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Protein

Cysteine dioxygenase type 1

Gene

Cdo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Pathwayi: taurine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes hypotaurine from L-cysteine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cysteine dioxygenase type 1 (Cdo1)
  2. Cysteine sulfinic acid decarboxylase (Csad)
This subpathway is part of the pathway taurine biosynthesis, which is itself part of Organosulfur biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes hypotaurine from L-cysteine, the pathway taurine biosynthesis and in Organosulfur biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Iron; via tele nitrogen; catalytic1 Publication1
Metal bindingi88Iron; via tele nitrogen; catalytic1 Publication1
Metal bindingi140Iron; via tele nitrogen; catalytic1 Publication1

GO - Molecular functioni

  • cysteine dioxygenase activity Source: UniProtKB
  • ferrous iron binding Source: RGD

GO - Biological processi

  • cysteine metabolic process Source: RGD
  • lactation Source: RGD
  • L-cysteine catabolic process Source: RGD
  • L-cysteine metabolic process Source: RGD
  • response to amino acid Source: RGD
  • response to cAMP Source: RGD
  • response to ethanol Source: RGD
  • response to glucagon Source: RGD
  • response to glucocorticoid Source: RGD
  • response to organonitrogen compound Source: RGD
  • taurine biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-8844
BRENDAi1.13.11.20 5301
ReactomeiR-RNO-1614558 Degradation of cysteine and homocysteine
SABIO-RKiP21816
UniPathwayiUPA00012; UER00537

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:Cdo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi69262 Cdo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066091 – 200Cysteine dioxygenase type 1Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)1 Publication

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.1 Publication

Keywords - PTMi

Thioether bond

Proteomic databases

PaxDbiP21816
PRIDEiP21816

Expressioni

Tissue specificityi

Highest levels in liver. Significant expression also in kidney, lung and brain.1 Publication

Developmental stagei

From neonate to weaning.

Inductioni

By increase of sulfur amino acid intake.

Gene expression databases

BgeeiENSRNOG00000000158
GenevisibleiP21816 RN

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000172

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 22Combined sources11
Beta strandi24 – 27Combined sources4
Helixi30 – 39Combined sources10
Helixi44 – 47Combined sources4
Helixi48 – 50Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi59 – 64Combined sources6
Helixi66 – 68Combined sources3
Beta strandi71 – 77Combined sources7
Beta strandi92 – 100Combined sources9
Beta strandi102 – 107Combined sources6
Beta strandi112 – 114Combined sources3
Beta strandi121 – 125Combined sources5
Beta strandi130 – 133Combined sources4
Turni135 – 137Combined sources3
Beta strandi139 – 143Combined sources5
Beta strandi151 – 159Combined sources9
Beta strandi162 – 167Combined sources6
Turni169 – 171Combined sources3
Beta strandi174 – 178Combined sources5
Beta strandi182 – 184Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B5HX-ray1.50A1-200[»]
2GH2X-ray1.50A1-200[»]
3ELNX-ray1.42A1-200[»]
4IEOX-ray1.55A1-200[»]
4IEPX-ray1.45A1-200[»]
4IEQX-ray1.40A1-200[»]
4IERX-ray1.45A1-200[»]
4IESX-ray1.40A1-200[»]
4IETX-ray1.40A1-200[»]
4IEUX-ray1.25A1-200[»]
4IEVX-ray1.60A1-200[»]
4IEWX-ray1.45A1-200[»]
4IEXX-ray2.15A1-200[»]
4IEYX-ray1.63A1-200[»]
4IEZX-ray1.39A1-200[»]
4JTNX-ray1.59A1-200[»]
4JTOX-ray2.00A1-200[»]
4KWJX-ray1.75A1-200[»]
4KWKX-ray1.95A1-200[»]
4KWLX-ray1.63A1-200[»]
4PIXX-ray1.35A1-200[»]
4PIYX-ray1.60A1-200[»]
4PIZX-ray1.40A1-200[»]
4PJYX-ray1.50A1-200[»]
4UBGX-ray1.90A1-200[»]
4UBHX-ray1.81A1-200[»]
4XETX-ray1.30A1-200[»]
4XEZX-ray1.25A1-200[»]
4XF0X-ray1.40A1-200[»]
4XF1X-ray1.55A1-200[»]
4XF3X-ray1.55A1-200[»]
4XF4X-ray1.35A1-200[»]
4XF9X-ray1.30A1-200[»]
4XFAX-ray1.65A1-200[»]
4XFBX-ray1.35A1-200[»]
4XFCX-ray1.35A1-200[»]
4XFFX-ray1.25A1-200[»]
4XFGX-ray1.40A1-200[»]
4XFHX-ray1.35A1-200[»]
4XFIX-ray1.40A1-200[»]
4YNIX-ray2.40A1-200[»]
4YSFX-ray1.94A1-200[»]
4YYOX-ray1.77A1-200[»]
4Z82X-ray1.70A1-200[»]
5EFUX-ray2.80A1-200[»]
5EZWX-ray1.65A1-200[»]
5FDBX-ray1.75A1-200[»]
5I0RX-ray1.35A1-200[»]
5I0SX-ray1.30A1-200[»]
5I0TX-ray1.37A1-200[»]
5I0UX-ray1.25A1-200[»]
ProteinModelPortaliP21816
SMRiP21816
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21816

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG4064 Eukaryota
ENOG410XQM4 LUCA
GeneTreeiENSGT00390000018226
HOGENOMiHOG000177818
HOVERGENiHBG004469
InParanoidiP21816
KOiK00456
OMAiDHGNAHC
OrthoDBiEOG091G0LAR
PhylomeDBiP21816
TreeFamiTF105636

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR010300 CDO_1
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR12918 PTHR12918, 1 hit
PfamiView protein in Pfam
PF05995 CDO_I, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

P21816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTELLKPR TLADLIRILH ELFAGDEVNV EEVQAVLEAY ESNPAEWALY
60 70 80 90 100
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG
110 120 130 140 150
NLKETLFDWP DKKSNEMIKK SERTLRENQC AYINDSIGLH RVENVSHTEP
160 170 180 190 200
AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP FTTSGSLENN
Length:200
Mass (Da):23,026
Last modified:May 1, 1991 - v1
Checksum:i118F1A3326B340F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89T → S in AAH70509 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35266 mRNA Translation: AAA40904.1
D83481 Genomic DNA Translation: BAA11925.1
BC070509 mRNA Translation: AAH70509.1
PIRiA34632
RefSeqiNP_434696.1, NM_052809.1
UniGeneiRn.2589

Genome annotation databases

EnsembliENSRNOT00000000172; ENSRNOP00000000172; ENSRNOG00000000158
GeneIDi81718
KEGGirno:81718
UCSCiRGD:69262 rat

Entry informationi

Entry nameiCDO1_RAT
AccessioniPrimary (citable) accession number: P21816
Secondary accession number(s): Q6NS32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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