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P21818

- STMN2_RAT

UniProt

P21818 - STMN2_RAT

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Protein

Stathmin-2

Gene

Stmn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.3 Publications

GO - Biological processi

  1. cellular response to nerve growth factor stimulus Source: UniProtKB
  2. negative regulation of microtubule depolymerization Source: Ensembl
  3. negative regulation of microtubule polymerization Source: UniProtKB
  4. negative regulation of neuron projection development Source: Ensembl
  5. positive regulation of microtubule depolymerization Source: Ensembl
  6. positive regulation of neuron projection development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-2
Alternative name(s):
Superior cervical ganglion-10 protein
Short name:
Protein SCG10
Gene namesi
Name:Stmn2
Synonyms:Scg10, Scgn10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi68947. Stmn2.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region. Cell projectiongrowth cone. Cell projectionaxon. Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Golgi apparatus. Endosome. Cell projectionlamellipodium By similarity
Note: Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB-KW
  3. Golgi apparatus Source: RGD
  4. growth cone Source: RGD
  5. lamellipodium Source: UniProtKB
  6. membrane Source: UniProtKB-KW
  7. neuronal cell body Source: UniProtKB
  8. neuron projection Source: UniProtKB
  9. perinuclear region of cytoplasm Source: Ensembl
  10. vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi62 – 621S → A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-73. 1 Publication
Mutagenesisi62 – 621S → D: Increased microtubule stability but no effect on neurite length; when associated with A-73. 1 Publication
Mutagenesisi73 – 731S → A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-62. 1 Publication
Mutagenesisi73 – 731S → D: Increased microtubule stability but no effect on neurite length; when associated with A-62. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Stathmin-2PRO_0000182398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineSequence Analysis
Lipidationi22 – 221S-palmitoyl cysteineBy similarity
Lipidationi24 – 241S-palmitoyl cysteineBy similarity
Modified residuei50 – 501PhosphoserineSequence Analysis
Modified residuei62 – 621Phosphoserine; by MAPK81 Publication
Modified residuei73 – 731Phosphoserine; by MAPK81 Publication
Modified residuei80 – 801PhosphoserineSequence Analysis
Modified residuei97 – 971PhosphoserineSequence Analysis

Post-translational modificationi

Sumoylated.By similarity
Pphosphorylated by MAPK9 and MAPK10 in the developing brain cortex (By similarity). Phosphorylated mostly by MAPK8.By similarity1 Publication
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP21818.
PRIDEiP21818.

PTM databases

PhosphoSiteiP21818.

Expressioni

Tissue specificityi

Expressed in neurons (at protein level). Present in growth cones and abundant in developing neurons.1 Publication

Developmental stagei

In the developing cerebellum, maximal levels occur at postnatal day 7 and correlate with the onset of neuronal differentiation.

Inductioni

By nerve growth factor.

Gene expression databases

GenevestigatoriP21818.

Interactioni

Subunit structurei

Interacts with ITM2C (By similarity). Interacts with MAPK8. Interacts with KIAA1279 (By similarity). Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056024.

Structurei

3D structure databases

ProteinModelPortaliP21818.
SMRiP21818. Positions 40-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 179142SLDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2626Membrane attachmentSequence AnalysisAdd
BLAST
Regioni39 – 9658Regulatory/phosphorylation domainSequence AnalysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG71188.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP21818.
OMAiDQIKENR.
OrthoDBiEOG744TBN.

Family and domain databases

InterProiIPR026729. Stathmin-2.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21818-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS
60 70 80 90 100
GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEGRRKSQEA
110 120 130 140 150
QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL
160 170
AAIIERLQEK ERHAAEVRRN KELQVELSG
Length:179
Mass (Da):20,756
Last modified:April 13, 2004 - v2
Checksum:i8B827AA3977E61B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591K → L no nucleotide entry (PubMed:3272176)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306458 mRNA. Translation: AAG33230.1.
BC087660 mRNA. Translation: AAH87660.1.
PIRiA36110.
RefSeqiNP_445892.1. NM_053440.2.
UniGeneiRn.34335.

Genome annotation databases

EnsembliENSRNOT00000015720; ENSRNOP00000015720; ENSRNOG00000011705.
GeneIDi84510.
KEGGirno:84510.
UCSCiRGD:68947. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306458 mRNA. Translation: AAG33230.1 .
BC087660 mRNA. Translation: AAH87660.1 .
PIRi A36110.
RefSeqi NP_445892.1. NM_053440.2.
UniGenei Rn.34335.

3D structure databases

ProteinModelPortali P21818.
SMRi P21818. Positions 40-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000056024.

PTM databases

PhosphoSitei P21818.

Proteomic databases

PaxDbi P21818.
PRIDEi P21818.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015720 ; ENSRNOP00000015720 ; ENSRNOG00000011705 .
GeneIDi 84510.
KEGGi rno:84510.
UCSCi RGD:68947. rat.

Organism-specific databases

CTDi 11075.
RGDi 68947. Stmn2.

Phylogenomic databases

eggNOGi NOG71188.
GeneTreei ENSGT00390000003691.
HOGENOMi HOG000013197.
HOVERGENi HBG054037.
InParanoidi P21818.
OMAi DQIKENR.
OrthoDBi EOG744TBN.

Miscellaneous databases

NextBioi 617089.
PROi P21818.

Gene expression databases

Genevestigatori P21818.

Family and domain databases

InterProi IPR026729. Stathmin-2.
IPR000956. Stathmin_fam.
[Graphical view ]
PANTHERi PTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
Pfami PF00836. Stathmin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002285. Stathmin. 1 hit.
PRINTSi PR00345. STATHMIN.
SUPFAMi SSF101494. SSF101494. 1 hit.
PROSITEi PS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons."
    Stein R., Mori N., Matthews K., Lo L.-C., Anderson D.J.
    Neuron 1:463-476(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel genes expressed in rat dorsal root ganglion."
    Xiao H., Huang Q., Zhang F., Yang Z., Chen Z., Han Z., Zhang X.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: FUNCTION.
  5. "JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length."
    Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J., Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T.
    J. Cell Biol. 173:265-277(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-62 AND SER-73, INTERACTION WITH MAPK8, MUTAGENESIS OF SER-62 AND SER-73.
  6. "Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth."
    Sobczak A., Debowska K., Blazejczyk M., Kreutz M.R., Kuznicki J., Wojda U.
    Biochim. Biophys. Acta 1813:1025-1037(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: FUNCTION.

Entry informationi

Entry nameiSTMN2_RAT
AccessioniPrimary (citable) accession number: P21818
Secondary accession number(s): Q9ERH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3