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Protein

Biglycan

Gene

BGN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in collagen fiber assembly.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022870. Chondroitin sulfate biosynthesis.
R-BTA-2022923. Dermatan sulfate biosynthesis.
R-BTA-2024101. CS/DS degradation.
R-BTA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
Leucine-rich PG I
PG-S1
Gene namesi
Name:BGN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003268517 – 372 PublicationsAdd BLAST21
ChainiPRO_000003268638 – 369BiglycanAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42O-linked (Xyl...) (glycosaminoglycan)1
Glycosylationi48O-linked (Xyl...) (glycosaminoglycan)1
Disulfide bondi64 ↔ 701 Publication
Disulfide bondi68 ↔ 771 Publication
Glycosylationi181O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi199O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)1
Glycosylationi312N-linked (GlcNAc...)1 Publication1
Disulfide bondi322 ↔ 3551 Publication

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP21809.
PeptideAtlasiP21809.
PRIDEiP21809.

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

BgeeiENSBTAG00000005250.

Interactioni

Subunit structurei

Homodimer. Forms a ternary complex with MFAP2 and ELN.1 Publication

Protein-protein interaction databases

IntActiP21809. 4 interactors.
STRINGi9913.ENSBTAP00000044462.

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi69 – 71Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi95 – 97Combined sources3
Turni108 – 113Combined sources6
Beta strandi119 – 121Combined sources3
Helixi132 – 134Combined sources3
Beta strandi143 – 145Combined sources3
Beta strandi164 – 166Combined sources3
Helixi178 – 180Combined sources3
Beta strandi188 – 190Combined sources3
Helixi198 – 200Combined sources3
Beta strandi218 – 220Combined sources3
Beta strandi226 – 228Combined sources3
Helixi273 – 276Combined sources4
Beta strandi282 – 284Combined sources3
Helixi297 – 299Combined sources3
Beta strandi305 – 307Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi328 – 330Combined sources3
Beta strandi333 – 337Combined sources5
Beta strandi340 – 343Combined sources4
Helixi345 – 347Combined sources3
Helixi350 – 353Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FT3X-ray3.40A/B/C/D/E/F38-369[»]
ProteinModelPortaliP21809.
SMRiP21809.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21809.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati83 – 103LRR 1Add BLAST21
Repeati104 – 127LRR 2Add BLAST24
Repeati128 – 151LRR 3Add BLAST24
Repeati152 – 172LRR 4Add BLAST21
Repeati173 – 196LRR 5Add BLAST24
Repeati197 – 221LRR 6Add BLAST25
Repeati222 – 242LRR 7Add BLAST21
Repeati243 – 266LRR 8Add BLAST24
Repeati267 – 290LRR 9Add BLAST24
Repeati291 – 313LRR 10Add BLAST23
Repeati314 – 343LRR 11Add BLAST30
Repeati344 – 369LRR 12Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 77Cys-richAdd BLAST14

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP21809.
KOiK08118.
OMAiQRGFWDF.
OrthoDBiEOG091G044B.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028547. Biglycan.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPLWPLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI
60 70 80 90 100
PDLDSLPPTY SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN
110 120 130 140 150
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH
160 170 180 190 200
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG
210 220 230 240 250
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL
260 270 280 290 300
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL
310 320 330 340 350
KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP
360
ATFRCVTDRL AIQFGNYKK
Length:369
Mass (Da):41,590
Last modified:May 2, 2006 - v3
Checksum:iB86C2149723AD0DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152V → C in AAB46746 (PubMed:8673009).Curated1
Sequence conflicti188C → E AA sequence (PubMed:2656687).Curated1
Sequence conflicti354R → A in AAB46746 (PubMed:8673009).Curated1
Sequence conflicti368 – 369KK → Y AA sequence (PubMed:2656687).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82652 mRNA. Translation: AAB46746.2.
BT021201 mRNA. Translation: AAX31383.1.
BC118460 mRNA. Translation: AAI18461.1.
PIRiS32559.
RefSeqiNP_847888.2. NM_178318.4.
XP_005227715.1. XM_005227658.3.
UniGeneiBt.5351.

Genome annotation databases

EnsembliENSBTAT00000047242; ENSBTAP00000044462; ENSBTAG00000005250.
GeneIDi280733.
KEGGibta:280733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82652 mRNA. Translation: AAB46746.2.
BT021201 mRNA. Translation: AAX31383.1.
BC118460 mRNA. Translation: AAI18461.1.
PIRiS32559.
RefSeqiNP_847888.2. NM_178318.4.
XP_005227715.1. XM_005227658.3.
UniGeneiBt.5351.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FT3X-ray3.40A/B/C/D/E/F38-369[»]
ProteinModelPortaliP21809.
SMRiP21809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21809. 4 interactors.
STRINGi9913.ENSBTAP00000044462.

Proteomic databases

PaxDbiP21809.
PeptideAtlasiP21809.
PRIDEiP21809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000047242; ENSBTAP00000044462; ENSBTAG00000005250.
GeneIDi280733.
KEGGibta:280733.

Organism-specific databases

CTDi633.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP21809.
KOiK08118.
OMAiQRGFWDF.
OrthoDBiEOG091G044B.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022870. Chondroitin sulfate biosynthesis.
R-BTA-2022923. Dermatan sulfate biosynthesis.
R-BTA-2024101. CS/DS degradation.
R-BTA-3000178. ECM proteoglycans.

Miscellaneous databases

EvolutionaryTraceiP21809.

Gene expression databases

BgeeiENSBTAG00000005250.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028547. Biglycan.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGS1_BOVIN
AccessioniPrimary (citable) accession number: P21809
Secondary accession number(s): P79259, Q17QB0, Q5BIM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 2, 2006
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.