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Protein

Peripherin

Gene

Prph

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Class-III neuronal intermediate filament protein.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • intermediate filament cytoskeleton organization Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin
Gene namesi
Name:Prph
Synonyms:Prph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3414. Prph.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: MGI
  • type III intermediate filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637811 – 468PeripherinAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei17Nitrated tyrosine1 Publication1
Modified residuei28PhosphoserineCombined sources1
Modified residuei33PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei111N6-acetyllysine; alternateBy similarity1
Modified residuei111N6-succinyllysine; alternateBy similarity1
Modified residuei214N6-acetyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei226N6-acetyllysineBy similarity1
Modified residuei287N6-acetyllysine; alternateBy similarity1
Modified residuei287N6-succinyllysine; alternateBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei366N6-acetyllysineBy similarity1
Modified residuei376Nitrated tyrosine1 Publication1
Modified residuei402PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei468Phosphotyrosine1 Publication1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbiP21807.
PeptideAtlasiP21807.
PRIDEiP21807.

PTM databases

iPTMnetiP21807.
PhosphoSitePlusiP21807.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DstQ91ZU63EBI-446227,EBI-446159From a different organism.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP21807. 2 interactors.
MINTiMINT-7138936.
STRINGi10116.ENSRNOP00000021010.

Structurei

3D structure databases

ProteinModelPortaliP21807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96HeadAdd BLAST96
Regioni97 – 402RodAdd BLAST306
Regioni97 – 129Coil 1AAdd BLAST33
Regioni130 – 140Linker 1Add BLAST11
Regioni141 – 236Coil 1BAdd BLAST96
Regioni237 – 259Linker 2Add BLAST23
Regioni260 – 402Coil 2Add BLAST143
Regioni403 – 468TailAdd BLAST66

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE39. Eukaryota.
ENOG410YCMG. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP21807.
PhylomeDBiP21807.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR027700. PRPH/Plasticin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF29. PTHR23239:SF29. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHSSGLRS SISSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSGS
60 70 80 90 100
PSSSARLGSF RAPRAGALRL PSERLDFSMA EALNQEFLAT RSNEKQELQE
110 120 130 140 150
LNDRFANFIE KVRFLEQQNA ALRGELSQAR GQEPARADQL CQQELRELRR
160 170 180 190 200
ELELLGRERD RVQVERDGLA EDLGALKQRL EEETRKREDA EHNLVLFRKD
210 220 230 240 250
VDDATLSRLE LERKIESLMD EIEFLKKLHE EELRDLQVSV ESQQVQQVEV
260 270 280 290 300
EATVKPELTA ALRDIRAQYE NIAAKNLQEA EEWYKSKYAD LSDAANRNHE
310 320 330 340 350
ALRQAKQEMN ESRRQIQSLT CEVDGLRGTN EALLRQLREL EEQFALEAGG
360 370 380 390 400
YQAGAARLEE ELRQLKEEMA RHLREYQELL NVKMALDIEI ATYRKLLEGE
410 420 430 440 450
ESRISVPVHS FASLSLKTTV PEVEPPQDSH SRKMVLIRTI ETRDGEKVVT
460
ESQKEQHSEL DKSSIHSY
Length:468
Mass (Da):53,550
Last modified:May 1, 1991 - v1
Checksum:iE42543338EBA5C05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158 – 160ERD → SAY (PubMed:3339087).Curated3
Sequence conflicti291L → K (PubMed:3339087).Curated1
Sequence conflicti436L → K (PubMed:3339087).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA. Translation: AAA41829.1.
AF031878 mRNA. Translation: AAB87067.1.
PIRiJN0016.
UniGeneiRn.11086.

Genome annotation databases

UCSCiRGD:3414. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA. Translation: AAA41829.1.
AF031878 mRNA. Translation: AAB87067.1.
PIRiJN0016.
UniGeneiRn.11086.

3D structure databases

ProteinModelPortaliP21807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21807. 2 interactors.
MINTiMINT-7138936.
STRINGi10116.ENSRNOP00000021010.

PTM databases

iPTMnetiP21807.
PhosphoSitePlusiP21807.

Proteomic databases

PaxDbiP21807.
PeptideAtlasiP21807.
PRIDEiP21807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3414. rat.

Organism-specific databases

RGDi3414. Prph.

Phylogenomic databases

eggNOGiENOG410IE39. Eukaryota.
ENOG410YCMG. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP21807.
PhylomeDBiP21807.

Miscellaneous databases

PROiP21807.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR027700. PRPH/Plasticin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF29. PTHR23239:SF29. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPERI_RAT
AccessioniPrimary (citable) accession number: P21807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.