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Protein

Pulmonary surfactant-associated protein C

Gene

Sftpc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein C
Short name:
SP-C
Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Val)
SP5
Gene namesi
Name:Sftpc
Synonyms:Sftp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109517. Sftpc.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2323PRO_0000033483Add
BLAST
Chaini24 – 5835Pulmonary surfactant-associated protein CPRO_0000033484Add
BLAST
Propeptidei59 – 193135PRO_0000033485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi28 – 281S-palmitoyl cysteineBy similarity
Lipidationi29 – 291S-palmitoyl cysteineBy similarity
Disulfide bondi121 ↔ 185By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21841.
PRIDEiP21841.

PTM databases

PhosphoSiteiP21841.

Expressioni

Gene expression databases

CleanExiMM_SFTPC.

Interactioni

Protein-protein interaction databases

IntActiP21841. 1 interaction.
MINTiMINT-4109026.
STRINGi10090.ENSMUSP00000022692.

Structurei

3D structure databases

ProteinModelPortaliP21841.
SMRiP21841. Positions 90-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 193100BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IY85. Eukaryota.
ENOG41118MZ. LUCA.
HOGENOMiHOG000115746.
HOVERGENiHBG000160.
InParanoidiP21841.
PhylomeDBiP21841.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
IPR001729. SP-C.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMITOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMSSKEVLM ESPPDYSAGP RSQFRIPCCP VHLKRLLIVV VVVVLVVVVI
60 70 80 90 100
VGALLMGLHM SQKHTEMVLE MSIGAPETQK RLAPSERADT IATFSIGSTG
110 120 130 140 150
IVVYDYQRLL TAYKPAPGTY CYIMKMAPES IPSLEAFARK LQNFRAKPST
160 170 180 190
PTSKLGQEEG HDTGSESDSS GRDLAFLGLA VSTLCGELPL YYI
Length:193
Mass (Da):21,055
Last modified:May 1, 1991 - v1
Checksum:i10CCD91889AC8301
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38314 Genomic DNA. Translation: AAA40010.1.
CCDSiCCDS27254.1.
PIRiA36534.
UniGeneiMm.24040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38314 Genomic DNA. Translation: AAA40010.1.
CCDSiCCDS27254.1.
PIRiA36534.
UniGeneiMm.24040.

3D structure databases

ProteinModelPortaliP21841.
SMRiP21841. Positions 90-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21841. 1 interaction.
MINTiMINT-4109026.
STRINGi10090.ENSMUSP00000022692.

PTM databases

PhosphoSiteiP21841.

Proteomic databases

PaxDbiP21841.
PRIDEiP21841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109517. Sftpc.

Phylogenomic databases

eggNOGiENOG410IY85. Eukaryota.
ENOG41118MZ. LUCA.
HOGENOMiHOG000115746.
HOVERGENiHBG000160.
InParanoidiP21841.
PhylomeDBiP21841.

Miscellaneous databases

PROiP21841.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SFTPC.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
IPR001729. SP-C.
IPR018051. SP-C_palmitoylation_site.
IPR015091. Surfactant_protein_propep.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
PF08999. SP_C-Propep. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
SM00019. SF_P. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
PS00341. SURFACT_PALMITOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse."
    Glasser S.W., Korehagen T.R., Bruno M.D., Dey C., Whitsett J.A.
    J. Biol. Chem. 265:21986-21991(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiPSPC_MOUSE
AccessioniPrimary (citable) accession number: P21841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.