P21854 (CD72_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-cell differentiation antigen CD72

Alternative name(s):
Lyb-2
CD_antigen=CD72

Gene names

Name:

CD72

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in B-cell proliferation and differentiation.
Subunit structure	Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Post-translational modification	Phosphorylated upon engagement of the B cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 By similarity.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	axon guidance Traceable author statement. Source: Reactome cell adhesion Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Inferred from direct assay. Source: UniProtKB
Molecular function	receptor binding Traceable author statement. Source: ProtInc sugar binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane signaling receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	B-cell differentiation antigen CD72		PRO_0000046585
Regions
	Topological domain	1 – 95	95	Cytoplasmic Potential
	Transmembrane	96 – 116	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	117 – 359	243	Extracellular Potential
	Domain	232 – 352	121	C-type lectin
Amino acid modifications
	Modified residue	7	1	Phosphotyrosine; by LYN By similarity
	Modified residue	39	1	Phosphotyrosine; by LYN By similarity
	Glycosylation	136	1	N-linked (GlcNAc...) Potential
	Disulfide bond	233 ↔ 244		By similarity
	Disulfide bond	261 ↔ 350		By similarity
	Disulfide bond	325 ↔ 342		By similarity
Natural variations
	Natural variant	234	1	P → L. Corresponds to variant rs34791102 [ dbSNP | Ensembl ].		VAR_033729

Sequences

	Sequence		Length	Mass (Da)
	P21854 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 87A52C028AC17E44	FASTA	359	40,220
	10 20 30 40 50 60 MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG 70 80 90 100 110 120 DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ 130 140 150 160 170 180 VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA 190 200 210 220 230 240 AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH 250 260 270 280 290 300 QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG 310 320 330 340 350 LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA." von Hoegen I., Nakayama E., Parnes J.R. J. Immunol. 144:4870-4877(1990) [PubMed: 2141045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

CD72

Cross-references

Sequence databases
EMBL GenBank DDBJ	M54992 mRNA. Translation: AAA36189.1. BC030227 mRNA. Translation: AAH30227.1.
IPI	IPI00010851.
PIR	A43532.
RefSeq	NP_001773.1. NM_001782.2.
UniGene	Hs.116481.
3D structure databases
ProteinModelPortal	P21854.
SMR	P21854. Positions 232-354.
ModBase	Search...
Protein-protein interaction databases
IntAct	P21854. 1 interaction.
STRING	P21854.
PTM databases
PhosphoSite	P21854.
Polymorphism databases
DMDM	116029.
Proteomic databases
PRIDE	P21854.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259633; ENSP00000259633; ENSG00000137101. ENST00000396757; ENSP00000379980; ENSG00000137101.
GeneID	971.
KEGG	hsa:971.
UCSC	uc003zxb.1. human.
Organism-specific databases
CTD	971.
GeneCards	GC09M035599.
H-InvDB	HIX0008016.
HGNC	HGNC:1696. CD72.
HPA	CAB002505.
MIM	107272. gene.
neXtProt	NX_P21854.
PharmGKB	PA26235.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11019.
HOGENOM	HBG126416.
HOVERGEN	HBG002477.
InParanoid	P21854.
OMA	ICEMTAF.
OrthoDB	EOG473PSC.
PhylomeDB	P21854.
Enzyme and pathway databases
Pathway_Interaction_DB	bcr_5pathway. BCR signaling pathway.
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P21854.
Bgee	P21854.
CleanEx	HS_CD72.
Genevestigator	P21854.
GermOnline	ENSG00000137101. Homo sapiens.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
KO	K06504.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	4064.
SOURCE	Search...

Entry information

Entry name

CD72_HUMAN

Accession

Primary (citable) accession number: P21854

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	December 14, 2011
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.