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P21859 (VM2T_PROFL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disintegrin triflavin
Alternative name(s):
Platelet aggregation activation inhibitor
RGD-containing peptide
Trimestatin
OrganismProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifier88087 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-2b/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

Sequence similarities

Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.

Contains 1 disintegrin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7070Disintegrin triflavin
PRO_0000101810

Regions

Domain1 – 7070Disintegrin
Motif49 – 513Cell attachment site

Amino acid modifications

Disulfide bond4 ↔ 19 Ref.3
Disulfide bond6 ↔ 14 Ref.3
Disulfide bond13 ↔ 36 Ref.3
Disulfide bond27 ↔ 33 Ref.3
Disulfide bond32 ↔ 57 Ref.3
Disulfide bond45 ↔ 64 Ref.3

Secondary structure

.......... 70
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21859 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: D8D256789E903415

FASTA707,576
        10         20         30         40         50         60 
GEECDCGSPS NPCCDAATCK LRPGAQCADG LCCDQCRFKK KRTICRIARG DFPDDRCTGQ 

        70 
SADCPRWNGL 

« Hide

References

[1]"Triflavin, an antiplatelet Arg-Gly-Asp-containing peptide, is a specific antagonist of platelet membrane glycoprotein IIb-IIIa complex."
Huang T.-F., Sheu J.-R., Teng C.-M., Chen S.-W., Liu C.-S.
J. Biochem. 109:328-334(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom."
Huang T.-F., Sheu J.-R., Teng C.-M.
Biochem. J. 277:351-357(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-17.
Tissue: Venom.
[3]"Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD."
Fujii Y., Okuda D., Fujimoto Z., Horii K., Morita T., Mizuno H.
J. Mol. Biol. 332:1115-1122(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), DISULFIDE BONDS.

Cross-references

Sequence databases

PIRA58649.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2LX-ray1.70A1-70[»]
ProteinModelPortalP21859.
SMRP21859. Positions 1-68.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005487.

Family and domain databases

Gene3D4.10.70.10. 1 hit.
InterProIPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
[Graphical view]
PfamPF00200. Disintegrin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
SMARTSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMSSF57552. SSF57552. 1 hit.
PROSITEPS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP21859.

Entry information

Entry nameVM2T_PROFL
AccessionPrimary (citable) accession number: P21859
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: December 11, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references