Reviewed, UniProtKB/Swiss-Prot P21805 (ANFC_CHICK)

Names and origin

Protein names

Recommended name:
    C-type natriuretic peptide
      Short name=CNP

Gene names

Name:

NPPC

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	22 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Vasorelaxant activity. Has a cGMP-stimulating activity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the natriuretic peptide family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone Vasoactive
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	regulation of blood vessel size Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 22	22	C-type natriuretic peptide		PRO_0000043486
Amino acid modifications
	Disulfide bond	6 ↔ 22

Sequences

	Sequence		Length	Mass (Da)
	P21805-1 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: FC2A4706D8DAC025	FASTA	22	2,244
	10 20 GLSRSCFGVK LDRIGSMSGL GC

References

[1]	"Isolation and identification of C-type natriuretic peptide in chicken brain." Arimura J.J., Minamino N., Kangawa K., Matsuo H. Biochem. Biophys. Res. Commun. 174:142-148(1991) [PubMed: 1989595] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Brain.

Cross-references

Sequence databases
IPI	IPI00582534.
PIR	JT0581.
UniGene	Gga.12392
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000004572. Gallus gallus. [Contig view]
Phylogenomic databases
HOGENOM	P21805.
HOVERGEN	P21805.
Family and domain databases
InterPro	IPR002408. Br__natriurtcpep. IPR000663. Natr_peptide. [Graphical view]
Pfam	PF00212. ANP. 1 hit. [Graphical view]
PRINTS	PR00712. BNATPEPTIDE. PR00710. NATPEPTIDES.
ProDom	PD005617. Natr_peptide. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00183. NAT_PEP. 1 hit. [Graphical view]
PROSITE	PS00263. NATRIURETIC_PEPTIDE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANFC_CHICK

Accession

Primary (citable) accession number: P21805

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)