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P21859

- VM2T_PROFL

UniProt

P21859 - VM2T_PROFL

Protein

Disintegrin triflavin

Gene
N/A
Organism
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.

    Keywords - Molecular functioni

    Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin triflavin
    Alternative name(s):
    Platelet aggregation activation inhibitor
    RGD-containing peptide
    Trimestatin
    OrganismiProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
    Taxonomic identifieri88087 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070Disintegrin triflavinPRO_0000101810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 191 PublicationPROSITE-ProRule annotation
    Disulfide bondi6 ↔ 141 PublicationPROSITE-ProRule annotation
    Disulfide bondi13 ↔ 361 PublicationPROSITE-ProRule annotation
    Disulfide bondi27 ↔ 331 PublicationPROSITE-ProRule annotation
    Disulfide bondi32 ↔ 571 PublicationPROSITE-ProRule annotation
    Disulfide bondi45 ↔ 641 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    Secondary structure

    1
    70
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni16 – 183
    Beta strandi19 – 213
    Beta strandi28 – 303
    Beta strandi44 – 463
    Beta strandi49 – 524

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J2LX-ray1.70A1-70[»]
    ProteinModelPortaliP21859.
    SMRiP21859. Positions 1-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP21859.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7070DisintegrinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 513Cell attachment site

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG005487.

    Family and domain databases

    Gene3Di4.10.70.10. 1 hit.
    InterProiIPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    [Graphical view]
    PfamiPF00200. Disintegrin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21859-1 [UniParc]FASTAAdd to Basket

    « Hide

    GEECDCGSPS NPCCDAATCK LRPGAQCADG LCCDQCRFKK KRTICRIARG   50
    DFPDDRCTGQ SADCPRWNGL 70
    Length:70
    Mass (Da):7,576
    Last modified:May 1, 1991 - v1
    Checksum:iD8D256789E903415
    GO

    Sequence databases

    PIRiA58649.

    Cross-referencesi

    Sequence databases

    PIRi A58649.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J2L X-ray 1.70 A 1-70 [» ]
    ProteinModelPortali P21859.
    SMRi P21859. Positions 1-68.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005487.

    Miscellaneous databases

    EvolutionaryTracei P21859.

    Family and domain databases

    Gene3Di 4.10.70.10. 1 hit.
    InterProi IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    [Graphical view ]
    Pfami PF00200. Disintegrin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Triflavin, an antiplatelet Arg-Gly-Asp-containing peptide, is a specific antagonist of platelet membrane glycoprotein IIb-IIIa complex."
      Huang T.-F., Sheu J.-R., Teng C.-M., Chen S.-W., Liu C.-S.
      J. Biochem. 109:328-334(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom."
      Huang T.-F., Sheu J.-R., Teng C.-M.
      Biochem. J. 277:351-357(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-17.
      Tissue: Venom.
    3. "Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD."
      Fujii Y., Okuda D., Fujimoto Z., Horii K., Morita T., Mizuno H.
      J. Mol. Biol. 332:1115-1122(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), DISULFIDE BONDS.

    Entry informationi

    Entry nameiVM2T_PROFL
    AccessioniPrimary (citable) accession number: P21859
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The disintegrin belongs to the medium disintegrin subfamily.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3