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Protein

B-cell differentiation antigen CD72

Gene

CD72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in B-cell proliferation and differentiation.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor binding Source: ProtInc
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-416700. Other semaphorin interactions.
SIGNORiP21854.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell differentiation antigen CD72
Alternative name(s):
Lyb-2
CD_antigen: CD72
Gene namesi
Name:CD72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1696. CD72.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini117 – 359243ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26235.

Polymorphism and mutation databases

BioMutaiCD72.
DMDMi116029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359B-cell differentiation antigen CD72PRO_0000046585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphotyrosine; by LYNBy similarity
Modified residuei39 – 391Phosphotyrosine; by LYNBy similarity
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi233 ↔ 244PROSITE-ProRule annotation
Disulfide bondi261 ↔ 350PROSITE-ProRule annotation
Disulfide bondi325 ↔ 342PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21854.
PRIDEiP21854.

PTM databases

iPTMnetiP21854.
PhosphoSiteiP21854.
SwissPalmiP21854.

Expressioni

Tissue specificityi

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Gene expression databases

BgeeiP21854.
CleanExiHS_CD72.
ExpressionAtlasiP21854. baseline and differential.
GenevisibleiP21854. HS.

Organism-specific databases

HPAiCAB002505.
HPA044658.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi107409. 9 interactions.
IntActiP21854. 1 interaction.
STRINGi9606.ENSP00000259633.

Structurei

3D structure databases

ProteinModelPortaliP21854.
SMRiP21854. Positions 233-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 352121C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000231523.
HOVERGENiHBG002477.
InParanoidiP21854.
KOiK06504.
OMAiHQKSCFY.
OrthoDBiEOG7W1553.
PhylomeDBiP21854.
TreeFamiTF337121.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV
60 70 80 90 100
PSSLASSVLG DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL
110 120 130 140 150
LLTCLLLGVT AICLGVRYLQ VSQQLQQTNR VLEVTNSSLR QQLRLKITQL
160 170 180 190 200
GQSAEDLQGS RRELAQSQEA LQVEQRAHQA AEGQLQACQA DRQKTKETLQ
210 220 230 240 250
SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH QKSCFYISLT
260 270 280 290 300
SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG
310 320 330 340 350
LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC

EMTAFRFPD
Length:359
Mass (Da):40,220
Last modified:May 1, 1991 - v1
Checksum:i87A52C028AC17E44
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341P → L.
Corresponds to variant rs34791102 [ dbSNP | Ensembl ].
VAR_033729

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54992 mRNA. Translation: AAA36189.1.
BC030227 mRNA. Translation: AAH30227.1.
CCDSiCCDS6581.1.
PIRiA43532.
RefSeqiNP_001773.1. NM_001782.2.
UniGeneiHs.116481.

Genome annotation databases

EnsembliENST00000259633; ENSP00000259633; ENSG00000137101.
ENST00000396757; ENSP00000379980; ENSG00000137101.
GeneIDi971.
KEGGihsa:971.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54992 mRNA. Translation: AAA36189.1.
BC030227 mRNA. Translation: AAH30227.1.
CCDSiCCDS6581.1.
PIRiA43532.
RefSeqiNP_001773.1. NM_001782.2.
UniGeneiHs.116481.

3D structure databases

ProteinModelPortaliP21854.
SMRiP21854. Positions 233-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107409. 9 interactions.
IntActiP21854. 1 interaction.
STRINGi9606.ENSP00000259633.

PTM databases

iPTMnetiP21854.
PhosphoSiteiP21854.
SwissPalmiP21854.

Polymorphism and mutation databases

BioMutaiCD72.
DMDMi116029.

Proteomic databases

PaxDbiP21854.
PRIDEiP21854.

Protocols and materials databases

DNASUi971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259633; ENSP00000259633; ENSG00000137101.
ENST00000396757; ENSP00000379980; ENSG00000137101.
GeneIDi971.
KEGGihsa:971.

Organism-specific databases

CTDi971.
GeneCardsiCD72.
HGNCiHGNC:1696. CD72.
HPAiCAB002505.
HPA044658.
MIMi107272. gene.
neXtProtiNX_P21854.
PharmGKBiPA26235.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000231523.
HOVERGENiHBG002477.
InParanoidiP21854.
KOiK06504.
OMAiHQKSCFY.
OrthoDBiEOG7W1553.
PhylomeDBiP21854.
TreeFamiTF337121.

Enzyme and pathway databases

ReactomeiR-HSA-416700. Other semaphorin interactions.
SIGNORiP21854.

Miscellaneous databases

GenomeRNAii971.
PROiP21854.
SOURCEiSearch...

Gene expression databases

BgeeiP21854.
CleanExiHS_CD72.
ExpressionAtlasiP21854. baseline and differential.
GenevisibleiP21854. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA."
    von Hoegen I., Nakayama E., Parnes J.R.
    J. Immunol. 144:4870-4877(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiCD72_HUMAN
AccessioniPrimary (citable) accession number: P21854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 8, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.