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P21859

- VM2T_PROFL

UniProt

P21859 - VM2T_PROFL

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Protein

Disintegrin triflavin

Gene
N/A
Organism
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.

Keywords - Molecular functioni

Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin triflavin
Alternative name(s):
Platelet aggregation activation inhibitor
RGD-containing peptide
Trimestatin
OrganismiProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifieri88087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Disintegrin triflavinPRO_0000101810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 191 PublicationPROSITE-ProRule annotation
Disulfide bondi6 ↔ 141 PublicationPROSITE-ProRule annotation
Disulfide bondi13 ↔ 361 PublicationPROSITE-ProRule annotation
Disulfide bondi27 ↔ 331 PublicationPROSITE-ProRule annotation
Disulfide bondi32 ↔ 571 PublicationPROSITE-ProRule annotation
Disulfide bondi45 ↔ 641 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

Secondary structure

1
70
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni16 – 183
Beta strandi19 – 213
Beta strandi28 – 303
Beta strandi44 – 463
Beta strandi49 – 524

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2LX-ray1.70A1-70[»]
ProteinModelPortaliP21859.
SMRiP21859. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21859.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7070DisintegrinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 513Cell attachment site

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiIPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
[Graphical view]
PfamiPF00200. Disintegrin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21859-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GEECDCGSPS NPCCDAATCK LRPGAQCADG LCCDQCRFKK KRTICRIARG
60 70
DFPDDRCTGQ SADCPRWNGL
Length:70
Mass (Da):7,576
Last modified:May 1, 1991 - v1
Checksum:iD8D256789E903415
GO

Sequence databases

PIRiA58649.

Cross-referencesi

Sequence databases

PIRi A58649.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J2L X-ray 1.70 A 1-70 [» ]
ProteinModelPortali P21859.
SMRi P21859. Positions 1-68.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005487.

Miscellaneous databases

EvolutionaryTracei P21859.

Family and domain databases

Gene3Di 4.10.70.10. 1 hit.
InterProi IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
[Graphical view ]
Pfami PF00200. Disintegrin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Triflavin, an antiplatelet Arg-Gly-Asp-containing peptide, is a specific antagonist of platelet membrane glycoprotein IIb-IIIa complex."
    Huang T.-F., Sheu J.-R., Teng C.-M., Chen S.-W., Liu C.-S.
    J. Biochem. 109:328-334(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.
  2. "A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom."
    Huang T.-F., Sheu J.-R., Teng C.-M.
    Biochem. J. 277:351-357(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-17.
    Tissue: Venom.
  3. "Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD."
    Fujii Y., Okuda D., Fujimoto Z., Horii K., Morita T., Mizuno H.
    J. Mol. Biol. 332:1115-1122(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), DISULFIDE BONDS.

Entry informationi

Entry nameiVM2T_PROFL
AccessioniPrimary (citable) accession number: P21859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3