.
U00096 Genomic DNA. Translation: AAC73788.1.
AP009048 Genomic DNA. Translation: BAA35351.2.
PIRE64804.
RefSeqNP_415222.1. NC_000913.3.
YP_488974.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZH2X-ray2.00A/B1-121[»]
1ZH4X-ray2.20A/B1-121[»]
3ZQ7X-ray2.52A124-225[»]
4KFCX-ray2.53A/B3-225[»]
4KNYX-ray2.94A/B3-225[»]
4L85X-ray2.20A/B/C3-121[»]
ProteinModelPortalP21866.
SMRP21866. Positions 1-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-10063N.
IntActP21866. 2 interactions.
STRING511145.b0694.

Proteomic databases

PaxDbP21866.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73788; AAC73788; b0694.
BAA35351; BAA35351; BAA35351.
GeneID12930930.
945302.
KEGGecj:Y75_p0673.
eco:b0694.
PATRIC32116583. VBIEscCol129921_0724.

Organism-specific databases

EchoBASEEB0512.
EcoGeneEG10517. kdpE.

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07667.
OMAQPNLIQT.
OrthoDBEOG6G4VQG.
PhylomeDBP21866.

Enzyme and pathway databases

BioCycEcoCyc:KDPE-MONOMER.
ECOL316407:JW5096-MONOMER.
RETL1328306-WGS:GSTH-6121-MONOMER.

Gene expression databases

GenevestigatorP21866.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP21866.
PROP21866.

Entry information

Entry nameKDPE_ECOLI
AccessionPrimary (citable) accession number: P21866
Secondary accession number(s): P75739, P76822
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene