Reviewed, UniProtKB/Swiss-Prot P21813 (CHEA_ENTAE)

Names and origin

Protein names

Recommended name:
    Chemotaxis protein cheA
    EC=2.7.13.3

Gene names

Name:

cheA

Organism

Enterobacter aerogenes (Aerobacter aerogenes)

Taxonomic identifier

548 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length	226 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either cheB or cheY By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cytoplasm.
Sequence similarities	Contains 1 cheW-like domain. Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Chemotaxis Two-component regulatory system
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 226	›226	Chemotaxis protein cheA		PRO_0000074713
Regions
	Domain	‹1 – 82	›82	Histidine kinase
	Domain	84 – 218	135	CheW-like
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P21813-1 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 948551B969D2D449	FASTA	226	24,186
	10 20 30 40 50 60 EKILAKAAAQ GLAVTDTMSD EEVGMLIFAP GFSTAEQVTD VSGRGVGMDV VKRNIQEMGG 70 80 90 100 110 120 HVEIHSRAGK GTSIRILLPL TLAILDGMSV KVNEEVFILP LNAVMESLQP QREDLHPMAG 130 140 150 160 170 180 GERMLQVRGE YLPLVELYRV FECAGAKTEA TQGIVVILQS AGRRNALLVD QLIGQHQCVK 190 200 210 220 NLETNYRKVP GISAATILGD GSVALIVDVS ALQMLNREKL LSAAAA

References

[1]	"Evolution of chemotactic-signal transducers in enteric bacteria." Dahl M.K., Boos W., Manson M.D. J. Bacteriol. 171:2361-2371(1989) [PubMed: 2496104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13048 / DSM 30053 / IFO 13534 / JCM 1235 / NCTC 10006.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M26411 Genomic DNA. Translation: AAA24795.1.
PIR	A32302.
3D structure databases
HSSP	HSSP built from PDB template 1I59 based on UniProtKB Q56310.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.13.3. 759.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR002545. CheW. IPR004358. Sig_transdc_His_kin-like_C. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF01584. CheW. 1 hit. PF02518. HATPase_c. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00260. CheW. 1 hit. SM00387. HATPase_c. 1 hit. [Graphical view]
PROSITE	PS50851. CHEW. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHEA_ENTAE

Accession

Primary (citable) accession number: P21813

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)