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P21818

- STMN2_RAT

UniProt

P21818 - STMN2_RAT

Protein

Stathmin-2

Gene

Stmn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.3 Publications

    GO - Molecular functioni

    1. protein binding Source: RGD

    GO - Biological processi

    1. cellular response to nerve growth factor stimulus Source: UniProtKB
    2. negative regulation of microtubule depolymerization Source: Ensembl
    3. negative regulation of microtubule polymerization Source: UniProtKB
    4. negative regulation of neuron projection development Source: Ensembl
    5. positive regulation of microtubule depolymerization Source: Ensembl
    6. positive regulation of neuron projection development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stathmin-2
    Alternative name(s):
    Superior cervical ganglion-10 protein
    Short name:
    Protein SCG10
    Gene namesi
    Name:Stmn2
    Synonyms:Scg10, Scgn10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi68947. Stmn2.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region. Cell projectiongrowth cone. Cell projectionaxon. Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Golgi apparatus. Endosome. Cell projectionlamellipodium By similarity
    Note: Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia By similarity. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB
    3. endosome Source: UniProtKB-SubCell
    4. Golgi apparatus Source: RGD
    5. growth cone Source: RGD
    6. lamellipodium Source: UniProtKB
    7. membrane Source: UniProtKB-SubCell
    8. neuronal cell body Source: UniProtKB
    9. neuron projection Source: UniProtKB
    10. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    11. vesicle Source: RGD

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi62 – 621S → A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-73. 1 Publication
    Mutagenesisi62 – 621S → D: Increased microtubule stability but no effect on neurite length; when associated with A-73. 1 Publication
    Mutagenesisi73 – 731S → A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-62. 1 Publication
    Mutagenesisi73 – 731S → D: Increased microtubule stability but no effect on neurite length; when associated with A-62. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Stathmin-2PRO_0000182398Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161PhosphoserineSequence Analysis
    Lipidationi22 – 221S-palmitoyl cysteineBy similarity
    Lipidationi24 – 241S-palmitoyl cysteineBy similarity
    Modified residuei50 – 501PhosphoserineSequence Analysis
    Modified residuei62 – 621Phosphoserine; by MAPK81 Publication
    Modified residuei73 – 731Phosphoserine; by MAPK81 Publication
    Modified residuei80 – 801PhosphoserineSequence Analysis
    Modified residuei97 – 971PhosphoserineSequence Analysis

    Post-translational modificationi

    Sumoylated.By similarity
    Pphosphorylated by MAPK9 and MAPK10 in the developing brain cortex By similarity. Phosphorylated mostly by MAPK8.By similarity1 Publication
    N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP21818.
    PRIDEiP21818.

    PTM databases

    PhosphoSiteiP21818.

    Expressioni

    Tissue specificityi

    Expressed in neurons (at protein level). Present in growth cones and abundant in developing neurons.1 Publication

    Developmental stagei

    In the developing cerebellum, maximal levels occur at postnatal day 7 and correlate with the onset of neuronal differentiation.

    Inductioni

    By nerve growth factor.

    Gene expression databases

    GenevestigatoriP21818.

    Interactioni

    Subunit structurei

    Interacts with ITM2C By similarity. Interacts with MAPK8. Interacts with KIAA1279 By similarity. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000056024.

    Structurei

    3D structure databases

    ProteinModelPortaliP21818.
    SMRiP21818. Positions 40-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 179142SLDPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2626Membrane attachmentSequence AnalysisAdd
    BLAST
    Regioni39 – 9658Regulatory/phosphorylation domainSequence AnalysisAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili75 – 179105Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the stathmin family.Curated
    Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG71188.
    GeneTreeiENSGT00390000003691.
    HOGENOMiHOG000013197.
    HOVERGENiHBG054037.
    OMAiDQIKENR.
    OrthoDBiEOG744TBN.

    Family and domain databases

    InterProiIPR026729. Stathmin-2.
    IPR000956. Stathmin_fam.
    [Graphical view]
    PANTHERiPTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF18. PTHR10104:SF18. 1 hit.
    PfamiPF00836. Stathmin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002285. Stathmin. 1 hit.
    PRINTSiPR00345. STATHMIN.
    SUPFAMiSSF101494. SSF101494. 1 hit.
    PROSITEiPS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21818-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS    50
    GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEGRRKSQEA 100
    QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL 150
    AAIIERLQEK ERHAAEVRRN KELQVELSG 179
    Length:179
    Mass (Da):20,756
    Last modified:April 13, 2004 - v2
    Checksum:i8B827AA3977E61B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591K → L no nucleotide entry (PubMed:3272176)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306458 mRNA. Translation: AAG33230.1.
    BC087660 mRNA. Translation: AAH87660.1.
    PIRiA36110.
    RefSeqiNP_445892.1. NM_053440.2.
    UniGeneiRn.34335.

    Genome annotation databases

    EnsembliENSRNOT00000015720; ENSRNOP00000015720; ENSRNOG00000011705.
    GeneIDi84510.
    KEGGirno:84510.
    UCSCiRGD:68947. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306458 mRNA. Translation: AAG33230.1 .
    BC087660 mRNA. Translation: AAH87660.1 .
    PIRi A36110.
    RefSeqi NP_445892.1. NM_053440.2.
    UniGenei Rn.34335.

    3D structure databases

    ProteinModelPortali P21818.
    SMRi P21818. Positions 40-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000056024.

    PTM databases

    PhosphoSitei P21818.

    Proteomic databases

    PaxDbi P21818.
    PRIDEi P21818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015720 ; ENSRNOP00000015720 ; ENSRNOG00000011705 .
    GeneIDi 84510.
    KEGGi rno:84510.
    UCSCi RGD:68947. rat.

    Organism-specific databases

    CTDi 11075.
    RGDi 68947. Stmn2.

    Phylogenomic databases

    eggNOGi NOG71188.
    GeneTreei ENSGT00390000003691.
    HOGENOMi HOG000013197.
    HOVERGENi HBG054037.
    OMAi DQIKENR.
    OrthoDBi EOG744TBN.

    Miscellaneous databases

    NextBioi 617089.
    PROi P21818.

    Gene expression databases

    Genevestigatori P21818.

    Family and domain databases

    InterProi IPR026729. Stathmin-2.
    IPR000956. Stathmin_fam.
    [Graphical view ]
    PANTHERi PTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF18. PTHR10104:SF18. 1 hit.
    Pfami PF00836. Stathmin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002285. Stathmin. 1 hit.
    PRINTSi PR00345. STATHMIN.
    SUPFAMi SSF101494. SSF101494. 1 hit.
    PROSITEi PS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons."
      Stein R., Mori N., Matthews K., Lo L.-C., Anderson D.J.
      Neuron 1:463-476(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Novel genes expressed in rat dorsal root ganglion."
      Xiao H., Huang Q., Zhang F., Yang Z., Chen Z., Han Z., Zhang X.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Spinal ganglion.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: FUNCTION.
    5. "JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length."
      Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J., Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T.
      J. Cell Biol. 173:265-277(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-62 AND SER-73, INTERACTION WITH MAPK8, MUTAGENESIS OF SER-62 AND SER-73.
    6. "Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth."
      Sobczak A., Debowska K., Blazejczyk M., Kreutz M.R., Kuznicki J., Wojda U.
      Biochim. Biophys. Acta 1813:1025-1037(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. Cited for: FUNCTION.

    Entry informationi

    Entry nameiSTMN2_RAT
    AccessioniPrimary (citable) accession number: P21818
    Secondary accession number(s): Q9ERH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3