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P21810

- PGS1_HUMAN

UniProt

P21810 - PGS1_HUMAN

Protein

Biglycan

Gene

BGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    May be involved in collagen fiber assembly.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl
    2. extracellular matrix structural constituent Source: UniProtKB
    3. glycosaminoglycan binding Source: Ensembl

    GO - Biological processi

    1. blood vessel remodeling Source: Ensembl
    2. carbohydrate metabolic process Source: Reactome
    3. chondroitin sulfate biosynthetic process Source: Reactome
    4. chondroitin sulfate catabolic process Source: Reactome
    5. chondroitin sulfate metabolic process Source: Reactome
    6. dermatan sulfate biosynthetic process Source: Reactome
    7. extracellular matrix organization Source: Reactome
    8. glycosaminoglycan metabolic process Source: Reactome
    9. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
    10. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_163906. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biglycan
    Alternative name(s):
    Bone/cartilage proteoglycan I
    PG-S1
    Gene namesi
    Name:BGN
    Synonyms:SLRR1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:1044. BGN.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. extracellular region Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi lumen Source: Reactome
    5. lysosomal lumen Source: Reactome
    6. proteinaceous extracellular matrix Source: UniProtKB
    7. sarcolemma Source: Ensembl
    8. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25346.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 37182 PublicationsPRO_0000032691Add
    BLAST
    Chaini38 – 368331BiglycanPRO_0000032692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan)1 Publication
    Glycosylationi47 – 471O-linked (Xyl...) (glycosaminoglycan)1 Publication
    Disulfide bondi63 ↔ 69By similarity
    Disulfide bondi67 ↔ 76By similarity
    Glycosylationi180 – 1801O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi198 – 1981O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi270 – 2701N-linked (GlcNAc...)1 Publication
    Glycosylationi311 – 3111N-linked (GlcNAc...)1 Publication
    Disulfide bondi321 ↔ 354By similarity

    Post-translational modificationi

    The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiP21810.
    PaxDbiP21810.
    PRIDEiP21810.

    PTM databases

    PhosphoSiteiP21810.

    Miscellaneous databases

    PMAP-CutDBP21810.

    Expressioni

    Tissue specificityi

    Found in several connective tissues, especially in articular cartilages.

    Gene expression databases

    ArrayExpressiP21810.
    BgeeiP21810.
    CleanExiHS_BGN.
    GenevestigatoriP21810.

    Organism-specific databases

    HPAiCAB003678.
    HPA003157.

    Interactioni

    Subunit structurei

    Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107102. 9 interactions.
    IntActiP21810. 9 interactions.
    MINTiMINT-4529946.
    STRINGi9606.ENSP00000327336.

    Structurei

    3D structure databases

    ProteinModelPortaliP21810.
    SMRiP21810. Positions 61-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati82 – 10221LRR 1Add
    BLAST
    Repeati103 – 12624LRR 2Add
    BLAST
    Repeati127 – 15024LRR 3Add
    BLAST
    Repeati151 – 17121LRR 4Add
    BLAST
    Repeati172 – 19524LRR 5Add
    BLAST
    Repeati196 – 22025LRR 6Add
    BLAST
    Repeati221 – 24121LRR 7Add
    BLAST
    Repeati242 – 26524LRR 8Add
    BLAST
    Repeati266 – 28924LRR 9Add
    BLAST
    Repeati290 – 31223LRR 10Add
    BLAST
    Repeati313 – 34230LRR 11Add
    BLAST
    Repeati343 – 36826LRR 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi63 – 7614Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000261690.
    HOVERGENiHBG016052.
    InParanoidiP21810.
    KOiK08118.
    OMAiIQFGNYK.
    PhylomeDBiP21810.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view]
    PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002490. SLRP_I. 1 hit.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21810-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL    50
    DPDSVTPTYS AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN 100
    DISELRKDDF KGLQHLYALV LVNNKISKIH EKAFSPLRKL QKLYISKNHL 150
    VEIPPNLPSS LVELRIHDNR IRKVPKGVFS GLRNMNCIEM GGNPLENSGF 200
    EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK IQAIELEDLL 250
    RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK 300
    LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA 350
    TFRCVTDRLA IQFGNYKK 368
    Length:368
    Mass (Da):41,654
    Last modified:April 1, 1993 - v2
    Checksum:iBF16F304C5CD3B3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1402KL → NV in AAA52287. (PubMed:2647739)Curated
    Sequence conflicti163 – 1642EL → DV(PubMed:2647739)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti266 – 2661R → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036605
    Natural varianti288 – 2881K → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036606

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04599 mRNA. Translation: AAA36009.1.
    M65153, M65152 Genomic DNA. Translation: AAA52287.1. Sequence problems.
    U82695 Genomic DNA. No translation available.
    BT007323 mRNA. Translation: AAP35987.1.
    CH471172 Genomic DNA. Translation: EAW72863.1.
    CH471172 Genomic DNA. Translation: EAW72864.1.
    BC002416 mRNA. Translation: AAH02416.1.
    BC004244 mRNA. Translation: AAH04244.1.
    U11686 mRNA. Translation: AAC50117.1.
    CCDSiCCDS14721.1.
    PIRiA40757. BGHUN.
    RefSeqiNP_001702.1. NM_001711.4.
    UniGeneiHs.821.

    Genome annotation databases

    EnsembliENST00000331595; ENSP00000327336; ENSG00000182492.
    GeneIDi633.
    KEGGihsa:633.
    UCSCiuc004fhr.2. human.

    Polymorphism databases

    DMDMi266762.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04599 mRNA. Translation: AAA36009.1 .
    M65153 , M65152 Genomic DNA. Translation: AAA52287.1 . Sequence problems.
    U82695 Genomic DNA. No translation available.
    BT007323 mRNA. Translation: AAP35987.1 .
    CH471172 Genomic DNA. Translation: EAW72863.1 .
    CH471172 Genomic DNA. Translation: EAW72864.1 .
    BC002416 mRNA. Translation: AAH02416.1 .
    BC004244 mRNA. Translation: AAH04244.1 .
    U11686 mRNA. Translation: AAC50117.1 .
    CCDSi CCDS14721.1.
    PIRi A40757. BGHUN.
    RefSeqi NP_001702.1. NM_001711.4.
    UniGenei Hs.821.

    3D structure databases

    ProteinModelPortali P21810.
    SMRi P21810. Positions 61-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107102. 9 interactions.
    IntActi P21810. 9 interactions.
    MINTi MINT-4529946.
    STRINGi 9606.ENSP00000327336.

    PTM databases

    PhosphoSitei P21810.

    Polymorphism databases

    DMDMi 266762.

    Proteomic databases

    MaxQBi P21810.
    PaxDbi P21810.
    PRIDEi P21810.

    Protocols and materials databases

    DNASUi 633.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331595 ; ENSP00000327336 ; ENSG00000182492 .
    GeneIDi 633.
    KEGGi hsa:633.
    UCSCi uc004fhr.2. human.

    Organism-specific databases

    CTDi 633.
    GeneCardsi GC0XP152762.
    HGNCi HGNC:1044. BGN.
    HPAi CAB003678.
    HPA003157.
    MIMi 301870. gene.
    neXtProti NX_P21810.
    PharmGKBi PA25346.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000261690.
    HOVERGENi HBG016052.
    InParanoidi P21810.
    KOi K08118.
    OMAi IQFGNYK.
    PhylomeDBi P21810.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_163906. ECM proteoglycans.

    Miscellaneous databases

    ChiTaRSi BGN. human.
    GeneWikii Biglycan.
    GenomeRNAii 633.
    NextBioi 2558.
    PMAP-CutDB P21810.
    PROi P21810.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21810.
    Bgeei P21810.
    CleanExi HS_BGN.
    Genevestigatori P21810.

    Family and domain databases

    InterProi IPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view ]
    PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002490. SLRP_I. 1 hit.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species."
      Fisher L.W., Termine J.D., Young M.F.
      J. Biol. Chem. 264:4571-4576(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.
    2. "Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization."
      Fisher L.W., Heegaard A.M., Vetter U., Vogel W., Just W., Termine J.D., Young M.F.
      J. Biol. Chem. 266:14371-14377(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II."
      Roughley P.J., White R.J.
      Biochem. J. 262:823-827(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 38-57.
    9. "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."
      Fisher L.W., Hawkins G.R., Tuross N., Termine J.D.
      J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 38-66.
    10. "Dinucleotide repeat polymorphism at the human biglycan (BGN) locus."
      Just W., Rau W., Muller R., Geerkens C., Vogel W.
      Hum. Mol. Genet. 3:2268-2268(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 361-368.
      Tissue: Skin.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-270 AND ASN-311.
      Tissue: Liver.
    12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-266 AND ASN-288.

    Entry informationi

    Entry nameiPGS1_HUMAN
    AccessioniPrimary (citable) accession number: P21810
    Secondary accession number(s): D3DWU3, P13247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3