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Protein

Peripherin

Gene

Prph

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Class-III neuronal intermediate filament protein.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • intermediate filament cytoskeleton organization Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin
Gene namesi
Name:Prph
Synonyms:Prph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3414. Prph.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: MGI
  • type III intermediate filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468PeripherinPRO_0000063781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Nitrated tyrosine1 Publication
Modified residuei28 – 281PhosphoserineCombined sources
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei376 – 3761Nitrated tyrosine1 Publication
Modified residuei468 – 4681Phosphotyrosine1 Publication

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiP21807.
PRIDEiP21807.

PTM databases

iPTMnetiP21807.
PhosphoSiteiP21807.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DstQ91ZU63EBI-446227,EBI-446159From a different organism.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP21807. 2 interactions.
MINTiMINT-7138936.
STRINGi10116.ENSRNOP00000021010.

Structurei

3D structure databases

ProteinModelPortaliP21807.
SMRiP21807. Positions 92-128, 321-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696HeadAdd
BLAST
Regioni97 – 402306RodAdd
BLAST
Regioni97 – 12933Coil 1AAdd
BLAST
Regioni130 – 14011Linker 1Add
BLAST
Regioni141 – 23696Coil 1BAdd
BLAST
Regioni237 – 25923Linker 2Add
BLAST
Regioni260 – 402143Coil 2Add
BLAST
Regioni403 – 46866TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE39. Eukaryota.
ENOG410YCMG. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP21807.
PhylomeDBiP21807.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR027700. PRPH/Plasticin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF29. PTHR23239:SF29. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHSSGLRS SISSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSGS
60 70 80 90 100
PSSSARLGSF RAPRAGALRL PSERLDFSMA EALNQEFLAT RSNEKQELQE
110 120 130 140 150
LNDRFANFIE KVRFLEQQNA ALRGELSQAR GQEPARADQL CQQELRELRR
160 170 180 190 200
ELELLGRERD RVQVERDGLA EDLGALKQRL EEETRKREDA EHNLVLFRKD
210 220 230 240 250
VDDATLSRLE LERKIESLMD EIEFLKKLHE EELRDLQVSV ESQQVQQVEV
260 270 280 290 300
EATVKPELTA ALRDIRAQYE NIAAKNLQEA EEWYKSKYAD LSDAANRNHE
310 320 330 340 350
ALRQAKQEMN ESRRQIQSLT CEVDGLRGTN EALLRQLREL EEQFALEAGG
360 370 380 390 400
YQAGAARLEE ELRQLKEEMA RHLREYQELL NVKMALDIEI ATYRKLLEGE
410 420 430 440 450
ESRISVPVHS FASLSLKTTV PEVEPPQDSH SRKMVLIRTI ETRDGEKVVT
460
ESQKEQHSEL DKSSIHSY
Length:468
Mass (Da):53,550
Last modified:May 1, 1991 - v1
Checksum:iE42543338EBA5C05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1603ERD → SAY (PubMed:3339087).Curated
Sequence conflicti291 – 2911L → K (PubMed:3339087).Curated
Sequence conflicti436 – 4361L → K (PubMed:3339087).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA. Translation: AAA41829.1.
AF031878 mRNA. Translation: AAB87067.1.
PIRiJN0016.
UniGeneiRn.11086.

Genome annotation databases

UCSCiRGD:3414. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26232 Genomic DNA. Translation: AAA41829.1.
AF031878 mRNA. Translation: AAB87067.1.
PIRiJN0016.
UniGeneiRn.11086.

3D structure databases

ProteinModelPortaliP21807.
SMRiP21807. Positions 92-128, 321-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21807. 2 interactions.
MINTiMINT-7138936.
STRINGi10116.ENSRNOP00000021010.

PTM databases

iPTMnetiP21807.
PhosphoSiteiP21807.

Proteomic databases

PaxDbiP21807.
PRIDEiP21807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3414. rat.

Organism-specific databases

RGDi3414. Prph.

Phylogenomic databases

eggNOGiENOG410IE39. Eukaryota.
ENOG410YCMG. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP21807.
PhylomeDBiP21807.

Miscellaneous databases

PROiP21807.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR027700. PRPH/Plasticin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF29. PTHR23239:SF29. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein."
    Thompson M.A., Ziff E.B.
    Neuron 2:1043-1053(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Translation initiation and assembly of peripherin in cultured cells."
    Ho C.L., Chin S.S., Carnevale K., Liem R.K.
    Eur. J. Cell Biol. 68:103-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein."
    Leonard D.G., Gorham J.D., Cole P., Greene L.A., Ziff E.B.
    J. Cell Biol. 106:181-193(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-468.
  4. "Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin)."
    Aletta J.M., Angeletti R., Liem R.K., Purcell C., Shelanski M.L., Greene L.A.
    J. Neurochem. 51:1317-1320(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 267-280.
  5. "A type III intermediate filament gene is expressed in mature neurons."
    Parysek L.M., Chisholm R.L., Ley C.A., Goldman R.D.
    Neuron 1:395-401(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 296-468.
  6. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 339-357 AND 404-417, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  7. "Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine."
    Angelastro J.M., Ho C.L., Frappier T., Liem R.K., Greene L.A.
    J. Neurochem. 70:540-549(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-468.
  8. "Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin."
    Tedeschi G., Cappelletti G., Nonnis S., Taverna F., Negri A., Ronchi C., Ronchi S.
    Neurochem. Res. 32:433-441(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NITRATION AT TYR-17 AND TYR-376, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPERI_RAT
AccessioniPrimary (citable) accession number: P21807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.