Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sensor protein KdpD

Gene

kdpD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  • aspartate kinase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • phosphorelay sensor kinase activity Source: EcoCyc

GO - Biological processi

  • detection of chemical stimulus Source: EcoCyc
  • osmosensory signaling via phosphorelay pathway Source: EcoCyc
  • protein autophosphorylation Source: EcoCyc

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:KDPD-MONOMER
BRENDAi2.7.13.3 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein KdpD (EC:2.7.13.3)
Gene namesi
Name:kdpD
Ordered Locus Names:b0695, JW0683
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10516 kdpD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 400CytoplasmicCuratedAdd BLAST400
Transmembranei401 – 423HelicalCuratedAdd BLAST23
Topological domaini424 – 427PeriplasmicCurated4
Transmembranei428 – 444HelicalCuratedAdd BLAST17
Topological domaini445CytoplasmicCurated1
Transmembranei446 – 466HelicalCuratedAdd BLAST21
Topological domaini467 – 474PeriplasmicCurated8
Transmembranei475 – 498HelicalCuratedAdd BLAST24
Topological domaini499 – 894CytoplasmicCuratedAdd BLAST396

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747721 – 894Sensor protein KdpDAdd BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei673Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21865
PRIDEiP21865

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4259925, 12 interactors
DIPiDIP-10062N
IntActiP21865, 5 interactors
STRINGi316385.ECDH10B_0761

Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi399 – 401Combined sources3
Helixi402 – 420Combined sources19
Helixi430 – 443Combined sources14
Helixi450 – 461Combined sources12
Helixi475 – 498Combined sources24
Helixi515 – 523Combined sources9
Helixi528 – 543Combined sources16
Beta strandi545 – 552Combined sources8
Helixi572 – 581Combined sources10
Beta strandi589 – 592Combined sources4
Beta strandi595 – 604Combined sources10
Beta strandi607 – 617Combined sources11
Helixi619 – 622Combined sources4
Helixi625 – 646Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSFNMR-A397-502[»]
4QPRX-ray1.55A515-646[»]
4Y2FX-ray1.40A515-646[»]
ProteinModelPortaliP21865
SMRiP21865
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21865

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini670 – 883Histidine kinasePROSITE-ProRule annotationAdd BLAST214

Sequence similaritiesi

In the central section; belongs to the universal stress protein A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C08 Bacteria
COG2205 LUCA
HOGENOMiHOG000082933
InParanoidiP21865
KOiK07646
OMAiLWATAFQ
PhylomeDBiP21865

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di1.20.120.620, 1 hit
3.30.450.40, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR038318 KdpD_sf
IPR025201 KdpD_TM
IPR004358 Sig_transdc_His_kin-like_C
IPR003852 Sig_transdc_His_kinase_KdpD_N
PfamiView protein in Pfam
PF13493 DUF4118, 1 hit
PF13492 GAF_3, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF02702 KdpD, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

P21865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNEPLRPDP DRLLEQTAAP HRGKLKVFFG ACAGVGKTWA MLAEAQRLRA
60 70 80 90 100
QGLDIVVGVV ETHGRKDTAA MLEGLAVLPL KRQAYRGRHI SEFDLDAALA
110 120 130 140 150
RRPALILMDE LAHSNAPGSR HPKRWQDIEE LLEAGIDVFT TVNVQHLESL
160 170 180 190 200
NDVVSGVTGI QVRETVPDPF FDAADDVVLV DLPPDDLRQR LKEGKVYIAG
210 220 230 240 250
QAERAIEHFF RKGNLIALRE LALRRTADRV DEQMRAWRGH PGEEKVWHTR
260 270 280 290 300
DAILLCIGHN TGSEKLVRAA ARLASRLGSV WHAVYVETPA LHRLPEKKRR
310 320 330 340 350
AILSALRLAQ ELGAETATLS DPAEEKAVVR YAREHNLGKI ILGRPASRRW
360 370 380 390 400
WRRETFADRL ARIAPDLDQV LVALDEPPAR TINNAPDNRS FKDKWRVQIQ
410 420 430 440 450
GCVVAAALCA VITLIAMQWL MAFDAANLVM LYLLGVVVVA LFYGRWPSVV
460 470 480 490 500
ATVINVVSFD LFFIAPRGTL AVSDVQYLLT FAVMLTVGLV IGNLTAGVRY
510 520 530 540 550
QARVARYREQ RTRHLYEMSK ALAVGRSPQD IAATSEQFIA STFHARSQVL
560 570 580 590 600
LPDDNGKLQP LTHPQGMTPW DDAIAQWSFD KGLPAGAGTD TLPGVPYQIL
610 620 630 640 650
PLKSGEKTYG LVVVEPGNLR QLMIPEQQRL LETFTLLVAN ALERLTLTAS
660 670 680 690 700
EEQARMASER EQIRNALLAA LSHDLRTPLT VLFGQAEILT LDLASEGSPH
710 720 730 740 750
ARQASEIRQH VLNTTRLVNN LLDMARIQSG GFNLKKEWLT LEEVVGSALQ
760 770 780 790 800
MLEPGLSSPI NLSLPEPLTL IHVDGPLFER VLINLLENAV KYAGAQAEIG
810 820 830 840 850
IDAHVEGENL QLDVWDNGPG LPPGQEQTIF DKFARGNKES AVPGVGLGLA
860 870 880 890
ICRAIVDVHG GTITAFNRPE GGACFRVTLP QQTAPELEEF HEDM
Length:894
Mass (Da):98,718
Last modified:February 1, 1996 - v2
Checksum:iE9D2749B4CAA12DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36066 Genomic DNA Translation: AAA24041.1
U00096 Genomic DNA Translation: AAC73789.1
AP009048 Genomic DNA Translation: BAA35352.1
PIRiB42372
RefSeqiNP_415223.1, NC_000913.3
WP_001310640.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73789; AAC73789; b0695
BAA35352; BAA35352; BAA35352
GeneIDi946744
KEGGiecj:JW0683
eco:b0695
PATRICifig|1411691.4.peg.1580

Entry informationi

Entry nameiKDPD_ECOLI
AccessioniPrimary (citable) accession number: P21865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health